{ "uniprot_canonical_ac": "A6H5Y1-1", "sequence": { "header": "sp|A6H5Y1-1|MPP9_MOUSE Isoform 1 of M-phase phosphoprotein 9 OS=Mus musculus OX=10090 GN=Mphosph9 PE=2 SV=1 CANONICAL=A6H5Y1-1", "length": 991, "sequence": "MGFFSENSERNESVVSSPASKEPETQPASSTSYPDCHVDSSSVSSGYGTFCILDMNTHKAKEPTEPLEPGAASQGQHPASVVQAHGPAGGAAAINFFTQTPEELCASLKEDGSTFPGEFDRNFLGENKISEVYSGKANSGKSVTSWAQRLKQNQSKQAHTEDDCSGPKPGSELNWKPPADTFDLAADAARPCAFYINKPAESPSSWLSDSGTGLTYWKLEEKDMYHSLPETLEKTFAPSPAERPLSQVLTLDPGAIRMKPKEHVAGIQAHGFLHALDDRISFSPDSVLEPSLSRHSDTDSSSQASHNPSQVSGFSKYPSTTRASPVDTWKNHAFQRESRTSSTIPSRYTITSNDISVKTVDEENTVTVASVSQSQLPGTANSVPECISLASLEDPVMLSKIRQNLKEKHARHVADLRAYYESEISSLKQKLEAKDISAVEEWKKKNEILADRCGQLDSALNEATSRVRTLEKNNNLLEIEVSDLRERFNAASSASKVLQERIEEMRTSNKEKDNTITRLKCRLQDLEEAFENAYKLSDDKEARLRQENKMFQDLLGEYESLGKEHGRVKDTLNTTENKLLDAHTQISDLKRTISKLEAQVKQAEHESMLSLRNGAKVPERPSRSNSVATSDVSRRKWLIPGAEYSIFTGQPLDPRDRKLDKQLEEALVPGYHSPPEKDSSLGSSPASLLVKKKRDTPDTPPIIKALKELDEERVFKSWGTQTEKEDSSSKLVNSRQTEPSVNTGRSPEKCAQQRPKRQTSASQRSSSLPPSSRKANTPTKREIMLTPVTVAYSPKRSPKENLSPGFSHLLSKNESSPVRFDILLDDLDTVPVSTLQQTTAKKQLQFLLDDSEEKKYSEKNSDDPVNPSSCPEHSPNGLKKVSTRQAWEKSKSVSLEQCQPGSAAPQDNGFEYTAKIRTLAETERFFDELTKEKDQIEAALSRMPSPGGRITLQTRLNQEALEDRLEKINRELGSVRMTLKKFHVLRSSANL" }, "uniprot_id": "MPP9_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "M-phase phosphoprotein 9 isoform b" ], "uniprotkb": [ "M-phase phosphoprotein 9" ] }, "gene": { "refseq": [ "Mphosph9", "4930548D04Rik", "9630025B04Rik", "AW413446", "AW547060", "B930097C17Rik", "C87456", "MPP-9", "MPP9" ], "uniprotkb": [ "Mphosph9", "4930548D04Rik", "9630025B04Rik", "AW413446", "AW547060", "B930097C17Rik", "C87456", "MPP-9", "MPP9" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H5Y1", "id": "A6H5Y1", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "M-phase phosphoprotein 9." }, "publication": [ { "title": "M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/30375385", "journal": "Nature communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074792.1", "id": "NP_001074792.1", "database": "RefSeq" } ], "authors": "Huang N, Zhang D, Li F, Chai P, Wang S, Teng J, Chen J", "date": "2018", "pmid": "30375385" }, { "title": "The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/20178780", "journal": "Developmental biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074792.1", "id": "NP_001074792.1", "database": "RefSeq" } ], "authors": "Jerome-Majewska LA, Achkar T, Luo L, Lupu F, Lacy