{
    "uniprot_canonical_ac": "A6NC78-1", 
    "sequence": {
        "header": "sp|A6NC78-1|GOG8I_HUMAN Isoform 1 of Putative golgin subfamily A member 8I  OS=Homo sapiens OX=9606 GN=GOLGA8IP PE=5 SV=2 CANONICAL=A6NC78-1", 
        "length": 632, 
        "sequence": "MAEETQHNKLAAAKKKLKEYWQKNSPRVPAGANRNRKTNGSIPQTATSGGCQPPGDSATGFHREGPTSSATLKDLESPCQERAVVLDSRSVEISQLKNTIKSLKQQKKQVEHQLEEEKKANIKKQKAKRVLEVQIQTLNIQKEELNTDLYHMKRSLRYFEEKSKDLAVRLQHSLQRKGELESVLSDVMATQKKKANQLSSPSKAGTEWKLEQSMREEALLKVQLTQLKESFQQLQLERHEYAEHLKGERARWQQRMRKMSQEICTLKKEKQQDMRRVEKLERSLSKLKNQMAEPLPPEPPAVPSEVELQHLRKELERVAGALQAQVKNNQRISLLNRGQEERIREQEERLRKQEERIQEQHKSLQQLAKPQSVFEEPNNENKSALQLEQQVKELQEKLGEEHLEAASQQNQQLTAQLSLMALPGEGHGGEHLDSEGEEAPQPMPSVPEDLESREAMSSFMDHLEEKADLSELVKKKELCFIHHWRERCHQKTHHLLSEPGGRAKDAALGGGHHQAGAQGGDEGEAAGAAADGIAAYSNYNNGHRKFLAAAHNPADEPGPGAPAPQELGAADKHGDLCEVSLTSSAQGEAREDPLLDKPTAQPIVQDHQEHPGLGSNCCVPFFCWAWLPRRRR"
    }, 
    "uniprot_id": "GOG8I_HUMAN", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [], 
            "uniprotkb": [
                "Putative golgin subfamily A member 8I", 
                "Golgin subfamily A member 8I pseudogene"
            ]
        }, 
        "gene": {
            "refseq": [], 
            "uniprotkb": [
                "GOLGA8IP", 
                "GOLGA8I", 
                "GOLGA9P"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A6NC78", 
                    "id": "A6NC78", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "recommendedname": {
        "full": "Putative golgin subfamily A member 8I; Golgin subfamily A member 8I pseudogene."
    }, 
    "publication": [], 
    "glycosylation": [], 
    "mutation": [
        {
            "start_pos": 169, 
            "subjects_positive": "2", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NC78", 
                    "id": "A6NC78", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "3.0", 
            "annotation": "Filters passed (2/5): patient freq. (3.0%); num. of cancers (3).", 
            "sequence_org": "R", 
            "disease": {
                "doid": "1324", 
                "url": "http://disease-ontology.org/term/DOID:1324", 
                "icd10": "", 
                "name": "Lung cancer"
            }, 
            "sequence_mut": "C", 
            "subjects_tested": "66", 
            "end_pos": 169, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 321, 
            "subjects_positive": "3", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NC78", 
                    "id": "A6NC78", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "2.4", 
            "annotation": "Filters passed (2/5): patient freq. (2.4%); num. of cancers (7).", 
            "sequence_org": "A", 
            "disease": {
                "doid": "2531", 
                "url": "http://disease-ontology.org/term/DOID:2531", 
                "icd10": "", 
                "name": "Hematologic cancer"
            }, 
            "sequence_mut": "E", 
            "subjects_tested": "125", 
            "end_pos": 321, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 553, 
            "subjects_positive": "2", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NC78", 
                    "id": "A6NC78", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "1.6", 
            "annotation": "Filters passed (1/5): patient freq. (1.6%).", 
            "sequence_org": "P", 
            "disease": {
                "doid": "2531", 
                "url": "http://disease-ontology.org/term/DOID:2531", 
                "icd10": "", 
                "name": "Hematologic cancer"
            }, 
            "sequence_mut": "L", 
            "subjects_tested": "125", 
            "end_pos": 553, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 169, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NC78", 
                    "id": "A6NC78", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.8", 
            "annotation": "Filters passed (1/5): num. of cancers (3).", 
            "sequence_org": "R", 
            "disease": {
                "doid": "2531", 
                "url": "http://disease-ontology.org/term/DOID:2531", 
                "icd10": "", 
                "name": "Hematologic cancer"
            }, 
            "sequence_mut": "C", 
            "subjects_tested": "125", 
            "end_pos": 169, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 321, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NC78", 
                    "id": "A6NC78", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.1", 
