{ "uniprot_canonical_ac": "A6H6E2-1", "sequence": { "header": "sp|A6H6E2-1|MMRN2_MOUSE Isoform 1 of Multimerin-2 OS=Mus musculus OX=10090 GN=Mmrn2 PE=1 SV=1 CANONICAL=A6H6E2-1", "length": 943, "sequence": "MIPTLLLGFGVYLSWGLLGSWAQDPGTKFSHLNRPGMPEGWRLGAEDTSRDPIRRNWCPYQKSRLVTFVAACKTEKFLVHSQQPCPQGAPDCQGVRVMYRVAQKPVYQVQQKVLISVDWRCCPGFQGPDCQDHNPTANPEPTEPSGKLQETWDSMDGFELGHPVPEFNEIKVPQEQQENLLQNLQNDAQSVEDGFPGSWEAPPSNLTDEMTEANLTEFEFPGRTSEHLLQPHIDAFLKAHFSPIWKNFNDSLHSLSQAIRNLSLDVEANHQAIKMIQEGTVARADFQELGAKFEAKVQQNSQRLGQLWQDVEDQLHAQRRSVHHALSDVQAEVSTKLKQLVKAQELPGANGSLVMASAAAAARPEPESLQARLGQLQRNLSALHMVTSQREEELQSTLKNMDSVLKQHAEEIKELYSESDETFDQISKVERQVEELLVNHTGLRELRVILMEKSLIMEENKEEIERQLLELNLTLQHLHAGHADLIKYVKDCNCQRVNSDVDVAPEGHRDVMHTLEETQVSLDEQHQLDGSSLQALQSTVDAMSSAMDAYRGEGERARAERARIRSQLRALDHAVEALKTAANGTRKEIRLLHGSFTALLEDALRHQAVLAALFGEEMIDEMSEEAPRPLPLDYEQIRLALQDAASGLQEQAIGWEDLATRVEALEKAAGGFVEQHPQLAEGLEPSHDSGREEEAMTLAELEQEIRRLSSDVKQIGQCCEASWAASLNSSLEDLHSMLLDTQHGLRQHRQLFHNLFQNFQGLVASNISLDLGKLQAMLSKKDKKQPRGPGESRKRDKKQVVMSTDAHAKGLELWETGSPVAFYAGSSEGATALQMVKFNTTSINVGSSYFPEHGYFRAPKRGVYLFAVSITFGPGPGMGQLVFEGHHRVPVYSTEQRGGSTATTFAMVELQKGERAWFELIQGSATKGSQPGTAFGGFLMFKT" }, "uniprot_id": "MMRN2_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "multimerin-2 precursor", "elastin microfibril interfacer 3; Multimerin-2; mmrn2" ], "uniprotkb": [ "Multimerin-2" ] }, "gene": { "refseq": [ "Mmrn2", "AA986839", "Emilin3", "EndoGlyx-1", "ENDOGLYX1" ], "uniprotkb": [ "Mmrn2", "AA986839", "Emilin3", "EndoGlyx-1", "ENDOGLYX1" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6E2", "id": "A6H6E2", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Multimerin-2." }, "publication": [ { "title": "Altered feto-placental vascularization, feto-placental malperfusion and fetal growth restriction in mice with Egfl7 loss of function.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/28526753", "journal": "Development (Cambridge, England)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694767.3", "id": "NP_694767.3", "database": "RefSeq" } ], "authors": "Lacko LA, Hurtado R, Hinds S, Poulos MG, Butler JM, Stuhlmann H", "date": "2017", "pmid": "28526753" }, { "title": "Blocking CLEC14A-MMRN2 binding inhibits sprouting angiogenesis and tumour growth.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/25745997", "journal": "Oncogene", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694767.3", "id": "NP_694767.3", "database": "RefSeq" } ], "authors": "Noy PJ, Lodhia P, Khan K, Zhuang X, Ward DG, Verissimo AR, Bacon A, Bicknell R", "date": "2015", "pmid": "25745997" }, { "title": "The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22159717", "journal": "Molecular & cellular proteomics : MCP", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694767.3", "id": "NP_694767.3", "database": "RefSeq" } ], "authors": "Naba A, Clauser KR, Hoersch S, Liu H, Carr SA, Hynes RO", "date": "2012", "pmid": "22159717" }, { "title": "MULTIMERIN2 impairs tumor angiogenesis and growth by interfering with VEGF-A/VEGFR2 pathway.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22020326", "journal": "Oncogene", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694767.3", "id": "NP_694767.3", "database": "RefSeq" } ], "authors": "Lorenzon E, Colladel R, Andreuzzi E, Marastoni S, Todaro F, Schiappacassi M, Ligresti G, Colombatti A, Mongiat M", "date": "2012", "pmid": "22020326" }, { "title": "EMILINs interact with anthrax protective antigen and inhibit toxin action in vitro.