{
    "uniprot_canonical_ac": "A6NCF5-1", 
    "sequence": {
        "header": "sp|A6NCF5-1|KLH33_HUMAN Isoform 1 of Kelch-like protein 33  OS=Homo sapiens OX=9606 GN=KLHL33 PE=4 SV=2 CANONICAL=A6NCF5-1", 
        "length": 533, 
        "sequence": "MLLSGMRESQGTEVSLRTISTQDLRLLVSFAYSGVVRARWPGLLRAAQAALQYQSSSCLDLCQKGLARGLSPARCLALFPMAEAPGLERLWSKARHYLLTHLPAVALCPAFPSLPAACLAELLDSDELHVQEEFEAFVAARCWLAANPETQESEAKALLRCVRFGRMSTRELRRVRAAGLLPPLTPDLLHQLMVEADVPGQERRREPDRALVVIGGDGLRPDMALRQPSRAVWWARAFRCGVGLVRTVEWGQLPALPAPGRFRHGAASLAGSELYVCGGQDFYSHSNTLASTLRWEPSQEDWEEMAPLSQARSLFSLVALDGKLYALGGRHNDVALDSVETYNPELNVWRPAPALPAPCFAHAAAILEGQLYVSGGCGGTGQYLASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYELRTDSWTHLAPLPSPHVGAASAVLQGELLVLGGYSHRTYALSHLIHAYCPGLGRWLCLGTLPRPRAEMPACILTLPAVQHIALVPTPHQTKPAG"
    }, 
    "uniprot_id": "KLH33_HUMAN", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [
                "kelch-like protein 33 isoform 2", 
                "kelch-like protein 33"
            ], 
            "uniprotkb": [
                "Kelch-like protein 33"
            ]
        }, 
        "gene": {
            "refseq": [
                "KLHL33"
            ], 
            "uniprotkb": [
                "KLHL33"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A6NCF5", 
                    "id": "A6NCF5", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "recommendedname": {
        "full": "Kelch-like protein 33."
    }, 
    "publication": [
        {
            "title": "Update on the Kelch-like (KLHL) gene family.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/23676014", 
            "journal": "Human genomics", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103467.2", 
                    "id": "NP_001103467.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Dhanoa BS, Cogliati T, Satish AG, Bruford EA, Friedman JS", 
            "date": "2013", 
            "pmid": "23676014"
        }, 
        {
            "title": "Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/16368877", 
            "journal": "Physiological genomics", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103467.2", 
                    "id": "NP_001103467.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Choy KW, Wang CC, Ogura A, Lau TK, Rogers MS, Ikeo K, Gojobori T, Lam DS, Pang CP", 
            "date": "2006", 
            "pmid": "16368877"
        }
    ], 
    "glycosylation": [], 
    "mutation": [
        {
            "start_pos": 50, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NCF5", 
                    "id": "A6NCF5", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "2.0", 
            "annotation": "Filters passed (1/5): patient freq. (2.0%).", 
            "sequence_org": "A", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "T", 
            "subjects_tested": "50", 
            "end_pos": 50, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 345, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NCF5", 
                    "id": "A6NCF5", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "2.0", 
            "annotation": "Filters passed (1/5): patient freq. (2.0%).", 
            "sequence_org": "E", 
            "disease": {
                "doid": "1612", 
                "url": "http://disease-ontology.org/term/DOID:1612", 
                "icd10": "", 
                "name": "Breast cancer"
            }, 
            "sequence_mut": "G", 
            "subjects_tested": "50", 
            "end_pos": 345, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 455, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NCF5", 
                    "id": "A6NCF5", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "2.3", 
            "annotation": "Filters passed (1/5): patient freq. (2.3%).", 
            "sequence_org": "H", 
            "disease": {
                "doid": "11934", 
                "url": "http://disease-ontology.org/term/DOID:11934", 
                "icd10": "", 
                "name": "Head and neck cancer"
            }, 
            "sequence_mut": "Y", 
            "subjects_tested": "44", 
