{
    "uniprot_canonical_ac": "A6NC05-1", 
    "sequence": {
        "header": "sp|A6NC05-1|YD286_HUMAN Isoform 1 of Glutaredoxin-like protein C5orf63  OS=Homo sapiens OX=9606 GN=C5orf63 PE=2 SV=3 CANONICAL=A6NC05-1", 
        "length": 138, 
        "sequence": "MLWFQGNSMQLARSSFGLFLRNCSASKTTLPVLTLFTKDPCPLCDEAKEVLKPYENRQPYKDQKLPGTRRRRSPSSPSHPHMASQSGKRYNLTLNQVLSFDYDMGLDAPKTISSDCGAFYCLRMFKSPDMTCCFYPKQ"
    }, 
    "uniprot_id": "YD286_HUMAN", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [
                "glutaredoxin-like protein C5orf63 isoform 2", 
                "glutaredoxin-like protein C5orf63; glutaredoxin-like protein YDR286C homolog"
            ], 
            "uniprotkb": [
                "Glutaredoxin-like protein C5orf63"
            ]
        }, 
        "gene": {
            "refseq": [
                "C5orf63", 
                "YDR286C"
            ], 
            "uniprotkb": [
                "C5orf63", 
                "YDR286C"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A6NC05", 
                    "id": "A6NC05", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "recommendedname": {
        "full": "Glutaredoxin-like protein C5orf63."
    }, 
    "publication": [
        {
            "title": "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/16344560", 
            "journal": "Genome research", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157950.1", 
                    "id": "NP_001157950.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S", 
            "date": "2006", 
            "pmid": "16344560"
        }
    ], 
    "glycosylation": [], 
    "mutation": [
        {
            "start_pos": 38, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NC05", 
                    "id": "A6NC05", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "2.0", 
            "annotation": "Filters passed (1/5): patient freq. (2.0%).", 
            "sequence_org": "K", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "R", 
            "subjects_tested": "50", 
            "end_pos": 38, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 86, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6NC05", 
                    "id": "A6NC05", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "1.1", 
            "annotation": "Filters passed (1/5): patient freq. (1.1%).", 
            "sequence_org": "S", 
            "disease": {
                "doid": "9256", 
                "url": "http://disease-ontology.org/term/DOID:9256", 
                "icd10": "", 
                "name": "Colorectal cancer"
            }, 
            "sequence_mut": "L", 
            "subjects_tested": "94", 
            "end_pos": 86, 
            "type": "Point mutation"
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A6NC05#A6NC05-1", 
            "isoform_ac": "A6NC05-1", 
            "locus": {
                "end_pos": 127047673, 
                "start_pos": 127058995, 
                "chromosome": "5", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000535381", 
                        "id": "ENST00000535381", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000454153", 
                        "id": "ENSP00000454153", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A6NC05-1|YD286_HUMAN Isoform 1 of Glutaredoxin-like protein C5orf63  OS=Homo sapiens OX=9606 GN=C5orf63 PE=2 SV=3 CANONICAL=A6NC05-1", 
                "length": 138, 
                "sequence": "MLWFQGNSMQLARSSFGLFLRNCSASKTTLPVLTLFTKDPCPLCDEAKEVLKPYENRQPYKDQKLPGTRRRRSPSSPSHPHMASQSGKRYNLTLNQVLSFDYDMGLDAPKTISSDCGAFYCLRMFKSPDMTCCFYPKQ"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A6NC05#U3KQ05-1", 
            "isoform_ac": "U3KQ05-1", 
            "locus": {
                "end_pos": 127052607, 
                "start_pos": 127058995, 
                "chromosome": "5", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000509733", 
                        "id": "ENST00000509733", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000475415", 
                        "id": "ENSP00000475415", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|U3KQ05-1|YD286_HUMAN Computationally mapped isoform of Glutaredoxin-like protein C5orf63  OS=Homo sapiens OX=9606 GN=C5orf63 PE=2 SV=1 CANONICAL=A6NC05-1", 
                "length": 59, 
                "sequence": "MLWFQGNSMQLARSSFGLFLRNCSASKTTLPVLTLFTKDPCPLCDEAKEVLKPYENRVI"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A6NC05#A6NC05-2", 
            "isoform_ac": "A6NC05-2", 
            "locus": {
                "end_pos": 127051774, 
                "start_pos": 127058995, 
                "chromosome": "5", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000296662", 
                        "id": "ENST00000296662", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000453964", 
                        "id": "ENSP00000453964", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A6NC05-2|YD286_HUMAN Isoform 2 of Glutaredoxin-like protein C5orf63  OS=Homo sapiens OX=9606 GN=C5orf63 PE=2 SV=3 CANONICAL=A6NC05-1", 
                "length": 115, 
                "sequence": "MLWFQGNSMQLARSSFGLFLRNCSASKTTLPVLTLFTKDPCPLCDEAKEVLKPYENRFILQEVNITLPENSVWYERYKFDIPVFHLNGQFLMMHRVNTSKLEKQLLKLEQQSTGG"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A6NC05#U3KQB8-1", 
            "isoform_ac": "U3KQB8-1", 
            "locus": {
                "end_pos": 127051774, 
                "start_pos": 127058917, 
                "chromosome": "5", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000606042", 
                        "id": "ENST00000606042", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000475733", 
                        "id": "ENSP00000475733", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|U3KQB8-1|YD286_HUMAN Computationally mapped isoform of Glutaredoxin-like protein C5orf63  OS=Homo sapiens OX=9606 GN=C5orf63 PE=2 SV=1 CANONICAL=A6NC05-1", 
