{
    "uniprot_canonical_ac": "A6H909-1", 
    "sequence": {
        "header": "sp|A6H909-1|TBPL2_RAT Isoform 1 of TATA box-binding protein-like protein 2  OS=Rattus norvegicus OX=10116 GN=Tbpl2 PE=2 SV=1 CANONICAL=A6H909-1", 
        "length": 344, 
        "sequence": "MEEDMYVDIFLDPYTFQDDFPPATSQLFSPGAPLDVHPLNPSNPETVFHSHLGAVKKAPSDFSSVDLSFLPDELTQENKDRTVTGNKVTNEESFRTQDWQSQLQLPDEQGSGLNLNSNSSPDTQSCLCSHDADSNQLSSETPNSNALPVVLISSMTPMNPVTECSGIVPQLQNVVSTANLACKLDLRKIALNAKNTEYNPKRFAAVIMRIREPRTTALIFSSGKVVCTGAKSEDESRLAARKYARVVQKLGFPVRFFNFKIQNMVASCDVKFPIRLEILALTHRQFSSYEPELFPGLIYKMVKPQVVLLIFASGKVVLTGAKERSEIYEAFENMYPILESFKKV"
    }, 
    "uniprot_id": "TBPL2_RAT", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [
                "TATA box-binding protein-like protein 2", 
                "TBP-like protein 2; TBP-related factor 3; TATA box-binding protein-related factor 3"
            ], 
            "uniprotkb": [
                "TATA box-binding protein-like protein 2", 
                "TBP-like protein 2", 
                "TATA box-binding protein-related factor 3", 
                "TBP-related factor 3"
            ]
        }, 
        "gene": {
            "refseq": [
                "Tbpl2"
            ], 
            "uniprotkb": [
                "Tbpl2", 
                "Tbp2", 
                "Trf3"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A6H909", 
                    "id": "A6H909", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "recommendedname": {
        "full": "TATA box-binding protein-like protein 2; TBP-like protein 2; TATA box-binding protein-related factor 3; TBP-related factor 3.", 
        "short": "TBP-like protein 2"
    }, 
    "publication": [
        {
            "title": "Genomics, evolution, and expression of TBPL2, a member of the TBP family.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/17570761", 
            "journal": "DNA and cell biology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092831.1", 
                    "id": "NP_001092831.1", 
                    "database": "RefSeq"
                }, 
                {
                    "url": "https://www.uniprot.org/uniprot/A6H909/publications", 
                    "id": "A6H909", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Di Pietro C, Ragusa M, Duro L, Guglielmino MR, Barbagallo D, Carnemolla A, Lagana A, Buffa P, Angelica R, Rinaldi A, Calafato MS, Milicia I, Caserta C, Giugno R, Pulvirenti A, Giunta V, Rapisarda A, Di Pietro V, Grillo A, Messina A, Ferro A, Grzeschik KH, Purrello M", 
            "date": "2007", 
            "pmid": "17570761"
        }, 
        {
            "title": "Analysis of TATA-binding protein 2 (TBP2) and TBP expression suggests different roles for the two proteins in regulation of gene expression during oogenesis and early mouse development.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/17641088", 
            "journal": "Reproduction (Cambridge, England)", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092831.1", 
                    "id": "NP_001092831.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Gazdag E, Rajkovic A, Torres-Padilla ME, Tora L", 
            "date": "2007", 
            "pmid": "17641088"
        }, 
        {
            "title": "TRF3, a TATA-box-binding protein-related factor, is vertebrate-specific and widely expressed.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/14634207", 
            "journal": "Proceedings of the National Academy of Sciences of the United States of America", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092831.1", 
                    "id": "NP_001092831.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Persengiev SP, Zhu X, Dixit BL, Maston GA, Kittler EL, Green MR", 
            "date": "2003", 
            "pmid": "14634207"
        }
    ], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A6H909#A6H909-1", 
            "isoform_ac": "A6H909-1", 
            "locus": {
                "end_pos": 1095886, 
                "start_pos": 1116677, 
                "chromosome": "3", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000050371", 
                        "id": "ENSRNOT00000050371", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000039739", 
                        "id": "ENSRNOP00000039739", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A6H909-1|TBPL2_RAT Isoform 1 of TATA box-binding protein-like protein 2  OS=Rattus norvegicus OX=10116 GN=Tbpl2 PE=2 SV=1 CANONICAL=A6H909-1", 
                "length": 344, 
                "sequence": "MEEDMYVDIFLDPYTFQDDFPPATSQLFSPGAPLDVHPLNPSNPETVFHSHLGAVKKAPSDFSSVDLSFLPDELTQENKDRTVTGNKVTNEESFRTQDWQSQLQLPDEQGSGLNLNSNSSPDTQSCLCSHDADSNQLSSETPNSNALPVVLISSMTPMNPVTECSGIVPQLQNVVSTANLACKLDLRKIALNAKNTEYNPKRFAAVIMRIREPRTTALIFSSGKVVCTGAKSEDESRLAARKYARVVQKLGFPVRFFNFKIQNMVASCDVKFPIRLEILALTHRQFSSYEPELFPGLIYKMVKPQVVLLIFASGKVVLTGAKERSEIYEAFENMYPILESFKKV"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?rno:680050", 
            "resource": "KEGG Pathway", 
            "id": "rno:680050", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A6H909#function", 
            "annotation": "Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process (By similarity).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A6H909#function", 
                    "id": "A6H909", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q6SJ96-1", 
            "protein_name": "TATA box-binding protein-like protein 2; TBP-like protein 2; TATA box-binding protein-related factor 3; TBP-related factor 3.", 
            "sequence": {
                "length": 375, 
                "sequence": "MASAPWPERVPRLLAPRLPSYPPPPPTVGLRSMEQEETYLELYLDQCAAQDGLAPPRSPLFSPVVPYDMYILNASNPDTAFNSNPEVKETSGDFSSVDLSFLPDEVTQENKDQPVISKHETEENSESQSPQSRLPSPSEQDVGLGLNSSSLSNSHSQLHPGDTDSVQPSPEKPNSDSLSLASITPMTPMTPISECCGIVPQLQNIVSTVNLACKLDLKKIALHAKNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPARFLDFKIQNMVGSCDVRFPIRLEGLVLTHQQFSSYEPELFPGLIYRMVKPRIVLLIFVSGKVVLTGAKERSEIYEAFENIYPILKGFKKA"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A6H909/", 
                    "id": "A6H909", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/133152", 
                    "id": "133152", 
                    "database": "MGI"
                }
            ], 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }, 
        {
            "uniprot_canonical_ac": "Q6SJ95-1", 
            "protein_name": "TATA box-binding protein-like protein 2; TBP-like protein 2; TATA box-binding protein-related factor 3; TBP-related factor 3.", 
            "sequence": {
                "length": 350, 
