{ "uniprot_canonical_ac": "A6H8Y1-1", "sequence": { "header": "sp|A6H8Y1-1|BDP1_HUMAN Isoform 1 of Transcription factor TFIIIB component B'' homolog OS=Homo sapiens OX=9606 GN=BDP1 PE=1 SV=3 CANONICAL=A6H8Y1-1", "length": 2624, "sequence": "MFRRARLSVKPNVRPGVGARGSTASNPQRGRESPRPPDPATDSASKPAEPTDVPTVDFGGAEPQEKAPRSSTEKTGGDNDVEESSRSSSTVSQRRKRISSTSSLVKSSVSVPSESHPLSTINQEAPQPTATSTKEKQPCSDRYRIYKAQKLREMLKEELRKEKKQWKNKYAINESQRPPDRSKMTMRDFIYYLPDNNPMTSSLEQEKKTEKPSTPVQTREQEGKSTPNAEDNEMEEETDDGPLLVPRVKVAEDGSIILDEESLTVEVLRTKGPCVVEENDPIFERGSTTTYSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNLARAALKRETTESEKYIYEKKSETKKMETIVMQENNEQTDTLPSQHDEASLMISREKDTLGHRNEEAVILPCTQTERNLSPSNSCEPKEESQSAPVQKNDSVVSVGTNNVNTFQQEMKESVIQTARQVRGRLQRPRPNIRKTGQRQIVDKGEAKGIIKEGRTILPKDETEKKVLTVSNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLHVNKTNETIRHENKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEGKPEDHLLQKGASNTQLLLKEKAELLTSLEVSARKDCVGSKESALAKIDAELEEVGPSRRVGEETVGDNSPSSVVEEQYLNKLTSCPQPLNETSYSKIALDGKTTISSTSEYERNRGERRSHKKFKPNVTRGRGSKRVRGKTSKKEPRASKAMLVTLRASQEEDDDADDFESDYEEESYHLAPEEVNKAPVFVPVGLRSPEPVSAQIEETMEELEITVNVPDVGCIAVVEHELPNTDVTTEEMKQEENLSVPFEMTTSEHIQDEPGTNDGSTEAAITLLTMGDLVLQSEISSEQGDVGVCIIPHVHSKDKSHIPSSLDNVNHKIVHECQELSSPVITTSPASFEENKIVLEEQSSREEISLMEKVKENATPTRNTISKVTSNLRIRSRLAKPKPNLEKTLGTNRLDDYQEVSSLCVTKGAEMETQRETEKNASKATELENKNLGPVTTAENKDQSKLACVHGIKGTSISSEVNLTERNENQEESSQEVHMLSVAPVASSETGPCTLGLDRGLGENSVEEPQIKDSKGDSVLTLPVPEYTPTSIPEVQQENIINPQDLTVNLVANVPQDGEDEQAFILTLVEIPANAVEEFTDATAQFMPNPLLPAPILVKSVNTEERGDMSICLPATSVGQDAMGLSISGRDNSKKPPDNLDLVSRKRFQCRLDKNDHIPPAKKRSLTLRDDCQEYTTEVHSKELTNVFEETGESHKGQDIFLTSGSTLTTPEPQRQQVEAAFQSRGSRSPDACMDKNVPQLPQDEMIVSDKEERTDAAPKSQQMDSRTSSSKASLSRPGRRPLGFLSLICSKNSLESDEPMQVHSKKRLKPLIPGLRKKLKRSNPFNESQEKNRESSDLLPSPSVITTQSENISSSATQVSCDQPLLKEGYKSAQKRAPQGEATTVSEYFFNDIFIEVDETE" }, "uniprot_id": "BDP1_HUMAN", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "transcription factor TFIIIB component B'' homolog", "TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 1; transcription factor-like nuclear regulator; transcription factor IIIB 150; RNA polymerase III transcription initiation factor B''" ], "uniprotkb": [ "Transcription factor TFIIIB component B'' homolog", "Transcription factor IIIB 150", "TFIIIB150", "Transcription factor-like nuclear regulator" ] }, "gene": { "refseq": [ "BDP1", "DFNB112", "HSA238520", "TAF3B1", "TFC5", "TFIIIB''", "TFIIIB150", "TFIIIB90", "TFNR" ], "uniprotkb": [ "BDP1", "KIAA1241", "KIAA1689", "TFNR", "DFNB112", "HSA238520", "TAF3B1", "TFC5", "TFIIIB''", "TFIIIB150", "TFIIIB90" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8Y1", "id": "A6H8Y1", "database": "UniProtKB" } ], "name": "Homo sapiens", "taxid": 9606 } ], "recommendedname": { "full": "Transcription factor TFIIIB component B'' homolog; Transcription factor IIIB 150; TFIIIB150; Transcription factor-like nuclear regulator." }, "publication": [ { "title": "Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase III transcription initiation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/28743884", "journal": "Nature communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060899.2", "id": "NP_060899.2", "database": "RefSeq" } ], "authors": "Gouge J, Guthertz N, Kramm K, Dergai O, Abascal-Palacios G, Satia K, Cousin P, Hernandez N, Grohmann D, Vannini A", "date": "2017", "pmid": "28743884" }, { "title": "Linkage study and exome sequencing identify a BDP1 mutation associated with hereditary hearing loss.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/24312468", "journal": "PloS one", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060899.2", "id": "NP_060899.2", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A6H8Y1/publications", "id": "A6H8Y1", "database": "UniProtKB" } ], "authors": "Girotto G, Abdulhadi K, Buniello A, Vozzi D, Licastro D, d'Eustacchio A, Vuckovic D, Alkowari MK, Steel KP, Badii R, Gasparini P", "date": "2013", "pmid": "24312468" }, { "title": "PTEN represses RNA polymerase III-dependent transcription by targeting the TFIIIB complex.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/18391023", "journal": "Molecular and cellular biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060899.2", "id": "NP_060899.2", "database": "RefSeq" } ], "authors": "Woiwode A, Johnson SA, Zhong S, Zhang C, Roeder RG, Teichmann M, Johnson DL", "date": "2008", "pmid": "18391023" }, { "title": "Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17499043", "journal": "Molecular cell", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060899.2", "id": "NP_060899.2", "database": "RefSeq" } ], "authors": "Johnson SS, Zhang C, Fromm J, Willis IM, Johnson DL", "date": "2007", "pmid": "17499043" }, { "title": "The zinc finger protein ZNF297B interacts with BDP1, a subunit of TFIIIB.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/16542149", "journal": "Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8Y1/publications", "id": "A6H8Y1", "database": "UniProtKB" } ], "authors": "Wirth B., Schoenen F.", "date": "2006", "pmid": "16542149" }, { "title": "A role for Yin Yang-1 (YY1) in the assembly of snRNA transcription complexes.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/16769183", "journal": "Gene", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8Y1/publications", "id": "A6H8Y1", "database": "UniProtKB" } ], "authors": "Florens L., Swanson S.K., Washburn M.P., Emran F., Hernandez N., Ma B.", "date": "2006", "pmid": "16769183" }, { "title": "Epstein-Barr virus induces cellular transcription factors to allow active expression of EBER genes by RNA polymerase III.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/16956891", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8Y1/publications", "id": "A6H8Y1", "database": "UniProtKB" } ], "authors": "Arrand J.R., Dawson C.W., Fairley J.A., Felton-Edkins Z.A., Karali D., Kondrashov A., White R.J., Young L.S.", "date": "2006", "pmid": "16956891" }, { "title": "CK2 phosphorylation of Bdp1 executes cell cycle-specific RNA polymerase III transcription repression.