{ "uniprot_canonical_ac": "A6BM72-1", "sequence": { "header": "sp|A6BM72-1|MEG11_HUMAN Isoform 1 of Multiple epidermal growth factor-like domains protein 11 OS=Homo sapiens OX=9606 GN=MEGF11 PE=2 SV=3 CANONICAL=A6BM72-1", "length": 1044, "sequence": "MVLSLTGLIAFSFLQATLALNPEDPNVCSHWESYAVTVQESYAHPFDQIYYTRCTDILNWFKCTRHRISYKTAYRRGLRTMYRRRSQCCPGYYESGDFCIPLCTEECVHGRCVSPDTCHCEPGWGGPDCSSGCDSDHWGPHCSNRCQCQNGALCNPITGACVCAAGFRGWRCEELCAPGTHGKGCQLPCQCRHGASCDPRAGECLCAPGYTGVYCEELCPPGSHGAHCELRCPCQNGGTCHHITGECACPPGWTGAVCAQPCPPGTFGQNCSQDCPCHHGGQCDHVTGQCHCTAGYMGDRCQEECPFGSFGFQCSQHCDCHNGGQCSPTTGACECEPGYKGPRCQERLCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPGWSGHHCNESCPVGYYGDGCQLPCTCQNGADCHSITGGCTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNNGGTCSPVDGSCTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDGSCSCTPGWLGDTCELPCPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSCENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVHSSRPCHHISGICECLPGFSGALCNQVCAGGYFGQDCAQLCSCANNGTCSPIDGSCQCFPGWIGKDCSQACPPGFWGPACFHACSCHNGASCSAEDGACHCTPGWTGLFCTQRCPAAFFGKDCGRVCQCQNGASCDHISGKCTCRTGFTGQHCEQRCAPGTFGYGCQQLCECMNNSTCDHVTGTCYCSPGFKGIRCDQAALMMEELNPYTKISPALGAERHSVGAVTGIMLLLFLIVVLLGLFAWHRRRQKEKGRDLAPRVSYTPAMRMTSTDYSLSGACGMDRRQNTYIMDKGFKDYMKESVCSSSTCSLNSSENPYATIKDPPILTCKLPESSYVEMKSPVHMGSPYTDVPSLSTSNKNIYEVEPTVSVVQEGCGHNSSYIQNAYDLPRNSHIPGHYDLLPVRQSPANGPSQDKQS" }, "uniprot_id": "MEG11_HUMAN", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "multiple epidermal growth factor-like domains protein 11 precursor", "multiple epidermal growth factor-like domains protein 11; multiple EGF-like domains protein 11" ], "uniprotkb": [ "Multiple epidermal growth factor-like domains protein 11", "Multiple EGF-like domains protein 11" ] }, "gene": { "refseq": [ "MEGF11" ], "uniprotkb": [ "MEGF11", "KIAA1781", "PRO4432" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6BM72", "id": "A6BM72", "database": "UniProtKB" } ], "name": "Homo sapiens", "taxid": 9606 } ], "recommendedname": { "full": "Multiple epidermal growth factor-like domains protein 11; Multiple EGF-like domains protein 11.", "short": "Multiple EGF-like domains protein 11" }, "publication": [ { "title": "Association of genetic variants with hemorrhagic stroke in Japanese individuals.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/20198315", "journal": "International journal of molecular medicine", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_115821.2", "id": "NP_115821.2", "database": "RefSeq" } ], "authors": "Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y", "date": "2010", "pmid": "20198315" }, { "title": "Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/19851296", "journal": "American journal of hypertension", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_115821.2", "id": "NP_115821.2", "database": "RefSeq" } ], "authors": "Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y", "date": "2010", "pmid": "19851296" }, { "title": "The mammalian Ced-1 ortholog MEGF10/KIAA1780 displays a novel adhesion pattern.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17498693", "journal": "Experimental cell research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_115821.2", "id": "NP_115821.2", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A6BM72/publications", "id": "A6BM72", "database": "UniProtKB" } ], "authors": "Suzuki E, Nakayama M", "date": "2007", "pmid": "17498693" }, { "title": "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/12975309", "journal": "Genome Res.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6BM72/publications", "id": "A6BM72", "database": "UniProtKB" } ], "authors": "Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Clark H.F., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Goddard A.D., Godowski P.J., Gray A.M., Grimaldi C., Gu Q., Gurney A.L., Hass P.E., Heldens S., Huang A., Jin Y., Johnson S., Kim H.S., Klimowski L., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Wood W.I., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Xie M.H., Goddard A., Foster J., Mark M., Gray A., Vandlen R., Yansura D., Baldwin D., Godowski P.", "date": "2003", "pmid": "12975309" } ], "glycosylation": [ { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6BM72", "id": "A6BM72", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 531, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6BM72", "id": "A6BM72", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 270, "glytoucan_ac": "", "type": "N-linked" } ], "mutation": [ { "start_pos": 67, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6BM72", "id": "A6BM72", "database": "BioMuta" } ], "frequency": "1.1", "annotation": "Filters passed (2/5): patient freq. (1.1%); num. of cancers (3). In dbSNP: rs1440418292.", "sequence_org": "R", "disease": { "doid": "2394", "url": "http://disease-ontology.org/term/DOID:2394", "icd10": "", "name": "Ovarian cancer" }, "sequence_mut": "W", "subjects_tested": "93", "end_pos": 67, "type": "Point mutation" }, { "start_pos": 95, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6BM72", "id": "A6BM72", "database": "BioMuta" } ], "frequency": "2.1", "annotation": "Filters passed (2/5): patient freq. (2.1%); num. of cancers (5).", "sequence_org": "S", "disease": { "doid": "2531", "url": "http://disease-ontology.org/term/DOID:2531", "icd10": "", "name": "Hematologic cancer" }, "sequence_mut": "N", "subjects_tested": "48", "end_pos": 95, "type": "Point mutation" }, { "start_pos": 95, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6BM72", "id": "A6BM72", "database": "BioMuta" } ], "frequency": "1.5", "annotation": "Filters passed (2/5): patient freq. (1.5%); num. of cancers (5).", "sequence_org": "S", "disease": { "doid": "1324", "url": "http://disease-ontology.org/term/DOID:1324", "icd10": "", "name": "Lung cancer" }, "sequence_mut": "N", "subjects_tested": "66", "end_pos": 95, "type": "Point mutation" }, { "start_pos": 149, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6BM72", "id": "A6BM72", "database": "BioMuta" } ], "frequency": "1.3", "annotation": "Filters passed (1/5): patient freq. (1.3%).", "sequence_org": "Q", "disease": { "doid": "1319", "url": "http://disease-ontology.org/term/DOID:1319", "icd10": "", "name": "Brain cancer" }, "sequence_mut": "R", "subjects_tested": "78", "end_pos": 149, "type": "Point mutation" }, { "start_pos": 712, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6BM72", "id": "A6BM72", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "C", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "F", "subjects_tested": "50", "end_pos": 712, "type": "Point mutation" }, { "start_pos": 130, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6BM72", "id": "A6BM72", "database": "BioMuta" } ], "frequency": "1.5", "annotation": "Filters passed (1/5): patient freq. (1.5%).", "sequence_org": "S", "disease": { "doid": "1324", "url": "http://disease-ontology.org/term/DOID:1324", "icd10": "", "name": "Lung cancer" }, "sequence_mut": "P", "subjects_tested": "66", "end_pos": 130, "type": "Point mutation" }, { "start_pos": 125, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6BM72", "id": "A6BM72", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "G", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "*", "subjects_tested": "50", "end_pos": 125, "type": "Point mutation" }, { "start_pos": 184, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6BM72", "id": "A6BM72", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "G", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "*", "subjects_tested": "50", "end_pos": 184, "type": "Point mutation" }, { "start_pos": 113, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6BM72", "id": "A6BM72", "database": "BioMuta" } ], "frequency": "0.7", "annotation": "Filters passed (1/5): num. of cancers (3). In dbSNP: rs753304245.", "sequence_org": "V", "disease": { "doid": "1612", "url": "http://disease-ontology.org/term/DOID:1612", "icd10": "", "name": "Breast cancer" }, "sequence_mut": "I", "subjects_tested": "141", "end_pos": 113, "type": "Point mutation" }, { "start_pos": 368, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6BM72", "id": "A6BM72", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "N", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "S", "subjects_tested": "50", "end_pos": 368, "type": "Point mutation" }, { "start_pos": 422, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6BM72", "id": "A6BM72", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "C", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "R", "subjects_tested": "50", "end_pos": 422, "type": "Point mutation" }, { "start_pos": 113, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6BM72", "id": "A6BM72", "database": "BioMuta" } ], "frequency": "0.2", "annotation": "Filters passed (1/5): num. of cancers (3). In dbSNP: rs753304245.", "sequence_org": "V", "disease": { "doid": "363", "url": "http://disease-ontology.org/term/DOID:363", "icd10": "", "name": "Uterine cancer" }, "sequence_mut": "I", "subjects_tested": "558", "end_pos": 113, "type": "Point