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17988845", "journal": "Matrix biology : journal of the International Society for Matrix Biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694767.3", "id": "NP_694767.3", "database": "RefSeq" } ], "authors": "Doliana R, Veljkovic V, Prljic J, Veljkovic N, De Lorenzo E, Mongiat M, Ligresti G, Marastoni S, Colombatti A", "date": "2008", "pmid": "17988845" }, { "title": "Transcriptome-based systematic identification of extracellular matrix proteins.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/18757743", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694767.3", "id": "NP_694767.3", "database": "RefSeq" } ], "authors": "Manabe R, Tsutsui K, Yamada T, Kimura M, Nakano I, Shimono C, Sanzen N, Furutani Y, Fukuda T, Oguri Y, Shimamoto K, Kiyozumi D, Sato Y, Sado Y, Senoo H, Yamashina S, Fukuda S, Kawai J, Sugiura N, Kimata K, Hayashizaki Y, Sekiguchi K", "date": "2008", "pmid": "18757743" }, { "title": "Overlapping, complementary and site-specific expression pattern of genes of the EMILIN/Multimerin family.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/14996434", "journal": "Matrix biology : journal of the International Society for Matrix Biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694767.3", "id": "NP_694767.3", "database": "RefSeq" } ], "authors": "Braghetta P, Ferrari A, De Gemmis P, Zanetti M, Volpin D, Bonaldo P, Bressan GM", "date": "2004", "pmid": "14996434" } ], "glycosylation": [ { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6E2", "id": "A6H6E2", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 766, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6E2", "id": "A6H6E2", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 728, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6E2", "id": "A6H6E2", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 261, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6E2", "id": "A6H6E2", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 839, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6E2", "id": "A6H6E2", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 439, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://glyconnect.expasy.org/browser/proteins/2515", "id": "2515", "database": "GlyConnect" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30899004", "id": "30899004", "database": "PubMed" }, { "url": "https://www.uniprot.org/uniprot/A6H6E2", "id": "A6H6E2", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 249, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6E2", "id": "A6H6E2", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 379, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6E2", "id": "A6H6E2", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 214, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6E2", "id": "A6H6E2", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 350, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6E2", "id": "A6H6E2", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 205, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6E2", "id": "A6H6E2", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 472, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6E2", "id": "A6H6E2", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 583, "glytoucan_ac": "", "type": "N-linked" } ], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A6H6E2#A6H6E2-1", "isoform_ac": "A6H6E2-1", "locus": { "end_pos": 34375615, "start_pos": 34403292, "chromosome": "14", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000111908", "id": "ENSMUST00000111908", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000107539", "id": "ENSMUSP00000107539", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A6H6E2-1|MMRN2_MOUSE Isoform 1 of Multimerin-2 