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/15469824", "journal": "Mol. Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8Y1/publications", "id": "A6H8Y1", "database": "UniProtKB" } ], "authors": "Hu P., Sun Y., Wu S., Hernandez N., Samudre K.", "date": "2004", "pmid": "15469824" }, { "title": "Transcription factor (TF)-like nuclear regulator, the 250-kDa form of Homo sapiens TFIIIB', is an essential component of human TFIIIC1 activity.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/15096501", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8Y1/publications", "id": "A6H8Y1", "database": "UniProtKB" } ], "authors": "Gruber C., Roeder R.G., Hafner H.M., Meissner W., Seifart K.H., Teichmann M., Weser S.", "date": "2004", "pmid": "15096501" }, { "title": "TFIIIB is phosphorylated, disrupted and selectively released from tRNA promoters during mitosis in vivo.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/14592981", "journal": "EMBO J.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8Y1/publications", "id": "A6H8Y1", "database": "UniProtKB" } ], "authors": "Fairley J.A., Scott P.H., White R.J.", "date": "2003", "pmid": "14592981" }, { "title": "The transcription factor-like nuclear regulator (TFNR) contains a novel 55-amino-acid motif repeated nine times and maps closely to SMN1.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/11161782", "journal": "Genomics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060899.2", "id": "NP_060899.2", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A6H8Y1/publications", "id": "A6H8Y1", "database": "UniProtKB" } ], "authors": "Kelter AR, Herchenbach J, Wirth B", "date": "2000", "pmid": "11161782" }, { "title": "Different human TFIIIB activities direct RNA polymerase III transcription from TATA-containing and TATA-less promoters.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/11040218", "journal": "Genes Dev.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8Y1/publications", "id": "A6H8Y1", "database": "UniProtKB" } ], "authors": "Sun Y., Hernandez N., Pendergrast P.S., Schramm L.", "date": "2000", "pmid": "11040218" }, { "title": "A stable complex of a novel transcription factor IIB- related factor, human TFIIIB50, and associated proteins mediate selective transcription by RNA polymerase III of genes with upstream promoter elements.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/11121026", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8Y1/publications", "id": "A6H8Y1", "database": "UniProtKB" } ], "authors": "Wang Z., Roeder R.G., Teichmann M.", "date": "2000", "pmid": "11121026" }, { "title": "Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/9171375", "journal": "Genes & development", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060899.2", "id": "NP_060899.2", "database": "RefSeq" } ], "authors": "Wang Z, Roeder RG", "date": "1997", "pmid": "9171375" } ], "glycosylation": [], "mutation": [ { "start_pos": 654, "subjects_positive": "36", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6H8Y1", "id": "A6H8Y1", "database": "BioMuta" } ], "frequency": "2.4", "annotation": "Filters passed (2/5): patient freq. (2.4%); patient count (36/1514). In dbSNP: rs754948193.", "sequence_org": "H", "disease": { "doid": "1324", "url": "http://disease-ontology.org/term/DOID:1324", "icd10": "", "name": "Lung cancer" }, "sequence_mut": "L", "subjects_tested": "1514", "end_pos": 654, "type": "Point mutation" }, { "start_pos": 220, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6H8Y1", "id": "A6H8Y1", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "E", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "G", "subjects_tested": "50", "end_pos": 220, "type": "Point mutation" }, { "start_pos": 1515, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6H8Y1", "id": "A6H8Y1", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "P", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "S", "subjects_tested": "50", "end_pos": 1515, "type": "Point mutation" }, { "start_pos": 1940, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6H8Y1", "id": "A6H8Y1", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "V", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "A", "subjects_tested": "50", "end_pos": 1940, "type": "Point mutation" }, { "start_pos": 351, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6H8Y1", "id": "A6H8Y1", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "R", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "G", "subjects_tested": "50", "end_pos": 351, "type": "Point mutation" }, { "start_pos": 1792, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6H8Y1", "id": "A6H8Y1", "database": "BioMuta" } ], "frequency": "1.0", "annotation": "Filters passed (1/5): patient freq. (1.0%). In dbSNP: rs764263078.", "sequence_org": "N", "disease": { "doid": "11054", "url": "http://disease-ontology.org/term/DOID:11054", "icd10": "", "name": "Urinary bladder cancer" }, "sequence_mut": "S", "subjects_tested": "103", "end_pos": 1792, "type": "Point mutation" }, { "start_pos": 537, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6H8Y1", "id": "A6H8Y1", "database": "BioMuta" } ], "frequency": "2.3", "annotation": "Filters passed (1/5): patient freq. (2.3%).", "sequence_org": "E", "disease": { "doid": "11934", "url": "http://disease-ontology.org/term/DOID:11934", "icd10": "", "name": "Head and neck cancer" }, "sequence_mut": "G", "subjects_tested": "44", "end_pos": 537, "type": "Point mutation" }, { "start_pos": 501, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6H8Y1", "id": "A6H8Y1", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "Q", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "*", "subjects_tested": "50", "end_pos": 501, "type": "Point mutation" }, { "start_pos": 1304, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6H8Y1", "id": "A6H8Y1", "database": "BioMuta" } ], "frequency": "0.2", "annotation": "Filters passed (1/5): num. of cancers (3).", "sequence_org": "K", "disease": { "doid": "9256", "url": "http://disease-ontology.org/term/DOID:9256", "icd10": "", "name": "Colorectal