{
    "uniprot_canonical_ac": "A6NC86-1", 
    "sequence": {
        "header": "sp|A6NC86-1|PINLY_HUMAN Isoform 1 of phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein  OS=Homo sapiens OX=9606 GN=PINLYP PE=2 SV=3 CANONICAL=A6NC86-1", 
        "length": 204, 
        "sequence": "MRLSRRPETFLLAFVLLCTLLGLGCPLHCEICTAAGSRCHGQMKTCSSDKDTCVLLVGKATSKGKELVHTYKGCIRSQDCYSGVISTTMGPKDHMVTSSFCCQSDGCNSAFLSVPLTNLTENGLMCPACTASFRDKCMGPMTHCTGKENHCVSLSGHVQAGIFKPRFAMRGCATESMCFTKPGAEVPTGTNVLFLHHIECTHSP"
    }, 
    "uniprot_id": "PINLY_HUMAN", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [
                "phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein isoform 1 precursor", 
                "phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein"
            ], 
            "uniprotkb": [
                "phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein"
            ]
        }, 
        "gene": {
            "refseq": [], 
            "uniprotkb": [
                "PINLYP"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A6NC86", 
                    "id": "A6NC86", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "recommendedname": {
        "full": "phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein."
    }, 
    "publication": [], 
    "glycosylation": [], 
    "mutation": [
        {
            "start_pos": 64, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NC86", 
                    "id": "A6NC86", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "2.0", 
            "annotation": "Filters passed (1/5): patient freq. (2.0%).", 
            "sequence_org": "G", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "D", 
            "subjects_tested": "50", 
            "end_pos": 64, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 105, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NC86", 
                    "id": "A6NC86", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "2.2", 
            "annotation": "Filters passed (1/5): patient freq. (2.2%).", 
            "sequence_org": "D", 
            "disease": {
                "doid": "263", 
                "url": "http://disease-ontology.org/term/DOID:263", 
                "icd10": "", 
                "name": "Kidney cancer"
            }, 
            "sequence_mut": "H", 
            "subjects_tested": "45", 
            "end_pos": 105, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 121, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NC86", 
                    "id": "A6NC86", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "1.1", 
            "annotation": "Filters passed (1/5): patient freq. (1.1%).", 
            "sequence_org": "E", 
            "disease": {
                "doid": "9256", 
                "url": "http://disease-ontology.org/term/DOID:9256", 
                "icd10": "", 
                "name": "Colorectal cancer"
            }, 
            "sequence_mut": "D", 
            "subjects_tested": "94", 
            "end_pos": 121, 
            "type": "Point mutation"
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A6NC86#A6NC86-1", 
            "isoform_ac": "A6NC86-1", 
            "locus": {
                "end_pos": 43577192, 
                "start_pos": 43581998, 
                "chromosome": "19", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000599207", 
                        "id": "ENST00000599207", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000469886", 
                        "id": "ENSP00000469886", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A6NC86-1|PINLY_HUMAN Isoform 1 of phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein  OS=Homo sapiens OX=9606 GN=PINLYP PE=2 SV=3 CANONICAL=A6NC86-1", 
                "length": 204, 
                "sequence": "MRLSRRPETFLLAFVLLCTLLGLGCPLHCEICTAAGSRCHGQMKTCSSDKDTCVLLVGKATSKGKELVHTYKGCIRSQDCYSGVISTTMGPKDHMVTSSFCCQSDGCNSAFLSVPLTNLTENGLMCPACTASFRDKCMGPMTHCTGKENHCVSLSGHVQAGIFKPRFAMRGCATESMCFTKPGAEVPTGTNVLFLHHIECTHSP"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A6NC86#A6NC86-2", 
            "isoform_ac": "A6NC86-2", 
            "locus": {
                "end_pos": 43577120, 
                "start_pos": 43581998, 
                "chromosome": "19", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000612042", 
                        "id": "ENST00000612042", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000479240", 
                        "id": "ENSP00000479240", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A6NC86-2|PINLY_HUMAN Isoform 2 of phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein  OS=Homo sapiens OX=9606 GN=PINLYP PE=2 SV=3 CANONICAL=A6NC86-1", 
                "length": 228, 
                "sequence": "MWVQTHPSSASYKSWGPGTADTHTMRLSRRPETFLLAFVLLCTLLGLGCPLHCEICTAAGSRCHGQMKTCSSDKDTCVLLVGKATSKGKELVHTYKGCIRSQDCYSGVISTTMGPKDHMVTSSFCCQSDGCNSAFLSVPLTNLTENGLMCPACTASFRDKCMGPMTHCTGKENHCVSLSGHVQAGIFKPRFAMRGCATESMCFTKPGAEVPTGTNVLFLHHIECTHSP"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A6NC86#A6NC86-3", 
            "isoform_ac": "A6NC86-3", 
            "locus": {
                "end_pos": 0, 
                "start_pos": 0, 
                "chromosome": "", 
                "evidence": []
            }, 
            "sequence": {
                "header": "sp|A6NC86-3|PINLY_HUMAN Isoform 3 of phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein  OS=Homo sapiens OX=9606 GN=PINLYP PE=2 SV=3 CANONICAL=A6NC86-1", 
                "length": 143, 
                "sequence": "MWVQTHPSSASYKSWGPGTADTHTMRLSRRPETFLLAFVLLCTLLGLGCPLHCEICTAAGSRCHGQMKTCSSDKDTCVLLVGKATSSKRMWPGTWWGGGVYLQGGRDYHAEGGSSRFSRRERGKKSVESRKEGKTIMRWREQK"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A6NC86#A6NC86-4", 
            "isoform_ac": "A6NC86-4", 
            "locus": {
                "end_pos": 43581289, 
                "start_pos": 43581998, 
                "chromosome": "19", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000569031", 
                        "id": "ENST00000569031", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000457369", 
                        "id": "ENSP00000457369", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A6NC86-4|PINLY_HUMAN Isoform 4 of phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein  OS=Homo sapiens OX=9606 GN=PINLYP PE=2 SV=3 CANONICAL=A6NC86-1", 
                "length": 116, 
                "sequence": "MGPKDHMVTSSFCCQSDGCNSAFLSVPLTNLTENGLMCPACTASFRDKCMGPMTHCTGKENHCVSLSGHVQAGIFKPRFAMRGCATESMCFTKPGAEVPTGTNVLFLHHIECTHSP"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:390940", 
            "resource": "KEGG Pathway", 
            "id": "hsa:390940", 
            "name": ""
        }
    ], 
    "function": [], 
    "orthologs": [], 
    "refseq": {
        "url": "", 
        "ac": "", 
        "name": "phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein isoform 1 precursor; phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein.", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004859", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6NC86", 
                                "id": "A6NC86", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "phospholipase inhibitor activity", 
                        "id": "GO:0004859"
                    }
                ], 
                "total": 1, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6NC86", 
                                "id": "A6NC86", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "extracellular region", 
                        "id": "GO:0005576"
                    }
