{
    "uniprot_canonical_ac": "A6NC42-1", 
    "sequence": {
        "header": "sp|A6NC42-1|DPPA5_HUMAN Isoform 1 of Developmental pluripotency-associated 5 protein  OS=Homo sapiens OX=9606 GN=DPPA5 PE=2 SV=1 CANONICAL=A6NC42-1", 
        "length": 116, 
        "sequence": "MGTLPARRHIPPWVKVPEDLKDPEVFQVQTRLLKAIFGPDGSRIPYIEQVSKAMLELKALESSDLTEVVVYGSYLYKLRTKWMLQSMAEWHRQRQERGMLKLAEAMNALELGPWMK"
    }, 
    "uniprot_id": "DPPA5_HUMAN", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [
                "developmental pluripotency-associated 5 protein", 
                "embryonal stem cell specific gene 1"
            ], 
            "uniprotkb": [
                "Developmental pluripotency-associated 5 protein", 
                "hDPPA5", 
                "Embryonal stem cell-specific gene 1 protein", 
                "ESG-1"
            ]
        }, 
        "gene": {
            "refseq": [
                "DPPA5", 
                "ESG1"
            ], 
            "uniprotkb": [
                "DPPA5", 
                "ESG1"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A6NC42", 
                    "id": "A6NC42", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "recommendedname": {
        "full": "Developmental pluripotency-associated 5 protein; hDPPA5; Embryonal stem cell-specific gene 1 protein; ESG-1.", 
        "short": "hDPPA5"
    }, 
    "publication": [
        {
            "title": "DPPA5 Supports Pluripotency and Reprogramming by Regulating NANOG Turnover.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/26661329", 
            "journal": "Stem cells (Dayton, Ohio)", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020461.1", 
                    "id": "NP_001020461.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Qian X, Kim JK, Tong W, Villa-Diaz LG, Krebsbach PH", 
            "date": "2016", 
            "pmid": "26661329"
        }, 
        {
            "title": "Generation of induced pluripotent stem cells from human adipose-derived stem cells without c-MYC.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/20146561", 
            "journal": "Tissue engineering. Part A", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020461.1", 
                    "id": "NP_001020461.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Aoki T, Ohnishi H, Oda Y, Tadokoro M, Sasao M, Kato H, Hattori K, Ohgushi H", 
            "date": "2010", 
            "pmid": "20146561"
        }, 
        {
            "title": "The role of promoter CpG methylation in the epigenetic control of stem cell related genes during differentiation.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/19221495", 
            "journal": "Cell cycle (Georgetown, Tex.)", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020461.1", 
                    "id": "NP_001020461.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Dansranjavin T, Krehl S, Mueller T, Mueller LP, Schmoll HJ, Dammann RH", 
            "date": "2009", 
            "pmid": "19221495"
        }, 
        {
            "title": "Gene birth, death, and divergence: the different scenarios of reproduction-related gene evolution.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/19129511", 
            "journal": "Biology of reproduction", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020461.1", 
                    "id": "NP_001020461.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Tian X, Pascal G, Fouchecourt S, Pontarotti P, Monget P", 
            "date": "2009", 
            "pmid": "19129511"
        }, 
        {
            "title": "Atypical structure and phylogenomic evolution of the new eutherian oocyte- and embryo-expressed KHDC1/DPPA5/ECAT1/OOEP gene family.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/17913455", 
            "journal": "Genomics", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020461.1", 
                    "id": "NP_001020461.1", 
                    "database": "RefSeq"
                }, 
                {
                    "url": "https://www.uniprot.org/uniprot/A6NC42/publications", 
                    "id": "A6NC42", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Pierre A, Gautier M, Callebaut I, Bontoux M, Jeanpierre E, Pontarotti P, Monget P", 
            "date": "2007", 
            "pmid": "17913455"
        }, 
        {
            "title": "Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/17967063", 
            "journal": "PLoS genetics", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020461.1", 
                    "id": "NP_001020461.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Shen L, Kondo Y, Guo Y, Zhang J, Zhang L, Ahmed S, Shu J, Chen X, Waterland RA, Issa JP", 
            "date": "2007", 
            "pmid": "17967063"
        }, 
        {
            "title": "Identification of developmental pluripotency associated 5 expression in human pluripotent stem cells.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/15790765", 
            "journal": "Stem cells (Dayton, Ohio)", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020461.1", 
                    "id": "NP_001020461.1", 
                    "database": "RefSeq"
                }, 
                {
                    "url": "https://www.uniprot.org/uniprot/A6NC42/publications", 
                    "id": "A6NC42", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Kim SK, Suh MR, Yoon HS, Lee JB, Oh SK, Moon SY, Moon SH, Lee JY, Hwang JH, Cho WJ, Kim KS", 
            "date": "2005", 
            "pmid": "15790765"
        }, 
        {
            "title": "Primary differentiation in the human blastocyst: comparative molecular portraits of inner cell mass and trophectoderm cells.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/16081659", 
            "journal": "Stem cells (Dayton, Ohio)", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020461.1", 
                    "id": "NP_001020461.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Adjaye J, Huntriss J, Herwig R, BenKahla A, Brink TC, Wierling C, Hultschig C, Groth D, Yaspo ML, Picton HM, Gosden RG, Lehrach H", 
            "date": "2005", 
            "pmid": "16081659"
        }, 
        {
            "title": "Analysis of Esg1 expression in pluripotent cells and the germline reveals similarities with Oct4 and Sox2 and differences between human pluripotent cell lines.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/16166252", 
            "journal": "Stem cells (Dayton, Ohio)", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020461.1", 
