{ "uniprot_canonical_ac": "A2AR02-1", "sequence": { "header": "sp|A2AR02-1|PPIG_MOUSE Isoform 1 of Peptidyl-prolyl cis-trans isomerase G OS=Mus musculus OX=10090 GN=Ppig PE=1 SV=1 CANONICAL=A2AR02-1", "length": 752, "sequence": "MGIKVQRPRCFFDIAINNQPAGRVVFELFSDVCPKTCENFRCLCTGEKGTGKSTQKPLHYKSCLFHRVVKDFMVQGGDFSEGNGRGGESIYGGFFEDESFAVKHNKEFLLSMANRGKDTNGSQFFITTKPTPHLDGHHVVFGQVISGQEVVREIENQKTDAASKPFAEVRILSCGELIPKSKVKKEEKKRHKSSSSSSSSDSDSSSDSQSSSESSDSESASEEKSRKRKKKHRKNSRKHKKEKKKRKKSKKSPSSESEAENVDAQPQSTVRPEEIPPIPENRFLMRKSPPKADDKERKNRERERERECNPPNSQPASYQRRFLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKEKKITDHRHMSESPNRKVEKEKKAKDHKSESKERDIRRNSEKDDKYNKNKVKKRGKSKSRSKSKERSKSKERDSKHSRHEDKRVRSRSKERDHETTKEKEKPLDPKGKDQERSRSKENSKQVESKSNEHDHSKSKEKDRRAQSRSRERDLTKSKHSYNSRTRERSRSRDRSRRVRSRSHDRDRSRSKEYHRYREQEYRRRGRSRSRDRRTPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYRSQESKSSHRKENSEGEKRTYSKSRDHNSSSNNREKKADREQSPVSKTKQSSQDNEVKSSTLKNQEDEKTRSPVEKENQKSKGQENDHVHDKNKKCDHESSPGTDEDKSG" }, "uniprot_id": "PPIG_MOUSE", "enzyme_annotation": [ { "ec": "5.2.1.8", "activity": "Peptidylproline (omega=180) = peptidylproline (omega=0)." }, { "ec": "5.2.1.8", "activity": "" } ], "synonyms": { "protein": { "refseq": [ "peptidyl-prolyl cis-trans isomerase G", "peptidylprolyl isomerase G; PPIase G; rotamase G; cyclophilin G" ], "uniprotkb": [ "Peptidyl-prolyl cis-trans isomerase G", "PPIase G", "5.2.1.8", "Peptidyl-prolyl isomerase G", "Rotamase G", "Cyclophilin G" ] }, "gene": { "refseq": [ "Ppig", "AU019516", "AU022200", "B230312B02Rik", "CYP", "SRCyp" ], "uniprotkb": [ "Ppig", "AU019516", "AU022200", "B230312B02Rik", "CYP", "SRCyp" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Peptidyl-prolyl cis-trans isomerase G; PPIase G; 5.2.1.8; Peptidyl-prolyl isomerase G; Rotamase G; Cyclophilin G.", "short": "PPIase G" }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AR02#A2AR02-1", "isoform_ac": "A2AR02-1", "locus": { "end_pos": 69732214, "start_pos": 69750379, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000040915", "id": "ENSMUST00000040915", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000045945", "id": "ENSMUSP00000045945", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AR02-1|PPIG_MOUSE Isoform 1 of Peptidyl-prolyl cis-trans isomerase G OS=Mus musculus OX=10090 GN=Ppig PE=1 SV=1 CANONICAL=A2AR02-1", "length": 752, "sequence": "MGIKVQRPRCFFDIAINNQPAGRVVFELFSDVCPKTCENFRCLCTGEKGTGKSTQKPLHYKSCLFHRVVKDFMVQGGDFSEGNGRGGESIYGGFFEDESFAVKHNKEFLLSMANRGKDTNGSQFFITTKPTPHLDGHHVVFGQVISGQEVVREIENQKTDAASKPFAEVRILSCGELIPKSKVKKEEKKRHKSSSSSSSSDSDSSSDSQSSSESSDSESASEEKSRKRKKKHRKNSRKHKKEKKKRKKSKKSPSSESEAENVDAQPQSTVRPEEIPPIPENRFLMRKSPPKADDKERKNRERERERECNPPNSQPASYQRRFLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKEKKITDHRHMSESPNRKVEKEKKAKDHKSESKERDIRRNSEKDDKYNKNKVKKRGKSKSRSKSKERSKSKERDSKHSRHEDKRVRSRSKERDHETTKEKEKPLDPKGKDQERSRSKENSKQVESKSNEHDHSKSKEKDRRAQSRSRERDLTKSKHSYNSRTRERSRSRDRSRRVRSRSHDRDRSRSKEYHRYREQEYRRRGRSRSRDRRTPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYRSQESKSSHRKENSEGEKRTYSKSRDHNSSSNNREKKADREQSPVSKTKQSSQDNEVKSSTLKNQEDEKTRSPVEKENQKSKGQENDHVHDKNKKCDHESSPGTDEDKSG" } }, { "url": "https://www.uniprot.org/uniprot/A2AR02#A2AR01-1", "isoform_ac": "A2AR01-1", "locus": { "end_pos": 69732214, "start_pos": 69735871, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000144652", "id": "ENSMUST00000144652", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000114570", "id": "ENSMUSP00000114570", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2AR01-1|PPIG_MOUSE Computationally mapped isoform of Peptidyl-prolyl cis-trans isomerase G OS=Mus musculus OX=10090 GN=Ppig PE=1 SV=1 CANONICAL=A2AR02-1", "length": 127, "sequence": "MGIKVQRPRCFFDIAINNQPAGRVVFELFSDVCPKTCENFRCLCTGEKGTGKSTQKPLHYKSCLFHRVVKDFMVQGGDFSEGNGRGGESIYGGFFEDESFAVKHNKEFLLSMANRGKDTNGSQFFIT" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:228005", "resource": "KEGG Pathway", "id": "mmu:228005", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2AR02#function", "annotation": "PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02#function", "id": "A2AR02", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "O55035-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase G; PPIase G; 5.2.1.8; Peptidyl-prolyl isomerase G; Matrin cyclophilin; Matrin-cyp; Rotamase G; Cyclophilin G.", "sequence": { "length": 