                ], 
                "total": 1, 
                "name": "Cellular Component"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 120, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 118
        }
    ], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180550.1", 
            "id": "NP_001180550.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=44206", 
            "id": "44206", 
            "database": "HGNC"
        }, 
        {
            "url": "https://pharos.nih.gov/targets/A6NC86", 
            "id": "A6NC86", 
            "database": "PHAROS"
        }, 
        {
            "url": "https://www.nextprot.org/entry/NX_A6NC86", 
            "id": "NX_A6NC86", 
            "database": "neXtProt"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=PINLYP", 
            "id": "PINLYP", 
            "database": "GeneCards"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:390940", 
            "id": "hsa:390940", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000234465", 
            "id": "ENSG00000234465", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/KFATRGC/", 
            "id": "KFATRGC", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR004126", 
            "id": "IPR004126", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR016054", 
            "id": "IPR016054", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF02988", 
            "id": "PF02988", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00021", 
            "id": "PF00021", 
            "database": "Pfam"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A6NC86", 
            "id": "PR_A6NC86", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/390940", 
            "id": "390940", 
            "database": "GeneID"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A6NC86", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 21926.0, 
        "chemical_mass": 21926.0
    }, 
    "expression_tissue": [
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0009853", 
                "uberon": "0009853", 
                "name": "Body of uterus"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000234465", 
                    "id": "ENSG00000234465", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000458", 
                "uberon": "0000458", 
                "name": "Endocervix"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000234465", 
                    "id": "ENSG00000234465", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000948", 
                "uberon": "0000948", 
                "name": "Heart"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000234465", 
                    "id": "ENSG00000234465", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000473", 
                "uberon": "0000473", 
                "name": "Testis"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000234465", 
                    "id": "ENSG00000234465", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002369", 
                "uberon": "0002369", 
                "name": "Adrenal gland"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000234465", 
                    "id": "ENSG00000234465", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000992", 
                "uberon": "0000992", 
                "name": "Ovary"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000234465", 
                    "id": "ENSG00000234465", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000996", 
                "uberon": "0000996", 
                "name": "Vagina"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000234465", 
                    "id": "ENSG00000234465", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001155", 
                "uberon": "0001155", 
                "name": "Colon"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000234465", 
                    "id": "ENSG00000234465", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001987", 
                "uberon": "0001987", 
                "name": "Placenta"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000234465", 
                    "id": "ENSG00000234465", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000955", 
                "uberon": "0000955", 
                "name": "Brain"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000234465", 
                    "id": "ENSG00000234465", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001160", 
                "uberon": "0001160", 
                "name": "Fundus of stomach"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000234465", 
                    "id": "ENSG00000234465", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001150", 
                "uberon": "0001150", 
                "name": "Body of pancreas"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000234465", 
                    "id": "ENSG00000234465", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002048", 
                "uberon": "0002048", 
                "name": "Lung"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000234465", 
                    "id": "ENSG00000234465", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000007", 
                "uberon": "0000007", 
                "name": "Pituitary gland"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000234465", 
                    "id": "ENSG00000234465", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002107", 
                "uberon": "0002107", 
                "name": "Liver"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000234465", 
                    "id": "ENSG00000234465", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002046", 
                "uberon": "0002046", 
                "name": "Thyroid gland"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000234465", 
                    "id": "ENSG00000234465", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178", 
                "uberon": "0000178", 
                "name": "Blood"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000234465", 
                    "id": "ENSG00000234465", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001043", 
                "uberon": "0001043", 
                "name": "Esophagus"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000234465", 
                    "id": "ENSG00000234465", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002367", 
                "uberon": "0002367", 
                "name": "Prostate gland"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000234465", 
                    "id": "ENSG00000234465", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001161", 
                "uberon": "0001161", 
                "name": "Body of stomach"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000234465", 
                    "id": "ENSG00000234465", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001255", 
                "uberon": "0001255", 
                "name": "Urinary bladder"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000234465", 
                    "id": "ENSG00000234465", 
                    "database": "Bgee"
                }
            ]
        }
    ], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A6NC86", 
            "name": "PINLYP.", 
            "locus": {
                "end_pos": 43583964, 
                "start_pos": 43576800, 
                "chromosome": "19", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSG00000234465", 
                        "id": "ENSG00000234465", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}