{ "uniprot_canonical_ac": "A6H6A9-1", "sequence": { "header": "sp|A6H6A9-1|RBG1L_MOUSE Isoform 1 of Rab GTPase-activating protein 1-like OS=Mus musculus OX=10090 GN=Rabgap1l PE=1 SV=1 CANONICAL=A6H6A9-1", "length": 815, "sequence": "MEVRASFQKVSGSSDSVATLNSEEFVLVSQHTDATSIKDDGKPQLKIASNGDEQLEKAMEEILRDSEKGQSGLPVDCQGSSEISDCPFGDVPASQTTKPPLQLILDPSNTEISTPRPSSPSRFPEEDSVLFNKLTYLGCMKVSSPRSEVEALRAMATMRASSQYPFAVTLYVPNVPEGSVRIIDQSSNVEIASFPIYKVLFCARGHDGTAESNCFAFTESSHGSEEFQIHVFSCEIKEAVSRILYSFCTAFKRSSRQVSDVKDSVIPTPDSDVFTFSVSLEVKEDDGKGNFSPVPKDRDKFYFKIKQGIEKKVVITVQQLSNKELAIERCFGMLLSPGRNVKNSDMHLLDMESMGKSYDGRAYVITGMWNPNAPIFLALNEETPKDKRVYMTVAVDMVVTEVVEPVRFLLETVVRVYPANERFWYFSRKTFTETFFMRLKQSEGKGHSSAGDAIYEVVSLQRESDKEEPITPTSAGGPMSPQEDEAEEESDNELSSGTGDVSKDCPEKILYSWGELLGRWHNNLGGRPKGLFTLVKSGVPEALRAEVWQLLAGCHDNQEMLDKYRILITKDSAQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVFDEDIGYCQGQSFLAAVLLLHMPEEQAFCVLVTIMYGYKLRDLYRNNFEDLHCKFYQLEKLMQEQLPDLYSHFCDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQADFEGALKFFRVQLPKRYRAEENARRLMEQACNIKVPTKKLKKYEKEYQAMRENQLQQEDPMDRYKFVYL" }, "uniprot_id": "RBG1L_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "rab GTPase-activating protein 1-like isoform b", "rab6 GTPase activating protein-like; rabgap1l; rab GTPase-activating protein 1-like" ], "uniprotkb": [ "Rab GTPase-activating protein 1-like" ] }, "gene": { "refseq": [ "Rabgap1l", "5830411O09Rik", "8430421H08Rik", "9630005B12Rik", "AW049894", "Hh1", "HHL", "mKIAA0471" ], "uniprotkb": [ "Rabgap1l", "Hhl", "Kiaa0471", "5830411O09Rik", "8430421H08Rik", "9630005B12Rik", "AW049894", "Hh1", "HHL", "mKIAA0471" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6A9", "id": "A6H6A9", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Rab GTPase-activating protein 1-like." }, "publication": [ { "title": "Ankyrin-B is a PI3P effector that promotes polarized alpha5beta1-integrin recycling via recruiting RabGAP1L to early endosomes.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/27718357", "journal": "eLife", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033710.1", "id": "NP_001033710.1", "database": "RefSeq" } ], "authors": "Qu F, Lorenzo DN, King SJ, Brooks R, Bear JE, Bennett V", "date": "2016", "pmid": "27718357" }, { "title": "Large-scale phosphorylation analysis of mouse liver.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17242355", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033710.1", "id": "NP_001033710.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A6H6A9/publications", "id": "A6H6A9", "database": "UniProtKB" } ], "authors": "Villen J, Beausoleil SA, Gerber SA, Gygi SP", "date": "2007", "pmid": "17242355" }, { "title": "Tagging genes with cassette-exchange sites.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/15741177", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033710.1", "id": "NP_001033710.1", "database": "RefSeq" } ], "authors": "Cobellis G, Nicolaus G, Iovino M, Romito A, Marra E, Barbarisi M, Sardiello M, Di Giorgio FP, Iovino N, Zollo M, Ballabio A, Cortese R", "date": "2005", "pmid": "15741177" }, { "title": "Genomic analysis of mouse retinal development.