{ "uniprot_canonical_ac": "A6H630-1", "sequence": { "header": "sp|A6H630-1|ARMT1_MOUSE Isoform 1 of Damage-control phosphatase ARMT1 OS=Mus musculus OX=10090 GN=Armt1 PE=1 SV=1 CANONICAL=A6H630-1", "length": 439, "sequence": "MAESPAFLSAKDEGSFAYLTIKDRTPQILTKVIDTLHRHKSEFFEKHGEEGIEAEKKAISLLSKLRNELQTDKPITPLVDKCVDTHIWNQYLEYQRSLLNEGDGEPRWFFSPWLFVECYMYRRIHEAIMQSPPIHDFDVFKESKEENFFESQGSIDALCSHLLQLKPVKGLREEQIQDEFFKLLQISLWGNKCDLSLSGGESSSQKANIINCLQDLKPFILINDTESLWALLSKLKKTVETPVVRVDIVLDNSGFELITDLVLADFLFSSELATEIHFHGKSIPWFVSDVTEHDFNWIVEHMKSSNLESMSTCGACWEAYARMGRWAYHDHAFWTLPHPYCVMPQVAPDLYAELQKAHLILFKGDLNYRKLMGDRKWKFTFPFHQALSGFHPAPLCSIRTLKCELQVGLQPGQAEQLTASDPHWLTTGRYGILQFDGPL" }, "uniprot_id": "ARMT1_MOUSE", "enzyme_annotation": [ { "ec": "3.1.3.-", "activity": "" }, { "ec": "2.1.1.-", "activity": "" } ], "synonyms": { "protein": { "refseq": [ "damage-control phosphatase ARMT1", "UPF0364 protein C6orf211 homolog; protein-glutamate O-methyltransferase; sugar phosphate phosphatase ARMT1" ], "uniprotkb": [ "Damage-control phosphatase ARMT1", "3.1.3.-", "Acidic residue methyltransferase 1", "Protein-glutamate O-methyltransferase", "2.1.1.-", "Sugar phosphate phosphatase ARMT1" ] }, "gene": { "refseq": [ "Armt1", "1700052N19Rik", "AW320013", "AW536799" ], "uniprotkb": [ "Armt1", "1700052N19Rik", "AW320013", "AW536799" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H630", "id": "A6H630", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Damage-control phosphatase ARMT1; 3.1.3.-; Acidic residue methyltransferase 1; Protein-glutamate O-methyltransferase; 2.1.1.-; Sugar phosphate phosphatase ARMT1." }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A6H630#A6H630-1", "isoform_ac": "A6H630-1", "locus": { "end_pos": 4432671, "start_pos": 4454233, "chromosome": "10", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000095893", "id": "ENSMUST00000095893", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000093581", "id": "ENSMUSP00000093581", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A6H630-1|ARMT1_MOUSE Isoform 1 of Damage-control phosphatase ARMT1 OS=Mus musculus OX=10090 GN=Armt1 PE=1 SV=1 CANONICAL=A6H630-1", "length": 439, "sequence": "MAESPAFLSAKDEGSFAYLTIKDRTPQILTKVIDTLHRHKSEFFEKHGEEGIEAEKKAISLLSKLRNELQTDKPITPLVDKCVDTHIWNQYLEYQRSLLNEGDGEPRWFFSPWLFVECYMYRRIHEAIMQSPPIHDFDVFKESKEENFFESQGSIDALCSHLLQLKPVKGLREEQIQDEFFKLLQISLWGNKCDLSLSGGESSSQKANIINCLQDLKPFILINDTESLWALLSKLKKTVETPVVRVDIVLDNSGFELITDLVLADFLFSSELATEIHFHGKSIPWFVSDVTEHDFNWIVEHMKSSNLESMSTCGACWEAYARMGRWAYHDHAFWTLPHPYCVMPQVAPDLYAELQKAHLILFKGDLNYRKLMGDRKWKFTFPFHQALSGFHPAPLCSIRTLKCELQVGLQPGQAEQLTASDPHWLTTGRYGILQFDGPL" } }, { "url": "https://www.uniprot.org/uniprot/A6H630#D6RG65-1", "isoform_ac": "D6RG65-1", "locus": { "end_pos": 4432671, "start_pos": 4450658, "chromosome": "10", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000152294", "id": "ENSMUST00000152294", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000115624", "id": "ENSMUSP00000115624", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D6RG65-1|ARMT1_MOUSE Computationally mapped isoform of Damage-control phosphatase ARMT1 OS=Mus musculus OX=10090 GN=Armt1 PE=1 SV=1 CANONICAL=A6H630-1", "length": 53, "sequence": "MAESPAFLSAKDEGSFAYLTIKDRTPQILTKVIDTLHRHKSEFFEKHGESANP" } }, { "url": "https://www.uniprot.org/uniprot/A6H630#A6H630-2", "isoform_ac": "A6H630-2", "locus": { "end_pos": 4432671, "start_pos": 4450878, "chromosome": "10", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000118544", "id": "ENSMUST00000118544", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000114073", "id": "ENSMUSP00000114073", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A6H630-2|ARMT1_MOUSE