{ "uniprot_canonical_ac": "A6N6J5-1", "sequence": { "header": "sp|A6N6J5-1|WDR35_RAT Isoform 1 of WD repeat-containing protein 35 OS=Rattus norvegicus OX=10116 GN=Wdr35 PE=1 SV=1 CANONICAL=A6N6J5-1", "length": 1170, "sequence": "MFFYLSKKIAVPNNVKLKCISWNKDQGFIACGGEDGLLKVLRLETQTDDSKLRGLAAPSNLSMNQNLEGHSGAVQVVTWNEQYQKLTTSDQNGLIIVWMLYKGSWYEEMINNRNKSVVRSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQLCHVTWSADSKILLFGMANGEIHIYDNQGNFIMKMKLNCLVNVTGAISIAGIHWYHGTEGYVEPDCPCLAICFDNGRCQIMRHENDQNPVLIDTGMYVVGIQWNHIGSVLAVAGSQKVVTQDKDVNIVQFYTPFGEHLGTLKVPGKQMCSLSWEGGGLKIALAVDSFIYFANIRPDYKWGYCSNTVVYAYTRPDRPEYCVVFWDTKNNEKYVKYVKSLISITTCGDFCILATKADENHPQFVLVLCNSIGTPLDPKYIDLVPLFVAMTKTHVIAASKEALYTWQYRVAKKLTALEINQITRSRKEGRERIYHVDDVPSGSVDGVFDYSKAIQGTRDPICAITASDKTLIVGRESGVIQRYSFPNVALIQKYSLDCRACQLSLNCNSSRLAIIDIAGVLTFFDLDTRVTDSTGQQVVGELLKLERKDVWDMKWAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKNPEHPSKDYIMNFEIRSLRDSRALIEKVGIEDASQFIEDNPHPRLWRLLAEAALQKLDLYTAQQAFVRCKDYQGIKFVKRLGNLQSESMKQAEVIAYFGRFEEAERMYLDMDRRDLAIGLRLKLGDWFRVLQLLKTGSGDADDSLLEQAHNAIGDYFADRQKWMNAVQYYVKGRNQERLAECYYMLEDYEGLENLANSLPENHKLLPEIAQMFVRVGMCEQAVSAFLKCNQPKAAVDTCVHLNQWNKAVELAKSHSMKEIGSLLARYASHLLEKNKTLDAIELYRKASYFFDAAKLMYKIADEEAKKRTKPLRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKNSEATSALAGLLEEEVLSTTSRFTDNAWRGAEAYHFFILAQRQLYEGYVDTALKTALHLRDYEDIIPSVEIYSLLALCACASRAFGTCSKAFIKLESLETLSAEQKQQYEDLALEIFTKHTPKDNRKSELNSLLEGGEGKLPTCIATGSPIIEYQFWVCKVCKHYVLAQEISNYNFCPLCHSSVE" }, "uniprot_id": "WDR35_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "WD repeat-containing protein 35", "naofen" ], "uniprotkb": [ "WD repeat-containing protein 35", "Naofen" ] }, "gene": { "refseq": [ "Wdr35", "RGD1564116" ], "uniprotkb": [ "Wdr35", "RGD1564116" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6N6J5", "id": "A6N6J5", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "WD repeat-containing protein 35; Naofen." }, "publication": [ { "title": "Ciliopathy-associated mutations of IFT122 impair ciliary protein trafficking but not ciliogenesis.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/29220510", "journal": "Human molecular genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092810.1", "id": "NP_001092810.1", "database": "RefSeq" } ], "authors": "Takahara M, Katoh Y, Nakamura K, Hirano T, Sugawa M, Tsurumi Y, Nakayama K", "date": "2018", "pmid": "29220510" }, { "title": "Intraflagellar transport-A complex mediates ciliary entry and retrograde trafficking of ciliary G protein-coupled receptors.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/27932497", "journal": "Molecular biology of the cell", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092810.1", "id": "NP_001092810.1", "database": "RefSeq" } ], "authors": "Hirano T, Katoh Y, Nakayama K", "date": "2017", "pmid": "27932497" }, { "title": "Specific variants in WDR35 cause a distinctive form of Ellis-van Creveld syndrome by disrupting the recruitment of the EvC complex and SMO into the cilium.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/25908617", "journal": "Human molecular genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092810.1", "id": "NP_001092810.1", "database": "RefSeq" } ], "authors": "Caparros-Martin JA, De Luca A, Cartault F, Aglan M, Temtamy S, Otaify GA, Mehrez M, Valencia M, Vazquez L, Alessandri JL, Nevado J, Rueda-Arenas I, Heath KE, Digilio MC, Dallapiccola B, Goodship JA, Mill P, Lapunzina P, Ruiz-Perez VL", "date": "2015", "pmid": "25908617" }, { "title": "Naofen promotes TNF-alpha-mediated apoptosis of hepatocytes by activating caspase-3 in lipopolysaccharide-treated rats.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/24803807", "journal": "World journal of gastroenterology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092810.1", "id": "NP_001092810.1", "database": "RefSeq" } ], "authors": "Fan JH, Feng GG, Huang L, Tang GD, Jiang HX, Xu J", "date": "2014", "pmid": "24803807" }, { "title": "Enhanced expression of WD repeat-containing protein 35 (WDR35) stimulated by domoic acid in rat hippocampus: involvement of reactive oxygen species generation and p38 mitogen-activated protein kinase activation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/23289926", "journal": "BMC neuroscience", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092810.1", "id": "NP_001092810.1", "database": "RefSeq" } ], "authors": "Tsunekawa K, Kondo F, Okada T, Feng GG, Huang L, Ishikawa N, Okada S", "date": "2013", "pmid": "23289926" }, { "title": "Naofen, a novel WD40-repeat protein, mediates spontaneous and tumor necrosis factor-induced apoptosis.