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/15226823", "journal": "PLoS biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033710.1", "id": "NP_001033710.1", "database": "RefSeq" } ], "authors": "Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL", "date": "2004", "pmid": "15226823" }, { "title": "Gene trapping of two novel genes, Hzf and Hhl, expressed in hematopoietic cells.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/10585558", "journal": "Mechanisms of development", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033710.1", "id": "NP_001033710.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A6H6A9/publications", "id": "A6H6A9", "database": "UniProtKB" } ], "authors": "Hidaka M, Caruana G, Stanford WL, Sam M, Correll PH, Bernstein A", "date": "2000", "pmid": "10585558" }, { "title": "Exchangeable gene trap using the Cre/mutated lox system.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/10512203", "journal": "Cellular and molecular biology (Noisy-le-Grand, France)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033710.1", "id": "NP_001033710.1", "database": "RefSeq" } ], "authors": "Araki K, Imaizumi T, Sekimoto T, Yoshinobu K, Yoshimuta J, Akizuki M, Miura K, Araki M, Yamamura K", "date": "1999", "pmid": "10512203" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A6H6A9#A6H6A9-1", "isoform_ac": "A6H6A9-1", "locus": { "end_pos": 160257255, "start_pos": 160740889, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000028049", "id": "ENSMUST00000028049", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000028049", "id": "ENSMUSP00000028049", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A6H6A9-1|RBG1L_MOUSE Isoform 1 of Rab GTPase-activating protein 1-like OS=Mus musculus OX=10090 GN=Rabgap1l PE=1 SV=1 CANONICAL=A6H6A9-1", "length": 815, "sequence": "MEVRASFQKVSGSSDSVATLNSEEFVLVSQHTDATSIKDDGKPQLKIASNGDEQLEKAMEEILRDSEKGQSGLPVDCQGSSEISDCPFGDVPASQTTKPPLQLILDPSNTEISTPRPSSPSRFPEEDSVLFNKLTYLGCMKVSSPRSEVEALRAMATMRASSQYPFAVTLYVPNVPEGSVRIIDQSSNVEIASFPIYKVLFCARGHDGTAESNCFAFTESSHGSEEFQIHVFSCEIKEAVSRILYSFCTAFKRSSRQVSDVKDSVIPTPDSDVFTFSVSLEVKEDDGKGNFSPVPKDRDKFYFKIKQGIEKKVVITVQQLSNKELAIERCFGMLLSPGRNVKNSDMHLLDMESMGKSYDGRAYVITGMWNPNAPIFLALNEETPKDKRVYMTVAVDMVVTEVVEPVRFLLETVVRVYPANERFWYFSRKTFTETFFMRLKQSEGKGHSSAGDAIYEVVSLQRESDKEEPITPTSAGGPMSPQEDEAEEESDNELSSGTGDVSKDCPEKILYSWGELLGRWHNNLGGRPKGLFTLVKSGVPEALRAEVWQLLAGCHDNQEMLDKYRILITKDSAQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVFDEDIGYCQGQSFLAAVLLLHMPEEQAFCVLVTIMYGYKLRDLYRNNFEDLHCKFYQLEKLMQEQLPDLYSHFCDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQADFEGALKFFRVQLPKRYRAEENARRLMEQACNIKVPTKKLKKYEKEYQAMRENQLQQEDPMDRYKFVYL" } }, { "url": "https://www.uniprot.org/uniprot/A6H6A9#A0A0A6YX13-1", "isoform_ac": "A0A0A6YX13-1", "locus": { "end_pos": 160308995, "start_pos": 160309171, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000191941", "id": "ENSMUST00000191941", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000141790", "id": "ENSMUSP00000141790", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0A6YX13-1|RBG1L_MOUSE Computationally mapped isoform of Rab GTPase-activating protein 1-like OS=Mus musculus OX=10090 GN=Rabgap1l PE=1 SV=1 CANONICAL=A6H6A9-1", "length": 59, "sequence": "XCYSAIRVAALSHCRKGRGEAVALAFTSGEPRCEVNLQVCCPDENMTRSTLSLKILLKR" } }, { "url": "https://www.uniprot.org/uniprot/A6H6A9#A6H6A9-2", "isoform_ac": "A6H6A9-2", "locus": { "end_pos": 