{
    "bcoid": "GLY_000320",
    "title": "Human Protein Reactions (Reactome)",
    "description": "The Human Protein Reactions (Reactome) dataset contains reactions information for pathways for human ...",
    "filename": "human_protein_reactions_reactome.csv",
    "filetype": "csv",
    "categories": {
        "species": "Homo sapiens",
        "molecule": "Protein",
        "tags": "Reactions Reactome",
        "file_type": "csv",
        "status": "Reviewed",
        "scope": "internal"
    },
    "minitable": {
        "content": [
            [
                "R-HSA-110141...",
                "(d)ADP + ADP..."
            ],
            [
                "R-HSA-110141...",
                "(d)ADP + ADP..."
            ]
        ],
        "headers": [
            "reaction_id...",
            "reaction_nam..."
        ],
        "colwidth": [
            "40%",
            "20%"
        ]
    },
    "sampledata": {
        "type": "table",
        "data": [
            [
                {
                    "type": "string",
                    "label": "reaction_id"
                },
                {
                    "type": "string",
                    "label": "reaction_name"
                },
                {
                    "type": "string",
                    "label": "cellular_location"
                },
                {
                    "type": "string",
                    "label": "pmid"
                },
                {
                    "type": "string",
                    "label": "pathway_id"
                }
            ],
            [
                "R-HSA-110141",
                "(d)ADP + ADP <=> (d)AMP + ATP (AK1)",
                "plasma membrane",
                "211388",
                "R-HSA-499943"
            ],
            [
                "R-HSA-110141",
                "(d)ADP + ADP <=> (d)AMP + ATP (AK1)",
                "plasma membrane",
                " 2542324",
                "R-HSA-499943"
            ],
            [
                "R-HSA-1222685",
                "Cathelicidin LL-37 binds to bacterial cell wall",
                "plasma membrane",
                "18160480",
                "R-HSA-6803157"
            ],
            [
                "R-HSA-1222685",
                "Cathelicidin LL-37 binds to bacterial cell wall",
                "plasma membrane",
                " 22701042",
                "R-HSA-6803157"
            ],
            [
                "R-HSA-1362417",
                "Mitoferrin translocates iron from the mitochondrial intermembrane space to the mitochondrial matrix",
                "plasma membrane",
                "",
                "R-HSA-1362409"
            ],
            [
                "R-HSA-140806",
                "antithrombin III + heparin -> antithrombin III:heparin",
                "plasma membrane",
                "12907439",
                "R-HSA-140875"
            ],
            [
                "R-HSA-1467457",
                "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region",
                "plasma membrane",
                "12379217",
                "R-HSA-382556"
            ],
            [
                "R-HSA-1467457",
                "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region",
                "plasma membrane",
                " 15899824",
                "R-HSA-382556"
            ],
            [
                "R-HSA-1467457",
                "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region",
                "plasma membrane",
                " 3457471",
                "R-HSA-382556"
            ],
            [
                "R-HSA-1482775",
                "MLCL is acylated to CL by HADH (IM)",
                "plasma membrane",
                "19737925",
                "R-HSA-1482798"
            ],
            [
                "R-HSA-1482889",
                "DAG is acylated to TAG by DGAT1/2",
                "plasma membrane",
                "11481335",
                "R-HSA-1482883"
            ],
            [
                "R-HSA-1482889",
                "DAG is acylated to TAG by DGAT1/2",
                "plasma membrane",
                " 14521909",
                "R-HSA-1482883"
            ],
            [
                "R-HSA-1482889",
                "DAG is acylated to TAG by DGAT1/2",
                "plasma membrane",
                " 9756920",
                "R-HSA-1482883"
            ],
            [
                "R-HSA-1482962",
                "CDP-ETA and DAG are converted to PE by CEPT1/EPT1",
                "plasma membrane",
                "10893425",
                "R-HSA-1483213"
            ],
            [
                "R-HSA-1482962",
                "CDP-ETA and DAG are converted to PE by CEPT1/EPT1",
                "plasma membrane",
                " 12221122",
                "R-HSA-1483213"
            ],
            [
                "R-HSA-1482962",
                "CDP-ETA and DAG are converted to PE by CEPT1/EPT1",
                "plasma membrane",
                " 10191259",
                "R-HSA-1483213"
            ],
            [
                "R-HSA-1482962",
                "CDP-ETA and DAG are converted to PE by CEPT1/EPT1",
                "plasma membrane",
                " 12216837",
                "R-HSA-1483213"
            ],
            [
                "R-HSA-1482962",
                "CDP-ETA and DAG are converted to PE by CEPT1/EPT1",
                "plasma membrane",
                " 17132865",
                "R-HSA-1483213"
            ],
            [
                "R-HSA-1592362",
                "Activation of proMMP7 by MMP3",
                "plasma membrane",