                    "id": "NP_001020461.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Western P, Maldonado-Saldivia J, van den Bergen J, Hajkova P, Saitou M, Barton S, Surani MA", 
            "date": "2005", 
            "pmid": "16166252"
        }
    ], 
    "glycosylation": [], 
    "mutation": [
        {
            "start_pos": 39, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NC42", 
                    "id": "A6NC42", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.1", 
            "annotation": "Filters passed (1/5): num. of cancers (3).", 
            "sequence_org": "P", 
            "disease": {
                "doid": "4159", 
                "url": "http://disease-ontology.org/term/DOID:4159", 
                "icd10": "", 
                "name": "Skin cancer"
            }, 
            "sequence_mut": "L", 
            "subjects_tested": "820", 
            "end_pos": 39, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 39, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NC42", 
                    "id": "A6NC42", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.2", 
            "annotation": "Filters passed (1/5): num. of cancers (3).", 
            "sequence_org": "P", 
            "disease": {
                "doid": "9256", 
                "url": "http://disease-ontology.org/term/DOID:9256", 
                "icd10": "", 
                "name": "Colorectal cancer"
            }, 
            "sequence_mut": "L", 
            "subjects_tested": "456", 
            "end_pos": 39, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 39, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NC42", 
                    "id": "A6NC42", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "0.1", 
            "annotation": "Filters passed (1/5): num. of cancers (3).", 
            "sequence_org": "P", 
            "disease": {
                "doid": "1319", 
                "url": "http://disease-ontology.org/term/DOID:1319", 
                "icd10": "", 
                "name": "Brain cancer"
            }, 
            "sequence_mut": "L", 
            "subjects_tested": "1042", 
            "end_pos": 39, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 2, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NC42", 
                    "id": "A6NC42", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "1.5", 
            "annotation": "Filters passed (1/5): patient freq. (1.5%). In dbSNP: rs1427771623.", 
            "sequence_org": "G", 
            "disease": {
                "doid": "1324", 
                "url": "http://disease-ontology.org/term/DOID:1324", 
                "icd10": "", 
                "name": "Lung cancer"
            }, 
            "sequence_mut": "V", 
            "subjects_tested": "66", 
            "end_pos": 2, 
            "type": "Point mutation"
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A6NC42#A6NC42-1", 
            "isoform_ac": "A6NC42-1", 
            "locus": {
                "end_pos": 73353323, 
                "start_pos": 73354225, 
                "chromosome": "6", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000370370", 
                        "id": "ENST00000370370", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000359396", 
                        "id": "ENSP00000359396", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A6NC42-1|DPPA5_HUMAN Isoform 1 of Developmental pluripotency-associated 5 protein  OS=Homo sapiens OX=9606 GN=DPPA5 PE=2 SV=1 CANONICAL=A6NC42-1", 
                "length": 116, 
                "sequence": "MGTLPARRHIPPWVKVPEDLKDPEVFQVQTRLLKAIFGPDGSRIPYIEQVSKAMLELKALESSDLTEVVVYGSYLYKLRTKWMLQSMAEWHRQRQERGMLKLAEAMNALELGPWMK"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:340168", 
            "resource": "KEGG Pathway", 
            "id": "hsa:340168", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A6NC42#function", 
            "annotation": "Involved in the maintenance of embryonic stem (ES) cell pluripotency. Dispensable for self-renewal of pluripotent ES cells and establishment of germ cells. Associates with specific target mRNAs (By similarity).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A6NC42#function", 
                    "id": "A6NC42", 
                    "database": "UniProtKB"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020461.1", 
            "annotation": "Our study provides new insight into the function of DPPA5 and NANOG regulation in human pluripotent stem cell .", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020461.1", 
                    "id": "NP_001020461.1", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020461.1", 
            "annotation": "Dppa5 is specifically and differentially expressed in human cells that have pluripotency and can be used as a marker of pluripotent stem cells.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020461.1", 
                    "id": "NP_001020461.1", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q9CQS7-1", 
            "protein_name": "Developmental pluripotency-associated protein 5A; mDppa5; Embryonal stem cell-specific gene 1 protein; ESG-1; Protein pH 34; ES cell-associated transcript 2 protein.", 
            "sequence": {
                "length": 118, 
                "sequence": "MMVTLVTRKDIPPWVKVPEDLKDPEVFQVQSLVLKYLFGPQGSRMSHIEQVSQAMFELKNLESPEELIEVFIYGSQNNKIRAKWMLQSMAERYHLRQQKGVLKLEESMKTLELGQCIE"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/104905", 
                    "id": "104905", 
                    "database": "MGI"
                }
            ], 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }, 
        {
            "uniprot_canonical_ac": "F1LVJ7-1", 
            "protein_name": "Developmental pluripotency-associated 5.", 
            "sequence": {
                "length": 117, 
                "sequence": "KMATLVTRKDIPPWVKVPEDLKDPEVFQVHTLVLKSLFGPQGSRMPHIEQVSRAMFELKILESSGLTEVLIYGSCNHKLRAKWMLQSMAERYRLRQERGMLKLEEAMKTLELGQCLE"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A6NC42/", 
                    "id": "A6NC42", 
                    "database": "OMA"
                }
            ], 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020461.1", 
        "ac": "NP_001020461.1", 
        "name": "developmental pluripotency-associated 5 protein; embryonal stem cell specific gene 1.", 
        "summary": "This gene encodes a protein that may function in the control of cell pluripotency and early embryogenesis. Expression of this gene is a specific marker for pluripotent stem cells. Pseudogenes of this gene are located on the short arm of chromosome 10 and the long arm of chromosomes 14 and 19. [provided by RefSeq, Dec 2010]."