160672652, "start_pos": 160740889, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000195442", "id": "ENSMUST00000195442", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000141666", "id": "ENSMUSP00000141666", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A6H6A9-2|RBG1L_MOUSE Isoform 2 of Rab GTPase-activating protein 1-like OS=Mus musculus OX=10090 GN=Rabgap1l PE=1 SV=1 CANONICAL=A6H6A9-1", "length": 477, "sequence": "MEHTDATSIKDDGKPQLKIASNGDEQLEKAMEEILRDSEKGQSGLPVDCQGSSEISDCPFGDVPASQTTKPPLQLILDPSNTEISTPRPSSPSRFPEEDSVLFNKLTYLGCMKVSSPRSEVEALRAMATMRASSQYPFAVTLYVPNVPEGSVRIIDQSSNVEIASFPIYKVLFCARGHDGTAESNCFAFTESSHGSEEFQIHVFSCEIKEAVSRILYSFCTAFKRSSRQVSDVKDSVIPTPDSDVFTFSVSLEVKEDDGKGNFSPVPKDRDKFYFKIKQGIEKKVVITVQQLSNKELAIERCFGMLLSPGRNVKNSDMHLLDMESMGKSYDGRAYVITGMWNPNAPIFLALNEETPKDKRVYMTVAVDMVVTEVVEPVRFLLETVVRVYPANERFWYFSRKTFTETFFMRLKQSEGKGHSSAGDAIYEVVSLQRESDKEEPITPTSAGGPMSPQEDEAEEDPGHASPDTVGFLTLFL" } }, { "url": "https://www.uniprot.org/uniprot/A6H6A9#A0A0A6YW18-1", "isoform_ac": "A0A0A6YW18-1", "locus": { "end_pos": 160257255, "start_pos": 160441867, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000191651", "id": "ENSMUST00000191651", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000141357", "id": "ENSMUSP00000141357", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0A6YW18-1|RBG1L_MOUSE Computationally mapped isoform of Rab GTPase-activating protein 1-like OS=Mus musculus OX=10090 GN=Rabgap1l PE=1 SV=1 CANONICAL=A6H6A9-1", "length": 107, "sequence": "PLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQADFEGALKFFRVQLPKRYRAEENARRLMEQACNIKVPTKKLKKYEKEYQAMRENQLQQEDPMDRYKFVYL" } }, { "url": "https://www.uniprot.org/uniprot/A6H6A9#A6H6A9-3", "isoform_ac": "A6H6A9-3", "locus": { "end_pos": 160224219, "start_pos": 160351388, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000028052", "id": "ENSMUST00000028052", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000028052", "id": "ENSMUSP00000028052", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A6H6A9-3|RBG1L_MOUSE Isoform 3 of Rab GTPase-activating protein 1-like OS=Mus musculus OX=10090 GN=Rabgap1l PE=1 SV=1 CANONICAL=A6H6A9-1", "length": 370, "sequence": "MEEGVPCPAPAAKLTPPVKKSQDMHDERSKLVNEYACRVLELLGMGHRLFVPRLLATSKEDLLQADFEGALKFFRVQLPKRYRAEENARRLMEQACNIKVPTKKLKKYEKEYQAMRENQLQQEDPMDRYKRENRRLQEASMRLEQENDDLAHELVTSKIALRNDLDQAEDKADVLNKELLFTKQRLVETEEEKRKQEEETAQLKEVFRKQLEKAEYEIKKTTAIIAEYKQICSQLSTRLEKQQAASKEELEAVKGKMMACKHCSDIFSKEGALKPVAVNREDQGLEADDEKDSLKKQLREMELELAQTKLQLVEAKCKIQELEHQRGALMNEIQAAKNSWFSKTLNSIKTATGTQPLQPPQAPQPPKEST" } }, { "url": "https://www.uniprot.org/uniprot/A6H6A9#A0A0A6YWT4-1", "isoform_ac": "A0A0A6YWT4-1", "locus": { "end_pos": 160226558, "start_pos": 160251443, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000191909", "id": "ENSMUST00000191909", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000141688", "id": "ENSMUSP00000141688", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0A6YWT4-1|RBG1L_MOUSE Computationally mapped isoform of Rab GTPase-activating protein 1-like OS=Mus musculus OX=10090 GN=Rabgap1l PE=1 SV=1 CANONICAL=A6H6A9-1", "length": 