{ "uniprot_canonical_ac": "A6H6J2-1", "sequence": { "header": "tr|A6H6J2-1|A6H6J2_MOUSE Isoform 1 of Cytochrome P450, family 2, subfamily b, polypeptide 13 OS=Mus musculus OX=10090 GN=Cyp2b13 PE=1 SV=1 CANONICAL=A6H6J2-1", "length": 491, "sequence": "MDPSVLLLLAVLLSLFLLLVRGHAKIHGHLPPGPRPLPLLGNLLQMDRGGLLKCFIHLQEKHGDVFTVHLGPRPVVVLCGTQTIREALVNNAEAFSGRGTIAAAQLVMQDYGIFFSSGERWKTLRRFSLATMKEFGMGKRSVEERIKEEAQCLVEELKKYQGAPLDPTFFFQCVTANIICSIVFGERFDYTDEQFLRLLNLMYQIYSLLRSFSCQMFELFSGLLKYFPGVHRQIAKNQQEILNFITHRVEKHRATLDPSEPRDFIDTYLLRMEKEKSNHNTEFHHQNLMMSVLSLFFAGTETTSTTLCCGFLLMLMYPHVAEKVQKEIDQVIGSHRLPTLDDRTKMPYTDAVIHEIQRFSDIVPTGAPHRVTKDTMFRGYLLPKNTEVYPILSSALHDPQYFEQPDSFNPDHFLDANGALKKSEAFLPFSTGKRICLGESIARNELFLFFTSILQNFSVASPVASKDIDLTPKESGIGKIPPTYQICFLAR" }, "uniprot_id": "A6H6J2_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "cytochrome P450, family 2, subfamily b, polypeptide 13 precursor", "phenobarbital inducible, type c; cytochrome P450, 2b13, phenobarbitol inducible, type c" ], "uniprotkb": [ "Cytochrome P450, family 2, subfamily b, polypeptide 13" ] }, "gene": { "refseq": [ "Cyp2b13" ], "uniprotkb": [ "Cyp2b13" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6J2", "id": "A6H6J2", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Cytochrome P450, family 2, subfamily b, polypeptide 13." }, "publication": [ { "title": "High-throughput discovery of novel developmental phenotypes.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/27626380", "journal": "Nature", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031839.2", "id": "NP_031839.2", "database": "RefSeq" } ], "authors": "Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M, Murray SA", "date": "2016", "pmid": "27626380" }, { "title": "Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/27197076", "journal": "Gene expression", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031839.2", "id": "NP_031839.2", "database": "RefSeq" } ], "authors": "Creasy KT, Jiang J, Ren H, Peterson ML, Spear BT", "date": "2016", "pmid": "27197076" }, { "title": "Lentiviral-mediated RNAi knockdown yields a novel mouse model for studying Cyp2b function.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22083726", "journal": "Toxicological sciences : an official journal of the Society of Toxicology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031839.2", "id": "NP_031839.2", "database": "RefSeq" } ], "authors": "Damiri B, Holle E, Yu X, Baldwin WS", "date": "2012", "pmid": "22083726" }, { "title": "Viral infection and PBDE exposure interact on CYP gene expression and enzyme activities in the mouse liver.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17964055", "journal": "Toxicology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031839.2", "id": "NP_031839.2", "database": "RefSeq" } ], "authors": "Lundgren M, Darnerud PO, Molin Y, Lilienthal H, Blomberg J, Ilback NG", "date": "2007", "pmid": "17964055" }, { "title": "Organization and evolution of the Cyp2 gene cluster on mouse chromosome 7, and comparison with the syntenic human cluster.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/14630516", "journal": "Environmental health perspectives", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031839.2", "id": "NP_031839.2", "database": "RefSeq" } ], "authors": "Wang H, Donley KM, Keeney DS, Hoffman SM", "date": "2003", "pmid": "14630516" }, { "title": "Structures and characterization of sex-specific mouse cytochrome P-450 genes as members within a large family. Duplication boundary and evolution.