E", "date": "2010", "pmid": "20178780" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A6H5Y1#A6H5Y1-1", "isoform_ac": "A6H5Y1-1", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A6H5Y1-1|MPP9_MOUSE Isoform 1 of M-phase phosphoprotein 9 OS=Mus musculus OX=10090 GN=Mphosph9 PE=2 SV=1 CANONICAL=A6H5Y1-1", "length": 991, "sequence": "MGFFSENSERNESVVSSPASKEPETQPASSTSYPDCHVDSSSVSSGYGTFCILDMNTHKAKEPTEPLEPGAASQGQHPASVVQAHGPAGGAAAINFFTQTPEELCASLKEDGSTFPGEFDRNFLGENKISEVYSGKANSGKSVTSWAQRLKQNQSKQAHTEDDCSGPKPGSELNWKPPADTFDLAADAARPCAFYINKPAESPSSWLSDSGTGLTYWKLEEKDMYHSLPETLEKTFAPSPAERPLSQVLTLDPGAIRMKPKEHVAGIQAHGFLHALDDRISFSPDSVLEPSLSRHSDTDSSSQASHNPSQVSGFSKYPSTTRASPVDTWKNHAFQRESRTSSTIPSRYTITSNDISVKTVDEENTVTVASVSQSQLPGTANSVPECISLASLEDPVMLSKIRQNLKEKHARHVADLRAYYESEISSLKQKLEAKDISAVEEWKKKNEILADRCGQLDSALNEATSRVRTLEKNNNLLEIEVSDLRERFNAASSASKVLQERIEEMRTSNKEKDNTITRLKCRLQDLEEAFENAYKLSDDKEARLRQENKMFQDLLGEYESLGKEHGRVKDTLNTTENKLLDAHTQISDLKRTISKLEAQVKQAEHESMLSLRNGAKVPERPSRSNSVATSDVSRRKWLIPGAEYSIFTGQPLDPRDRKLDKQLEEALVPGYHSPPEKDSSLGSSPASLLVKKKRDTPDTPPIIKALKELDEERVFKSWGTQTEKEDSSSKLVNSRQTEPSVNTGRSPEKCAQQRPKRQTSASQRSSSLPPSSRKANTPTKREIMLTPVTVAYSPKRSPKENLSPGFSHLLSKNESSPVRFDILLDDLDTVPVSTLQQTTAKKQLQFLLDDSEEKKYSEKNSDDPVNPSSCPEHSPNGLKKVSTRQAWEKSKSVSLEQCQPGSAAPQDNGFEYTAKIRTLAETERFFDELTKEKDQIEAALSRMPSPGGRITLQTRLNQEALEDRLEKINRELGSVRMTLKKFHVLRSSANL" } }, { "url": "https://www.uniprot.org/uniprot/A6H5Y1#D6RDQ9-1", "isoform_ac": "D6RDQ9-1", "locus": { "end_pos": 124320873, "start_pos": 124324980, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000141203", "id": "ENSMUST00000141203", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000117437", "id": "ENSMUSP00000117437", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D6RDQ9-1|MPP9_MOUSE Computationally mapped isoform of M-phase phosphoprotein 9 OS=Mus musculus OX=10090 GN=Mphosph9 PE=2 SV=1 CANONICAL=A6H5Y1-1", "length": 63, "sequence": "MEDFDLVENLQKTSPSVESDIKSAPQSLGLSLHANREDRATCHSRDSGSPHCFKTRPTEQWPD" } }, { "url": "https://www.uniprot.org/uniprot/A6H5Y1#D6RI17-1", "isoform_ac": "D6RI17-1", "locus": { "end_pos": 124315872, "start_pos": 124324980, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000130502", "id": "ENSMUST00000130502", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000120827", "id": "ENSMUSP00000120827", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D6RI17-1|MPP9_MOUSE Computationally mapped isoform of M-phase phosphoprotein 9 OS=Mus musculus OX=10090 GN=Mphosph9 PE=2 SV=1 CANONICAL=A6H5Y1-1", "length": 