230, "sequence": "XVTERTSLSDILDKQRSINKCLFLLLLFPKCISRCEISLDIPFLFFSIVFVPMVENSSWSLTFEERENRRLQEASMRLEQENDDLAHELVTSKIALRNDLDQAEDKADVLNKELLFTKQRLVETEEEKRKQEEETAQLKEVFRKQLEKAEYEIKKTTAIIAEYKQICSQLSTRLEKQQAASKEELEAVKGKMMACKHCSDIFSKEGALKPVAVNREDQGLEADDEKDSLK" } }, { "url": "https://www.uniprot.org/uniprot/A6H6A9#A6H6A9-4", "isoform_ac": "A6H6A9-4", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A6H6A9-4|RBG1L_MOUSE Isoform 4 of Rab GTPase-activating protein 1-like OS=Mus musculus OX=10090 GN=Rabgap1l PE=1 SV=1 CANONICAL=A6H6A9-1", "length": 72, "sequence": "MMEEISIMVAYDAHVFSQLHDEDFLTSLVATSKPRSMVPTKKLKKYEKEYQAMRENQLQQEDPMDRYKFVYL" } }, { "url": "https://www.uniprot.org/uniprot/A6H6A9#A0A0A6YWY0-1", "isoform_ac": "A0A0A6YWY0-1", "locus": { "end_pos": 160735649, "start_pos": 160740889, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000193810", "id": "ENSMUST00000193810", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000141749", "id": "ENSMUSP00000141749", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0A6YWY0-1|RBG1L_MOUSE Computationally mapped isoform of Rab GTPase-activating protein 1-like OS=Mus musculus OX=10090 GN=Rabgap1l PE=1 SV=1 CANONICAL=A6H6A9-1", "length": 147, "sequence": "MEVRASFQKVSGSSDSVATLNSEEFVLVSQHTDATSIKDDGKPQLKIASNGDEQLEKAMEEILRDSEKGQSGLPVDCQGSSEISDCPFGDVPASQTTKPPLQLILDPSNTEISTPRPSSPSRFPEEDSVLFNKLTYLGCMKVSSPRS" } }, { "url": "https://www.uniprot.org/uniprot/A6H6A9#A0A0A6YY35-1", "isoform_ac": "A0A0A6YY35-1", "locus": { "end_pos": 160226610, "start_pos": 160307339, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000193185", "id": "ENSMUST00000193185", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000142258", "id": "ENSMUSP00000142258", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0A6YY35-1|RBG1L_MOUSE Computationally mapped isoform of Rab GTPase-activating protein 1-like OS=Mus musculus OX=10090 GN=Rabgap1l PE=1 SV=1 CANONICAL=A6H6A9-1", "length": 234, "sequence": "XWSGAGAAAAAVKKPTGKMMEEISIMVAYDAHVFSQLHDEDFLTSLVATSKPRSMVPTKKLKKYEKEYQAMRENQLQQEDPMDRYKRENRRLQEASMRLEQENDDLAHELVTSKIALRNDLDQAEDKADVLNKELLFTKQRLVETEEEKRKQEEETAQLKEVFRKQLEKAEYEIKKTTAIIAEYKQICSQLSTRLEKQQAASKEELEAVKGKMMACKHCSDIFSKEGALKPVAV" } }, { "url": "https://www.uniprot.org/uniprot/A6H6A9#A0A3Q4L343-1", "isoform_ac": "A0A3Q4L343-1", "locus": { "end_pos": 160236678, "start_pos": 160441904, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000235109", "id": "ENSMUST00000235109", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000157276", "id": "ENSMUSP00000157276", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A3Q4L343-1|RBG1L_MOUSE Computationally mapped isoform of Rab GTPase-activating protein 1-like OS=Mus musculus OX=10090 GN=Rabgap1l PE=1 SV=1 CANONICAL=A6H6A9-1", "length": 198, "sequence": "XSQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQADFEGALKFFRVQLPKRYRAEENARRLMEQACNIKVPTKKLKKYEKEYQAMRENQLQQEDPMDRYKRENRRLQEASMRLEQENDDLAHELVTSKIALRNDLDQAEDKADVLNKELLFTKQRLVETEEEKRKQEEETAQLKEVFRKQLE" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:29809", "resource": "KEGG Pathway", "id": "mmu:29809", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A6H6A9#function", "annotation": "GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (By similarity). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (PubMed:27718357).