            "annotation": "Filters passed (1/5): num. of cancers (7).", 
            "sequence_org": "A", 
            "disease": {
                "doid": "1324", 
                "url": "http://disease-ontology.org/term/DOID:1324", 
                "icd10": "", 
                "name": "Lung cancer"
            }, 
            "sequence_mut": "E", 
            "subjects_tested": "689", 
            "end_pos": 321, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 321, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NC78", 
                    "id": "A6NC78", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.2", 
            "annotation": "Filters passed (1/5): num. of cancers (7).", 
            "sequence_org": "A", 
            "disease": {
                "doid": "363", 
                "url": "http://disease-ontology.org/term/DOID:363", 
                "icd10": "", 
                "name": "Uterine cancer"
            }, 
            "sequence_mut": "E", 
            "subjects_tested": "558", 
            "end_pos": 321, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 321, 
            "subjects_positive": "2", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NC78", 
                    "id": "A6NC78", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.5", 
            "annotation": "Filters passed (1/5): num. of cancers (7).", 
            "sequence_org": "A", 
            "disease": {
                "doid": "3571", 
                "url": "http://disease-ontology.org/term/DOID:3571", 
                "icd10": "", 
                "name": "Liver cancer"
            }, 
            "sequence_mut": "E", 
            "subjects_tested": "412", 
            "end_pos": 321, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 321, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NC78", 
                    "id": "A6NC78", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.1", 
            "annotation": "Filters passed (1/5): num. of cancers (7).", 
            "sequence_org": "A", 
            "disease": {
                "doid": "1319", 
                "url": "http://disease-ontology.org/term/DOID:1319", 
                "icd10": "", 
                "name": "Brain cancer"
            }, 
            "sequence_mut": "E", 
            "subjects_tested": "678", 
            "end_pos": 321, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 321, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NC78", 
                    "id": "A6NC78", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.1", 
            "annotation": "Filters passed (1/5): num. of cancers (7).", 
            "sequence_org": "A", 
            "disease": {
                "doid": "1612", 
                "url": "http://disease-ontology.org/term/DOID:1612", 
                "icd10": "", 
                "name": "Breast cancer"
            }, 
            "sequence_mut": "E", 
            "subjects_tested": "1144", 
            "end_pos": 321, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 321, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NC78", 
                    "id": "A6NC78", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.1", 
            "annotation": "Filters passed (1/5): num. of cancers (7).", 
            "sequence_org": "A", 
            "disease": {
                "doid": "11054", 
                "url": "http://disease-ontology.org/term/DOID:11054", 
                "icd10": "", 
                "name": "Urinary bladder cancer"
            }, 
            "sequence_mut": "E", 
            "subjects_tested": "742", 
            "end_pos": 321, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 169, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NC78", 
                    "id": "A6NC78", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.1", 
            "annotation": "Filters passed (1/5): num. of cancers (3).", 
            "sequence_org": "R", 
            "disease": {
                "doid": "1612", 
                "url": "http://disease-ontology.org/term/DOID:1612", 
                "icd10": "", 
                "name": "Breast cancer"
            }, 
            "sequence_mut": "C", 
            "subjects_tested": "955", 
            "end_pos": 169, 
            "type": "Point mutation"
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A6NC78#A6NC78-1", 
            "isoform_ac": "A6NC78-1", 
            "locus": {
                "end_pos": 0, 
                "start_pos": 0, 
                "chromosome": "", 
                "evidence": []
            }, 