OS=Mus musculus OX=10090 GN=Mmrn2 PE=1 SV=1 CANONICAL=A6H6E2-1", "length": 943, "sequence": "MIPTLLLGFGVYLSWGLLGSWAQDPGTKFSHLNRPGMPEGWRLGAEDTSRDPIRRNWCPYQKSRLVTFVAACKTEKFLVHSQQPCPQGAPDCQGVRVMYRVAQKPVYQVQQKVLISVDWRCCPGFQGPDCQDHNPTANPEPTEPSGKLQETWDSMDGFELGHPVPEFNEIKVPQEQQENLLQNLQNDAQSVEDGFPGSWEAPPSNLTDEMTEANLTEFEFPGRTSEHLLQPHIDAFLKAHFSPIWKNFNDSLHSLSQAIRNLSLDVEANHQAIKMIQEGTVARADFQELGAKFEAKVQQNSQRLGQLWQDVEDQLHAQRRSVHHALSDVQAEVSTKLKQLVKAQELPGANGSLVMASAAAAARPEPESLQARLGQLQRNLSALHMVTSQREEELQSTLKNMDSVLKQHAEEIKELYSESDETFDQISKVERQVEELLVNHTGLRELRVILMEKSLIMEENKEEIERQLLELNLTLQHLHAGHADLIKYVKDCNCQRVNSDVDVAPEGHRDVMHTLEETQVSLDEQHQLDGSSLQALQSTVDAMSSAMDAYRGEGERARAERARIRSQLRALDHAVEALKTAANGTRKEIRLLHGSFTALLEDALRHQAVLAALFGEEMIDEMSEEAPRPLPLDYEQIRLALQDAASGLQEQAIGWEDLATRVEALEKAAGGFVEQHPQLAEGLEPSHDSGREEEAMTLAELEQEIRRLSSDVKQIGQCCEASWAASLNSSLEDLHSMLLDTQHGLRQHRQLFHNLFQNFQGLVASNISLDLGKLQAMLSKKDKKQPRGPGESRKRDKKQVVMSTDAHAKGLELWETGSPVAFYAGSSEGATALQMVKFNTTSINVGSSYFPEHGYFRAPKRGVYLFAVSITFGPGPGMGQLVFEGHHRVPVYSTEQRGGSTATTFAMVELQKGERAWFELIQGSATKGSQPGTAFGGFLMFKT" } }, { "url": "https://www.uniprot.org/uniprot/A6H6E2#A0A2I3BPZ4-1", "isoform_ac": "A0A2I3BPZ4-1", "locus": { "end_pos": 34375721, "start_pos": 34397928, "chromosome": "14", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000227130", "id": "ENSMUST00000227130", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000153972", "id": "ENSMUSP00000153972", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A2I3BPZ4-1|MMRN2_MOUSE Computationally mapped isoform of Multimerin-2 OS=Mus musculus OX=10090 GN=Mmrn2 PE=1 SV=1 CANONICAL=A6H6E2-1", "length": 173, "sequence": "XMPEGWRLGAEDTSRDPIRRYRVAQKPVYQVQQKVLISVDWRCCPGFQGPDCQDHNPTANPEPTEPSGKLQETWDSMDGFELGHPVPEFNEIKVPQEQQENLLQNLQNDAQSVEDGFPGSWEAPPSNLTDEMTEANLTEFEFPGRTSEHLLQPHIDAFLKAHFSPIWKNFNDS" } }, { "url": "https://www.uniprot.org/uniprot/A6H6E2#A6H6E2-2", "isoform_ac": "A6H6E2-2", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A6H6E2-2|MMRN2_MOUSE Isoform 2 of Multimerin-2 OS=Mus musculus OX=10090 GN=Mmrn2 PE=1 SV=1 CANONICAL=A6H6E2-1", "length": 417, "sequence": "MIPTLLLGFGVYLSWGLLGSWAQDPGTKFSHLNRPGMPEGWRLGAEDTSRDPIRRNWCPYQKSRLVTFVAACKTEKFLVHSQQPCPQGAPDCQGVRVMYRVAQKPVYQVQQKVLISVDWRCCPGFQGPDCQDHNPTANPEPTEPSGKLQETWDSMDGFELGHPVPEFNEIKVPQEQQEIRRLSSDVKQIGQCCEASWAASLNSSLEDLHSMLLDTQHGLRQHRQLFHNLFQNFQGLVASNISLDLGKLQAMLSKKDKKQPRGPGESRKRDKKQVVMSTDAHAKGLELWETGSPVAFYAGSSEGATALQMVKFNTTSINVGSSYFPEHGYFRAPKRGVYLFAVSITFGPGPGMGQLVFEGHHRVPVYSTEQRGGSTATTFAMVELQKGERAWFELIQGSATKGSQPGTAFGGFLMFKT" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:105450", "resource": "KEGG Pathway", "id": "mmu:105450", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A6H6E2#function", "annotation": "Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6E2#function", "id": "A6H6E2", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694767.3", "annotation": "MMRN2 as a crucial player in the regulation of EC function, neo-angiogenesis and hence tumor growth", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694767.3", "id": "NP_694767.3", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694767.3", "annotation": "Mmrn2 interacts with anthrax protective antigen.