Isoform 2 of Damage-control phosphatase ARMT1 OS=Mus musculus OX=10090 GN=Armt1 PE=1 SV=1 CANONICAL=A6H630-1", "length": 208, "sequence": "MAESPAFLSAKDEGSFAYLTIKDRTPQILTKVIDTLHRHKSEFFEKHGEEGIEAEKKAISLLSKLRNELQTDKPITPLVDKCVDTHIWNQYLEYQRSLLNEGDGEPRWFFSPWLFVECYMYRRIHEAIMQSPPIHDFDVFKESKEENFFESQGSIDALCSHLLQLKPVKGLREEQIQDEFFKLLQVYKEYSTQDPMQPRRVMQTVTLQ" } }, { "url": "https://www.uniprot.org/uniprot/A6H630#A6H630-3", "isoform_ac": "A6H630-3", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A6H630-3|ARMT1_MOUSE Isoform 3 of Damage-control phosphatase ARMT1 OS=Mus musculus OX=10090 GN=Armt1 PE=1 SV=1 CANONICAL=A6H630-1", "length": 121, "sequence": "MLWSFAYLTIKDRTPQILTKVIDTLHRHKSEFFEKHGEEGIEAEKKAISLLSKLRNELQTDKPITPLVDKCVDTHIWNQYLEYQRSLLNEGDGEPRWFFSPWLFVECYMYRRIHEAIMQRF" } }, { "url": "https://www.uniprot.org/uniprot/A6H630#A6H630-4", "isoform_ac": "A6H630-4", "locus": { "end_pos": 4432671, "start_pos": 4439752, "chromosome": "10", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000117489", "id": "ENSMUST00000117489", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000114025", "id": "ENSMUSP00000114025", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A6H630-4|ARMT1_MOUSE Isoform 4 of Damage-control phosphatase ARMT1 OS=Mus musculus OX=10090 GN=Armt1 PE=1 SV=1 CANONICAL=A6H630-1", "length": 136, "sequence": "MAESPAFLSAKDEGSFAYLTIKDRTPQILTKVIDTLHRHKSEFFEKHGEEGIEAEKKAISLLSKLRNELQTDKPITPLVDKCVDTHIWNQYLEYQRSLLNEGDGEPRWFFSPWLFVECYMYRRIHEAIMQRQVYSQ" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:73419", "resource": "KEGG Pathway", "id": "mmu:73419", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A6H630#function", "annotation": "Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate (By similarity). Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism (By similarity). Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues (By similarity). Possibly methylates PCNA, suggesting it is involved in the DNA damage response (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H630#function", "id": "A6H630", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q6AYT5-1", "protein_name": "Damage-control phosphatase ARMT1; 3.1.3.-; Protein-glutamate O-methyltransferase; 2.1.1.-; Sugar phosphate phosphatase ARMT1; Acidic residue methyltransferase 1.", "sequence": { "length": 439, "sequence": "MAESPAFLSAQDVGSFAYLTIKDRTPQILTKVIDTLHRHKSEFFEKHGEEGVEAEKKAISLLSKLRNELQTDKPIIPLVDKCVDTDIWNQYLEYQRSLLNEGDGEPRWFFSPWLFVECYMYRRIHEAIMQSPPIHDFDVFKESKDENFFESQDSINALCTHLLQLKPITDLGEKQIQDEFFKLLQISLWGNKCDLSLSGGESSSQKADIINSLKDLKPFILVNETESLWALLSKLKKTAEPPAVRVDIVLDNSGFELVTDLVFADFLLSSELATEIHFHGKIIPWFVSDVTVRDFEWIVEHMKGSHLESMSACGAAWEAYVGMKKWVYHDHAFWTLPHPFCAMPQVAPDLYAELQKAGVVLFKGDLNYRKLMGDRKWKFTVPFHQALSGFHPAPLCSIRTLKCELQVGLQPGQAEHLTASDPHWLTTGKYGIFQFDGPL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/41557", "id": "41557", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q9H993-1", "protein_name": "Damage-control phosphatase ARMT1; 3.1.3.-; Acidic residue methyltransferase 1; Protein-glutamate O-methyltransferase; 2.1.1.-; Sugar phosphate phosphatase ARMT1.", "sequence": { "length": 441, "sequence": "MAVVPASLSGQDVGSFAYLTIKDRIPQILTKVIDTLHRHKSEFFEKHGEEGVEAEKKAISLLSKLRNELQTDKPFIPLVEKFVDTDIWNQYLEYQQSLLNESDGKSRWFYSPWLLVECYMYRRIHEAIIQSPPIDYFDVFKESKEQNFYGSQESIIALCTHLQQLIRTIEDLDENQLKDEFFKLLQISLWGNKCDLSLSGGESSSQNTNVLNSLEDLKPFILLNDMEHLWSLLSNCKKTREKASATRVYIVLDNSGFELVTDLILADFLLSSELATEVHFYGKTIPWFVSDTTIHDFNWLIEQVKHSNHKWMSKCGADWEEYIKMGKWVYHNHIFWTLPHEYCAMPQVAPDLYAELQKAHLILFKGDLNYRKLTGDRKWEFSVPFHQALNGFHPAPLCTIRTLKAEIQVGLQPGQGEQLLASEPSWWTTGKYGIFQYDGPL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/41557", "id": "41557", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077223.2", "ac": "NP_077223.2", "name": "damage-control phosphatase ARMT1; UPF0364 protein C6orf211 homolog; protein-glutamate O-methyltransferase; sugar phosphate phosphatase ARMT1.