cancer" }, "sequence_mut": "R", "subjects_tested": "456", "end_pos": 1304, "type": "Point mutation" }, { "start_pos": 657, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6H8Y1", "id": "A6H8Y1", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "K", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "E", "subjects_tested": "50", "end_pos": 657, "type": "Point mutation" }, { "start_pos": 245, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6H8Y1", "id": "A6H8Y1", "database": "BioMuta" } ], "frequency": "1.0", "annotation": "Filters passed (1/5): patient freq. (1.0%).", "sequence_org": "V", "disease": { "doid": "11054", "url": "http://disease-ontology.org/term/DOID:11054", "icd10": "", "name": "Urinary bladder cancer" }, "sequence_mut": "F", "subjects_tested": "103", "end_pos": 245, "type": "Point mutation" }, { "start_pos": 2383, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6H8Y1", "id": "A6H8Y1", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "A", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "D", "subjects_tested": "50", "end_pos": 2383, "type": "Point mutation" }, { "start_pos": 2375, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6H8Y1", "id": "A6H8Y1", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "D", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "Y", "subjects_tested": "50", "end_pos": 2375, "type": "Point mutation" }, { "start_pos": 2556, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6H8Y1", "id": "A6H8Y1", "database": "BioMuta" } ], "frequency": "0.3", "annotation": "Filters passed (1/5): num. of cancers (3). In dbSNP: rs746088956.", "sequence_org": "R", "disease": { "doid": "4362", "url": "http://disease-ontology.org/term/DOID:4362", "icd10": "", "name": "Cervical cancer" }, "sequence_mut": "*", "subjects_tested": "350", "end_pos": 2556, "type": "Point mutation" }, { "start_pos": 2061, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6H8Y1", "id": "A6H8Y1", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "L", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "F", "subjects_tested": "50", "end_pos": 2061, "type": "Point mutation" }, { "start_pos": 529, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6H8Y1", "id": "A6H8Y1", "database": "BioMuta" } ], "frequency": "1.0", "annotation": "Filters passed (1/5): patient freq. (1.0%).", "sequence_org": "G", "disease": { "doid": "11054", "url": "http://disease-ontology.org/term/DOID:11054", "icd10": "", "name": "Urinary bladder cancer" }, "sequence_mut": "A", "subjects_tested": "103", "end_pos": 529, "type": "Point mutation" }, { "start_pos": 2556, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6H8Y1", "id": "A6H8Y1", "database": "BioMuta" } ], "frequency": "0.2", "annotation": "Filters passed (1/5): num. of cancers (3). In dbSNP: rs746088956.", "sequence_org": "R", "disease": { "doid": "363", "url": "http://disease-ontology.org/term/DOID:363", "icd10": "", "name": "Uterine cancer" }, "sequence_mut": "*", "subjects_tested": "558", "end_pos": 2556, "type": "Point mutation" }, { "start_pos": 365, "subjects_positive": "2", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6H8Y1", "id": "A6H8Y1", "database": "BioMuta" } ], "frequency": "1.2", "annotation": "Filters passed (1/5): patient freq. (1.2%). In dbSNP: rs756417651.", "sequence_org": "D", "disease": { "doid": "9256", "url": "http://disease-ontology.org/term/DOID:9256", "icd10": "", "name": "Colorectal cancer" }, "sequence_mut": "N", "subjects_tested": "162", "end_pos": 365, "type": "Point mutation" }, { "start_pos": 330, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6H8Y1", "id": "A6H8Y1", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "P", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "L", "subjects_tested": "50", "end_pos": 330, "type": "Point mutation" }, { "start_pos": 59, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6H8Y1", "id": "A6H8Y1", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "G", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "D", "subjects_tested": "50", "end_pos": 59, "type": "Point mutation" }, { "start_pos": 2052, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6H8Y1", "id": "A6H8Y1", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "A", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "T", "subjects_tested": "50", "end_pos": 2052, "type": "Point mutation" }, { "start_pos": 1304, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6H8Y1", "id": "A6H8Y1", "database": "BioMuta" } ], "frequency": "0.1", "annotation": "Filters passed (1/5): num. of cancers (3).", "sequence_org": "K", "disease": { "doid": "1319", "url": "http://disease-ontology.org/term/DOID:1319", "icd10": "", "name": "Brain cancer" }, "sequence_mut": "R", "subjects_tested": "1042", "end_pos": 1304, "type": "Point mutation" }, { "start_pos": 1384, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6H8Y1", "id": "A6H8Y1", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "F", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "L", "subjects_tested": "50", "end_pos": 1384, "type": "Point mutation" }, { "start_pos": 1966, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6H8Y1", "id": "A6H8Y1", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "M", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "K", "subjects_tested": "50", "end_pos": 1966, "type": "Point mutation" }, { "start_pos": 1304, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6H8Y1", "id": "A6H8Y1", "database": "BioMuta" } ], "frequency": "0.2", "annotation": "Filters passed (1/5): num. of cancers (3).", "sequence_org": "K", "disease": { "doid": "263", "url": "http://disease-ontology.org/term/DOID:263", "icd10": "", "name": "Kidney cancer" }, "sequence_mut": "R", "subjects_tested": "655", "end_pos": 1304, "type": "Point mutation" }, { "start_pos": 1440, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6H8Y1", "id": "A6H8Y1", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "R", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "*", "subjects_tested": "50", "end_pos": 