                "7896811",
                "R-HSA-1592389"
            ],
            [
                "R-HSA-1604763",
                "Autocatalytic activation of MMP7",
                "plasma membrane",
                "1390635",
                "R-HSA-1592389"
            ],
            [
                "R-HSA-170799",
                "cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP)",
                "plasma membrane",
                "14627435",
                "R-HSA-170822"
            ],
            [
                "R-HSA-170799",
                "cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP)",
                "plasma membrane",
                " 10601273",
                "R-HSA-170822"
            ],
            [
                "R-HSA-170810",
                "nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP)",
                "plasma membrane",
                "10601273",
                "R-HSA-170822"
            ],
            [
                "R-HSA-170824",
                "glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex",
                "plasma membrane",
                "14627435",
                "R-HSA-170822"
            ],
            [
                "R-HSA-170825",
                "glucokinase [nucleoplasm] => glucokinase [cytosol]",
                "plasma membrane",
                "10601273",
                "R-HSA-170822"
            ],
            [
                "R-HSA-174374",
                "MTR transfers CH3 from MeCbl to HCYS",
                "plasma membrane",
                "8968737",
                "R-HSA-196741"
            ],
            [
                "R-HSA-176606",
                "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate",
                "plasma membrane",
                "10224133",
                "R-HSA-156584"
            ],
            [
                "R-HSA-1791122",
                "Expression of PDIA5",
                "plasma membrane",
                "16539657",
                "R-HSA-381038"
            ],
            [
                "R-HSA-1791123",
                "Expression of KDELR3",
                "plasma membrane",
                "16539657",
                "R-HSA-381038"
            ],
            [
                "R-HSA-1793209",
                "HYAL1 hydrolyses Chondroitin chains",
                "plasma membrane",
                "9223416",
                "R-HSA-2024101"
            ],
            [
                "R-HSA-188979",
                "Digestion of linear starch (amylose) by extracellular amylase",
                "plasma membrane",
                "15299664",
                "R-HSA-189085"
            ],
            [
                "R-HSA-188979",
                "Digestion of linear starch (amylose) by extracellular amylase",
                "plasma membrane",
                " 2452973",
                "R-HSA-189085"
            ],
            [
                "R-HSA-188979",
                "Digestion of linear starch (amylose) by extracellular amylase",
                "plasma membrane",
                " 10769135",
                "R-HSA-189085"
            ],
            [
                "R-HSA-189425",
                "UROD decarboxylates URO3 to COPRO3",
                "plasma membrane",
                "8644733",
                "R-HSA-189451"
            ],
            [
                "R-HSA-189425",
                "UROD decarboxylates URO3 to COPRO3",
                "plasma membrane",
                " 6822570",
                "R-HSA-189451"
            ],
            [
                "R-HSA-189465",
                "FECH binds Fe2+ to PRIN9 to form heme",
                "plasma membrane",
                "11175906",
                "R-HSA-189451"
            ],
            [
                "R-HSA-190182",
                "UROD decarboxylates URO1 to COPRO1",
                "plasma membrane",
                "8644733",
                "R-HSA-189451"
            ],
            [
                "R-HSA-190182",
                "UROD decarboxylates URO1 to COPRO1",
                "plasma membrane",
                " 6822570",
                "R-HSA-189451"
            ],
            [
                "R-HSA-191114",
                "Digestion of branched starch (amylopectin) by extracellular amylase",
                "plasma membrane",
                "15299664",
                "R-HSA-189085"
            ],
            [
                "R-HSA-191114",
                "Digestion of branched starch (amylopectin) by extracellular amylase",
                "plasma membrane",
                " 2452973",
                "R-HSA-189085"
            ],
            [
                "R-HSA-191114",
                "Digestion of branched starch (amylopectin) by extracellular amylase",
                "plasma membrane",
                " 10769135",
                "R-HSA-189085"
            ],
            [
                "R-HSA-194674",
                "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR]",
                "plasma membrane",
                "12618959",
                "R-HSA-191273"
            ],
            [
                "R-HSA-196754",
                "COASY transfers an adenylyl group from ATP to PPANT",
                "plasma membrane",
                "11994049",
                "R-HSA-196783"
            ],
            [
                "R-HSA-196754",
                "COASY transfers an adenylyl group from ATP to PPANT",
                "plasma membrane",
                " 14514684",
                "R-HSA-196783"
            ],
            [
                "R-HSA-196773",
                "COASY phosphorylates DP-CoA",
                "plasma membrane",