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6A9#function", "id": "A6H6A9", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033710.1", "annotation": "We demonstrate that AnkB binds to Rab GTPase Activating Protein 1-Like (RabGAP1L) and recruits it to PI3P-positive organelles, where RabGAP1L inactivates Rab22A, and promotes polarized trafficking to the leading edge of migrating fibroblasts. We further determine that a5b1-integrin depends on an AnkB/RabGAP1L complex for polarized recycling Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033710.1", "id": "NP_001033710.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q5R372-1", "protein_name": "Rab GTPase-activating protein 1-like.", "sequence": { "length": 815, "sequence": "MEVRASLQKVSGSSDSVATMNSEEFVLVPQYADDNSTKHEEKPQLKIVSNGDEQLEKAMEEILRDSEKRPSSLLVDCQSSSEISDHSFGDIPASQTNKPSLQLILDPSNTEISTPRPSSPGGLPEEDSVLFNKLTYLGCMKVSSPRNEVEALRAMATMKSSSQYPFPVTLYVPNVPEGSVRIIDQSSNVEIASFPIYKVLFCARGHDGTTESNCFAFTESSHGSEEFQIHVFSCEIKEAVSRILYSFCTAFKRSSRQVSDVKDSVIPTPDSDVFTFSVSLEVKEDDGKGNFSPVPKDRDKFYFKLKQGIEKKVVITVQQLSNKELAIERCFGMLLSPGRNVKNSDMHLLDMESMGKSYDGRAYVITGMWNPNAPVFLALNEETPKDKQVYMTVAVDMVVTEVVEPVRFLLETVVRVYPANERFWYFSRKTFTETFFMRLKQSEGKGHTNAGDAIYEVVSLQRESDKEEPVTPTSGGGPMSPQDDEAEEESDNELSSGTGDVSKDCPEKILYSWGELLGKWHSNLGARPKGLSTLVKSGVPEALRAEVWQLLAGCHDNQAMLDRYRILITKDSAQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQAFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQADFEGALKFFRVQLPKRYRAEENARRLMEQACNIKVPTKKLKKYEKEYQTMRESQLQQEDPMDRYKFVYL" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A6H6A9/", "id": "A6H6A9", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/8143", "id": "8143", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "D3ZKH6-1", "protein_name": "RCG46052; RAB GTPase-activating protein 1-like.", "sequence": { "length": 815, "sequence": "MEVRASLQKVSGSPDSAATLNSEEFVLVPQHTDDTSIKDDGKPQLKIASNGDEQLEKAMEEILRDSEKGQSSLPVDGQGSSEISDHSFGDVPASQSNKPPLQLILDPSNTEISTPRPSSPSGFPEEDSVLFNKLTYLGCMKVSSPRSEGEALRAMATMRASSQYPFAVTLYVPNVPEGSVRIIDQSSNVEIASFPIYKVLFCARGHDGTTESNCFAFTESSHGSEEFQIHVFSCEIKEAVSRILYSFCTAFKRSSRQVSDVKDSIIPTPDSDVFTFSVSLEVKEDDGKGNFSPVPKDRDKFYFKIKQGIEKKVVITVQQLSNKELAIERCFGMLLSPGRNVKNSDMHLLDMESMGKSYDGRAYVITGMWNPNAPIFLALNEETPKDKRVYMTVAVDMVVTEVVEPVRFLLETVVRVYPANERFWYFSRKTFTETFFMRLKQSEGKGHSSAGDAIYEVVSLQRESDKEEPVTPTSGGGPASPQEDEAEEESDNELSSGTGDVSKDCPEKILYSWGELLGRWHNNLNARPKGLPTLVKSGVPEALRAEVWQLLAGCHDNQAMLDKYRILITKDSAQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQAFCVLVNIMYKYKLRDLYKNNFEDLHCKFYQLEKLMQEQLPDLYSHFCDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQADFEGALKFFRVQLPKRYRAEENARRLMEQACNIKVPTKKLKKYEKEYQAMRENQLQQEDPMDRYKFVYL" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A6H6A9/", "id": "A6H6A9", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/8143", "id": "8143", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033710.1", "ac": "NP_001033710.1", "name": "rab GTPase-activating protein 1-like isoform b; rab6 GTPase activating protein-like; rabgap1l; rab GTPase-activating protein 1-like.