                "length": 57, 
                "sequence": "KTTLPVLTLFTKDPCPLCDEAKEVLKPYENRFLMMHRVNTSKLEKQLLKLEQQSTGG"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A6NC05#U3KQR4-1", 
            "isoform_ac": "U3KQR4-1", 
            "locus": {
                "end_pos": 127051389, 
                "start_pos": 127058995, 
                "chromosome": "5", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000607731", 
                        "id": "ENST00000607731", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000476160", 
                        "id": "ENSP00000476160", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|U3KQR4-1|YD286_HUMAN Computationally mapped isoform of Glutaredoxin-like protein C5orf63  OS=Homo sapiens OX=9606 GN=C5orf63 PE=2 SV=1 CANONICAL=A6NC05-1", 
                "length": 89, 
                "sequence": "MLWFQGNSMQLARSSFGLFLRNCSASKTTLPVLTLFTKDPCPLCDEAKEVLKPYENRRSTSQSLGNAIYRKKVLHSCCCPGGLNFLMKE"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A6NC05#U3KPR6-1", 
            "isoform_ac": "U3KPR6-1", 
            "locus": {
                "end_pos": 127056456, 
                "start_pos": 127058995, 
                "chromosome": "5", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000508527", 
                        "id": "ENST00000508527", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000475157", 
                        "id": "ENSP00000475157", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|U3KPR6-1|YD286_HUMAN Computationally mapped isoform of Glutaredoxin-like protein C5orf63  OS=Homo sapiens OX=9606 GN=C5orf63 PE=2 SV=1 CANONICAL=A6NC05-1", 
                "length": 55, 
                "sequence": "MLWFQGNSMQLARSSFGLFLRNCSASKTTLPVLTLFTKEFLSTRSLFACCHPCKM"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:401207", 
            "resource": "KEGG Pathway", 
            "id": "hsa:401207", 
            "name": ""
        }
    ], 
    "function": [], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "G3V7R5-1", 
            "protein_name": "Glutaredoxin-like protein.", 
            "sequence": {
                "length": 115, 
                "sequence": "MLWFQGNSLQIARSSFGLLRNLSASNTALPVLTLFTKHPCPLCDEAKEVLQPYKNRFILQEVDITLPENSTWYERYKFDIPVFHLNGQFLMKHRVNTSKLETQLLKLEQQVLETN"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/35412", 
                    "id": "35412", 
                    "database": "MGI"
                }
            ], 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "Q9CWB7-1", 
            "protein_name": "Glutaredoxin-like protein C5orf63 homolog.", 
            "sequence": {
                "length": 115, 
                "sequence": "MLWFQGKSLQIAKSSFGLLRNLSASNRALPVLTLFTKAPCPLCDEAKEVLQPYKDRFILQEVDITLPENSTWYERYKFDIPVFHLNGQFLMMHRVNTSKLEKQLRKLEQQVLATN"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/35412", 
                    "id": "35412", 
                    "database": "MGI"
                }
            ], 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157950.1", 
        "ac": "NP_001157950.1", 
        "name": "glutaredoxin-like protein C5orf63 isoform 2; glutaredoxin-like protein C5orf63; glutaredoxin-like protein YDR286C homolog.", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055114", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6NC05", 
                                "id": "A6NC05", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "oxidation-reduction process", 
                        "id": "GO:0055114"
                    }
                ], 
                "total": 1, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 24, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 22
        }, 
        {
            "end_pos": 93, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 91
        }
    ], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157950.1", 
            "id": "NP_001157950.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=40051", 
            "id": "40051", 
            "database": "HGNC"
        }, 
        {
            "url": "https://pharos.nih.gov/targets/A6NC05", 
            "id": "A6NC05", 
            "database": "PHAROS"
        }, 
        {
            "url": "https://www.nextprot.org/entry/NX_A6NC05", 
            "id": "NX_A6NC05", 
            "database": "neXtProt"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=C5orf63", 
            "id": "C5orf63", 
            "database": "GeneCards"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:401207", 
            "id": "hsa:401207", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000164241", 
            "id": "ENSG00000164241", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/EPYKHRF/", 
            "id": "EPYKHRF", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", 
            "id": "IPR036249", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR008554", 
            "id": "IPR008554", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF05768", 
            "id": "PF05768", 
            "database": "Pfam"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A6NC05", 
            "id": "PR_A6NC05", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/401207", 
            "id": "401207", 
            "database": "GeneID"
        }
    ], 
    "expression_disease": [
        {
            "trend": "Up", 
            "disease": {
                "doid": "11054", 
                "url": "http://disease-ontology.org/term/DOID:11054", 
                "icd10": "", 
                "name": "DOID:11054 / Urinary bladder cancer [UBC]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6NC05", 
                    "id": "A6NC05", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "5041", 
