{
    "uniprot_canonical_ac": "A6H639-1", 
    "sequence": {
        "header": "sp|A6H639-1|DRC5_MOUSE Isoform 1 of Dynein regulatory complex subunit 5  OS=Mus musculus OX=10090 GN=Tcte1 PE=1 SV=1 CANONICAL=A6H639-1", 
        "length": 498, 
        "sequence": "MQETPSVPSNSSSHSQSVLTIQRQVSALGSSSTGPTSLKTSSTPTPGQLKTKVPNVRRMRRIISEDAEWSLAIVPLLTELCIQHIVKNFQNNPILKQLPLEHQKKVLSNLPPELPLTVTANLIDDENYWHRCCIKRWSVCHVSRHGGSWKRMFFERHLENLLKLFIPGTTDPNVILDLLPLCRNYVRRIHVDQFLPPVRMPTPLQGEEQSDSGSEGEGSEPEKDHYQLQTLVGGLKHLEELDLVYGVKDCGMNFEWNLFLFTYRDCYSLAATIKACHTLKIFKLTRSKVDDDKARILIRSLLDHPALEELDLSHNLIGDRGARAAAKLLSHSRLRVLNLANNQLQAPGAQSLAHALAHNTNLVFLNLRLNCIEDEGGQAIAHALETNKCLSVLHLGGNKLSEPTATLLSQMLTVNTTLVSLNLSCNHIGQDGGKQLLEGISDNKTILEFDLRLSDVSQESEYLIGQVLHANREAARQRTLNPGHFSSPTNNCTENSVV"
    }, 
    "uniprot_id": "DRC5_MOUSE", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [
                "dynein regulatory complex subunit 5", 
                "T-complex-associated testis-expressed protein 1"
            ], 
            "uniprotkb": [
                "Dynein regulatory complex subunit 5", 
                "T-complex-associated testis-expressed protein 1", 
                "Tcte-1"
            ]
        }, 
        "gene": {
            "refseq": [
                "Tcte1", 
                "D17Sil1", 
                "Tcte-1"
            ], 
            "uniprotkb": [
                "Tcte1", 
                "D17sil1", 
                "Drc5", 
                "D17Sil1", 
                "Tcte-1"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A6H639", 
                    "id": "A6H639", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "recommendedname": {
        "full": "Dynein regulatory complex subunit 5; T-complex-associated testis-expressed protein 1; Tcte-1."
    }, 
    "publication": [
        {
            "title": "TCTE1 is a conserved component of the dynein regulatory complex and is required for motility and metabolism in mouse spermatozoa.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/28630322", 
            "journal": "Proceedings of the National Academy of Sciences of the United States of America", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038716.2", 
                    "id": "NP_038716.2", 
                    "database": "RefSeq"
                }, 
                {
                    "url": "https://www.uniprot.org/uniprot/A6H639/publications", 
                    "id": "A6H639", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Castaneda JM, Hua R, Miyata H, Oji A, Guo Y, Cheng Y, Zhou T, Guo X, Cui Y, Shen B, Wang Z, Hu Z, Zhou Z, Sha J, Prunskaite-Hyyrylainen R, Yu Z, Ramirez-Solis R, Ikawa M, Matzuk MM, Liu M", 
            "date": "2017", 
            "pmid": "28630322"
        }, 
        {
            "title": "Identification of quantitative trait loci controlling activation of TRBV4 CD8+ T cells during murine gamma-herpesvirus-induced infectious mononucleosis.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/11486276", 
            "journal": "Immunogenetics", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038716.2", 
                    "id": "NP_038716.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Hardy CL, Lu L, Nguyen P, Woodland DL, Williams RW, Blackman MA", 
            "date": "2001", 
            "pmid": "11486276"
        }, 
        {
            "title": "Differences in intracisternal A-particle and GLN proviral loci suggest a genetic contribution from a DBA/2-like strain in generation of the C57BL/Ks strain.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/7766998", 
            "journal": "Mammalian genome : official journal of the International Mammalian Genome Society", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038716.2", 
                    "id": "NP_038716.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Lueders KK", 
            "date": "1995", 
            "pmid": "7766998"
        }, 
        {
            "title": "High-resolution comparative mapping of mouse chromosome 17.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/8406442", 
            "journal": "Genomics", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038716.2", 
                    "id": "NP_038716.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Himmelbauer H, Silver LM", 