            "end_pos": 455, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 516, 
            "subjects_positive": "2", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NCF5", 
                    "id": "A6NCF5", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "4.2", 
            "annotation": "Filters passed (1/5): patient freq. (4.2%).", 
            "sequence_org": "A", 
            "disease": {
                "doid": "2531", 
                "url": "http://disease-ontology.org/term/DOID:2531", 
                "icd10": "", 
                "name": "Hematologic cancer"
            }, 
            "sequence_mut": "T", 
            "subjects_tested": "48", 
            "end_pos": 516, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 372, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NCF5", 
                    "id": "A6NCF5", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "1.1", 
            "annotation": "Filters passed (1/5): patient freq. (1.1%).", 
            "sequence_org": "Y", 
            "disease": {
                "doid": "2394", 
                "url": "http://disease-ontology.org/term/DOID:2394", 
                "icd10": "", 
                "name": "Ovarian cancer"
            }, 
            "sequence_mut": "*", 
            "subjects_tested": "93", 
            "end_pos": 372, 
            "type": "Point mutation"
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A6NCF5#A6NCF5-1", 
            "isoform_ac": "A6NCF5-1", 
            "locus": {
                "end_pos": 20428852, 
                "start_pos": 20430675, 
                "chromosome": "14", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000344581", 
                        "id": "ENST00000344581", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000341549", 
                        "id": "ENSP00000341549", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A6NCF5-1|KLH33_HUMAN Isoform 1 of Kelch-like protein 33  OS=Homo sapiens OX=9606 GN=KLHL33 PE=4 SV=2 CANONICAL=A6NCF5-1", 
                "length": 533, 
                "sequence": "MLLSGMRESQGTEVSLRTISTQDLRLLVSFAYSGVVRARWPGLLRAAQAALQYQSSSCLDLCQKGLARGLSPARCLALFPMAEAPGLERLWSKARHYLLTHLPAVALCPAFPSLPAACLAELLDSDELHVQEEFEAFVAARCWLAANPETQESEAKALLRCVRFGRMSTRELRRVRAAGLLPPLTPDLLHQLMVEADVPGQERRREPDRALVVIGGDGLRPDMALRQPSRAVWWARAFRCGVGLVRTVEWGQLPALPAPGRFRHGAASLAGSELYVCGGQDFYSHSNTLASTLRWEPSQEDWEEMAPLSQARSLFSLVALDGKLYALGGRHNDVALDSVETYNPELNVWRPAPALPAPCFAHAAAILEGQLYVSGGCGGTGQYLASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYELRTDSWTHLAPLPSPHVGAASAVLQGELLVLGGYSHRTYALSHLIHAYCPGLGRWLCLGTLPRPRAEMPACILTLPAVQHIALVPTPHQTKPAG"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A6NCF5#A0A1B0GUB7-1", 
            "isoform_ac": "A0A1B0GUB7-1", 
            "locus": {
                "end_pos": 20428852, 
                "start_pos": 20435811, 
                "chromosome": "14", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000636854", 
                        "id": "ENST00000636854", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000490040", 
                        "id": "ENSP00000490040", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A1B0GUB7-1|KLH33_HUMAN Computationally mapped isoform of Kelch-like protein 33  OS=Homo sapiens OX=9606 GN=KLHL33 PE=4 SV=1 CANONICAL=A6NCF5-1", 
                "length": 797, 
                "sequence": "MSVSDTPHYPPELESVSHPVQRDCLGLLVHAQRTPSWPPSPDEDPRLPSFPLEEPGSRPLVPRNLPFPALSLEEEEEEEEDEDAAEPEWLRSEEHPSQFFAEAQRLREQRLLLDEEVSVAGRVYGVHRVILAAISSLFRDRLLGGGGPRPPFSLEVSPGGWEAVLTFAYEGVLGPASQGDVLAAAEALGAPRVKAAAQQTCERAGNAREDVKKPSQAEELRENLRGIELLYREGVGCDLKLEAGGCQLSVHRAALACGSEFFGAMLLSGMRESQGTEVSLRTISTQDLRLLVSFAYSGVVRARWPGLLRAAQAALQYQSSSCLDLCQKGLARGLSPARCLALFPMAEAPGLERLWSKARHYLLTHLPAVALCPAFPSLPAACLAELLDSDELHVQEEFEAFVAARCWLAANPETQESEAKALLRCVRFGRMSTRELRRVRAAGLLPPLTPDLLHQLMVEADVPGQERRREPDRALVVIGGDGLRPDMALRQPSRAVWWARAFRCGVGLVRTVEWGQLPALPAPGRFRHGAASLAGSELYVCGGQDFYSHSNTLASTLRWEPSQEDWEEMAPLSQARSLFSLVALDGKLYALGGRHNDVALDSVETYNPELNVWRPAPALPAPCFAHAAAILEGQLYVSGGCGGTGQYLASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYELRTDSWTHLAPLPSPHVGAASAVLQGELLVLGGYSHRTYALSHLIHAYCPGLGRWLCLGTLPRPRAEMPACILTLPAVQHIALVPTPHQTKPAG"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A6NCF5#A0A1B0GTK0-1", 