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/20193664", "journal": "Biochemical and biophysical research communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092810.1", "id": "NP_001092810.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A6N6J5/publications", "id": "A6N6J5", "database": "UniProtKB" } ], "authors": "Feng GG, Li C, Huang L, Tsunekawa K, Sato Y, Fujiwara Y, Komatsu T, Honda T, Fan JH, Goto H, Koide T, Hasegawa T, Ishikawa N", "date": "2010", "pmid": "20193664" }, { "title": "Enhanced expression of naofen in kidney of streptozotocin-induced diabetic rats: possible correlation to apoptosis of tubular epithelial cells.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/20224876", "journal": "Clinical and experimental nephrology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092810.1", "id": "NP_001092810.1", "database": "RefSeq" } ], "authors": "Sato Y, Feng GG, Huang L, Fan JH, Li C, An J, Tsunekawa K, Kurokawa S, Fujiwara Y, Komatsu T, Kondo F, Ishikawa N", "date": "2010", "pmid": "20224876" }, { "title": "Role of naofen, a novel WD repeat-containing protein, in reducing nitric oxide-induced relaxation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/18671723", "journal": "Clinical and experimental pharmacology & physiology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092810.1", "id": "NP_001092810.1", "database": "RefSeq" } ], "authors": "Feng GG, Yamada M, Wongsawatkul O, Li C, Huang L, An J, Komatsu T, Fujiwara Y, Naohisa I", "date": "2008", "pmid": "18671723" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A6N6J5#A6N6J5-1", "isoform_ac": "A6N6J5-1", "locus": { "end_pos": 34094410, "start_pos": 34151042, "chromosome": "6", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000051970", "id": "ENSRNOT00000051970", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000042019", "id": "ENSRNOP00000042019", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A6N6J5-1|WDR35_RAT Isoform 1 of WD repeat-containing protein 35 OS=Rattus norvegicus OX=10116 GN=Wdr35 PE=1 SV=1 CANONICAL=A6N6J5-1", "length": 1170, "sequence": "MFFYLSKKIAVPNNVKLKCISWNKDQGFIACGGEDGLLKVLRLETQTDDSKLRGLAAPSNLSMNQNLEGHSGAVQVVTWNEQYQKLTTSDQNGLIIVWMLYKGSWYEEMINNRNKSVVRSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQLCHVTWSADSKILLFGMANGEIHIYDNQGNFIMKMKLNCLVNVTGAISIAGIHWYHGTEGYVEPDCPCLAICFDNGRCQIMRHENDQNPVLIDTGMYVVGIQWNHIGSVLAVAGSQKVVTQDKDVNIVQFYTPFGEHLGTLKVPGKQMCSLSWEGGGLKIALAVDSFIYFANIRPDYKWGYCSNTVVYAYTRPDRPEYCVVFWDTKNNEKYVKYVKSLISITTCGDFCILATKADENHPQFVLVLCNSIGTPLDPKYIDLVPLFVAMTKTHVIAASKEALYTWQYRVAKKLTALEINQITRSRKEGRERIYHVDDVPSGSVDGVFDYSKAIQGTRDPICAITASDKTLIVGRESGVIQRYSFPNVALIQKYSLDCRACQLSLNCNSSRLAIIDIAGVLTFFDLDTRVTDSTGQQVVGELLKLERKDVWDMKWAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKNPEHPSKDYIMNFEIRSLRDSRALIEKVGIEDASQFIEDNPHPRLWRLLAEAALQKLDLYTAQQAFVRCKDYQGIKFVKRLGNLQSESMKQAEVIAYFGRFEEAERMYLDMDRRDLAIGLRLKLGDWFRVLQLLKTGSGDADDSLLEQAHNAIGDYFADRQKWMNAVQYYVKGRNQERLAECYYMLEDYEGLENLANSLPENHKLLPEIAQMFVRVGMCEQAVSAFLKCNQPKAAVDTCVHLNQWNKAVELAKSHSMKEIGSLLARYASHLLEKNKTLDAIELYRKASYFFDAAKLMYKIADEEAKKRTKPLRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKNSEATSALAGLLEEEVLSTTSRFTDNAWRGAEAYHFFILAQRQLYEGYVDTALKTALHLRDYEDIIPSVEIYSLLALCACASRAFGTCSKAFIKLESLETLSAEQKQQYEDLALEIFTKHTPKDNRKSELNSLLEGGEGKLPTCIATGSPIIEYQFWVCKVCKHYVLAQEISNYNFCPLCHSSVE" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:503018", "resource": "KEGG Pathway", "id": "rno:503018", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5610787", "resource": "Reactome", "id": "R-RNO-5610787", "name": "Hedgehog 'off' state" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5620924", "resource": "Reactome", "id": "R-RNO-5620924", "name": "Intraflagellar transport" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A6N6J5#function", "annotation": "As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking (By similarity). May promote CASP3 activation and TNF-stimulated apoptosis (PubMed:20193664).