            "date": "1993", 
            "pmid": "8406442"
        }, 
        {
            "title": "A mouse chromosome 17 gene encodes a testes-specific transcript with unusual properties.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/2568335", 
            "journal": "Immunogenetics", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038716.2", 
                    "id": "NP_038716.2", 
                    "database": "RefSeq"
                }, 
                {
                    "url": "https://www.uniprot.org/uniprot/A6H639/publications", 
                    "id": "A6H639", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Sarvetnick N, Tsai JY, Fox H, Pilder SH, Silver LM", 
            "date": "1989", 
            "pmid": "2568335"
        }, 
        {
            "title": "Identification of a testis-specific gene from the mouse t-complex next to a CpG-rich island.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/3653077", 
            "journal": "The EMBO journal", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038716.2", 
                    "id": "NP_038716.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Rappold GA, Stubbs L, Labeit S, Crkvenjakov RB, Lehrach H", 
            "date": "1987", 
            "pmid": "3653077"
        }
    ], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A6H639#A6H639-1", 
            "isoform_ac": "A6H639-1", 
            "locus": {
                "end_pos": 45533100, 
                "start_pos": 45541336, 
                "chromosome": "17", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000233588", 
                        "id": "ENSMUST00000233588", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000156920", 
                        "id": "ENSMUSP00000156920", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A6H639-1|DRC5_MOUSE Isoform 1 of Dynein regulatory complex subunit 5  OS=Mus musculus OX=10090 GN=Tcte1 PE=1 SV=1 CANONICAL=A6H639-1", 
                "length": 498, 
                "sequence": "MQETPSVPSNSSSHSQSVLTIQRQVSALGSSSTGPTSLKTSSTPTPGQLKTKVPNVRRMRRIISEDAEWSLAIVPLLTELCIQHIVKNFQNNPILKQLPLEHQKKVLSNLPPELPLTVTANLIDDENYWHRCCIKRWSVCHVSRHGGSWKRMFFERHLENLLKLFIPGTTDPNVILDLLPLCRNYVRRIHVDQFLPPVRMPTPLQGEEQSDSGSEGEGSEPEKDHYQLQTLVGGLKHLEELDLVYGVKDCGMNFEWNLFLFTYRDCYSLAATIKACHTLKIFKLTRSKVDDDKARILIRSLLDHPALEELDLSHNLIGDRGARAAAKLLSHSRLRVLNLANNQLQAPGAQSLAHALAHNTNLVFLNLRLNCIEDEGGQAIAHALETNKCLSVLHLGGNKLSEPTATLLSQMLTVNTTLVSLNLSCNHIGQDGGKQLLEGISDNKTILEFDLRLSDVSQESEYLIGQVLHANREAARQRTLNPGHFSSPTNNCTENSVV"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:21645", 
            "resource": "KEGG Pathway", 
            "id": "mmu:21645", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A6H639#function", 
            "annotation": "Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. May play a role in the assembly of N-DRC (By similarity). Required for sperm motility (PubMed:28630322).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A6H639#function", 
                    "id": "A6H639", 
                    "database": "UniProtKB"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038716.2", 
            "annotation": "Mouse TCTE1 is testis-enriched in its expression, with its mRNA appearing in early round spermatids and protein localized to the flagellum", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038716.2", 
                    "id": "NP_038716.2", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "D3ZQW5-1", 
            "protein_name": "T-complex-associated testis expressed 1 (Predicted); T-complex-associated testis-expressed 1.", 
            "sequence": {
                "length": 498, 
                "sequence": "MQETSTTASDPSSRSQSAFNIQRQVSTLGSTSPGPVSLKTSTSPAPSQLKTKTTNVRRMRRIISEDPEWSLAIVPLLTELCIQHIVKNFQNNPILKQLLPEHQKKVLSSLPPELPLSVTANLIEDENYWHRCCIKRWSVCHVSKHGDSWKRMFFERHLENLLKLFIPGTTDPNVILDLVPLCRNYVRRIHVDQFLPPVRMPTPPQGEEQSDSGSEGEGNEPEKNHYQLQALVGGLKYLEELDLVYGVKDCGMNFEWNLFLFTYRDCHSLAATIKACHTLKIFRLTRSKVDDDKARILIRSLLDHPALEELDLSHNLIGDRGARAAAKLLSHSRLRVLNLANNQLRASGAQSLAHALAHNTNLVSLNLRLNCIEDEGGQAIAHALETNKCLTVLNLGGNELSEPTATLLSQVLPVNTTLISLNLSCNHIGQDGGKQLLEGMSDNKTILEFDLRLSDVAQESEYLIGQVLHNNREAARQRTLSPGHLTLPTNNYSENSVG"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/8434", 
                    "id": "8434", 
                    "database": "MGI"