            "isoform_ac": "A0A1B0GTK0-1", 
            "locus": {
                "end_pos": 20429405, 
                "start_pos": 20435811, 
                "chromosome": "14", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000637228", 
                        "id": "ENST00000637228", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000489731", 
                        "id": "ENSP00000489731", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A1B0GTK0-1|KLH33_HUMAN Computationally mapped isoform of Kelch-like protein 33  OS=Homo sapiens OX=9606 GN=KLHL33 PE=4 SV=1 CANONICAL=A6NCF5-1", 
                "length": 623, 
                "sequence": "MSVSDTPHYPPELESVSHPVQRDCLGLLVHAQRTPSWPPSPDEDPRLPSFPLEEPGSRPLVPRNLPFPALSLEEEEEEEEDEDAAEPEWLRSEEHPSQFFAEAQRLREQRLLLDEEVSVAGRVYGVHRVILAAISSLFRDRLLGGGGPRPPFSLEVSPGGWEAVLTFAYEGVLGPASQGDVLAAAEALGAPRVKAAAQQTCERAGNAREDVKKPSQAEELRENLRGIELLYREGVGCDLKLEAGGCQLSVHRAALACGSEFFGAMLLSGMRESQGTEVSLRTISTQDLRLLVSFAYSGVVRARWPGLLRAAQAALQYQSSSCLDLCQKGLARGLSPARCLALFPMAEAPGLERLWSKARHYLLTHLPAVALCPAFPSLPAACLAELLDSDELHVQEEFEAFVAARCWLAANPETQESEAKALLRCVRFGRMSTRELRRVRAAGLLPPLTPDLLHQLMVEADVPGQERRREPDRALVVIGGDGLRPDMALRQPSRAVWWARAFRCGVGLVRTVEWGQLPALPAPGRFRHGAASLAGSELYVCGGQDFYSHSNTLASTLRWEPSQEDWEEMAPLSQARSLFSLVALDGKLYALGGRHNDVALDSVETYNPELNVWSCLILCPVLP"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:123103", 
            "resource": "KEGG Pathway", 
            "id": "hsa:123103", 
            "name": ""
        }
    ], 
    "function": [], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "A0A2I3BRZ3-1", 
            "protein_name": "Kelch-like 33.", 
            "sequence": {
                "length": 793, 
                "sequence": "MASLSSDLEHVSLPIEKDSLELPVPAGRTFSRSPSSDEDPGLFSFSLAEPDPPSPFVSGNLPFLASSPEKGKKQDDSDDSAEPEMLCSVEHPCQFFAEAQRLREQKLLLDEEVSVGGQVYGVHRVILAAISSLFRGRLLSGGGQQPSFSLDVTPRGWEAALTFAYEGVLGPASQDEVLAAAEALGAPRVKKAAQLKPEGLGKARGNEKKLSQAEELRENLHSIERLYREGIGCDLELEAEGYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVVRERWPGLLRAAQAALQYQSSSCLDLCQKALAQSLCPALCLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPTFSSLPVTCLAELLDSDELHVQEEFEAFSAARCWLAANPETHESEAKALLRCVRFGRMSTRELRKVRAAGLPPSLPPDLLYQLMVEAEVPGQERWREPDQALVVIGGDGLRPDMDRRQPSCKVWWARAFHCGMGLVRTVEWCRLPNLPAPGRFRHGAASLTGSELYVCGGQDFYSHNSTLASTLRWSSSQEDWEEMAPLCQARSFFPLVVFDGQLYALGGRDNGVALNSVETYNPELNVWRPAPALPAPCFAHAAAILEDRLYVSGGCSGTGQYLDSLIHYDPKLKRPGTLLSPMGVARASHVMAALGGKLYVAGGVGDTGDLLSFEAYEPKSDSWTQLASLPSPHVGAAGAVLQGELLVLGGYSHRTYAISHLVHAYCPGLDRWLCLGTLPRPRAEMPACILTLPSVQHIALVPTQHQNKPAG"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/52385", 
                    "id": "52385", 
                    "database": "MGI"
                }
            ], 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103467.2", 
        "ac": "NP_001103467.2", 
        "name": "kelch-like protein 33 isoform 2; kelch-like protein 33.", 
        "summary": ""
    }, 
    "go_annotation": {}, 
    "site_annotation": [], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103467.2", 
            "id": "NP_001103467.2", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=31952", 
            "id": "31952", 
            "database": "HGNC"
        }, 
        {
            "url": "https://pharos.nih.gov/targets/A6NCF5", 
            "id": "A6NCF5", 
            "database": "PHAROS"
        }, 
        {
            "url": "https://www.nextprot.org/entry/NX_A6NCF5", 
            "id": "NX_A6NCF5", 
            "database": "neXtProt"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=KLHL33", 
            "id": "KLHL33", 
            "database": "GeneCards"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:123103", 
            "id": "hsa:123103", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000185271", 
            "id": "ENSG00000185271", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR030609", 
            "id": "IPR030609", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", 
            "id": "IPR011333", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR006652", 
