{ "bcoid": "GLY_000324", "title": "Mouse Protein Enzyme Annotation (UniProtKB)", "description": "The Mouse Protein Enzyme Annotation (UniProtKB) dataset contains mouse [taxid:10090] enzyme annotations ...", "filename": "mouse_protein_enzyme_annotation_uniprotkb.csv", "filetype": "csv", "categories": { "species": "Mus musculus", "molecule": "Protein", "tags": "enzyme annotation", "file_type": "csv", "status": "Reviewed", "scope": "internal" }, "minitable": { "content": [ [ "E9Q0N2-1...", "3.1.3.48..." ], [ "E9Q0N2-1...", "3.1.3.48..." ] ], "headers": [ "uniprotkb_ca...", "enzyme_ec..." ], "colwidth": [ "40%", "20%" ] }, "sampledata": { "type": "table", "data": [ [ { "type": "string", "label": "uniprotkb_canonical_ac" }, { "type": "string", "label": "enzyme_ec" }, { "type": "string", "label": "enzyme_activity" } ], [ "E9Q0N2-1", "3.1.3.48", "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." ], [ "E9Q0N2-1", "3.1.3.48", "" ], [ "Q8C0S1-1", "3.1.13.-", "" ], [ "Q8C0S1-1", "3.1.13.-", "" ], [ "Q61831-1", "2.7.11.24", "ATP + a protein = ADP + a phosphoprotein." ], [ "Q61831-1", "2.7.11.24", "" ], [ "Q6P5D3-1", "3.6.4.13", "ATP + H(2)O = ADP + phosphate." ], [ "Q6P5D3-1", "3.6.4.13", "" ], [ "A2RSX7-1", "1.14.11.42", "7-(3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + 2-oxoglutarate + O(2) = 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + succinate + CO(2)." ], [ "A2RSX7-1", "1.14.11.42", "" ], [ "Q3U1C6-1", "3.1.21.-", "" ], [ "Q3U1C6-1", "3.1.21.-", "" ], [ "Q8BVU5-1", "3.6.1.13", "ADP-D-ribose + H(2)O = AMP + D-ribose 5-phosphate." ], [ "Q8BVU5-1", "3.6.1.13", "" ], [ "Q9D8H7-1", "3.4.24.-", "" ], [ "Q9D8H7-1", "3.4.24.-", "" ], [ "Q6UQ17-1", "7.6.2.1", "ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2)." ], [ "Q6UQ17-1", "7.6.2.1", "" ], [ "Q9D6L8-1", "5.2.1.8", "Peptidylproline (omega=180) = peptidylproline (omega=0)." ], [ "Q9D6L8-1", "5.2.1.8", "" ], [ "Q6NSR3-1", "2.7.11.-", "" ], [ "Q6NSR3-1", "2.7.11.-", "" ], [ "Q6NSR8-1", "3.4.11.-", "" ], [ "Q6NSR8-1", "3.4.11.-", "" ], [ "Q6SKR2-1", "2.1.1.-", "" ], [ "Q6SKR2-1", "2.1.1.72", "S-adenosyl-L-methionine + adenine in DNA = S-adenosyl-L-homocysteine + N-6-methyladenine in DNA." ], [ "Q8VDG5-1", "6.3.2.51", "ATP + (R)-4'-phosphopantothenate + L-cysteine = AMP + diphosphate + N-((R)-4'-phosphopantothenoyl)-L-cysteine." ], [ "Q8VDG5-1", "6.3.2.51", "" ], [ "P07628-1", "3.4.21.35", "Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa." ], [ "P07628-1", "3.4.21.35", "" ], [ "Q99P58-1", "3.6.5.2", "GTP + H(2)O = GDP + phosphate." ], [ "Q99P58-1", "3.6.5.2", "" ], [ "P58710-1", "1.1.3.8", "L-gulono-1,4-lactone + O(2) = L-ascorbate + H(2)O(2)." ], [ "P58710-1", "1.1.3.8", "" ], [ "Q9WUM5-1", "6.2.1.4", "GTP + succinate + CoA = GDP + phosphate + succinyl-CoA." ], [ "Q9WUM5-1", "6.2.1.5", "ATP + succinate + CoA = ADP + phosphate + succinyl-CoA." ], [ "Q9WUM5-1", "6.2.1.4", "" ], [ "Q9WUM5-1", "6.2.1.5", "" ], [ "P83855-1", "4.6.1.1", "ATP = 3',5'-cyclic AMP + diphosphate." ], [ "P83855-1", "4.6.1.1", "" ], [ "Q7TSS2-1", "2.3.2.23", "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine." ], [ "Q7TSS2-1", "2.3.2.23", "" ], [ "A2ATU0-1", "1.2.4.2", "2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO(2)." ], [ "A2ATU0-1", "1.2.4.2", "" ], [ "O70250-1", "5.4.2.11", "2-phospho-D-glycerate = 3-phospho-D-glycerate." ], [ "O70250-1", "5.4.2.4", "3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate." ], [ "O70250-1", "5.4.2.4", "" ], [ "O70250-1", "5.4.2.11", "" ], [ "O70252-1", "1.14.14.18", "Protoheme + 3 [reduced NADPH--hemoprotein reductase] + 3 O(2) = biliverdin + Fe(2+) + CO + 3 [oxidized NADPH--hemoprotein reductase] + 3 H(2)O." ], [ "O70252-1", "1.14.14.18", "" ], [ "Q8K0C4-1", "1.14.14.154", "A 14-alpha-methylsteroid + 3 [reduced NADPH--hemoprotein reductase] + 3 O(2) = a Delta(14)-steroid + formate + 3 [oxidized NADPH--hemoprotein reductase] + 4 H(2)O." ], [ "Q8K0C4-1", "1.14.14.154", "" ], [ "P21440-1", "7.6.2.1", "ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2)." ], [ "P21440-1", "7.6.2.1", "" ], [ "Q99L27-1", "1.7.1.7", "Inosine 5'-phosphate + NH(3) + NADP(+) = guanosine 5'-phosphate + NADPH." ], [ "Q99L27-1", "1.7.1.7", "" ], [ "P52480-1", "2.7.1.40", "ATP + pyruvate = ADP + phosphoenolpyruvate." ], [ "P52480-1", "2.7.1.40", "" ], [ "Q6ZPY7-1", "1.14.11.-", "" ], [ "Q6ZPY7-1", "1.14.11.-", "" ], [ "P24527-1", "3.3.2.6", "(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H(2)O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate." ], [ "P24527-1", "3.3.2.6", "" ], [ "Q9CR25-1", "2.5.1.108", "L-histidine-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-((3S)-3-amino-3-carboxypropyl)-L-histidine-[translation elongation factor 2] + S-methyl-5'-thioadenosine." ], [ "Q9CR25-1", "2.5.1.108", "" ], [ "Q9ER56-1", "3.4.22.-", "" ], [ "Q9ER56-1", "3.4.22.-", "" ], [ "A0PJN4-1", "2.3.2.23", "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine." ], [ "A0PJN4-1", "2.3.2.23", "" ], [ "E9PYK3-1", "2.4.2.-", "" ], [ "E9PYK3-1", "2.4.2.-", "" ], [ "Q811W2-1", "1.14.13.-", "" ], [ "Q811W2-1", "1.14.13.-", "" ], [ "Q6PDX6-1", "2.3.2.27", "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine." ], [ "Q6PDX6-1", "2.3.2.27", "" ], [ "Q9CXG3-1", "5.2.1.8", "Peptidylproline (omega=180) = peptidylproline (omega=0)." ], [ "Q9CXG3-1", "5.2.1.8", "" ], [ "P56376-1", "3.6.1.7", "An acylphosphate + H(2)O = a carboxylate + phosphate." ], [ "P56376-1", "3.6.1.7", "" ], [ "P56375-1", "3.6.1.7", "An acylphosphate + H(2)O = a carboxylate + phosphate." ], [ "P56375-1", "3.6.1.7", "" ], [ "Q9R0G8-1", "2.7.11.1", "ATP + a protein = ADP + a phosphoprotein." ], [ "Q9R0G8-1", "2.7.11.1", "" ], [ "E9Q7F2-1", "2.3.2.27", "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine." ], [ "E9Q7F2-1", "2.3.2.27", "" ] ] }, "readme": "Name\n - Mouse Protein Enzyme Annotation (UniProtKB)\n\nVersion\n - 1.5.23\n\nCreated on\n - 2019-12-01T15:59:48.968222\n\nModified on\n - 2020-04-10T12:48:22.718557\n\nCreated by\n - Jeet Vora [jeetvora@gwu.edu], Rahi Navelkar [rsn13@gwu.edu], Robel Kahsay [rykahsay@gwu.edu], Xavier Holmes [xavierh@email.gwu.edu]\n\nAuthors\n - Maria Martin [martin@ebi.ac.uk], Preethi Vasudev [pvasudev@ebi.ac.uk]\n\nChecksum\n - \n\nUsability Domain\n - The Mouse Protein Enzyme Annotation (UniProtKB) dataset contains mouse [taxid:10090] enzyme annotations for UniProtKB canonical accessions. The dataset contains ec numbers and enzyme activity that describes the enzymatic reactions. The dataset is derived form 2019-09 UniprotKB release. If you use this dataset please give proper attribution to UniProtKB and GlyGen\n\nDescription Domain\n Keywords\n - enzyme annotation\n - enzyme \n - UniProtKB\n - enzyme activity\n - EC number\n\n Pipeline Steps\n - Step-1: The script extracts the enzyme annotation triples from the triplestore for the UniProtKB canonical sequnces asnd extracts as a dataset in a csv format\n\nExecution Domain\n Scripts - https://github.com/GW-HIVE/glygen-backend-integration/blob/master/pipeline/integrator/make-protein-dataset.py\n\n\n Software Prerequisites\n Name: Python\n Version: 2.7.5\n URI: https://www.python.org/download/releases/2.7.5/\n\nI/O Domain\n Input Subdomain\n Name: uniprot-proteome-mus-musculus.nt\n URI: https://data.glygen.org/ln2data/releases/data/v-1.5.23/reviewed/uniprot-proteome-mus-musculus.nt\n Name: mouse_protein_masterlist.csv\n URI: https://data.glygen.org/ln2data/releases/data/v-1.5.23/reviewed/mouse_protein_masterlist.csv\n Output Subdomain\n Name: mouse_protein_enzyme_annotation_uniprotkb.csv\n URI: http://data.glygen.org/ln2data/releases/data/v-1.5.23/reviewed/mouse_protein_enzyme_annotation_uniprotkb.csv\n Name: mouse_protein_enzyme_annotation_uniprotkb.stat.csv\n URI: http://data.glygen.org/ln2data/releases/data/v-1.5.23/reviewed/mouse_protein_enzyme_annotation_uniprotkb.stat.csv\n\nFields\n Name: \"uniprotkb_canonical_ac\"\n Description: \"Accession assigned to the protein isoform chosen to be the canonical sequence to which all positional annotation refers in UniProtKB database\"\n Unique Values: \"4222\"\n Name: \"enzyme_ec\"\n Description: \"Enzyme Commision number assigned to an enzyme by Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB)\"\n Unique Values: \"1472\"\n Name: \"enzyme_activity\"\n Description: \"The catalytic reaction activity of an enzyme in UniProtKB\"\n Unique Values: \"1331\"", "downloadurl": "/ln2data/releases/data/v-1.5.23/reviewed/mouse_protein_enzyme_annotation_uniprotkb.csv" }