{ "uniprot_canonical_ac": "A6JFQ6-1", "sequence": { "header": "sp|A6JFQ6-1|CLVS1_RAT Isoform 1 of Clavesin-1 OS=Rattus norvegicus OX=10116 GN=Clvs1 PE=1 SV=1 CANONICAL=A6JFQ6-1", "length": 354, "sequence": "MGPVSVLPKPQSISTWEGDLAKMTHLQAGLSPDTIEKARLELNENPDVLHQDIQQVRDMIITRPDIGFLRTDDAFILRFLRARKFHQADAFRLLAQYFQYRQLNLDMFKNFKADDPGIKRALIDGFPGVLENRDHYGRKILLLFAANWDQSRNSFTDILRAILLSLEVLIEDPELQINGFILIIDWSNFSFKQASKLTPSILKLAIEGLQDSFPARFGGVHFVNQPWYIHALYTLIKPFLKDKTRKRIFLHGNNLNSLHQLIHPEFLPSEFGGTLPPYDMGTWARTLLGPDYSDENDYTHTSYNAMYVKHTCSNLERECSPKPMKRSQSVVEAGTLKHEEKGENENTQPLLALD" }, "uniprot_id": "CLVS1_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "clavesin-1", "Retinaldehyde-binding protein 1-like protein 1; retinaldehyde-binding protein 1-like 1" ], "uniprotkb": [ "Clavesin-1", "Retinaldehyde-binding protein 1-like 1" ] }, "gene": { "refseq": [ "Clvs1", "Clavesin-1", "RGD1564200", "Rlbp1l1" ], "uniprotkb": [ "Clvs1", "Rlbp1l1", "Clavesin-1", "RGD1564200" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6JFQ6", "id": "A6JFQ6", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Clavesin-1; Retinaldehyde-binding protein 1-like 1." }, "publication": [ { "title": "The clavesin family, neuron-specific lipid- and clathrin-binding Sec14 proteins regulating lysosomal morphology.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/19651769", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102439.1", "id": "NP_001102439.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A6JFQ6/publications", "id": "A6JFQ6", "database": "UniProtKB" } ], "authors": "Katoh Y, Ritter B, Gaffry T, Blondeau F, Honing S, McPherson PS", "date": "2009", "pmid": "19651769" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A6JFQ6#A6JFQ6-1", "isoform_ac": "A6JFQ6-1", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A6JFQ6-1|CLVS1_RAT Isoform 1 of Clavesin-1 OS=Rattus norvegicus OX=10116 GN=Clvs1 PE=1 SV=1 CANONICAL=A6JFQ6-1", "length": 354, "sequence": "MGPVSVLPKPQSISTWEGDLAKMTHLQAGLSPDTIEKARLELNENPDVLHQDIQQVRDMIITRPDIGFLRTDDAFILRFLRARKFHQADAFRLLAQYFQYRQLNLDMFKNFKADDPGIKRALIDGFPGVLENRDHYGRKILLLFAANWDQSRNSFTDILRAILLSLEVLIEDPELQINGFILIIDWSNFSFKQASKLTPSILKLAIEGLQDSFPARFGGVHFVNQPWYIHALYTLIKPFLKDKTRKRIFLHGNNLNSLHQLIHPEFLPSEFGGTLPPYDMGTWARTLLGPDYSDENDYTHTSYNAMYVKHTCSNLERECSPKPMKRSQSVVEAGTLKHEEKGENENTQPLLALD" } }, { "url": "https://www.uniprot.org/uniprot/A6JFQ6#A0A0G2K5H2-1", "isoform_ac": "A0A0G2K5H2-1", "locus": { "end_pos": 22392732, "start_pos": 22578098, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000087182", "id": "ENSRNOT00000087182", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000073425", "id": "ENSRNOP00000073425", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K5H2-1|CLVS1_RAT Computationally mapped isoform of Clavesin-1 OS=Rattus norvegicus OX=10116 GN=Clvs1 PE=1 SV=1 CANONICAL=A6JFQ6-1", "length": 352, "sequence": "MGPVSVPKPQSITTWKRFAKMTHLQAGLSPDTIEKARLELNENPDVLHQDIQQVRDMIITRPDIGFLRTDDAFILRFLRARKFHQADAFRLLAQYFQYRQLNLDMFKNFKADDPGIKRALIDGFPGVLENRDHYGRKILLLFAANWDQSRNSFTDILRAILLSLEVLIEDPELQINGFILIIDWSNFSFKQASKLTPSILKLAIEGLQDSFPARFGGVHFVNQPWYIHALYTLIKPFLKDKTRKRIFLHGNNLNSLHQLIHPEFLPSEFGGTLPPYDMGTWARTLLGPDYSDENDYTHTSYNAMYVKHTCSNLERECSPKPMKRSQSVVEAGTLKHEEKGENENTQPLLALD" } }, { "url": "https://www.uniprot.org/uniprot/A6JFQ6#F1LRF3-1", "isoform_ac": "F1LRF3-1", "locus": { "end_pos": 22392795, "start_pos": 22578098, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000009744", "id": "ENSRNOT00000009744", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000009744", "id": "ENSRNOP00000009744", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F1LRF3-1|CLVS1_RAT Computationally mapped isoform of Clavesin-1 OS=Rattus norvegicus OX=10116 GN=Clvs1 PE=1 SV=3 CANONICAL=A6JFQ6-1", "length": 332, "sequence": "MTHLQAGLSPDTIEKARLELNENPDVLHQDIQQVRDMIITRPDIGFLRTDDAFILRFLRARKFHQADAFRLLAQYFQYRQLNLDMFKNFKADDPGIKRALIDGFPGVLENRDHYGRKILLLFAANWDQSRNSFTDILRAILLSLEVLIEDPELQINGFILIIDWSNFSFKQASKLTPSILKLAIEGLQDSFPARFGGVHFVNQPWYIHALYTLIKPFLKDKTRKRIFLHGNNLNSLHQLIHPEFLPSEFGGTLPPYDMGTWARTLLGPDYSDENDYTHTSYNAMYVKHTCSNLERECSPKPMKRSQSVVEAGTLKHEEKGENENTQPLLALD" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:366311", "resource": "KEGG Pathway", "id": "rno:366311", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-432720", "resource": "Reactome", "id": "R-RNO-432720", "name": "Lysosome Vesicle Biogenesis" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A6JFQ6#function", "annotation": "Required for normal morphology of late endosomes and/or lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6JFQ6#function", "id": "A6JFQ6", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q8IUQ0-1", "protein_name": "Clavesin-1; Retinaldehyde-binding protein 1-like 1; Cellular retinaldehyde-binding protein-like; clathrin vesicle-associated Sec14 protein 1.", "sequence": { "length": 354, "sequence": "MGPVSLLPKYQKLNTWNGDLAKMTHLQAGLSPETIEKARLELNENPDVLHQDIQQVRDMIITRPDIGFLRTDDAFILRFLRARKFHQADAFRLLAQYFQYRQLNLDMFKNFKADDPGIKRALIDGFPGVLENRDHYGRKILLLFAANWDQSRNSFTDILRAILLSLEVLIEDPELQINGFILIIDWSNFSFKQASKLTPSILKLAIEGLQDSFPARFGGVHFVNQPWYIHALYTLIKPFLKDKTRKRIFLHGNNLNSLHQLIHPEFLPSEFGGTLPPYDMGTWARTLLGPDYSDENDYTHTSYNAMHVKHTSSNLERECSPKLMKRSQSVVEAGTLKHEEKGENENTQPLLALD" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/65267", "id": "65267", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q9D4C9-1", "protein_name": "Clavesin-1; Retinaldehyde-binding protein 1-like 1.", "sequence": { "length": 354, "sequence": "MGPVSVLPSPQSLSTWEGDLAKMTHLQAGLSPDTIEKARLELNENPDILHQDIQQVRDMIITRPDIGFLRTDDAFILRFLRARKFHQADAFRLLAQYFQYRQLNLDMFKNFKADDPGIKRALIDGFPGVLENRDHYGRKILLLFAANWDQSRNSFTDILRAILLSLEVLIEDPELQINGFILIIDWSNFSFKQASKLTPSILKLAIEGLQDSFPARFGGVHFVNQPWYIHALYTLIKPFLKDKTRKRIFLHGNNLNSLHQLIHPEFLPSEFGGTLPPYDMGTWARTLLGPDYSDENDYTHTSYNAMHVKHTCSNLERECSPKPMKRSQSVVEAGTLKHEEKGENENTQPLLALD" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/65267", "id": "65267", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102439.1", "ac": "NP_001102439.1", "name": "clavesin-1; Retinaldehyde-binding protein 1-like protein 1; retinaldehyde-binding protein 1-like 1.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0080025", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6JFQ6", "id": "A6JFQ6", "database": "UniProtKB" } ], "name": "phosphatidylinositol-3,5-bisphosphate binding", "id": "GO:0080025" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030136", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6JFQ6", "id": "A6JFQ6", "database": "UniProtKB" } ], "name": "clathrin-coated vesicle", "id": "GO:0030136" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6JFQ6", "id": "A6JFQ6", "database": "UniProtKB" } ], "name": "trans-Golgi network", "id": "GO:0005802" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6JFQ6", "id": "A6JFQ6", "database": "UniProtKB" } ], "name": "endosome", "id": "GO:0005768" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031901", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6JFQ6", "id": "A6JFQ6", "database": "UniProtKB" } ], "name": "early endosome membrane", "id": "GO:0031901" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007040", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6JFQ6", "id": "A6JFQ6", "database": "UniProtKB" } ], "name": "lysosome organization", "id": "GO:0007040" } ], "total": 1, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 190, "annotation": "n_glycosylation_sequon", "start_pos": 188 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102439.1", "id": "NP_001102439.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-432720", "id": "R-RNO-432720", "database": "Reactome" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:366311", "id": "rno:366311", "database": "KEGG Pathway" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00170", "id": "cd00170", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001251", "id": "IPR001251", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036865", "id": "IPR036865", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011074", "id": "IPR011074", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR028634", "id": "IPR028634", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036273", "id": "IPR036273", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00650", "id": "PF00650", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF03765", "id": "PF03765", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10174:SF72", "id": "PTHR10174:SF72", "database": "PANTHER" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A6JFQ6", "id": "PR_A6JFQ6", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/366311", "id": "366311", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1564200", "id": "1564200", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A6JFQ6", "disease": [], "mass": { "monoisotopic_mass": 40667.0, "chemical_mass": 40667.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A6JFQ6", "name": "Clvs1; Rlbp1l1; Clavesin-1; RGD1564200.", "locus": { "end_pos": 22578297, "start_pos": 22380334, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000006919", "id": "ENSRNOG00000006919", "database": "Ensembl Gene" } ] } } ] }