                "11994049",
                "R-HSA-196783"
            ],
            [
                "R-HSA-196773",
                "COASY phosphorylates DP-CoA",
                "plasma membrane",
                " 14514684",
                "R-HSA-196783"
            ],
            [
                "R-HSA-198513",
                "Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4",
                "plasma membrane",
                "9428641",
                "R-HSA-70263"
            ],
            [
                "R-HSA-198513",
                "Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4",
                "plasma membrane",
                " 9758626",
                "R-HSA-70263"
            ],
            [
                "R-HSA-198513",
                "Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4",
                "plasma membrane",
                " 18337460",
                "R-HSA-70263"
            ],
            [
                "R-HSA-202328",
                "Translocation of PKC theta to plasma membrane",
                "plasma membrane",
                "12473184",
                "R-HSA-202424"
            ],
            [
                "R-HSA-202328",
                "Translocation of PKC theta to plasma membrane",
                "plasma membrane",
                " 16978534",
                "R-HSA-202424"
            ],
            [
                "R-HSA-202328",
                "Translocation of PKC theta to plasma membrane",
                "plasma membrane",
                " 11358993",
                "R-HSA-202424"
            ],
            [
                "R-HSA-202328",
                "Translocation of PKC theta to plasma membrane",
                "plasma membrane",
                " 17548359",
                "R-HSA-202424"
            ],
            [
                "R-HSA-2046083",
                "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA",
                "plasma membrane",
                "10970790",
                "R-HSA-2046105"
            ],
            [
                "R-HSA-2046088",
                "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA",
                "plasma membrane",
                "10899997",
                "R-HSA-2046106"
            ],
            [
                "R-HSA-2046088",
                "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA",
                "plasma membrane",
                " 12716664",
                "R-HSA-2046106"
            ],
            [
                "R-HSA-2046090",
                "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA",
                "plasma membrane",
                "14636670",
                "R-HSA-2046106"
            ],
            [
                "R-HSA-2046090",
                "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA",
                "plasma membrane",
                " 1834642",
                "R-HSA-2046106"
            ],
            [
                "R-HSA-2046094",
                "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA",
                "plasma membrane",
                "10970790",
                "R-HSA-2046105"
            ],
            [
                "R-HSA-2046094",
                "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA",
                "plasma membrane",
                " 8609415",
                "R-HSA-2046105"
            ],
            [
                "R-HSA-2046094",
                "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA",
                "plasma membrane",
                " 9732298",
                "R-HSA-2046105"
            ],
            [
                "R-HSA-2046095",
                "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA",
                "plasma membrane",
                "14636670",
                "R-HSA-2046105"
            ],
            [
                "R-HSA-2046095",
                "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA",
                "plasma membrane",
                " 5411545",
                "R-HSA-2046105"
            ],
            [
                "R-HSA-2046095",
                "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA",
                "plasma membrane",
                " 9704073",
                "R-HSA-2046105"
            ],
            [
                "R-HSA-2046100",
                "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA",
                "plasma membrane",
                "12323085",
                "R-HSA-2046106"
            ],
            [
                "R-HSA-2046100",
                "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA",
                "plasma membrane",
                " 12323090",
                "R-HSA-2046106"
            ],
            [
                "R-HSA-2046100",
                "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA",
                "plasma membrane",
                " 8832760",
                "R-HSA-2046106"
            ],
            [
                "R-HSA-210282",
                "Interaction of GPVI and FceRI gamma",
                "plasma membrane",
                "16102042",
                "R-HSA-75892"
            ],
            [
                "R-HSA-210282",
                "Interaction of GPVI and FceRI gamma",
                "plasma membrane",
                " 9280292",
                "R-HSA-75892"
            ],
            [
                "R-HSA-211193",
                "Homodimerization  of DFF40",
                "plasma membrane",
                "10318789",
                "R-HSA-140342"
            ],
            [
                "R-HSA-211193",