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6N6J5#function", "id": "A6N6J5", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092810.1", "annotation": "TNF-alpha released from Kupffer cells treated with LPS may induce hepatic naofen expression, which then stimulates hepatocellular apoptosis through activation of caspase-3.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092810.1", "id": "NP_001092810.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092810.1", "annotation": "The results of this study indicated that domoic acid activated AMPA/KA receptors and induced ROS production and p38 MAPK phosphorylation, resulting in an increase in the expression of WDR35 in vivo. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092810.1", "id": "NP_001092810.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092810.1", "annotation": "Naofen expression may be upregulated by hyperglycemia, with possible correlation to apoptosis of tubular epithelial cells and thereby to diabetic nephropathy. Erratum:[Clin Exp Nephrol. 2010 Jun;14(3):213]", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092810.1", "id": "NP_001092810.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092810.1", "annotation": "These results indicated that naofen may function as a novel modulator activating caspase-3, and promoting TNF-alpha-stimulated apoptosis.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092810.1", "id": "NP_001092810.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092810.1", "annotation": "Naofen N-terminal protein causes a significant decrease in acetylcholine-induced relaxation of aortic strips from normotensive rats.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092810.1", "id": "NP_001092810.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q9P2L0-1", "protein_name": "WD repeat-containing protein 35; Intraflagellar transport protein 121 homolog.", "sequence": { "length": 1181, "sequence": "MFFYLSKKISIPNNVKLQCVSWNKEQGFIACGGEDGLLKVLKLETQTDDAKLRGLAAPSNLSMNQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVVRSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQLSHVTWSADSKVLLFGMANGEIHIYDNQGNFMIKMKLSCLVNVTGAISIAGIHWYHGTEGYVEPDCPCLAVCFDNGRCQIMRHENDQNPVLIDTGMYVVGIQWNHMGSVLAVAGFQKAAMQDKDVNIVQFYTPFGEHLGTLKVPGKEISALSWEGGGLKIALAVDSFIYFANIRPNYKWGYCSNTVVYAYTRPDRPEYCVVFWDTKNNEKYVKYVKGLISITTCGDFCILATKADENHPQEENEMETFGATFVLVLCNSIGTPLDPKYIDIVPLFVAMTKTHVIAASKEAFYTWQYRVAKKLTALEINQITRSRKEGRERIYHVDDTPSGSMDGVLDYSKTIQGTRDPICAITASDKILIVGRESGTIQRYSLPNVGLIQKYSLNCRAYQLSLNCNSSRLAIIDISGVLTFFDLDARVTDSTGQQVVGELLKLERRDVWDMKWAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKDPEHPNKDYLINFEIRSLRDSRALIEKVGIKDASQFIEDNPHPRLWRLLAEAALQKLDLYTAEQAFVRCKDYQGIKFVKRLGKLLSESMKQAEVVGYFGRFEEAERTYLEMDRRDLAIGLRLKLGDWFRVLQLLKTGSGDADDSLLEQANNAIGDYFADRQKWLNAVQYYVQGRNQERLAECYYMLEDYEGLENLAISLPENHKLLPEIAQMFVRVGMCEQAVTAFLKCSQPKAAVDTCVHLNQWNKAVELAKNHSMKEIGSLLARYASHLLEKNKTLDAIELYRKANYFFDAAKLMFKIADEEAKKGSKPLRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKSSEATSALAGLLEEEVLSTTDRFTDNAWRGAEAYHFFILAQRQLYEGCVDTALKTALHLKDYEDIIPPVEIYSLLALCACASRAFGTCSKAFIKLKSLETLSSEQKQQYEDLALEIFTKHTSKDNRKPELDSLMEGGEGKLPTCVATGSPITEYQFWMCSVCKHGVLAQEISHYSFCPLCHSPVG" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/10814", "id": "10814", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A6N6J5/", "id": "A6N6J5", "database": "OMA" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q8BND3-1", "protein_name": "WD repeat-containing protein 35.", "sequence": { "length": 