                "url": "http://disease-ontology.org/term/DOID:5041", 
                "icd10": "", 
                "name": "DOID:5041 / Esophageal cancer [EC]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6NC05", 
                    "id": "A6NC05", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "3910", 
                "url": "http://disease-ontology.org/term/DOID:3910", 
                "icd10": "", 
                "name": "DOID:3910 / Lung adenocarcinoma"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6NC05", 
                    "id": "A6NC05", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "3907", 
                "url": "http://disease-ontology.org/term/DOID:3907", 
                "icd10": "", 
                "name": "DOID:3907 / Lung squamous cell carcinoma"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6NC05", 
                    "id": "A6NC05", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "10283", 
                "url": "http://disease-ontology.org/term/DOID:10283", 
                "icd10": "", 
                "name": "DOID:10283 / Prostate cancer [PCa]"
            }, 
            "significant": "Yes", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6NC05", 
                    "id": "A6NC05", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "DOID:1781 / Thyroid cancer [Thyca]"
            }, 
            "significant": "Yes", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6NC05", 
                    "id": "A6NC05", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "3571", 
                "url": "http://disease-ontology.org/term/DOID:3571", 
                "icd10": "", 
                "name": "DOID:3571 / Liver cancer [Livca]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6NC05", 
                    "id": "A6NC05", 
                    "database": "BioXpress"
                }
            ]
        }
    ], 
    "uniprot_ac": "A6NC05", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 15764.0, 
        "chemical_mass": 15764.0
    }, 
    "expression_tissue": [
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0009853", 
                "uberon": "0009853", 
                "name": "Body of uterus"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000164241", 
                    "id": "ENSG00000164241", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000458", 
                "uberon": "0000458", 
                "name": "Endocervix"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000164241", 
                    "id": "ENSG00000164241", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000948", 
                "uberon": "0000948", 
                "name": "Heart"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000164241", 
                    "id": "ENSG00000164241", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000473", 
                "uberon": "0000473", 
                "name": "Testis"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000164241", 
                    "id": "ENSG00000164241", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002369", 
                "uberon": "0002369", 
                "name": "Adrenal gland"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000164241", 
                    "id": "ENSG00000164241", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000992", 
                "uberon": "0000992", 
                "name": "Ovary"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000164241", 
                    "id": "ENSG00000164241", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000996", 
                "uberon": "0000996", 
                "name": "Vagina"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000164241", 
                    "id": "ENSG00000164241", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001155", 
                "uberon": "0001155", 
                "name": "Colon"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000164241", 
                    "id": "ENSG00000164241", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001987", 
                "uberon": "0001987", 
                "name": "Placenta"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000164241", 
                    "id": "ENSG00000164241", 
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                {
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                    "id": "ENSG00000164241", 
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                "name": "Lung"
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            "evidence": [
                {
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                "name": "Pituitary gland"
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                {
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        {
            "tissue": {
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                "uberon": "0002046", 
                "name": "Thyroid gland"
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        {
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                "name": "Prostate gland"
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            "evidence": [
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        {
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    ], 
    "gene": [
        {
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            "name": "C5orf63; YDR286C.", 
            "locus": {
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                "chromosome": "5", 
                "evidence": [
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                        "id": "ENSG00000164241", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}