1440, "type": "Point mutation" }, { "start_pos": 2556, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6H8Y1", "id": "A6H8Y1", "database": "BioMuta" } ], "frequency": "0.1", "annotation": "Filters passed (1/5): num. of cancers (3). In dbSNP: rs746088956.", "sequence_org": "R", "disease": { "doid": "1612", "url": "http://disease-ontology.org/term/DOID:1612", "icd10": "", "name": "Breast cancer" }, "sequence_mut": "*", "subjects_tested": "1144", "end_pos": 2556, "type": "Point mutation" }, { "start_pos": 2533, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6H8Y1", "id": "A6H8Y1", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "P", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "T", "subjects_tested": "50", "end_pos": 2533, "type": "Point mutation" }, { "start_pos": 1665, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6H8Y1", "id": "A6H8Y1", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "H", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "N", "subjects_tested": "50", "end_pos": 1665, "type": "Point mutation" } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A6H8Y1#A6H8Y1-1", "isoform_ac": "A6H8Y1-1", "locus": { "end_pos": 71455878, "start_pos": 71564882, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000358731", "id": "ENST00000358731", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000351575", "id": "ENSP00000351575", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A6H8Y1-1|BDP1_HUMAN Isoform 1 of Transcription factor TFIIIB component B'' homolog OS=Homo sapiens OX=9606 GN=BDP1 PE=1 SV=3 CANONICAL=A6H8Y1-1", "length": 2624, "sequence": "MFRRARLSVKPNVRPGVGARGSTASNPQRGRESPRPPDPATDSASKPAEPTDVPTVDFGGAEPQEKAPRSSTEKTGGDNDVEESSRSSSTVSQRRKRISSTSSLVKSSVSVPSESHPLSTINQEAPQPTATSTKEKQPCSDRYRIYKAQKLREMLKEELRKEKKQWKNKYAINESQRPPDRSKMTMRDFIYYLPDNNPMTSSLEQEKKTEKPSTPVQTREQEGKSTPNAEDNEMEEETDDGPLLVPRVKVAEDGSIILDEESLTVEVLRTKGPCVVEENDPIFERGSTTTYSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNLARAALKRETTESEKYIYEKKSETKKMETIVMQENNEQTDTLPSQHDEASLMISREKDTLGHRNEEAVILPCTQTERNLSPSNSCEPKEESQSAPVQKNDSVVSVGTNNVNTFQQEMKESVIQTARQVRGRLQRPRPNIRKTGQRQIVDKGEAKGIIKEGRTILPKDETEKKVLTVSNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLHVNKTNETIRHENKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEGKPEDHLLQKGASNTQLLLKEKAELLTSLEVSARKDCVGSKESALAKIDAELEEVGPSRRVGEETVGDNSPSSVVEEQYLNKLTSCPQPLNETSYSKIALDGKTTISSTSEYERNRGERRSHKKFKPNVTRGRGSKRVRGKTSKKEPRASKAMLVTLRASQEEDDDADDFESDYEEESYHLAPEEVNKAPVFVPVGLRSPEPVSAQIEETMEELEITVNVPDVGCIAVVEHELPNTDVTTEEMKQEENLSVPFEMTTSEHIQDEPGTNDGSTEAAITLLTMGDLVLQSEISSEQGDVGVCIIPHVHSKDKSHIPSSLDNVNHKIVHECQELSSPVITTSPASFEENKIVLEEQSSREEISLMEKVKENATPTRNTISKVTSNLRIRSRLAKPKPNLEKTLGTNRLDDYQEVSSLCVTKGAEMETQRETEKNASKATELENKNLGPVTTAENKDQSKLACVHGIKGTSISSEVNLTERNENQEESSQEVHMLSVAPVASSETGPCTLGLDRGLGENSVEEPQIKDSKGDSVLTLPVPEYTPTSIPEVQQENIINPQDLTVNLVANVPQDGEDEQAFILTLVEIPANAVEEFTDATAQFMPNPLLPAPILVKSVNTEERGDMSICLPATSVGQDAMGLSISGRDNSKKPPDNLDLVSRKRFQCRLDKNDHIPPAKKRSLTLRDDCQEYTTEVHSKELTNVFEETGESHKGQDIFLTSGSTLTTPEPQRQQVEAAFQSRGSRSPDACMDKNVPQLPQDEMIVSDKEERTDAAPKSQQMDSRTSSSKASLSRPGRRPLGFLSLICSKNSLESDEPMQVHSKKRLKPLIPGLRKKLKRSNPFNESQEKNRESSDLLPSPSVITTQSENISSSATQVSCDQPLLKEGYKSAQKRAPQGEATTVSEYFFNDIFIEVDETE" } }, { "url": "https://www.uniprot.org/uniprot/A6H8Y1#H7C5U4-1", "isoform_ac": "H7C5U4-1", "locus": { "end_pos": 71522793, "start_pos": 71553289, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000514903", "id": "ENST00000514903", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000421910", "id": "ENSP00000421910", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|H7C5U4-1|BDP1_HUMAN Computationally mapped isoform of Transcription factor TFIIIB component B'' homolog OS=Homo sapiens OX=9606 GN=BDP1 PE=1 SV=1 CANONICAL=A6H8Y1-1", "length": 583, "sequence": "XRKDCVGSKESALAKIDAELEEVGPSRRVGEETVGDNSPSSVVEEQYLNKLTSCPQPLNETSYSKIALDGKTTISSTSEYERNRGERRSHKKFKPNVTRGRGSKRVRGKTSKKEPRASKAMLVTLRASQEEDDDADDFESDYEEESYHLAPEEVNKAPVFVPVGLRSPEPVSAQIEETMEELEITVNVPDVGCIAVVEHELPNTDVTTEEMKQEENLSVPFEMTTSEHIQDEPGTNDGSTEAAITLLTMGDLVLQSEISSEQGDGVCIIPHVHSKDKSHIPSSLDNVNHKIVHECQELSSPVITTSPASFEENKIVLEEQSSREEISLMEKVKENATPTRNTISKVTSNLRIRSRLAKPKPNLEKTLGTNRLDDYQEVSSLCVTKGAEMETQRETEKNASKATELENKNLGPVTTAENKDQSKLACVHGIKGTSISSEVNLTERNENQEESSQEVHMLSVAPVASSETGPCTLGLDRGLGENSVEEPQIKDSKGDSVLTLPVPEYTPTSIPEVQQENIINPQDLTVFVYQQLQLVKMPWVYLFLEEIILKSRLIIWILYLGRDFNAGLIKMTTFLLPKNVHSL" } }, { "url": "https://www.uniprot.org/uniprot/A6H8Y1#A6H8Y1-2", "isoform_ac": "A6H8Y1-2", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A6H8Y1-2|BDP1_HUMAN Isoform 2 of Transcription factor TFIIIB component B'' homolog OS=Homo sapiens OX=9606 GN=BDP1 PE=1 SV=3 CANONICAL=A6H8Y1-1", "length": 2254, "sequence": "MFRRARLSVKPNVRPGVGARGSTASNPQRGRESPRPPDPATDSASKPAEPTDVPTVDFGGAEPQEKAPRSSTEKTGGDNDVEESSRSSSTVSQRRKRISSTSSLVKSSVSVPSESHPLSTINQEAPQPTATSTKEKQPCSDRYRIYKAQKLREMLKEELRKEKKQWKNKYAINESQRPPDRSKMTMRDFIYYLPDNNPMTSSLEQEKKTEKPSTPVQTREQEGKSTPNAEDNEMEEETDDGPLLVPRVKVAEDGSIILDEESLTVEVLRTKGPCVVEENDPIFERGSTTTYSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNLARAALKRETTESEKYIYEKKSETKKMETIVMQENNEQTDTLPSQHDEASLMISREKDTLGHRNEEAVILPCTQTERNLSPSNSCEPKEESQSAPVQKNDSVVSVGTNNVNTFQQEMKESVIQTARQVRGRLQRPRPNIRKTGQRQIVDKGEAKGIIKEGRTILPKDETEKKVLTVSNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLHVNKTNETIRHENKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEGKPEDHLLQKGASNTQLLLKEKAELLTSLEVSARKDCVGSKESALAKIDAELEEVGPSRRVGEETVGDNSPSSVVEEQYLNKLTSCPQPLNETSYSKIALDGKTTISSTSEYERNRGERRSHKKFKPNVTRGRGSKRVRGKTSKKEPRASKAMLVTLRASQEEDDDADDFESDYEEESYHLAPEEVNKAPVFVPVGLRSPEPVSAQIEETMEELEITVNVPDVGCIAVVEHELPNTDVTTEEMKQEENLSVPFEMTTSEHIQDEPGTNDGSTEAAITLLTMGDLVLQSEISSEQGDVGVCIIPHVHSKDKSHIPSSLDNVNHKIVHECQELSSPVITTSPASFEENKIVLEEQSSREEISLMEKVKENATPTRNTISKVTSNLRIRSRLAKPKPNLEKTLGTNRLDDYQEVSSLCVTKGAEMETQRETEKNASKATELENKNLGPVTTAENKDQSKLACVHGIKGTSISSEVNLTERNENQEESSQEVHMLSVAPVASSETGPCTLGLDRGLGENSVEEPQIKDSKGDSVLTLPVPEVKECTV" } }, { "url": "https://www.uniprot.org/uniprot/A6H8Y1#A0A0G2JN16-1", "isoform_ac": "A0A0G2JN16-1", "locus": { "end_pos": 70781198, "start_pos": 