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016791", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H630", "id": "A6H630", "database": "UniProtKB" } ], "name": "phosphatase activity", "id": "GO:0016791" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H630", "id": "A6H630", "database": "UniProtKB" } ], "name": "enzyme binding", "id": "GO:0019899" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H630", "id": "A6H630", "database": "UniProtKB" } ], "name": "metal ion binding", "id": "GO:0046872" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008757", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H630", "id": "A6H630", "database": "UniProtKB" } ], "name": "S-adenosylmethionine-dependent methyltransferase activity", "id": "GO:0008757" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051998", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H630", "id": "A6H630", "database": "UniProtKB" } ], "name": "protein carboxyl O-methyltransferase activity", "id": "GO:0051998" } ], "total": 5, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H630", "id": "A6H630", "database": "UniProtKB" } ], "name": "cellular response to DNA damage stimulus", "id": "GO:0006974" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001020", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H630", "id": "A6H630", "database": "UniProtKB" } ], "name": "regulation of response to DNA damage stimulus", "id": "GO:2001020" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H630", "id": "A6H630", "database": "UniProtKB" } ], "name": "methylation", "id": "GO:0032259" } ], "total": 3, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 225, "annotation": "n_glycosylation_sequon", "start_pos": 223 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077223.2", "id": "NP_077223.2", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:73419", "id": "mmu:73419", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000061759", "id": "ENSMUSG00000061759", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/GFRPTNI/", "id": "GFRPTNI", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002791", "id": "IPR002791", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036075", "id": "IPR036075", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR039763", "id": "IPR039763", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF01937", "id": "PF01937", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12260", "id": "PTHR12260", "database": "PANTHER" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A6H630", "id": "PR_A6H630", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/73419", "id": "73419", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:1920669", "id": "1920669", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A6H630", "disease": [], "mass": { "monoisotopic_mass": 50549.0, "chemical_mass": 50549.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A6H630", "name": "Armt1; 1700052N19Rik; AW320013; AW536799.", "locus": { "end_pos": 4455141, "start_pos": 4432467, "chromosome": "10", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000061759", "id": "ENSMUSG00000061759", "database": "Ensembl Gene" } ] } } ] }