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/1997326", "journal": "European journal of biochemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031839.2", "id": "NP_031839.2", "database": "RefSeq" } ], "authors": "Lakso M, Masaki R, Noshiro M, Negishi M", "date": "1991", "pmid": "1997326" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A6H6J2#A6H6J2-1", "isoform_ac": "A6H6J2-1", "locus": { "end_pos": 26061520, "start_pos": 26095818, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000005669", "id": "ENSMUST00000005669", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000005669", "id": "ENSMUSP00000005669", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A6H6J2-1|A6H6J2_MOUSE Isoform 1 of Cytochrome P450, family 2, subfamily b, polypeptide 13 OS=Mus musculus OX=10090 GN=Cyp2b13 PE=1 SV=1 CANONICAL=A6H6J2-1", "length": 491, "sequence": "MDPSVLLLLAVLLSLFLLLVRGHAKIHGHLPPGPRPLPLLGNLLQMDRGGLLKCFIHLQEKHGDVFTVHLGPRPVVVLCGTQTIREALVNNAEAFSGRGTIAAAQLVMQDYGIFFSSGERWKTLRRFSLATMKEFGMGKRSVEERIKEEAQCLVEELKKYQGAPLDPTFFFQCVTANIICSIVFGERFDYTDEQFLRLLNLMYQIYSLLRSFSCQMFELFSGLLKYFPGVHRQIAKNQQEILNFITHRVEKHRATLDPSEPRDFIDTYLLRMEKEKSNHNTEFHHQNLMMSVLSLFFAGTETTSTTLCCGFLLMLMYPHVAEKVQKEIDQVIGSHRLPTLDDRTKMPYTDAVIHEIQRFSDIVPTGAPHRVTKDTMFRGYLLPKNTEVYPILSSALHDPQYFEQPDSFNPDHFLDANGALKKSEAFLPFSTGKRICLGESIARNELFLFFTSILQNFSVASPVASKDIDLTPKESGIGKIPPTYQICFLAR" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:13089", "resource": "KEGG Pathway", "id": "mmu:13089", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031839.2", "annotation": "Report lentiviral-mediated RNAi knockdown of multiple mouse Cyp2b enzymes.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031839.2", "id": "NP_031839.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "P12790-1", "protein_name": "Cytochrome P450 2B9; 1.14.14.1; CYPIIB9; Testosterone 16-alpha hydroxylase; Cytochrome P450 clone PF26; Cytochrome P450-16-alpha.", "sequence": { "length": 491, "sequence": "MDPSVLLLLAVLLSLFLLLVRGHAKIHGHLPPGPHPLPLLGNLLQMDRGGLLKCFIQLQEKHGDVFTVHLGPRPVVVLCGTQTIREALVDHAEAFSGRGTIAAAQLVMQDYGIFFASGQRWKTLRRFSLATMKEFGMGKRSVEERIKEEAQCLVEELKKYQGVPLDPTFLFQCITANIICSIVFGERFDYTDDQFLHLLNLMYKIFSLLSSFSGQMFELFSGFLKYFPGVHRQIVKKQQELLDYIAHSVEKHKATLDPSAPRDYIDTYLLRMEKEKSNHNTEFHHQNLMMSVLSLFFAGTETTSATLHYGVLLMLKYPHVTEKVQKEIDQVIGSHRLPTLDDRTKMPYTDAVIHEIQRFSDLVPIGLPHKVIKDTLFRGYLLPKNTEVYPVLSSALHDPQYFEQPDKFNPEHFLDANGALKKCEAFLPFSTGKRICLGESIARNELFIFFTTILQNFSVASPVAPKDIDLTPKESGIGKIPPAHQIYFLAR" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/74933", "id": "74933", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "P13107-1", "protein_name": "Cytochrome P450 2B3; 1.14.14.1; CYPIIB3.", "sequence": { "length": 491, "sequence": "MDTSVLLLLAVLLSFLLFLVRGHAKVHGHLPPGPRPLPLLGNLLQMDRGGFRKSFIQLQEKHGDVFTVYFGPRPVVMLCGTQTIREALVDHAEAFSGRGIIAVLQPIMQEYGVSFVNEERWKILRRLFVATMRDFGIGKQSVEDQIKEEAKCLVEELKNHQGVSLDPTFLFQCVTGNIICSIVFGERFDYRDRQFLRLLDLLYRTFSLISSFSSQMFEVYSDFLKYFPGVHREIYKNLKEVLDYIDHSVENHRATLDPNAPRDFIDTFLLHMEKEKLNHYTEFHHWNLMISVLFLFLAGTESTSNTLCYGFLLMLKYPHVAEKVQKEIDQVIGSQRVPTLDDRSKMPYTEAVIHEIQRFSDVSPMGLPCRITKDTLFRGYLLPKNTEVYFILSSALHDPQYFEQPDTFNPEHFLDANGALKKCEAFMPFSIGKRMCLGEGIARSELFLFFTTILQNYSVSSPVDPNTIDMTPKESGLAKVAPVYKICFVAR" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/74933", "id": "74933", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031839.2", "ac": "NP_031839.2", "name": "cytochrome P450, family 2, subfamily b, polypeptide 13 precursor; phenobarbital inducible, type c; cytochrome P450, 2b13, phenobarbitol inducible, type c.