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6A9", "id": "A6H6A9", "database": "UniProtKB" } ], "name": "GTPase activator activity", "id": "GO:0005096" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017137", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6A9", "id": "A6H6A9", "database": "UniProtKB" } ], "name": "Rab GTPase binding", "id": "GO:0017137" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6A9", "id": "A6H6A9", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6A9", "id": "A6H6A9", "database": "UniProtKB" } ], "name": "early endosome", "id": "GO:0005769" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6A9", "id": "A6H6A9", "database": "UniProtKB" } ], "name": "Golgi apparatus", "id": "GO:0005794" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6A9", "id": "A6H6A9", "database": "UniProtKB" } ], "name": "cilium", "id": "GO:0005929" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6A9", "id": "A6H6A9", "database": "UniProtKB" } ], "name": "intracellular protein transport", "id": "GO:0006886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032880", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6A9", "id": "A6H6A9", "database": "UniProtKB" } ], "name": "regulation of protein localization", "id": "GO:0032880" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035855", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6A9", "id": "A6H6A9", "database": "UniProtKB" } ], "name": "megakaryocyte development", "id": "GO:0035855" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090630", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6A9", "id": "A6H6A9", "database": "UniProtKB" } ], "name": "activation of GTPase activity", "id": "GO:0090630" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6A9", "id": "A6H6A9", "database": "UniProtKB" } ], "name": "endocytosis", "id": "GO:0006897" } ], "total": 5, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 292, "annotation": "n_glycosylation_sequon", "start_pos": 290 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033710.1", "id": "NP_001033710.1", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:29809", "id": "mmu:29809", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000026721", "id": "ENSMUSG00000026721", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/KVLFCVR/", "id": "KVLFCVR", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "id": "IPR011993", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR006020", "id": "IPR006020", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035969", "id": "IPR035969", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000195", "id": "IPR000195", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR022164", "id": "IPR022164", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00566", "id": "PF00566", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF12473", "id": "PF12473", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A6H6A9", "id": "PR_A6H6A9", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/29809", "id": "29809", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:1352507", "id": "1352507", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A6H6A9", "disease": [], "mass": { "monoisotopic_mass": 92404.0, "chemical_mass": 92404.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A6H6A9", "name": "Rabgap1l; Hhl; Kiaa0471; 5830411O09Rik; 8430421H08Rik; 9630005B12Rik; AW049894; Hh1; HHL; mKIAA0471.", "locus": { "end_pos": 160219174, "start_pos": 160793211, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000026721", "id": "ENSMUSG00000026721", "database": "Ensembl Gene" } ] } } ] }