{ "uniprot_canonical_ac": "A6H8H5-1", "sequence": { "header": "sp|A6H8H5-1|KCNB2_MOUSE Isoform 1 of Potassium voltage-gated channel subfamily B member 2 OS=Mus musculus OX=10090 GN=Kcnb2 PE=1 SV=2 CANONICAL=A6H8H5-1", "length": 907, "sequence": "MAEKAPPGLNRKTSRSTLSLPPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNEELRREAETMREREGEEFDNTCCPEKRKKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNTLPELQENDEFGQPSDNRKLAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNLKDAFARSMELIDVAVEKAGESANTKDSVDDNHLSPSRWKWARKALSETSSNKSYENKYQEVSQNDSHEHLNNTSSSSPQHLSAQKLEMLYNEITKTQPHSHPNPDCQEQPERPCVYEEEIEMEEVICPQEQLAVAQTEVIVDMKSTSSIDSFTSCATDFTETERSPLPPPSASHLQMKFPTDLPGTDEHQRARAPPFLTLSRDKGPAAREAAVDYAPIDITVNLDAGASHGPLQPDSASDSPKSSLKGSNPLKSRSLKVNFQENRASAPQTPPSTARPLPVTTADFPLTTPQHMSTILLEEALPQGQPPLLEADDSAHCQGPSKGFSPRFPKQKLFPFSSRERRSFTEIDTGEDEDFLDLQRSRPDKQADPSPNCLADKPGDARDSLREEGCVGSSSPQNTDHNCRQDIYQAVGEVKKDSSQEGYKMENHLFAPEIHSNPGDTGHCPTRETSM" }, "uniprot_id": "KCNB2_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "potassium voltage-gated channel subfamily B member 2", "voltage-gated potassium channel subunit Kv2.2" ], "uniprotkb": [ "Potassium voltage-gated channel subfamily B member 2", "Voltage-gated potassium channel subunit Kv2.2" ] }, "gene": { "refseq": [ "Kcnb2", "9630047L19Rik", "BB130875", "Kv2.2" ], "uniprotkb": [ "Kcnb2", "9630047L19Rik", "BB130875", "Kv2.2" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H5", "id": "A6H8H5", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Potassium voltage-gated channel subfamily B member 2; Voltage-gated potassium channel subunit Kv2.2." }, "publication": [ { "title": "Kv2 Ion Channels Determine the Expression and Localization of the Associated AMIGO-1 Cell Adhesion Molecule in Adult Brain Neurons.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/29403353", "journal": "Frontiers in molecular neuroscience", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091998.1", "id": "NP_001091998.1", "database": "RefSeq" } ], "authors": "Bishop HI, Cobb MM, Kirmiz M, Parajuli LK, Mandikian D, Philp AM, Melnik M, Kuja-Panula J, Rauvala H, Shigemoto R, Murray KD, Trimmer JS", "date": "2018", "pmid": "29403353" }, { "title": "Remodeling neuronal ER-PM junctions is a conserved nonconducting function of Kv2 plasma membrane ion channels.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/30091655", "journal": "Molecular biology of the cell", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091998.1", "id": "NP_001091998.1", "database": "RefSeq" } ], "authors": "Kirmiz M, Palacio S, Thapa P, King AN, Sack JT, Trimmer JS", "date": "2018", "pmid": "30091655" }, { "title": "The contribution of Kv2.2-mediated currents decreases during the postnatal development of mouse dorsal root ganglion neurons.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/27033450", "journal": "Physiological reports", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091998.1", "id": "NP_001091998.1", "database": "RefSeq" } ], "authors": "Regnier G, Bocksteins E, Van de Vijver G, Snyders DJ, van Bogaert PP", "date": "2016", "pmid": "27033450" }, { "title": "Distinct Cell- and Layer-Specific Expression Patterns and Independent Regulation of Kv2 Channel Subtypes in Cortical Pyramidal Neurons.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/26538660", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091998.1", "id": "NP_001091998.1", "database": "RefSeq" } ], "authors": "Bishop HI, Guan D, Bocksteins E, Parajuli LK, Murray KD, Cobb MM, Misonou H, Zito K, Foehring RC, Trimmer JS", "date": "2015", "pmid": "26538660" }, { "title": "Initial segment Kv2.2 channels mediate a slow delayed rectifier and maintain high frequency action potential firing in medial nucleus of the trapezoid body neurons.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/18511484", "journal": "The Journal of physiology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091998.1", "id": "NP_001091998.1", "database": "RefSeq" } ], "authors": "Johnston J, Griffin SJ, Baker C, Skrzypiec A, Chernova T, Forsythe ID", "date": "2008", "pmid": "18511484" }, { "title": "Molecular diversity of K+ channels.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/10414301", "journal": "Ann. N. Y. Acad. Sci.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H5/publications", "id": "A6H8H5", "database": "UniProtKB" } ], "authors": "McCormack T., Nadal M.S., Ozaita A., Rudy B., Moreno H., Coetzee W.A., Pountney D., Saganich M., Vega-Saenz de Miera E., Amarillo Y., Chiu J., Chow A., Lau D.", "date": "1999", "pmid": "10414301" }, { "title": "A new K+ channel beta subunit to specifically enhance Kv2.2 (CDRK) expression.