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694767.3", "id": "NP_694767.3", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "D4ABX6-1", "protein_name": "Multimerin 2.", "sequence": { "length": 933, "sequence": "MILTLLLGLAGYLSWGLLGSWAQDPGSRFSNPNRLSVPEGWRIGADDDTSRDPSQRNWCPYQKSRLVTFVAACKTEKFLVHSQQPCPQGAPDCQRVKVMYRVAQKPVYQVQQKVLMSVDWRCCPGFQGPDCQDHHPTANPEPTEASGKLQETWDSLDGFEPGHPVTEFNEIKAPQEHLLQNLQNDAQPVEDGFAGPWEAPSSNLTAAMTEANLTEFESLGRTSKHLLQPHIHAFLEAHFSPIWKSFNESLQSLFQAIRNLSLDVEANHRAIKMIQEGTVARADFRELGAKFEAKVQQNSQRLGQLWQDVEDQLHAQRRSVHHALSEVQAEVSTKLKQLVKAQELPGANGSLAVASAARPEPESLQARLGQLQRNLSALHMVTNQREEELRGTLKDMDSVLRQHTDEIKELYSESDETFDQISKVERQVEELLVNHTGLRELRVILMEKSLIMEENKEEMERQLLDLNLTLQHLQAAHADLIKYVKDCNCRRVYSDMDVIPEGRRDAMHTLEETQVSPDEQHQLDGSLQALQSTVDAMSSALDAYRGEGERARAERARMRSQLRALDHAVEALKTAANGTRKEIRLLHGSFAALLEDALRHQAVLAALFGEEMVDEMSEEPPRPLPLNYEQIRLALQDAASGLQEQAVGWEDLATRVEALEKAAGGFVEQHPRSAEGLEPSHDFGREEDTRALGDLEQEIQRLSSDVKQMGQCCEASWALNGSLEDLHSALSDTQHSLRQHQQLFRGLFHNFQGLLASNTSLDLDKLQAMLSKKDKKQQKGPGESRKRDKKQVVMSADAKGLGLWEAGSPVAFYASSSEEATALQMVKFNATSVNVGSGYFPEHGYFRAPKRGIYLFAVSVTFGPGPGMGQLVFEGHRRVPVYSAEQRGGSTATTFAMAELQKGERVWFELIQGSVTKGSRPGTAFGGFLMFKT" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/11697", "id": "11697", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A6H6E2/", "id": "A6H6E2", "database": "OMA" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q9H8L6-1", "protein_name": "Multimerin-2; Elastin microfibril interface located protein 3; Elastin microfibril interfacer 3; p140 subunit; EMILIN-3.", "sequence": { "length": 949, "sequence": "MILSLLFSLGGPLGWGLLGAWAQASSTSLSDLQSSRTPGVWKAEAEDTGKDPVGRNWCPYPMSKLVTLLALCKTEKFLIHSQQPCPQGAPDCQKVKVMYRMAHKPVYQVKQKVLTSLAWRCCPGYTGPNCEHHDSMAIPEPADPGDSHQEPQDGPVSFKPGHLAAVINEVEVQQEQQEHLLGDLQNDVHRVADSLPGLWKALPGNLTAAVMEANQTGHEFPDRSLEQVLLPHVDTFLQVHFSPIWRSFNQSLHSLTQAIRNLSLDVEANRQAISRVQDSAVARADFQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELHMTTARREEELQYTLEDMRATLTRHVDEIKELYSESDETFDQISKVERQVEELQVNHTALRELRVILMEKSLIMEENKEEVERQLLELNLTLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLAALFGEEVLEEMSEQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELAARVTALEQASEPPRPAEHLEPSHDAGREEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASLNASLHGLHNALFATQRSLEQHQRLFHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDLEAPRKRDKKEAEPLVDIRVTGPVPGALGAALWEAGSPVAFYASFSEGTAALQTVKFNTTYINIGSSYFPEHGYFRAPERGVYLFAVSVEFGPGPGTGQLVFGGHHRTPVCTTGQGSGSTATVFAMAELQKGERVWFELTQGSITKRSLSGTAFGGFLMFKT" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/11697", "id": "11697", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A6H6E2/", "id": "A6H6E2", "database": "OMA" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694767.3", "ac": "NP_694767.3", "name": "multimerin-2 precursor; elastin microfibril interfacer 3; Multimerin-2; mmrn2.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6E2", "id": "A6H6E2", "database": "UniProtKB" } ], "name": "extracellular matrix", "id": "GO:0031012" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005604", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6E2", "id": "A6H6E2", "database": "UniProtKB" } ], "name": "basement membrane", "id": "GO:0005604" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062023", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6E2", "id": "A6H6E2", "database": "UniProtKB" } ], "name": "collagen-containing extracellular matrix", "id": "GO:0062023" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6E2", "id": "A6H6E2", "database": "UniProtKB" } ], "name": "extracellular space", "id": "GO:0005615" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002042", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6E2", "id": "A6H6E2", "database": "UniProtKB" } ], "name": "cell migration involved in sprouting angiogenesis", "id": "GO:0002042" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090051", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6E2", "id": "A6H6E2", "database": "UniProtKB" } ], "name": "negative regulation of cell migration involved in sprouting angiogenesis", "id": "GO:0090051" }, { "url": 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