70834942, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000613844", "id": "ENST00000613844", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000480411", "id": "ENSP00000480411", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JN16-1|BDP1_HUMAN Computationally mapped isoform of Transcription factor TFIIIB component B'' homolog OS=Homo sapiens OX=9606 GN=BDP1 PE=1 SV=1 CANONICAL=A6H8Y1-1", "length": 846, "sequence": "MFRRARLSVKPNVRPGVGARGSTASNPQRGRESPRPPEPATDSASKPAEPTDVPTVDFGGAEPQEKAPRSSTEKTGGDNDVEESSRSSSTVSQRRKRISSTSSLVKSSVSVPSESHPLSTINQEAPQPTATSTKEKQPCSDRYRIYKAQKLREMLKEELRKEKKQWKNKYAINESQRPPDRSKMTMRDFIYYLPDNNPMTSSLEQEKKTEKPSTPVQTREQEGKSTPNAEDNEMEEETDDGPLLVPRVKVAEDGSIILDEESLTVEVLRTKGPCVVEENDPIFERGSTTTYSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILSLGKWRQH" } }, { "url": "https://www.uniprot.org/uniprot/A6H8Y1#A6H8Y1-3", "isoform_ac": "A6H8Y1-3", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A6H8Y1-3|BDP1_HUMAN Isoform 3 of Transcription factor TFIIIB component B'' homolog OS=Homo sapiens OX=9606 GN=BDP1 PE=1 SV=3 CANONICAL=A6H8Y1-1", "length": 1388, "sequence": "MFRRARLSVKPNVRPGVGARGSTASNPQRGRESPRPPDPATDSASKPAEPTDVPTVDFGGAEPQEKAPRSSTEKTGGDNDVEESSRSSSTVSQRRKRISSTSSLVKSSVSVPSESHPLSTINQEAPQPTATSTKEKQPCSDRYRIYKAQKLREMLKEELRKEKKQWKNKYAINESQRPPDRSKMTMRDFIYYLPDNNPMTSSLEQEKKTEKPSTPVQTREQEGKSTPNAEDNEMEEETDDGPLLVPRVKVAEDGSIILDEESLTVEVLRTKGPCVVEENDPIFERGSTTTYSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQVCIFLSFKSFLNAFSEEINNSMIILSLSPTTLKNL" } }, { "url": "https://www.uniprot.org/uniprot/A6H8Y1#A0A0A0MRX7-1", "isoform_ac": "A0A0A0MRX7-1", "locus": { "end_pos": 70671181, "start_pos": 70724934, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000616093", "id": "ENST00000616093", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000479517", "id": "ENSP00000479517", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0A0MRX7-1|BDP1_HUMAN Computationally mapped isoform of Transcription factor TFIIIB component B'' homolog OS=Homo sapiens OX=9606 GN=BDP1 PE=1 SV=1 CANONICAL=A6H8Y1-1", "length": 846, "sequence": "MFRRARLSVKPNVRPGVGARGSTASNPQRGRESPRPPDPATDSASKPAEPTDVPTVDFGGAEPQEKAPRSSTEKTGGDNDVEESSRSSSTVSQRRKRISSTSSLVKSSVSVPSESHPLSTINQEAPQPTATSTKEKQPCSDRYRIYKAQKLREMLKEELRKEKKQWKNKYAINESQRPPDRSKMTMRDFIYYLPDNNPMTSSLEQEKKTEKPSTPVQTREQEGKSTPNAEDNEMEEETDDGPLLVPRVKVAEDGSIILDEESLTVEVLRTKGPCVVEENDPIFERGSTTTYSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILSLGKWRQH" } }, { "url": "https://www.uniprot.org/uniprot/A6H8Y1#A6H8Y1-4", "isoform_ac": "A6H8Y1-4", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A6H8Y1-4|BDP1_HUMAN Isoform 4 of Transcription factor TFIIIB component B'' homolog OS=Homo sapiens OX=9606 GN=BDP1 PE=1 SV=3 CANONICAL=A6H8Y1-1", "length": 1372, "sequence": "MFRRARLSVKPNVRPGVGARGSTASNPQRGRESPRPPDPATDSASKPAEPTDVPTVDFGGAEPQEKAPRSSTEKTGGDNDVEESSRSSSTVSQRRKRISSTSSLVKSSVSVPSESHPLSTINQEAPQPTATSTKEKQPCSDRYRIYKAQKLREMLKEELRKEKKQWKNKYAINESQRPPDRSKMTMRDFIYYLPDNNPMTSSLEQEKKTEKPSTPVQTREQEGKSTPNAEDNEMEEETDDGPLLVPRVKVAEDGSIILDEESLTVEVLRTKGPCVVEENDPIFERGSTTTYSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQVCIFLSFKSFLNAFFRGNK" } }, { "url": "https://www.uniprot.org/uniprot/A6H8Y1#A0A0G2JNU3-1", "isoform_ac": "A0A0G2JNU3-1", "locus": { "end_pos": 70781198, "start_pos": 70890193, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000611966", "id": "ENST00000611966", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000482112", "id": "ENSP00000482112", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JNU3-1|BDP1_HUMAN Computationally mapped isoform of Transcription factor TFIIIB component B'' homolog OS=Homo sapiens OX=9606 GN=BDP1 PE=1 SV=1 CANONICAL=A6H8Y1-1", "length": 2624, "sequence": "MFRRARLSVKPNVRPGVGARGSTASNPQRGRESPRPPEPATDSASKPAEPTDVPTVDFGGAEPQEKAPRSSTEKTGGDNDVEESSRSSSTVSQRRKRISSTSSLVKSSVSVPSESHPLSTINQEAPQPTATSTKEKQPCSDRYRIYKAQKLREMLKEELRKEKKQWKNKYAINESQRPPDRSKMTMRDFIYYLPDNNPMTSSLEQEKKTEKPSTPVQTREQEGKSTPNAEDNEMEEETDDGPLLVPRVKVAEDGSIILDEESLTVEVLRTKGPCVVEENDPIFERGSTTTYSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNLARAALKRETTESEKYIYEKKSETKKMETIVMQENNEQTDTLPSQHDEASLMISREKDTLGHRNEEAVILPCTQTERNLSPSNSCEPKEESQSAPVQKNDSVVSVGTNNVNTFQQEMKESVIQTARQVRGRLQRPRPNIRKTGQRQIVDKGEAKGIIKEGRTILPKDETEKKVLTVSNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLHVNKTNETIRHENKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEGKPEDHLLQKGASNTQLLLKEKAELLTSLEVSARKDCVGSKESALAKIDAELEEVGPSRRVGEETVGDNSPSSVVEEQYLNKLTSCPQPLNETSYSKIALDGKTTISSTSEYERNRGERRSHKKFKPNVTRGRGSKRVRGKTSKKEPRASKAMLVTLRASQEEDDDADDFESDYEEESYHLAPEEVNKAPVFVPVGLRSPEPVSAQIEETMEELEITVNVPDVGCIAVVEHELPNTDVTTEEMKQEENLSVPFEMTTSEHIQDEPGTNDGSTEAAITLLTMGDLVLQSEISSEQGDVGVCIIPHVHSKDKSHIPSSLDNVNHKIVHECQELSSPVITTSPASFEENKIVLEEQSSREEISLMEKVKENATPTRNTISKVTSNLRIRSRLAKPKPNLEKTLGTNRLDDYQEVSSLCVTKGAEMETQRETEKNASKATELENKNLGPVTTAENKDQSKLACVHGIKGTSISSEVNLTERNENQEESSQEVHMLSVAPVASSETGPCTLGLDRGLGENSVEEPQIKDSKGDSVLTLPVPEYTPTSIPEVQQENIINPQDLTVNLVANVPQDGEDEQAFILTLVEIPANAVEEFTDATAQFMPNPLLPAPILVKSVNTEERGDMSICLPATSVGQDAMGLSISGRDNSKKPPDNLDLVSRKRFQCRLDKNDHIPPAKKRSLTLRDDCQEYTTEVHSKELTNVFEETGESHKGQDIFLTSGSTLTTPEPQRQQVEAAFQSRGSRSPDACMDKNVPQLPQDEMIVSDKEERTDAAPKSQQMDSRTSSSKASLSRPGRRPLGFLSLICSKNSLESDEPMQVHSKKRLKPLIPGLRKKLKRSNPFNESQEKNRESSDLLPSPSVITTQSENISSSATQVSCDQPLLKEGYKSAQKRAPQGEATTVSEYFFNDIFIEVDETE" } }, { "url": "https://www.uniprot.org/uniprot/A6H8Y1#A6H8Y1-5", "isoform_ac": "A6H8Y1-5", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A6H8Y1-5|BDP1_HUMAN Isoform 5 of Transcription factor TFIIIB component B'' homolog OS=Homo sapiens OX=9606 GN=BDP1 PE=1 SV=3 CANONICAL=A6H8Y1-1", "length": 778, "sequence": "MLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQVCIFLSFKSFLNAFSEEINNSMIILSLSPTTFKNL" } }, { "url": "https://www.uniprot.org/uniprot/A6H8Y1#H0YCV8-1", "isoform_ac": "H0YCV8-1", "locus": { "end_pos": 70747677, "start_pos": 70778086, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000614425", "id": "ENST00000614425", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000479247", "id": "ENSP00000479247", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|H0YCV8-1|BDP1_HUMAN Computationally mapped isoform of Transcription factor TFIIIB component B'' homolog OS=Homo