                }
            ], 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "Q5JU00-1", 
            "protein_name": "Dynein regulatory complex subunit 5; T-complex-associated testis-expressed protein 1; Tcte-1.", 
            "sequence": {
                "length": 501, 
                "sequence": "MQDTVTTSALLDPSHSSVSTQDNSSTGGHTSSTSPQLSKPSITPVPAKSRNPHPRANIRRMRRIIAEDPEWSLAIVPLLTELCIQHIIRNFQKNPILKQMLPEHQQKVLNHLSPDLPLAVTANLIDSENYWLRCCMHRWPVCHVAHHGGSWKRMFFERHLENLLKHFIPGTTDPAVILDLLPLCRNYVRRVHVDQFLPPVQLPAQLRPGDQSDSGSEGEMEEPTVDHYQLGDLVAGLSHLEELDLVYDVKDCGMNFEWNLFLFTYRDCLSLAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLSHSRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQALYANREAARQRALNPSHFMSTITANGPENSVG"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/8434", 
                    "id": "8434", 
                    "database": "MGI"
                }
            ], 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038716.2", 
        "ac": "NP_038716.2", 
        "name": "dynein regulatory complex subunit 5; T-complex-associated testis-expressed protein 1.", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6H639", 
                                "id": "A6H639", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "sperm flagellum", 
                        "id": "GO:0036126"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6H639", 
                                "id": "A6H639", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytoplasm", 
                        "id": "GO:0005737"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6H639", 
                                "id": "A6H639", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytoskeleton", 
                        "id": "GO:0005856"
                    }
                ], 
                "total": 3, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6H639", 
                                "id": "A6H639", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "flagellated sperm motility", 
                        "id": "GO:0030317"
                    }
                ], 
                "total": 1, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 12, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 10
        }, 
        {
            "end_pos": 417, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 415
        }, 
        {
            "end_pos": 424, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 422
        }, 
        {
            "end_pos": 445, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 443
        }, 
        {
            "end_pos": 493, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 491
        }
    ], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038716.2", 
            "id": "NP_038716.2", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:21645", 
            "id": "mmu:21645", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000023949", 
            "id": "ENSMUSG00000023949", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/LFMMLIC/", 
            "id": "LFMMLIC", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", 
            "id": "IPR001611", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", 
            "id": "IPR032675", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF13516", 
            "id": "PF13516", 
            "database": "Pfam"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A6H639", 
            "id": "PR_A6H639", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/21645", 
            "id": "21645", 
            "database": "GeneID"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:98640", 
            "id": "98640", 
            "database": "MGI"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A6H639", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 55518.0, 
        "chemical_mass": 55518.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A6H639", 
            "name": "Tcte1; D17sil1; Drc5; D17Sil1; Tcte-1.", 
            "locus": {
                "end_pos": 45542680, 
                "start_pos": 45523434, 
                "chromosome": "17", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000023949", 
                        "id": "ENSMUSG00000023949", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}