                "sequence": "MVGSLIMEEDIYLDLFLDPYTIQDDFPPAMSQLFSPGVPLDMHSLPSNPETVFHPHLGGVKKASTDFSSVDLSFLPDELTQENRDQTVTGNKLASEESCRTRDRQSQLQLPDEHGSELNLNSNSSPDPQSCLCFDDAHSNQPSPETPNSNALPVALIASMMPMNPVPGFSGIVPQLQNVVSTANLACKLDLRKIALNAKNTEYNPKRFAAVIMRIREPRTTALIFSSGKVVCTGAKSEEESRLAARKYARVVQKLGFPVRFFNFKIQNMVGSCDVKFPIRLEILALTHRQFSSSYEPELFPGLIYKMVKPQVVLLIFASGKVVLTGAKERSEIYEAFENMYPILESFKKV"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A6H909/", 
                    "id": "A6H909", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/133152", 
                    "id": "133152", 
                    "database": "MGI"
                }
            ], 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092831.1", 
        "ac": "NP_001092831.1", 
        "name": "TATA box-binding protein-like protein 2; TBP-like protein 2; TBP-related factor 3; TATA box-binding protein-related factor 3.", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001016", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6H909", 
                                "id": "A6H909", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "RNA polymerase III regulatory region DNA binding", 
                        "id": "GO:0001016"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6H909", 
                                "id": "A6H909", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "DNA-binding transcription factor activity", 
                        "id": "GO:0003700"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008134", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6H909", 
                                "id": "A6H909", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "transcription factor binding", 
                        "id": "GO:0008134"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6H909", 
                                "id": "A6H909", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "RNA polymerase II proximal promoter sequence-specific DNA binding", 
                        "id": "GO:0000978"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000979", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6H909", 
                                "id": "A6H909", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "RNA polymerase II core promoter sequence-specific DNA binding", 
                        "id": "GO:0000979"
                    }
                ], 
                "total": 5, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6H909", 
                                "id": "A6H909", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "transcription factor complex", 
                        "id": "GO:0005667"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005669", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6H909", 
                                "id": "A6H909", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "transcription factor TFIID complex", 
                        "id": "GO:0005669"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000126", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6H909", 
                                "id": "A6H909", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "transcription factor TFIIIB complex", 
                        "id": "GO:0000126"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6H909", 
                                "id": "A6H909", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytoplasm", 
                        "id": "GO:0005737"
                    }
                ], 
                "total": 4, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006366", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6H909", 
                                "id": "A6H909", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "transcription by RNA polymerase II", 
                        "id": "GO:0006366"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070898", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6H909", 
                                "id": "A6H909", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "RNA polymerase III preinitiation complex assembly", 
                        "id": "GO:0070898"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007275", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6H909", 
                                "id": "A6H909", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "multicellular organism development", 
                        "id": "GO:0007275"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6H909", 
                                "id": "A6H909", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of transcription, DNA-templated", 
                        "id": "GO:0045892"
                    }
                ], 
                "total": 4, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 120, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 118
        }
    ], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092831.1", 
            "id": "NP_001092831.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?rno:680050", 
            "id": "rno:680050", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/MEQEETY/", 
            "id": "MEQEETY", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04516", 
            "id": "cd04516", 
            "database": "CDD"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000814", 
            "id": "IPR000814", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR030491", 
            "id": "IPR030491", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR033710", 
            "id": "IPR033710", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR012295", 
            "id": "IPR012295", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00352", 
            "id": "PF00352", 
            "database": "Pfam"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10126", 
            "id": "PTHR10126", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A6H909", 
            "id": "PR_A6H909", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/680050", 
            "id": "680050", 
            "database": "GeneID"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1596837", 
            "id": "1596837", 
            "database": "RGD"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A6H909", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 38355.0, 
        "chemical_mass": 38355.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A6H909", 
            "name": "Tbpl2; Tbp2; Trf3.", 
            "locus": {
                "end_pos": 1095883, 
                "start_pos": 1116677, 
                "chromosome": "3", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000033682", 
                        "id": "ENSRNOG00000033682", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}