sapiens OX=9606 GN=BDP1 PE=1 SV=1 CANONICAL=A6H8Y1-1", "length": 606, "sequence": "TDVTTEEMKQEENLSVPFEMTTSEHIQDEPGVCIIPHVHSKDKSHIPSSLDNVNHKIVHECQELSSPVITTSPASFEENKIVLEEQSSREEISLMEKVKENATPTRNTISKVTSNLRIRSRLAKPKPNLEKTLGTNRLDDYQEVSSLCVTKGAEMETQRETEKNASKATELENKNLGPVTTAENKDQSKLACVHGIKGTSISSEVNLTERNENQEESSQEVHMLSVAPVASSETGPCTLGLDRGLGENSVEEPQIKDSKGDSVLTLPVPEYTPTSIPEVQQENIINPQDLTVNLVANVPQDGEDEQAFILTLVEIPANAVEEFTDATAQFMPNPLLPAPILVKSVNTEERGDMSICLPATSVGQDAMGLSISGRDNSKKPPDNLDLVSRKRFQCRLDKNDHIPPAKKRSLTLRDDCQEYTTEVHSKELTNVFEETGESHKGQDIFLTSGSTLTTPEPQRQQVEAAFQSRGSRSPDACMDKNVPQLPQDEMIVSDKEERTDAAPKSQQMDSRTSSSKASLSRPGRRPLGFLSLICSKNSLESDEPMQVHSKKRLKPLIPGLRKKLKRSNPFNESQEKNRESSDLLPSPSVITTQSENISSSATQRPF" } }, { "url": "https://www.uniprot.org/uniprot/A6H8Y1#A6H8Y1-6", "isoform_ac": "A6H8Y1-6", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A6H8Y1-6|BDP1_HUMAN Isoform 6 of Transcription factor TFIIIB component B'' homolog OS=Homo sapiens OX=9606 GN=BDP1 PE=1 SV=3 CANONICAL=A6H8Y1-1", "length": 2604, "sequence": "MFRRARLSVKPNVRPGVGARGSTASKPAEPTDVPTVDFGGAEPQEKAPRSSTEKTGGDNDVEESSRSSSTVSQRRKRISSTSSLVKSSVSVPSESHPLSTINQEAPQPTATSTKEKQPCSDRYRIYKAQKLREMLKEELRKEKKQWKNKYAINESQRPPDRSKMTMRDFIYYLPDNNPMTSSLEQEKKTEKPSTPVQTREQEGKSTPNAEDNEMEEETDDGPLLVPRVKVAEDGSIILDEESLTVEVLRTKGPCVVEENDPIFERGSTTTYSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNLARAALKRETTESEKYIYEKKSETKKMETIVMQENNEQTDTLPSQHDEASLMISREKDTLGHRNEEAVILPCTQTERNLSPSNSCEPKEESQSAPVQKNDSVVSVGTNNVNTFQQEMKESVIQTARQVRGRLQRPRPNIRKTGQRQIVDKGEAKGIIKEGRTILPKDETEKKVLTVSNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLHVNKTNETIRHENKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEGKPEDHLLQKGASNTQLLLKEKAELLTSLEVSARKDCVGSKESALAKIDAELEEVGPSRRVGEETVGDNSPSSVVEEQYLNKLTSCPQPLNETSYSKIALDGKTTISSTSEYERNRGERRSHKKFKPNVTRGRGSKRVRGKTSKKEPRASKAMLVTLRASQEEDDDADDFESDYEEESYHLAPEEVNKAPVFVPVGLRSPEPVSAQIEETMEELEITVNVPDVGCIAVVEHELPNTDVTTEEMKQEENLSVPFEMTTSEHIQDEPGTNDGSTEAAITLLTMGDLVLQSEISSEQGDVGVCIIPHVHSKDKSHIPSSLDNVNHKIVHECQELSSPVITTSPASFEENKIVLEEQSSREEISLMEKVKENATPTRNTISKVTSNLRIRSRLAKPKPNLEKTLGTNRLDDYQEVSSLCVTKGAEMETQRETEKNASKATELENKNLGPVTTAENKDQSKLACVHGIKGTSISSEVNLTERNENQEESSQEVHMLSVAPVASSETGPCTLGLDRGLGENSVEEPQIKDSKGDSVLTLPVPEYTPTSIPEVQQENIINPQDLTVNLVANVPQDGEDEQAFILTLVEIPANAVEEFTDATAQFMPNPLLPAPILVKSVNTEERGDMSICLPATSVGQDAMGLSISGRDNSKKPPDNLDLVSRKRFQCRLDKNDHIPPAKKRSLTLRDDCQEYTTEVHSKELTNVFEETGESHKGQDIFLTSGSTLTTPEPQRQQVEAAFQSRGSRSPDACMDKNVPQLPQDEMIVSDKEERTDAAPKSQQMDSRTSSSKASLSRPGRRPLGFLSLICSKNSLESDEPMQVHSKKRLKPLIPGLRKKLKRSNPFNESQEKNRESSDLLPSPSVITTQSENISSSATQVSCDQPLLKEGYKSAQKRAPQGEATTVSEYFFNDIFIEVDETE" } }, { "url": "https://www.uniprot.org/uniprot/A6H8Y1#A6H8Y1-7", "isoform_ac": "A6H8Y1-7", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A6H8Y1-7|BDP1_HUMAN Isoform 7 of Transcription factor TFIIIB component B'' homolog OS=Homo sapiens OX=9606 GN=BDP1 PE=1 SV=3 CANONICAL=A6H8Y1-1", "length": 2552, "sequence": "MFRRARLSVKPNVRPGVGARGSTASNPQRGRESPRPPDPATDSASKPAEPTDVPTVDFGGAEPQEKAPRSSTEKTGGDNDVEESSRSSSTVSQRRKRISSTSSLVKSSVSVPSESHPLSTINQEAPQPTATSTKEKQPCSDRYRIYKAQKLREMLKEELRKEKKQWKNKYAINESQRPPDRSKMTMRDFIYYLPDNNPMTSSLEQEKKTEKPSTPVQTREQEGKSTPNAEDNEMEEETDDGPLLVPRVKVAEDGSIILDEESLTVEVLRTKGPCVVEENDPIFERGSTTTYSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERSQKDAQTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLEETGRRKISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKRDIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKRPKPNLARAALKRETTESEKYIYEKKSETKKMETIVMQENNEQTDTLPSQHDEASLMISREKDTLGHRNEEAVILPCTQTERNLSPSNSCEPKEESQSAPVQKNDSVVSVGTNNVNTFQQEMKESVIQTARQVRGRLQRPRPNIRKTGQRQIVDKGEAKGIIKEGRTILPKDETEKKVLTVSNSQIETEIEVPSSAVPEHRMYENQSQVVLVENLHVNKTNETIRHENKPYVPSSAQMTRRKFQKAKPNLGRAHSKKEEPVLEKVTTDQSKEGKPEDHLLQKGASNTQLLLKEKAELLTSLEVSARKDCVGSKESALAKIDAELEEVGPSRRVGEETVGDNSPSSVVEEQYLNKLTSCPQPLNETSYSKIALDGKTTISSTSEYERNRGERRSHKKFKPNVTRGRGSKRVRGKTSKKEPRASKAMLVTLRASQEEDDDADDFESDYEEESYHLAPEEVNKAPVFVPVGLRSPEPVSAQIEETMEELEITVNVPDVGCIAVVEHELPNTDVTTEEMKQEENLSVPFEMTTSEHIQDEPGVCIIPHVHSKDKSHIPSSLDNVNHKIVHECQELSSPVITTSPASFEENKIVLEEQSSREEISLMEKVKENATPTRNTISKVTSNLRIRSRLAKPKPNLEKTLGTNRLDDYQEVSSLCVTKGAEMETQRETEKNASKATELENKNLGPVTTAENKDQSKLACVHGIKGTSISSEVNLTERNENQEESSQEVHMLSVAPVASSETGPCTLGLDRGLGENSVEEPQIKDSKGDSVLTLPVPEYTPTSIPEVQQENIINPQDLTVNLVANVPQDGEDEQAFILTLVEIPANAVEEFTDATAQFMPNPLLPAPILVKSVNTEERGDMSICLPATSVGQDAMGLSISGRDNSKKPPDNLDLVSRKRFQCRLDKNDHIPPAKKRSLTLRDDCQEYTTEVHSKELTNVFEETGESHKGQDIFLTSGSTLTTPEPQRQQVEAAFQSRGSRSPDACMDKNVPQLPQDEMIVSDKEERTDAAPKSQQMDSRTSSSKASLSRPGRRPLGFLSLICSKNSLESDEPMQVHSKKRLKPLIPGLRKKLKRSNPFNESQEKNRESSDLLPSPSVITTQSENISSSATQRPF" } }, { "url": "https://www.uniprot.org/uniprot/A6H8Y1#A6H8Y1-8", "isoform_ac": "A6H8Y1-8", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A6H8Y1-8|BDP1_HUMAN Isoform 8 of Transcription factor TFIIIB component B'' homolog OS=Homo sapiens OX=9606 GN=BDP1 PE=1 SV=3 CANONICAL=A6H8Y1-1", "length": 463, "sequence": "MLVTLRASQEEDDDADDFESDYEEESYHLAPEEVNKAPVFVPVGLRSPEPVSAQIEETMEELEITVNVPDVGCIAVVEHELPNTDVTTEEMKQEENLSVPFEMTTSEHIQDEPGTNDGSTEAAITLLTMGDLVLQSEISSEQGDGVCIIPHVHSKDKSHIPSSLDNVNHKIVHECQELSSPVITTSPASFEENKIVLEEQSSREEISLMEKVKENATPTRNTISKVTSNLRIRSRLAKPKPNLEKTLGTNRLDDYQEVSSLCVTKGAEMETQRETEKNASKATELENKNLGPVTTAENKDQSKLACVHGIKGTSISSEVNLTERNENQEESSQEVHMLSVAPVASSETGPCTLGLDRGLGENSVEEPQIKDSKGDSVLTLPVPEYTPTSIPEVQQENIINPQDLTVFVYQQLQLVKMPWVYLFLEEIILKSRLIIWILYLGRDFNAGLIKMTTFLLPKNVHSL" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:55814", "resource": "KEGG Pathway", "id": "hsa:55814", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-749476", "resource": "Reactome", "id": "R-HSA-749476", "name": "RNA Polymerase III Abortive And Retractive Initiation" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76066", "resource": "Reactome", "id": "R-HSA-76066", "name": "RNA Polymerase III Transcription Initiation From Type 2 Promoter" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76071", "resource": "Reactome", "id": "R-HSA-76071", "name": "RNA Polymerase III Transcription Initiation From Type 3 Promoter" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76061", "resource": "Reactome", "id": "R-HSA-76061", "name": "RNA Polymerase III Transcription Initiation From Type 1 Promoter" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A6H8Y1#function", "annotation": "General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8Y1#function", "id": "A6H8Y1", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060899.2", "annotation": "Data indicate the crystal structure of a Brf2-TBP-Bdp1 complex bound to a DNA promoter. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060899.2", "id": "NP_060899.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060899.2", "annotation": "Linkage study and exome sequencing identify a BDP1 mutation associated with hereditary hearing loss. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060899.2", "id": "NP_060899.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060899.2", "annotation": "PTEN represses RNA polymerase III-dependent transcription by targeting the TFIIIB complex", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060899.2", "id": "NP_060899.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060899.2", "annotation": "Maf1 occupancy of Pol III genes is inversely correlated with that of the initiation factor TFIIIB (subunit Bdp1) and Pol III", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060899.2", "id": "NP_060899.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZDI4-1", "protein_name": "B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB.", "sequence": { "length": 2486, "sequence": "MFRRARLSVKPNVRPGVGTRGSAAPNPQRGPEAPRPPEPATGSAPKPAEPTDVPAVDSGGAEPQEQAPGSSNNEKTGDGSNVEESSTLPSAASQRRKRVSGTSSLGQPPVSAPSQSRPLSTVNHDAPQPNPTPAKEKQPCSDRYRIYKARKLREMLKEELRKEKKQWKNKFATNESQRPPDRSKMTMRDFIYYLPDSNPMTSSVEQEKKCEKSLAPTPTRDRQENQSTQDANDNEDVEEEVDDGPLLVPRVKVAEDGSIILDEESLTVEVLRTKGPCVVEENDPIFERGSTTTYSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKSTKCQNVKEKAPKPRKNAKAKTVNREEVNDDPDESVNSDTADPERPQKDARTVREEQLPSSSAQHLHLAVLEQEQEQEQSQDKRRRNQGKANKREATTVLESVLDHSSPPAAEIHKSTCPSEENENECNKEQTPSFTQNTEDIAGLASCEETLMRMDPSPSTCNHQDIMPLASESSEPCAADLPVSEPGGAVSGDVNNAEPGGAVSGDVNNAESGCAGAGSADLKTKSPETEQTDSVKPKSRSRLQRPKPNLSRPVGKKSVVSQDRQDGSNKDSPSETAATKNHMEKERVTESENFVTENTERESPSAGTVSDLSEKSSAQEDSQTKVLRPTRLMRSRMQRPKPNVVKAAERKQILTSQEKVGSHVEKIEDDSCVVVPPQMGNESHKNLQCEGAASEPEQKDPVESLQSEQPRALSECPSIQEDNKGNKLKQAPIVRTRFQKPKPNTGRRRRRRRSSKEGIPVDMPVSGDLTATREEIPRPDTSPREEVPSVPLAPLTATASTMELESGVKDSSRNDTASNVKMPEMADVTMEIDTGLETTGRDTCPGEMEAEMIDIPMETEASLKASLNETPPMEKMPELIDNTGEICTNLGETARKEIFLQENGSKEVSPVSEPETGLQETGKKLAVKESTSDMMDGTEEREADSEETERQEISAPVKEAEEAKARGEVDSPLEEIGGETSQQAIAAGAPVEQSASEEDLGDSAGVEEVEVESTVGGKELKLKDAGEGHVSLMVVVSGEKTAIEETIGHLKEKERESSVPWERRSGEIDVGEEMVADLEKTEKVDVSPRDSEPEEQTSGQPEAEVIPSRSDGSTGPPQDRENISNKISVIPTLLEEKETTDKEVSSHGESSSQNSGHHVADQGTQLLDVQEQFSDTNLSKPLPQEQKPLQVKPAPFLRSRFKKPKPNLSRAALKRATLEAEHCVPGKKPEAYKMETVVLQQDRDQAASFSSPHNVPSLMASRENEKSGHEEEEEAVVLPCTQIEKDPSPPNSCEPKEDSQLTQNQEDSLVSPIGTPTVNMVPQETKPNVVQTTLPVRGRLQRPRPNVQKARQRQTVEKGKAEGITKNEGPELQKDEAKTCLTVANSSGVESEVAVEVSSRVSEFKVNESQGHVVPVENLSINKTSVLREQIRHENKPYVPSPALLIRRRFQKAKPNLGGARHKDEQPGVEKGPTSENTALTTEDHLLQKGDCDTQLSVQAREKTEMPLEVSMRKDCVHSEESGSDRNDAQLKAGPSGGAREEIAQEPTFSSSLEEQSLSKQISRPQLLKESSYSKTVPPRRTTVPSASECEIDHSGKRAHRKMKASVTKARGSKRIRGKTAKKEPRASKSVLVTLRASQKDDEDDAEDFESDYEEETCHLAPEELNKAPVFVPVGLRSPEPVSAQIEETMEELEITMDGADLGCLTVVDHQLSHVDIAARDEQPEKAVYPSSFEVVIGEQPQEEPGPGDGSTEAAITLLTMGDIVLQSEIIPGQGDVGVCVFPDDHSKDKNHVPFIPDNVNQKTVHDYQEVCSPVISMSHVSFEDNKIVLEEQSIREAAVLGEAMEEPLSTRDTACTMSTPLRMESMLVTPKAGSERILEISEPDGHQEVASLCMTKGTEVEIQRETEENDSTAVELDDKSLEPVPAAETKEQEQLLCVHGVEGARVSQEAILPARTEEHEDDLQGLQTLGAAVASSEIGQHTLESGQSLGDSVAEEALRESPEGSVVPMLHVPESVPSNIPEAQHENISPQDDTVNLFANVQQDGEDEQAFILTLVEIPTNTTEGFTDASMHLMPSSLLPAPILVRSGNAVERVDLSGSLQASSVVQDVTCSSPSRSGDSEKPPAIVELTSRKRFCCSPDESIHVPPAKKSSIAPGIDYQNCTSGVCSEELNVFEKTEESCMGQGIFPTSESTHATSKPQKEHSEQTSQNTGSSGSLGEIKDACVENTMTELPQSEVVSDKEEKTDPASNSKQRDSVTSSSKPPLTRPGRRPLGFLSLICPKNSLESDEVTQTHSKKRLKPHIPVSRRNLKKPNPLHASQKKNQESSDPLPPPSVTETVSDNTGSSESSAAEVSSDQPLVEEEKCKNGPKGASEEEVTTVSEFVFSDIFIEVDETE" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A6H8Y1/", "id": "A6H8Y1", "database": "OMA" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q571C7-1", "protein_name": "Transcription factor TFIIIB component B'' homolog; Transcription factor IIIB 150; TFIIIB150; Transcription factor-like nuclear regulator.", "sequence": { "length": 2467, "sequence": "MFRRARLSVKPNVRPGVGTRGSAAPNPQRGPEAPRPPEPATESAPKPAEPTDVPAVDSGGAEPQEQAPGSSDEKTGDKNNAAESSTLSSASSQRRKRVSSTSSLVQPSGSAPSQSRPLSTVDHDAPQPNPTPAKEKQPCSDRYRIYKARKLREMLKEELRKEKKQWKNKFSTNESQRPPDRSKMTMRDFIYYLPDNNPMTSSVEQEKKPEKSLAPTPTRDRQENQSTQDANDNEDVEEEVDDGPLLVPRVKVAEDGSIILDEESLTVEVLRTKGPCVVEENDPIFERGSTTTYSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKVLAEEEKRKQKSTKCQSLKEKASKPRKNLKAKTVTSEEVNDDPDESVNSNISDPERSQNDAETVNEEESPSSSGQHLEQAMLEQDQNQEKKRRRNQGEANKQEATNLLERVLVHSSPPAAEIHKNTCPSEENESECNKEQIPSLTQNIDDIAGLAPSEETEMRMDPIPSTCNQQDIMPLARESSESCAVALPVWEPGNTASADMAHAESSCSEGRGADLKTAAPETEQTENVKPKSRSRLQRPKPNLARAVGKKSAVSQDRQDERNKNSPSETAAEKNHMEKETMNESETSVAKNTDGESPGAKTVSDLSEKSCVQQDSQAKVLRPTRLMRSRMQRPKPNVVKAAERKEILTSQEKFGAHVEKSEDESCVVIPPQTENESHKNLQCEDTVSEPGRKDPFENIQPDQPQVLSDCPSIHEGNKENKRKQVPVLRTRFQKPKPNTGRRRRRISSKEGIPEETPISGEIPATWEEIPSLDTSLREEVLSVPLAPLTATASTKDSESDVKDSGRNDTASNAEMSEMTDVTMEMETGLETIGRDTCPGEMGAEMIDIPMETEAGLKASLNETSCMEKVPELIDTTGEICTNLGETGRKEVFLQENGPKEVGPVSEPETGLQETGKDLAMKESTPDTTDSTEEREAYSEETERQEKISALIKDAEEAKARGEMETPLEEIGGGTSQRGKAAGAPVEQSASEEEPQGSACREEVAVESSTAEGKELNLRETGEDDVSSMVVVLGEKTDIEETNGDPKETERESSVSWERGSGEIQVGEEMVEDLGKPEKIDVAPREREPEEHSSGQPEADVILSSSDGSTGSPQDKVNISSKISVMPTLVEEKETTDKDISSHLGHVESCSQNLGRHETDQGMPLPDALERFSDTNLSKPLPQEQQPLQVKPAPFLRSRFKKPKPNLSRAALKRATIEAEHCVPGKKSEACKVEAAMLQQDSDQAALSPQHNVPSLMASRENDKSGHEEEEEAAILPCTQTEKDASPPNSSEPKEGSQLTPNQENGLLVPIGTPMMNTVTQETRQNVVQTTLPVRGRLQRPRPNVQKARQRQIVEKGEARDIAKNEGPELQKDETRTCLTVANSSHIESGVAVDMSSRVSECQVSESQGHADPVENLSVNKASVVHEQMRHENKPYVPSPALLIRRRFQKAKPNLGGARRKDEQPGVEKGRTDESTALTAEDHLLQKEDCDTQLSLQAREKADMPLEVSVRKECIHSEESGSDRNDAQPNAGPSEGSRDETAKEQPTSLGLEEQSLSKQIRSSCPQLWKESSYPKTVSSRRTPLSSASECEIEHSWKRTQRKTKPNLTKGRGSKRIRGKTAKKEPRASKSVLVTLRASQKEDEDDAEDFDSDYEEETYHLAPEELSKAPVFVPVGLRSPEPVSAQIEETMEELEITMDVADMTVVEHQLSHMDTTAQAVQAEKAVYPPSFEMDVGEQTQEEPGPSDGSTEAAITLLTMGDIVLQSEIIPGQGDVGVCVFPDVHSEDKSHAPFSPDNVNQKVVHDYPEVCSPVISTSHASFEENRIVSKEQSNRDAAVEEEAVEETLPTRNTTSTMSTHLRMESMVVTPELNSEKTLEISESHGHQEVASFCITKETEVEIQRETEGDDSKAVELEDKSHAPVTAAETKEEEQSQCVGDVEGASVSQEAILPARIEDHEETLQEVQESGTAVASSEIGQQTLDSGQSFGESAAKEALKETPKGSDVPVLHGPESVPSHIPEAQQENTGPQAVTVNPFADGQQDGEDEQAFILTLVEIPTHATEGFTDAAMQLMPSSLLPAPILVRSGNAAERGDLSGSLQTSLVVQDAPSLSPSRSGSSEKPPANLDLTSRKRFCCSPDESIHVPPAKKSSLVPGIDYQECTSEVCSEELNVFEKTAESCMGQGIFPTSESTHATSKPQKEHSEPTDTGSSGSLDEIKDACVENMAQLPQSEIVSDKEEKTEPASNSEQRDIVTSSSKPPLTRPGRRPLGFLSLLCPKNSLESDEVTQTHSKKRLKPQIPVSRRNLRKPNLHNTSQKKNQDSSAPPPSPSVTAPLSGTAGSPESSAAQVSSDQPLLKEECKNGPKGAPEEEVTPVSEFVFSDIFIEVDETL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/34582", "id": "34582", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A6H8Y1/", "id": "A6H8Y1", "database": "OMA" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060899.2", "ac": "NP_060899.2", "name": "transcription