            "id": "IPR006652", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR015915", 
            "id": "IPR015915", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017096", 
            "id": "IPR017096", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011705", 
            "id": "IPR011705", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF01344", 
            "id": "PF01344", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF07707", 
            "id": "PF07707", 
            "database": "Pfam"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45632:SF14", 
            "id": "PTHR45632:SF14", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A6NCF5", 
            "id": "PR_A6NCF5", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ebi.ac.uk/intact/interactors/id:A6NCF5*", 
            "id": "A6NCF5", 
            "database": "IntAct"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/123103", 
            "id": "123103", 
            "database": "GeneID"
        }
    ], 
    "expression_disease": [
        {
            "trend": "Down", 
            "disease": {
                "doid": "10283", 
                "url": "http://disease-ontology.org/term/DOID:10283", 
                "icd10": "", 
                "name": "DOID:10283 / Prostate cancer [PCa]"
            }, 
            "significant": "Yes", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6NCF5", 
                    "id": "A6NCF5", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "3910", 
                "url": "http://disease-ontology.org/term/DOID:3910", 
                "icd10": "", 
                "name": "DOID:3910 / Lung adenocarcinoma"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6NCF5", 
                    "id": "A6NCF5", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "5041", 
                "url": "http://disease-ontology.org/term/DOID:5041", 
                "icd10": "", 
                "name": "DOID:5041 / Esophageal cancer [EC]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6NCF5", 
                    "id": "A6NCF5", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "11054", 
                "url": "http://disease-ontology.org/term/DOID:11054", 
                "icd10": "", 
                "name": "DOID:11054 / Urinary bladder cancer [UBC]"
            }, 
            "significant": "Yes", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6NCF5", 
                    "id": "A6NCF5", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "DOID:1781 / Thyroid cancer [Thyca]"
            }, 
            "significant": "Yes", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6NCF5", 
                    "id": "A6NCF5", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "3907", 
                "url": "http://disease-ontology.org/term/DOID:3907", 
                "icd10": "", 
                "name": "DOID:3907 / Lung squamous cell carcinoma"
            }, 
            "significant": "Yes", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6NCF5", 
                    "id": "A6NCF5", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "3571", 
                "url": "http://disease-ontology.org/term/DOID:3571", 
                "icd10": "", 
                "name": "DOID:3571 / Liver cancer [Livca]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6NCF5", 
                    "id": "A6NCF5", 
                    "database": "BioXpress"
                }
            ]
        }
    ], 
    "uniprot_ac": "A6NCF5", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 57810.0, 
        "chemical_mass": 57810.0
    }, 
    "expression_tissue": [
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0009853", 
                "uberon": "0009853", 
                "name": "Body of uterus"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000185271", 
                    "id": "ENSG00000185271", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000458", 
                "uberon": "0000458", 
                "name": "Endocervix"
            }, 
            "present": "yes", 
            "evidence": [
                {
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}