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/8824288", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091998.1", "id": "NP_001091998.1", "database": "RefSeq" } ], "authors": "Fink M, Duprat F, Lesage F, Heurteaux C, Romey G, Barhanin J, Lazdunski M", "date": "1996", "pmid": "8824288" }, { "title": "Voltage-gated potassium channel genes are clustered in paralogous regions of the mouse genome.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/8034307", "journal": "Genomics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091998.1", "id": "NP_001091998.1", "database": "RefSeq" } ], "authors": "Lock LF, Gilbert DJ, Street VA, Migeon MB, Jenkins NA, Copeland NG, Tempel BL", "date": "1994", "pmid": "8034307" } ], "glycosylation": [ { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H5", "id": "A6H8H5", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 287, "glytoucan_ac": "", "type": "N-linked" } ], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A6H8H5#A6H8H5-1", "isoform_ac": "A6H8H5-1", "locus": { "end_pos": 15312452, "start_pos": 15711626, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000175681", "id": "ENSMUST00000175681", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000135382", "id": "ENSMUSP00000135382", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A6H8H5-1|KCNB2_MOUSE Isoform 1 of Potassium voltage-gated channel subfamily B member 2 OS=Mus musculus OX=10090 GN=Kcnb2 PE=1 SV=2 CANONICAL=A6H8H5-1", "length": 907, "sequence": "MAEKAPPGLNRKTSRSTLSLPPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNEELRREAETMREREGEEFDNTCCPEKRKKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNTLPELQENDEFGQPSDNRKLAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNLKDAFARSMELIDVAVEKAGESANTKDSVDDNHLSPSRWKWARKALSETSSNKSYENKYQEVSQNDSHEHLNNTSSSSPQHLSAQKLEMLYNEITKTQPHSHPNPDCQEQPERPCVYEEEIEMEEVICPQEQLAVAQTEVIVDMKSTSSIDSFTSCATDFTETERSPLPPPSASHLQMKFPTDLPGTDEHQRARAPPFLTLSRDKGPAAREAAVDYAPIDITVNLDAGASHGPLQPDSASDSPKSSLKGSNPLKSRSLKVNFQENRASAPQTPPSTARPLPVTTADFPLTTPQHMSTILLEEALPQGQPPLLEADDSAHCQGPSKGFSPRFPKQKLFPFSSRERRSFTEIDTGEDEDFLDLQRSRPDKQADPSPNCLADKPGDARDSLREEGCVGSSSPQNTDHNCRQDIYQAVGEVKKDSSQEGYKMENHLFAPEIHSNPGDTGHCPTRETSM" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:98741", "resource": "KEGG Pathway", "id": "mmu:98741", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1296072", "resource": "Reactome", "id": "R-MMU-1296072", "name": "Voltage gated Potassium channels" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A6H8H5#function", "annotation": "Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H5#function", "id": "A6H8H5", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091998.1", "annotation": "These findings demonstrate a conserved in vivo function for Kv2 family members in remodeling neuronal endoplasmic reticulum-plasma membrane junctions.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091998.1", "id": "NP_001091998.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091998.1", "annotation": "The fractional contribution of Kv2.2-mediated currents relative to IK decreases during the postnatal maturation of dorsal root ganglion neurons.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091998.1", "id": "NP_001091998.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091998.1", "annotation": "It was concluded that Kv2.2-containing channels have a distinctive initial segment location and crucial function in maintaining AP amplitude by regulating the interspike potential during high frequency firing.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091998.1", "id": "NP_001091998.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q92953-1", "protein_name": "Potassium voltage-gated channel subfamily B member 2; Voltage-gated potassium channel subunit Kv2.2.", "sequence": { "length": 911, "sequence": "MAEKAPPGLNRKTSRSTLSLPPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNEELRREAETMREREGEEFDNTCCPDKRKKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNTLPELQETDEFGQLNDNRQLAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNLKDAFARSMELIDVAVEKAGESANTKDSADDNHLSPSRWKWARKALSETSSNKSFENKYQEVSQKDSHEQLNNTSSSSPQHLSAQKLEMLYNEITKTQPHSHPNPDCQEKPERPSAYEEEIEMEEVVCPQEQLAVAQTEVIVDMKSTSSIDSFTSCATDFTETERSPLPPPSASHLQMKFPTDLPGTEEHQRARGPPFLTLSREKGPAARDGTLEYAPVDITVNLDASGSQCGLHSPLQSDNATDSPKSSLKGSNPLKSRSLKVNFKENRGSAPQTPPSTARPLPVTTADFSLTTPQHISTILLEETPSQGDRPLLGTEVSAPCQGPSKGLSPRFPKQKLFPFSSRERRSFTEIDTGDDEDFLELPGAREEKQVDSSPNCFADKPSDGRDPLREEGSVGSSSPQDTGHNCRQDIYHAVSEVKKDSSQEGCKMENHLFAPEIHSNPGDTGYCPTRETSM" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/31263", "id": "31263", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091998.1", "ac": "NP_001091998.1", "name": "potassium voltage-gated channel subfamily B member 2; voltage-gated potassium channel subunit Kv2.2.