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6J2", "id": "A6H6J2", "database": "UniProtKB" } ], "name": "heme binding", "id": "GO:0020037" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016712", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6J2", "id": "A6H6J2", "database": "UniProtKB" } ], "name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "id": "GO:0016712" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008392", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6J2", "id": "A6H6J2", "database": "UniProtKB" } ], "name": "arachidonic acid epoxygenase activity", "id": "GO:0008392" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008395", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6J2", "id": "A6H6J2", "database": "UniProtKB" } ], "name": "steroid hydroxylase activity", "id": "GO:0008395" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6J2", "id": "A6H6J2", "database": "UniProtKB" } ], "name": "iron ion binding", "id": "GO:0005506" } ], "total": 5, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6J2", "id": "A6H6J2", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6J2", "id": "A6H6J2", "database": "UniProtKB" } ], "name": "intracellular membrane-bounded organelle", "id": "GO:0043231" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042738", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6J2", "id": "A6H6J2", "database": "UniProtKB" } ], "name": "exogenous drug catabolic process", "id": "GO:0042738" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055114", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6J2", "id": "A6H6J2", "database": "UniProtKB" } ], "name": "oxidation-reduction process", "id": "GO:0055114" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006805", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6J2", "id": "A6H6J2", "database": "UniProtKB" } ], "name": "xenobiotic metabolic process", "id": "GO:0006805" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019373", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6J2", "id": "A6H6J2", "database": "UniProtKB" } ], "name": "epoxygenase P450 pathway", "id": "GO:0019373" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006082", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6J2", "id": "A6H6J2", "database": "UniProtKB" } ], "name": "organic acid metabolic process", "id": "GO:0006082" } ], "total": 5, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 458, "annotation": "n_glycosylation_sequon", "start_pos": 456 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031839.2", "id": "NP_031839.2", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:13089", "id": "mmu:13089", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000040583", "id": "ENSMUSG00000040583", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/CKRYDEE/", "id": "CKRYDEE", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR008068", "id": "IPR008068", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001128", "id": "IPR001128", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002401", "id": "IPR002401", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017972", "id": "IPR017972", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036396", "id": "IPR036396", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00067", "id": "PF00067", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/13089", "id": "13089", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:88599", "id": "88599", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A6H6J2", "disease": [], "mass": { "monoisotopic_mass": 55846.0, "chemical_mass": 55846.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A6H6J2", "name": "Cyp2b13.", "locus": { "end_pos": 26096197, "start_pos": 26061497, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000040583", "id": "ENSMUSG00000040583", "database": "Ensembl Gene" } ] } } ] }