factor TFIIIB component B'' homolog; TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 1; transcription factor-like nuclear regulator; transcription factor IIIB 150; RNA polymerase III transcription initiation factor B''.", "summary": "The product of this gene is a subunit of the TFIIIB transcription initiation complex, which recruits RNA polymerase III to target promoters in order to initiate transcription. The encoded protein localizes to concentrated aggregates in the nucleus, and is required for transcription from all three types of polymerase III promoters. It is phosphorylated by casein kinase II during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription. [provided by RefSeq, Jul 2008]." }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001156", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8Y1", "id": "A6H8Y1", "database": "UniProtKB" } ], "name": "TFIIIC-class transcription factor complex binding", "id": "GO:0001156" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8Y1", "id": "A6H8Y1", "database": "UniProtKB" } ], "name": "DNA binding", "id": "GO:0003677" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000126", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8Y1", "id": "A6H8Y1", "database": "UniProtKB" } ], "name": "transcription factor TFIIIB complex", "id": "GO:0000126" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8Y1", "id": "A6H8Y1", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070898", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8Y1", "id": "A6H8Y1", "database": "UniProtKB" } ], "name": "RNA polymerase III preinitiation complex assembly", "id": "GO:0070898" } ], "total": 1, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 175, "annotation": "n_glycosylation_sequon", "start_pos": 173 }, { "end_pos": 390, "annotation": "n_glycosylation_sequon", "start_pos": 388 }, { "end_pos": 485, "annotation": "n_glycosylation_sequon", "start_pos": 483 }, { "end_pos": 599, "annotation": "n_glycosylation_sequon", "start_pos": 597 }, { "end_pos": 624, "annotation": "n_glycosylation_sequon", "start_pos": 622 }, { "end_pos": 742, "annotation": "n_glycosylation_sequon", "start_pos": 740 }, { "end_pos": 774, "annotation": "n_glycosylation_sequon", "start_pos": 772 }, { 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"n_glycosylation_sequon", "start_pos": 2079 }, { "end_pos": 2144, "annotation": "n_glycosylation_sequon", "start_pos": 2142 }, { "end_pos": 2186, "annotation": "n_glycosylation_sequon", "start_pos": 2184 }, { "end_pos": 2551, "annotation": "n_glycosylation_sequon", "start_pos": 2549 }, { "end_pos": 2576, "annotation": "n_glycosylation_sequon", "start_pos": 2574 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060899.2", "id": "NP_060899.2", "database": "RefSeq" }, { "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=13652", "id": "13652", "database": "HGNC" }, { "url": "https://pharos.nih.gov/targets/A6H8Y1", "id": "A6H8Y1", "database": "PHAROS" }, { "url": "https://www.nextprot.org/entry/NX_A6H8Y1", "id": "NX_A6H8Y1", "database": "neXtProt" }, { "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=BDP1", "id": "BDP1", "database": "GeneCards" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-749476", "id": "R-HSA-749476", "database": 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"https://www.ebi.ac.uk/interpro/entry/IPR039467", "id": "IPR039467", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF15963", "id": "PF15963", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A6H8Y1", "id": "PR_A6H8Y1", "database": "PRO" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A6H8Y1*", "id": "A6H8Y1", "database": "IntAct" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/55814", "id": "55814", "database": "GeneID" } ], "expression_disease": [ { "trend": "Down", "disease": { "doid": "5041", "url": "http://disease-ontology.org/term/DOID:5041", "icd10": "", "name": "DOID:5041 / Esophageal cancer [EC]" }, "significant": "Yes", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6H8Y1", "id": "A6H8Y1", "database": "BioXpress" } ] }, { "trend": "Down", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "DOID:1781 / Thyroid cancer [Thyca]" }, 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"database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001155", "uberon": "0001155", "name": "Colon" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000145734", "id": "ENSG00000145734", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001987", "uberon": "0001987", "name": "Placenta" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000145734", "id": "ENSG00000145734", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000955", "uberon": "0000955", "name": "Brain" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000145734", "id": "ENSG00000145734", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001160", "uberon": "0001160", "name": "Fundus of stomach" }, "present": "yes", "evidence": [ { "url": 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71455615, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSG00000145734", "id": "ENSG00000145734", "database": "Ensembl Gene" } ] } } ] }