1181, "sequence": "MFFYLSKKIAVPNNVKLKCISWNKDQGFIACGGEDGLLKVLRLETQTDDSKLRGLAAPSNLSMNQNLEGHSGAVQVVTWNEQYQKLTTSDQNGLIIVWMLYKGSWYEEMINNRNKSVVRSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQLCHVTWSADSKILLFGMANGEIHIYDNQGNFIMKMKLNCLVNVTGAISIAGIHWYHGTEGYVEPDCPCLAICFDNGRCQIMRHENDQNPVLIDTGMYVVGIQWNHIGSVLAVAGSQKVVTQDKDINIVQFYTPFGEHLGTLKVPGKQMCSLSWEGGGLKIALAVDSFIYFANIRPDYKWGYCSNTVVYAYTRPDRPEYCVVFWDTKNSEKYVKYVKSLISITTCGDFCILATKADENHPQEENEMETFGATFVLVLCNSIGTPLDPKYIDLVPLFVAMTKTHVIAASKEAFYTWQYRVAKKLTALEINQITRSRKEGRERIYHVDDVPSGSVDGVFDYSKAIQGTRDPICAITASDKTLIVGRESGVIQRYSFPNVALIQKYSLDCRACQLSLNCNSSRLAIIDIAGVLTFFDLDTRVTDSTGQQVVGELLKLERKDVWDMKWAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKDPEHPSKDYIMNFEIRSLRDSRALIEKVGIEDASQFIEDNPHPRLWRLLAEAALQKLDLYTAQQAFVRCKDYQGIKFVKLLGNLQSESMKQAEVIAYFGRFEDAERMYQDMDRRDLAIGLRMKLGDWFRVLQLLKTGSGDADDSLLEQANNAIGEYFADRQKWQNAVQYYVKGRNQERLAECYYMLEDYEGLETLANSLPENHKLLPEIAQMFVRVGMCEQAVSAFLKCNQPKAAVDTCVHLNQWNKAVELAKSHSMKEIGSLLARYASHLLEKNKTLDAIELYRKASYFFDAAKLMYKIADEEAKKRTKPLRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKNSEATSALAGLLEEEVLSTTSRFTDNAWRGAEAYHFFILAQRQLYEGYVDTALKTALHLRDYEDIIPSVEIYSLLALCACASRAFGTCSKAFIKLESLETLSAEQKQQYEDLALEIFTKHTPKDNRKSELNSLLEGGEGKLPTCIATGSPIIEYQFWVCKVCKHYVLAQEISNYNFCPLCHSSVE" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/10814", "id": "10814", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092810.1", "ac": "NP_001092810.1", "name": "WD repeat-containing protein 35; naofen.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6N6J5", "id": "A6N6J5", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6N6J5", "id": "A6N6J5", "database": "UniProtKB" } ], "name": "centrosome", "id": "GO:0005813" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6N6J5", "id": "A6N6J5", "database": "UniProtKB" } ], "name": "axoneme", "id": "GO:0005930" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6N6J5", "id": "A6N6J5", "database": "UniProtKB" } ], "name": "ciliary basal body", "id": "GO:0036064" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030991", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6N6J5", "id": "A6N6J5", "database": "UniProtKB" } ], "name": "intraciliary transport particle A", "id": "GO:0030991" } ], "total": 5, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6N6J5", "id": "A6N6J5", "database": "UniProtKB" } ], "name": "negative regulation of gene expression", "id": "GO:0010629" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032496", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6N6J5", "id": "A6N6J5", "database": "UniProtKB" } ], "name": "response to lipopolysaccharide", "id": "GO:0032496" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6N6J5", "id": "A6N6J5", "database": "UniProtKB" } ], "name": "positive regulation of apoptotic process", "id": "GO:0043065" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043280", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6N6J5", "id": "A6N6J5", "database": "UniProtKB" } ], "name": "positive regulation of cysteine-type endopeptidase activity involved in apoptotic process", "id": "GO:0043280" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071333", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6N6J5", "id": "A6N6J5", "database": "UniProtKB" } ], "name": "cellular response to glucose stimulus", "id": "GO:0071333" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097756", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6N6J5", "id": "A6N6J5", "database": "UniProtKB" } ], "name": "negative regulation of blood vessel diameter", "id": "GO:0097756" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009636", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6N6J5", "id": "A6N6J5", "database": "UniProtKB" } ], "name": "response to toxic substance", "id": "GO:0009636" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090200", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6N6J5", "id": "A6N6J5", "database": "UniProtKB" } ], "name": "positive regulation of release of cytochrome c from mitochondria", "id": "GO:0090200" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045019", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6N6J5", "id": "A6N6J5", "database": "UniProtKB" } ], "name": "negative regulation of nitric oxide biosynthetic