                "Homodimerization  of DFF40",
                "plasma membrane",
                " 12748178",
                "R-HSA-140342"
            ],
            [
                "R-HSA-211193",
                "Homodimerization  of DFF40",
                "plasma membrane",
                " 15149602",
                "R-HSA-140342"
            ],
            [
                "R-HSA-211207",
                "Cleaved fragments of DFF45 dissociate from  DFF40",
                "plasma membrane",
                "9108473",
                "R-HSA-140342"
            ],
            [
                "R-HSA-211224",
                "Association of DFF40 with DFF45",
                "plasma membrane",
                "9108473",
                "R-HSA-140342"
            ],
            [
                "R-HSA-211881",
                "Coumarin is 7-hydroxylated by CYP2A13",
                "plasma membrane",
                "15196988",
                "R-HSA-211981"
            ],
            [
                "R-HSA-211991",
                "Cyclophosphamide is 4-hydroxylated by CYP2B6",
                "plasma membrane",
                "12629583",
                "R-HSA-211981"
            ],
            [
                "R-HSA-212005",
                "CYP2F1 dehydrogenates 3-methylindole",
                "plasma membrane",
                "10383923",
                "R-HSA-211981"
            ],
            [
                "R-HSA-2160874",
                "HYAL1 hydrolyses (HA)50",
                "plasma membrane",
                "16104017",
                "R-HSA-2160916"
            ],
            [
                "R-HSA-2161538",
                "abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate",
                "plasma membrane",
                "17709369",
                "R-HSA-2161517"
            ],
            [
                "R-HSA-2161549",
                "PGH2 is reduced to PGF2a by AKR1C3",
                "plasma membrane",
                "10622721",
                "R-HSA-2162123"
            ],
            [
                "R-HSA-2161549",
                "PGH2 is reduced to PGF2a by AKR1C3",
                "plasma membrane",
                " 14979715",
                "R-HSA-2162123"
            ],
            [
                "R-HSA-2161549",
                "PGH2 is reduced to PGF2a by AKR1C3",
                "plasma membrane",
                " 16475787",
                "R-HSA-2162123"
            ],
            [
                "R-HSA-2161614",
                "PGD2 is reduced to 11-epi-PGF2a by AKRIC3",
                "plasma membrane",
                "15047184",
                "R-HSA-2162123"
            ],
            [
                "R-HSA-2161614",
                "PGD2 is reduced to 11-epi-PGF2a by AKRIC3",
                "plasma membrane",
                " 3862115",
                "R-HSA-2162123"
            ]
        ]
    },
    "readme": "Name\n   - Human Protein Reactions (Reactome)\n\nVersion\n   - 1.5.23\n\nCreated on\n  - 2019-11-30T15:06:36.890527\n\nModified on\n   - 2020-04-11T11:29:06.501899\n\nCreated by\n   - Jeet Vora [jeetvora@gwu.edu], Rahi Navelkar [rsn13@gwu.edu], Robel Kahsay [rykahsay@gwu.edu], Xavier Holmes [xavierh@email.gwu.edu]\n\nAuthors\n   - Maria Martin [martin@ebi.ac.uk], Preethi Vasudev [pvasudev@ebi.ac.uk]\n\nChecksum\n   - \n\nUsability Domain\n   - The Human Protein Reactions (Reactome) dataset contains reactions information for pathways for human [taxid:9606] UniProtKB accessions that includes reaction participants, pathway ID, reaction ID, PMID etc from Reactome database. The dataset is derived from 2019-09 UniProtKB release. If you use this dataset please provide proper attribution to EMBL-EBI-UniProtKB and GlyGen\n\nDescription Domain\n   Keywords\n   - Reactome\n   - Pathway\n   - Reactions\n   - PMID\n\n   Pipeline Steps\n   - Step-1: The script loads the Reactome reaction data from the triplestore containing triples from nt file to retrieve the information associated with the Reactome IDs and maps it to the UniProtKB canonical accessions and extracts the dataset in the csv format\n\nExecution Domain\n   Scripts   - https://github.com/GW-HIVE/glygen-backend-integration/blob/master/pipeline/integrator/make-protein-dataset.py\n\n\n   Software Prerequisites\n      Name: Python\n      Version: 2.7.5\n      URI: https://www.python.org/download/releases/2.7.5/\n\nI/O Domain\n   Input Subdomain\n      Name: uniprot-proteome-homo-sapiens.nt\n      URI: https://data.glygen.org/ln2wwwdata/source/uniprot-proteome-homo-sapiens.nt\n      Name: human_protein_masterlist.csv\n      URI: https://data.glygen.org/ln2wwwdata/reviewed/human_protein_masterlist.csv\n   Output Subdomain\n      Name: human_protein_reactions_reactome.csv\n      URI: http://data.glygen.org/ln2wwwdata/reviewed/human_protein_reactions_reactome.csv\n      Name: human_protein_reactions_reactome.stat.csv\n      URI: http://data.glygen.org/ln2wwwdata/reviewed/human_protein_reactions_reactome.stat.csv\n\nFields\n      Name: \"reaction_id\"\n     Description: \"The identifier assigned to a reaction in Reactome database\"\n      Unique Values: \"11879\"\n      Name: \"reaction_name\"\n     Description: \"The name assigned to a reaction in Reactome database\"\n      Unique Values: \"11814\"\n      Name: \"pmid\"\n     Description: \"NCBI PubMed database Identifier\"\n      Unique Values: \"17347\"\n      Name: \"pathway_id\"\n     Description: \"Pathway Identifier\"\n      Unique Values: \"1818\"\n      Name: \"cellular_location\"\n     Description: \"The loaction in the cell where reaction occurs\"\n      Unique Values: \"1\"",
    "downloadurl": "/ln2data/releases/data/v-1.5.23/reviewed/human_protein_reactions_reactome.csv"
}