752, "sequence": "MGIKVQRPRCFFDIAINNQPAGRVVFELFSDVCPKTCENFRCLCTGEKGTGKSTQKPLHYKSCLFHRVVKDFMVQGGDFSEGNGRGGESIYGGFFEDESFAVKHNKEFLLSMANRGKDTNGSQFFITTKPTPHLDGHHVVFGQVISGQEVVREIENQKTDAASKPFAEVRILSCGELVPKSKVKKEEKKRHKSSSSSSSSDSDSSSDSQSSSDSSDSESASEEKSRKRKKKHRKNSRKHKKEKKKRKKSKKSPSSESEADNVDAQPQSTVRPEEIPPIPENRFLMRKSPPKADDKERKNRERERERECNPPNSQPASYQRRFLVTRFGRKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKEKKITDHRHMSESPNRKIEKEKKVKDHKSESKERDIRRNSEKDDKYNKNKVKKRGKSKSRSKSKERSKSKERDSKHSRHEDKRVRSRSKERDHETTKEKEKQLDSKGKDQERSRSKENSKQVESKSNEHDHSKSKEKDRRAQSRSRERDLTKSKHSYNSRTRERSRSRDRSRRVRSRSHDRDRSRSKEYHRYREQEYRRRGRSRSRDRRTPGRSRSKDRRRRRRDSRSSEREESQSRNKEKYRSQDSKSSHRKENSEGEKRMYSKSRDHSSSNNNREKKADIDQSPVSKTKQSSQDNEVKSSTLKNQEDEKTRSPVEKENQKSKGQENDHVHDKNKKCDHESSPGTDEDKSG" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/3520", "id": "3520", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q13427-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase G; PPIase G; 5.2.1.8; Peptidyl-prolyl isomerase G; Clk-associating RS-cyclophilin; CARS-Cyp; CARS-cyclophilin; SR-cyclophilin; SR-cyp; SRcyp; Rotamase G; Cyclophilin G; CASP10.", "sequence": { "length": 754, "sequence": "MGIKVQRPRCFFDIAINNQPAGRVVFELFSDVCPKTCENFRCLCTGEKGTGKSTQKPLHYKSCLFHRVVKDFMVQGGDFSEGNGRGGESIYGGFFEDESFAVKHNKEFLLSMANRGKDTNGSQFFITTKPTPHLDGHHVVFGQVISGQEVVREIENQKTDAASKPFAEVRILSCGELIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPPKADEKERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFSKIKQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQENDHVHEKNKKFDHESSPGTDEDKSG" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/3520", "id": "3520", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2AR02/", "id": "A2AR02", "database": "OMA" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074555.1", "ac": "NP_001074555.1", "name": "peptidyl-prolyl cis-trans isomerase G; peptidylprolyl isomerase G; PPIase G; rotamase G; cyclophilin G.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051082", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "name": "unfolded protein binding", "id": "GO:0051082" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016018", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "name": "cyclosporin A binding", "id": "GO:0016018" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003755", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "name": "peptidyl-prolyl cis-trans isomerase activity", "id": "GO:0003755" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "name": "nuclear speck", "id": "GO:0016607" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016363", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "name": "nuclear matrix", "id": "GO:0016363" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042026", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "name": "protein refolding", "id": "GO:0042026" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000413", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "name": "protein peptidyl-prolyl isomerization", "id": "GO:0000413" } ], "total": 2, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 122, "annotation": "n_glycosylation_sequon", "start_pos": 120 }, { "end_pos": 672, "annotation": "n_glycosylation_sequon", "start_pos": 670 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074555.1", "id": "NP_001074555.1", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:228005", "id": "mmu:228005", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000042133", "id": "ENSMUSG00000042133", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/VNKRDAS/", "id": "VNKRDAS", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002130", "id": "IPR002130", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR020892", "id": "IPR020892", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR029000", "id": "IPR029000", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00160", "id": "PF00160", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2AR02", "id": "PR_A2AR02", "database": "PRO" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2AR02*", "id": "A2AR02", "database": "IntAct" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/228005", "id": "228005", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:2445173", "id": "2445173", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A2AR02", "disease": [], "mass": { "monoisotopic_mass": 88325.0, "chemical_mass": 88325.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "name": "Ppig; AU019516; AU022200; B230312B02Rik; CYP; SRCyp.", "locus": { "end_pos": 69754012, "start_pos": 69722545, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000042133", "id": "ENSMUSG00000042133", "database": "Ensembl Gene" } ] } } ] }