74, "sequence": "MEDFDLVENLQKTSPSVESDIKSAPQSLGLSLHANRPGGCSSSVWLSSTARSRLSPSRSSSIGRSGEYRRRSGS" } }, { "url": "https://www.uniprot.org/uniprot/A6H5Y1#V9GX48-1", "isoform_ac": "V9GX48-1", "locus": { "end_pos": 124255020, "start_pos": 124324980, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000184951", "id": "ENSMUST00000184951", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000138982", "id": "ENSMUSP00000138982", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|V9GX48-1|MPP9_MOUSE Computationally mapped isoform of M-phase phosphoprotein 9 OS=Mus musculus OX=10090 GN=Mphosph9 PE=2 SV=1 CANONICAL=A6H5Y1-1", "length": 1144, "sequence": "MEDFDLVENLQKTSPSVESDIKSAPQSLGLSLHANRSSPHLSTNGVSSFSGKTGPPVIQGTVEVLTALRQDLQNSGRTDSELWKSCEARWLQLFSVVEQHCQEQIVAQQEQFHRQIRRIQEEIRKLVKLQLSHASRPSCSSSSVSEQVSAETQMGFFSENSERNESVVSSPASKEPETQPASSTSYPDCHVDSSSVSSGYGTFCILDMNTHKAKEPTEPLEPGAASQGQHPASVVQAHGPAGGAAAINFFTQTPEELCASLKEDGSTFPGEFDRNFLGENKISEVYSGKANSGKSVTSWAQRLKQNQSKQAHTEDDCSGPKPGSELNWKPPADTFDLAADAARPCAFYINKPAESPSSWLSDSGTGLTYWKLEEKDMYHSLPETLEKTFAPSPAERPLSQVLTLDPGAIRMKPKEHVAGIQAHGFLHALDDRISFSPDSVLEPSLSRHSDTDSSSQASHNPSQVSGFSKYPSTTRASPVDTWKNHAFQRESRTSSTIPSRYTITSNDISVKTVDEENTVTVASVSQSQLPGTANSVPECISLASLEDPVMLSKIRQNLKEKHARHVADLRAYYESEISSLKQKLEAKDISAVEEWKKKNEILADRCGQLDSALNEATSRVRTLEKNNNLLEIEVSDLRERFNAASSASKVLQERIEEMRTSNKEKDNTITRLKCRLQDLEEAFENAYKLSDDKEARLRQENKMFQDLLGEYESLGKEHGRVKDTLNTTENKLLDAHTQISDLKRTISKLEAQVKQAEHESMLSLRNGAKVPERPSRSNSVATSDVSRRKWLIPGAEYSIFTGQPLDPRDRKLDKQLEEALVPGYHSPPEKDSSLGSSPASLLVKKKRDTPDTPPIIKALKELDEERVFKSWGTQTEKEDSSSKLVNSRQTEPSVNTGRSPEKCAQQRPKRQTSASQRSSSLPPSSRKANTPTKREIMLTPVTVAYSPKRSPKENLSPGFSHLLSKNESSPVRFDILLDDLDTVPVSTLQQTTAKKQLQFLLDDSEEKKYSEKNSDDPVNPSSCPEHSPNGLKKVSTRQAWEKSKSVSLEQCQPGSAAPQDNGFEYTAKIRTLAETERFFDELTKEKDQIEAALSRMPSPGGRITLQTRLNQEALEDRLEKINRELGSVRMTLKKFHVLRSSANL" } }, { "url": "https://www.uniprot.org/uniprot/A6H5Y1#E9QPF8-1", "isoform_ac": "E9QPF8-1", "locus": { "end_pos": 124255020, "start_pos": 124324980, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000031344", "id": "ENSMUST00000031344", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000031344", "id": "ENSMUSP00000031344", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|E9QPF8-1|MPP9_MOUSE Computationally mapped isoform of M-phase phosphoprotein 9 OS=Mus musculus OX=10090 GN=Mphosph9 PE=2 SV=1 CANONICAL=A6H5Y1-1", "length": 