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005249", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H5", "id": "A6H8H5", "database": "UniProtKB" } ], "name": "voltage-gated potassium channel activity", "id": "GO:0005249" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005251", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H5", "id": "A6H8H5", "database": "UniProtKB" } ], "name": "delayed rectifier potassium channel activity", "id": "GO:0005251" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H5", "id": "A6H8H5", "database": "UniProtKB" } ], "name": "protein heterodimerization activity", "id": "GO:0046982" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044325", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H5", "id": "A6H8H5", "database": "UniProtKB" } ], "name": "ion channel binding", "id": "GO:0044325" } ], "total": 4, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H5", "id": "A6H8H5", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H5", "id": "A6H8H5", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H5", "id": "A6H8H5", "database": "UniProtKB" } ], "name": "dendrite", "id": "GO:0030425" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H5", "id": "A6H8H5", "database": "UniProtKB" } ], "name": "neuronal cell body", "id": "GO:0043025" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043204", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H5", "id": "A6H8H5", "database": "UniProtKB" } ], "name": "perikaryon", "id": "GO:0043204" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008076", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H5", "id": "A6H8H5", "database": "UniProtKB" } ], "name": "voltage-gated potassium channel complex", "id": "GO:0008076" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032809", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H5", "id": "A6H8H5", "database": "UniProtKB" } ], "name": "neuronal cell body membrane", "id": "GO:0032809" } ], "total": 7, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051260", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H5", "id": "A6H8H5", "database": "UniProtKB" } ], "name": "protein homooligomerization", "id": "GO:0051260" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072659", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H5", "id": "A6H8H5", "database": "UniProtKB" } ], "name": "protein localization to plasma membrane", "id": "GO:0072659" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006813", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H5", "id": "A6H8H5", "database": "UniProtKB" } ], "name": "potassium ion transport", "id": "GO:0006813" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034765", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H5", "id": "A6H8H5", "database": "UniProtKB" } ], "name": "regulation of ion transmembrane transport", "id": "GO:0034765" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071805", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H5", "id": "A6H8H5", "database": "UniProtKB" } ], "name": "potassium ion transmembrane transport", "id": "GO:0071805" } ], "total": 5, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 189, "annotation": "n_glycosylation_sequon", "start_pos": 187 }, { "end_pos": 289, "annotation": "n_glycosylation_sequon", "start_pos": 287 }, { "end_pos": 421, "annotation": "n_glycosylation_sequon", "start_pos": 419 }, { "end_pos": 448, "annotation": "n_glycosylation_sequon", "start_pos": 446 }, { "end_pos": 507, "annotation": "n_glycosylation_sequon", "start_pos": 505 }, { "end_pos": 520, "annotation": "n_glycosylation_sequon", "start_pos": 518 }, { "end_pos": 527, "annotation": "n_glycosylation_sequon", "start_pos": 525 }, { "end_pos": 528, "annotation": "n_glycosylation_sequon", "start_pos": 526 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091998.1", "id": "NP_001091998.1", "database": "RefSeq" 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"IntAct" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/98741", "id": "98741", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:99632", "id": "99632", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A6H8H5", "disease": [], "mass": { "monoisotopic_mass": 102336.0, "chemical_mass": 102336.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A6H8H5", "name": "Kcnb2; 9630047L19Rik; BB130875; Kv2.2.", "locus": { "end_pos": 15723750, "start_pos": 15287254, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000092083", "id": "ENSMUSG00000092083", "database": "Ensembl Gene" } ] } } ] }