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6NC42", 
                                "id": "A6NC42", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "mRNA binding", 
                        "id": "GO:0003729"
                    }
                ], 
                "total": 1, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6NC42", 
                                "id": "A6NC42", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytoplasm", 
                        "id": "GO:0005737"
                    }
                ], 
                "total": 1, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6NC42", 
                                "id": "A6NC42", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of gene expression", 
                        "id": "GO:0010468"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007275", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6NC42", 
                                "id": "A6NC42", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "multicellular organism development", 
                        "id": "GO:0007275"
                    }
                ], 
                "total": 2, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020461.1", 
            "id": "NP_001020461.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=19201", 
            "id": "19201", 
            "database": "HGNC"
        }, 
        {
            "url": "https://pharos.nih.gov/targets/A6NC42", 
            "id": "A6NC42", 
            "database": "PHAROS"
        }, 
        {
            "url": "https://www.nextprot.org/entry/NX_A6NC42", 
            "id": "NX_A6NC42", 
            "database": "neXtProt"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=DPPA5", 
            "id": "DPPA5", 
            "database": "GeneCards"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:340168", 
            "id": "hsa:340168", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000203909", 
            "id": "ENSG00000203909", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/KLRTRWM/", 
            "id": "KLRTRWM", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12795", 
            "id": "cd12795", 
            "database": "CDD"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036612", 
            "id": "IPR036612", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR031952", 
            "id": "IPR031952", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF16005", 
            "id": "PF16005", 
            "database": "Pfam"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A6NC42", 
            "id": "PR_A6NC42", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/340168", 
            "id": "340168", 
            "database": "GeneID"
        }
    ], 
    "expression_disease": [
        {
            "trend": "Up", 
            "disease": {
                "doid": "5041", 
                "url": "http://disease-ontology.org/term/DOID:5041", 
                "icd10": "", 
                "name": "DOID:5041 / Esophageal cancer [EC]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6NC42", 
                    "id": "A6NC42", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "3910", 
                "url": "http://disease-ontology.org/term/DOID:3910", 
                "icd10": "", 
                "name": "DOID:3910 / Lung adenocarcinoma"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6NC42", 
                    "id": "A6NC42", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "10283", 
                "url": "http://disease-ontology.org/term/DOID:10283", 
                "icd10": "", 
                "name": "DOID:10283 / Prostate cancer [PCa]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6NC42", 
                    "id": "A6NC42", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "3907", 
                "url": "http://disease-ontology.org/term/DOID:3907", 
                "icd10": "", 
                "name": "DOID:3907 / Lung squamous cell carcinoma"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6NC42", 
                    "id": "A6NC42", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "3571", 
                "url": "http://disease-ontology.org/term/DOID:3571", 
                "icd10": "", 
                "name": "DOID:3571 / Liver cancer [Livca]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6NC42", 
                    "id": "A6NC42", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "11054", 
                "url": "http://disease-ontology.org/term/DOID:11054", 
                "icd10": "", 
                "name": "DOID:11054 / Urinary bladder cancer [UBC]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6NC42", 
                    "id": "A6NC42", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "DOID:1781 / Thyroid cancer [Thyca]"
            }, 
            "significant": "Yes", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6NC42", 
                    "id": "A6NC42", 
                    "database": "BioXpress"
                }
            ]
        }
    ], 
    "uniprot_ac": "A6NC42", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 13498.0, 
        "chemical_mass": 13498.0
    }, 
    "expression_tissue": [
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                "name": "Body of uterus"
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            "evidence": [
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                    "id": "ENSG00000203909", 
                    "database": "Bgee"
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        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000458", 
                "uberon": "0000458", 
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            "evidence": [
                {
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                    "id": "ENSG00000203909", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
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                "uberon": "0000948", 
                "name": "Heart"
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            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000203909", 
                    "id": "ENSG00000203909", 
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        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000473", 
                "uberon": "0000473", 
                "name": "Testis"