1114, "sequence": "MEDFDLVENLQKTSPSVESDIKSAPQSLGLSLHANRSSPHLSTNGVSSFSGKTGPPVIQGTVEVLTALRQDLQNSGRTDSELWKSCERIQEEIRKLVKLQLSHASRPSCSSSSVSEQVSAETQMGFFSENSERNESVVSSPASKEPETQPASSTSYPDCHVDSSSVSSGYGTFCILDMNTHKAKEPTEPLEPGAASQGQHPASVVQAHGPAGGAAAINFFTQTPEELCASLKEDGSTFPGEFDRNFLGENKISEVYSGKANSGKSVTSWAQRLKQNQSKQAHTEDDCSGPKPGSELNWKPPADTFDLAADAARPCAFYINKPAESPSSWLSDSGTGLTYWKLEEKDMYHSLPETLEKTFAPSPAERPLSQVLTLDPGAIRMKPKEHVAGIQAHGFLHALDDRISFSPDSVLEPSLSRHSDTDSSSQASHNPSQVSGFSKYPSTTRASPVDTWKNHAFQRESRTSSTIPSRYTITSNDISVKTVDEENTVTVASVSQSQLPGTANSVPECISLASLEDPVMLSKIRQNLKEKHARHVADLRAYYESEISSLKQKLEAKDISAVEEWKKKNEILADRCGQLDSALNEATSRVRTLEKNNNLLEIEVSDLRERFNAASSASKVLQERIEEMRTSNKEKDNTITRLKCRLQDLEEAFENAYKLSDDKEARLRQENKMFQDLLGEYESLGKEHGRVKDTLNTTENKLLDAHTQISDLKRTISKLEAQVKQAEHESMLSLRNGAKVPERPSRSNSVATSDVSRRKWLIPGAEYSIFTGQPLDPRDRKLDKQLEEALVPGYHSPPEKDSSLGSSPASLLVKKKRDTPDTPPIIKALKELDEERVFKSWGTQTEKEDSSSKLVNSRQTEPSVNTGRSPEKCAQQRPKRQTSASQRSSSLPPSSRKANTPTKREIMLTPVTVAYSPKRSPKENLSPGFSHLLSKNESSPVRFDILLDDLDTVPVSTLQQTTAKKQLQFLLDDSEEKKYSEKNSDDPVNPSSCPEHSPNGLKKVSTRQAWEKSKSVSLEQCQPGSAAPQDNGFEYTAKIRTLAETERFFDELTKEKDQIEAALSRMPSPGGRITLQTRLNQEALEDRLEKINRELGSVRMTLKKFHVLRSSANL" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:269702", "resource": "KEGG Pathway", "id": "mmu:269702", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074792.1", "annotation": "MPP9 acts as a regulator of ciliogenesis by regulating the localization of CP110-CEP97 at the mother centriole. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074792.1", "id": "NP_001074792.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q99550-1", "protein_name": "M-phase phosphoprotein 9.", "sequence": { "length": 1183, "sequence": "MEEFDLVKTLHKTSSSVGSDENSLHSLGLNLNTDRSSPHLSTNGVSSFSGKTRPSVIQGTVEVLTSLMQELQNSGKTDSELWKNCETRWLQLFNLVEKQCQEQIVAQQEQFHNQIQHIQEEIKNLVKLQTSSASLASCEGNSSNKQVSSESQMGFFSLSSERNESVIHYPESTEPEIQQEMSTSQPDCNVDSCSVSSGYGTFCISELNLYKSKDPKEFMEHIDVPKGQYVAPAVPAESLVDGVKNENFYIQTPEECHVSLKEDVSISPGEFEHNFLGENKVSEVYSGKTNSNAITSWAQKLKQNQPKRAHVEDGGSRSKQGNEQSKKTPIEKSDFAAATHPRAFYLSKPDETPNAWMSDSGTGLTYWKLEEKDMHHSLPETLEKTFISLSSTDVSPNQSNTSNEMKLPSLKDIYYKKQRENKQLPERNLTSASNPNHPPEVLTLDPTLHMKPKQQISGIQPHGLPNALDDRISFSPDSVLEPSMSSPSDIDSFSQASNVTSQLPGFPKYPSHTKASPVDSWKNQTFQNESRTSSTFPSVYTITSNDISVNTVDEENTVMVASASVSQSQLPGTANSVPECISLTSLEDPVILSKIRQNLKEKHARHIADLRAYYESEINSLKQKLEAKEISGVEDWKITNQILVDRCGQLDSALHEATSRVRTLENKNNLLEIEVNDLRERFSAASSASKILQERIEEMRTSSKEKDNTIIRLKSRLQDLEEAFENAYKLSDDKEAQLKQENKMFQDLLGEYESLGKEHRRVKDALNTTENKLLDAYTQISDLKRMISKLEAQVKQVEHENMLSLRHNSRIHVRPSRANTLATSDVSRRKWLIPGAEYSIFTGQPLDTQDSNVDNQLEETCSLGHRSPLEKDSSPGSSSTSLLIKKQRETSDTPIMRALKELDEGKIFKNWGTQTEKEDTSNINPRQTETSVNASRSPEKCAQQRQKRLNSASQRSSSLPPSNRKSSTPTKREIMLTPVTVAYSPKRSPKENLSPGFSHLLSKNESSPIRFDILLDDLDTVPVSTLQRTNPRKQLQFLPLDDSEEKTYSEKATDNHVNHSSCPEPVPNGVKKVSVRTAWEKNKSVSYEQCKPVSVTPQGNDFEYTAKIRTLAETERFFDELTKEKDQIEAALSRMPSPGGRITLQTRLNQEALEDRLERINRELGSVRMTLKKFHVLRTSANL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/11256", "id": "11256", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074792.1", "ac": "NP_001074792.1", "name": "M-phase phosphoprotein 9 isoform b.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H5Y1", "id": "A6H5Y1", "database": "UniProtKB" } ], "name": "Golgi membrane", "id": "GO:0000139" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H5Y1", "id": "A6H5Y1", "database": "UniProtKB" } ], "name": "Golgi apparatus", "id": "GO:0005794" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H5Y1", "id": "A6H5Y1", "database": "UniProtKB" } ], "name": "centriole", "id": "GO:0005814" } ], "total": 3, "name": "Cellular Component" } ] }, "site_annotation": [ { "end_pos": 13, "annotation": "n_glycosylation_sequon", "start_pos": 11 }, { "end_pos": 155, "annotation": "n_glycosylation_sequon", "start_pos": 153 }, { "end_pos": 575, "annotation": "n_glycosylation_sequon", "start_pos": 573 }, { "end_pos": 803, "annotation": "n_glycosylation_sequon", "start_pos": 801 }, { "end_pos": 815, "annotation": "n_glycosylation_sequon", "start_pos": 813 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074792.1", "id": "NP_001074792.1", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:269702", "id": "mmu:269702", "database": "KEGG Pathway" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR026636", "id": "IPR026636", "database": "InterPro" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14926", "id": "PTHR14926", "database": "PANTHER" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A6H5Y1", "id": "PR_A6H5Y1", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/269702", "id": "269702", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:2443138", "id": "2443138", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A6H5Y1", "disease": [], "mass": { "monoisotopic_mass": 109953.0, "chemical_mass": 109953.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A6H5Y1", "name": "Mphosph9; 4930548D04Rik; 9630025B04Rik; AW413446; AW547060; B930097C17Rik; C87456; MPP-9; MPP9.", "locus": { "end_pos": 124250959, "start_pos": 124327972, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000038126", "id": "ENSMUSG00000038126", "database": "Ensembl Gene" } ] } } ] }