            "sequence": {
                "header": "sp|A6NC78-1|GOG8I_HUMAN Isoform 1 of Putative golgin subfamily A member 8I  OS=Homo sapiens OX=9606 GN=GOLGA8IP PE=5 SV=2 CANONICAL=A6NC78-1", 
                "length": 632, 
                "sequence": "MAEETQHNKLAAAKKKLKEYWQKNSPRVPAGANRNRKTNGSIPQTATSGGCQPPGDSATGFHREGPTSSATLKDLESPCQERAVVLDSRSVEISQLKNTIKSLKQQKKQVEHQLEEEKKANIKKQKAKRVLEVQIQTLNIQKEELNTDLYHMKRSLRYFEEKSKDLAVRLQHSLQRKGELESVLSDVMATQKKKANQLSSPSKAGTEWKLEQSMREEALLKVQLTQLKESFQQLQLERHEYAEHLKGERARWQQRMRKMSQEICTLKKEKQQDMRRVEKLERSLSKLKNQMAEPLPPEPPAVPSEVELQHLRKELERVAGALQAQVKNNQRISLLNRGQEERIREQEERLRKQEERIQEQHKSLQQLAKPQSVFEEPNNENKSALQLEQQVKELQEKLGEEHLEAASQQNQQLTAQLSLMALPGEGHGGEHLDSEGEEAPQPMPSVPEDLESREAMSSFMDHLEEKADLSELVKKKELCFIHHWRERCHQKTHHLLSEPGGRAKDAALGGGHHQAGAQGGDEGEAAGAAADGIAAYSNYNNGHRKFLAAAHNPADEPGPGAPAPQELGAADKHGDLCEVSLTSSAQGEAREDPLLDKPTAQPIVQDHQEHPGLGSNCCVPFFCWAWLPRRRR"
            }
        }
    ], 
    "pathway": [], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A6NC78#function", 
            "annotation": "May be involved in maintaining Golgi structure.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A6NC78#function", 
                    "id": "A6NC78", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [], 
    "refseq": {
        "url": "", 
        "ac": "", 
        "name": "", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6NC78", 
                                "id": "A6NC78", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "Golgi apparatus", 
                        "id": "GO:0005794"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032580", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6NC78", 
                                "id": "A6NC78", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "Golgi cisterna membrane", 
                        "id": "GO:0032580"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005801", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6NC78", 
                                "id": "A6NC78", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cis-Golgi network", 
                        "id": "GO:0005801"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000137", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6NC78", 
                                "id": "A6NC78", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "Golgi cis cisterna", 
                        "id": "GO:0000137"
                    }
                ], 
                "total": 4, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007030", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6NC78", 
                                "id": "A6NC78", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "Golgi organization", 
                        "id": "GO:0007030"
                    }
                ], 
                "total": 1, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 41, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 39
        }, 
        {
            "end_pos": 383, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 381
        }
    ], 
    "crossref": [
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=26660", 
            "id": "26660", 
            "database": "HGNC"
        }, 
        {
            "url": "https://pharos.nih.gov/targets/A6NC78", 
            "id": "A6NC78", 
            "database": "PHAROS"
        }, 
        {
            "url": "https://www.nextprot.org/entry/NX_A6NC78", 
            "id": "NX_A6NC78", 
            "database": "neXtProt"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=GOLGA8IP", 
            "id": "GOLGA8IP", 
            "database": "GeneCards"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR024858", 
            "id": "IPR024858", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF15070", 
            "id": "PF15070", 
            "database": "Pfam"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10881", 
            "id": "PTHR10881", 
            "database": "PANTHER"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A6NC78", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 71330.0, 
        "chemical_mass": 71330.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A6NC78", 
            "name": "GOLGA8IP; GOLGA8I; GOLGA9P.", 
            "locus": {
                "end_pos": 22606022, 
                "start_pos": 22617854, 
                "chromosome": "15", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSG00000277561", 
                        "id": "ENSG00000277561", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}