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            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000203909", 
                    "id": "ENSG00000203909", 
                    "database": "Bgee"
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            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002369", 
                "uberon": "0002369", 
                "name": "Adrenal gland"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000203909", 
                    "id": "ENSG00000203909", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000992", 
                "uberon": "0000992", 
                "name": "Ovary"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000203909", 
                    "id": "ENSG00000203909", 
                    "database": "Bgee"
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            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000996", 
                "uberon": "0000996", 
                "name": "Vagina"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000203909", 
                    "id": "ENSG00000203909", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001155", 
                "uberon": "0001155", 
                "name": "Colon"
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            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000203909", 
                    "id": "ENSG00000203909", 
                    "database": "Bgee"
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            ]
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        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001987", 
                "uberon": "0001987", 
                "name": "Placenta"
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            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000203909", 
                    "id": "ENSG00000203909", 
                    "database": "Bgee"
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            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000955", 
                "uberon": "0000955", 
                "name": "Brain"
            }, 
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            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000203909", 
                    "id": "ENSG00000203909", 
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            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001160", 
                "uberon": "0001160", 
                "name": "Fundus of stomach"
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            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000203909", 
                    "id": "ENSG00000203909", 
                    "database": "Bgee"
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        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001150", 
                "uberon": "0001150", 
                "name": "Body of pancreas"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000203909", 
                    "id": "ENSG00000203909", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002048", 
                "uberon": "0002048", 
                "name": "Lung"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000203909", 
                    "id": "ENSG00000203909", 
                    "database": "Bgee"
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            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000007", 
                "uberon": "0000007", 
                "name": "Pituitary gland"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000203909", 
                    "id": "ENSG00000203909", 
                    "database": "Bgee"
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            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002107", 
                "uberon": "0002107", 
                "name": "Liver"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000203909", 
                    "id": "ENSG00000203909", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002046", 
                "uberon": "0002046", 
                "name": "Thyroid gland"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000203909", 
                    "id": "ENSG00000203909", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178", 
                "uberon": "0000178", 
                "name": "Blood"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000203909", 
                    "id": "ENSG00000203909", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001043", 
                "uberon": "0001043", 
                "name": "Esophagus"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000203909", 
                    "id": "ENSG00000203909", 
                    "database": "Bgee"
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        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002367", 
                "uberon": "0002367", 
                "name": "Prostate gland"
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            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000203909", 
                    "id": "ENSG00000203909", 
                    "database": "Bgee"
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            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001161", 
                "uberon": "0001161", 
                "name": "Body of stomach"
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            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000203909", 
                    "id": "ENSG00000203909", 
                    "database": "Bgee"
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            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001255", 
                "uberon": "0001255", 
                "name": "Urinary bladder"
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            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000203909", 
                    "id": "ENSG00000203909", 
                    "database": "Bgee"
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            ]
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    ], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A6NC42", 
            "name": "DPPA5; ESG1.", 
            "locus": {
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                "start_pos": 73354295, 
                "chromosome": "6", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSG00000203909", 
                        "id": "ENSG00000203909", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}