process", "id": "GO:0045019" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071356", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6N6J5", "id": "A6N6J5", "database": "UniProtKB" } ], "name": "cellular response to tumor necrosis factor", "id": "GO:0071356" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097421", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6N6J5", "id": "A6N6J5", "database": "UniProtKB" } ], "name": "liver regeneration", "id": "GO:0097421" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905705", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6N6J5", "id": "A6N6J5", "database": "UniProtKB" } ], "name": "cellular response to paclitaxel", "id": "GO:1905705" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035721", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6N6J5", "id": "A6N6J5", "database": "UniProtKB" } ], "name": "intraciliary retrograde transport", "id": "GO:0035721" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901555", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6N6J5", "id": "A6N6J5", "database": "UniProtKB" } ], "name": "response to paclitaxel", "id": "GO:1901555" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990830", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6N6J5", "id": "A6N6J5", "database": "UniProtKB" } ], "name": "cellular response to leukemia inhibitory factor", "id": "GO:1990830" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6N6J5", "id": "A6N6J5", "database": "UniProtKB" } ], "name": "cilium assembly", "id": "GO:0060271" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061512", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6N6J5", "id": "A6N6J5", "database": "UniProtKB" } ], "name": "protein localization to cilium", "id": "GO:0061512" } ], "total": 17, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 62, "annotation": "n_glycosylation_sequon", "start_pos": 60 }, { "end_pos": 116, "annotation": "n_glycosylation_sequon", "start_pos": 114 }, { "end_pos": 202, "annotation": "n_glycosylation_sequon", "start_pos": 200 }, { "end_pos": 545, "annotation": "n_glycosylation_sequon", "start_pos": 543 }, { "end_pos": 919, "annotation": "n_glycosylation_sequon", "start_pos": 917 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092810.1", "id": "NP_001092810.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5610787", "id": "R-RNO-5610787", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5620924", "id": "R-RNO-5620924", "database": "Reactome" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:503018", "id": "rno:503018", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000028783", "id": "ENSRNOG00000028783", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/WHCAEAY/", "id": "WHCAEAY", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "id": "IPR001680", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "id": "IPR011990", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "id": "IPR015943", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017986", "id": "IPR017986", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "id": "IPR036322", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR024977", "id": "IPR024977", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017233", "id": "IPR017233", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF12894", "id": "PF12894", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16517:SF1", "id": "PTHR16517:SF1", "database": "PANTHER" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A6N6J5", "id": "PR_A6N6J5", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/503018", "id": "503018", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1564116", "id": "1564116", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A6N6J5", "disease": [], "mass": { "monoisotopic_mass": 132779.0, "chemical_mass": 132779.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A6N6J5", "name": "Wdr35; RGD1564116.", "locus": { "end_pos": 34151622, "start_pos": 34094306, "chromosome": "6", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000028783", "id": "ENSRNOG00000028783", "database": "Ensembl Gene" } ] } } ] }