mutation" }, { "start_pos": 985, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6BM72", "id": "A6BM72", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "N", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "T", "subjects_tested": "50", "end_pos": 985, "type": "Point mutation" }, { "start_pos": 710, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6BM72", "id": "A6BM72", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "C", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "Y", "subjects_tested": "50", "end_pos": 710, "type": "Point mutation" }, { "start_pos": 413, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6BM72", "id": "A6BM72", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "A", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "D", "subjects_tested": "50", "end_pos": 413, "type": "Point mutation" }, { "start_pos": 522, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6BM72", "id": "A6BM72", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "P", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "S", "subjects_tested": "50", "end_pos": 522, "type": "Point mutation" }, { "start_pos": 796, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6BM72", "id": "A6BM72", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "C", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "S", "subjects_tested": "50", "end_pos": 796, "type": "Point mutation" }, { "start_pos": 308, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6BM72", "id": "A6BM72", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "G", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "R", "subjects_tested": "50", "end_pos": 308, "type": "Point mutation" }, { "start_pos": 113, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6BM72", "id": "A6BM72", "database": "BioMuta" } ], "frequency": "0.1", "annotation": "Filters passed (1/5): num. of cancers (3). In dbSNP: rs753304245.", "sequence_org": "V", "disease": { "doid": "4159", "url": "http://disease-ontology.org/term/DOID:4159", "icd10": "", "name": "Skin cancer" }, "sequence_mut": "I", "subjects_tested": "820", "end_pos": 113, "type": "Point mutation" }, { "start_pos": 67, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6BM72", "id": "A6BM72", "database": "BioMuta" } ], "frequency": "0.1", "annotation": "Filters passed (1/5): num. of cancers (3). In dbSNP: rs1440418292.", "sequence_org": "R", "disease": { "doid": "1324", "url": "http://disease-ontology.org/term/DOID:1324", "icd10": "", "name": "Lung cancer" }, "sequence_mut": "W", "subjects_tested": "689", "end_pos": 67, "type": "Point mutation" }, { "start_pos": 95, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6BM72", "id": "A6BM72", "database": "BioMuta" } ], "frequency": "0.3", "annotation": "Filters passed (1/5): num. of cancers (5).", "sequence_org": "S", "disease": { "doid": "4362", "url": "http://disease-ontology.org/term/DOID:4362", "icd10": "", "name": "Cervical cancer" }, "sequence_mut": "N", "subjects_tested": "350", "end_pos": 95, "type": "Point mutation" }, { "start_pos": 67, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6BM72", "id": "A6BM72", "database": "BioMuta" } ], "frequency": "0.2", "annotation": "Filters passed (1/5): num. of cancers (3). In dbSNP: rs1440418292.", "sequence_org": "R", "disease": { "doid": "363", "url": "http://disease-ontology.org/term/DOID:363", "icd10": "", "name": "Uterine cancer" }, "sequence_mut": "W", "subjects_tested": "558", "end_pos": 67, "type": "Point mutation" }, { "start_pos": 499, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6BM72", "id": "A6BM72", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "A", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "V", "subjects_tested": "50", "end_pos": 499, "type": "Point mutation" }, { "start_pos": 301, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6BM72", "id": "A6BM72", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "C", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "F", "subjects_tested": "50", "end_pos": 301, "type": "Point mutation" }, { "start_pos": 95, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6BM72", "id": "A6BM72", "database": "BioMuta" } ], "frequency": "0.8", "annotation": "Filters passed (1/5): num. of cancers (5).", "sequence_org": "S", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "N", "subjects_tested": "129", "end_pos": 95, "type": "Point mutation" }, { "start_pos": 95, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6BM72", "id": "A6BM72", "database": "BioMuta" } ], "frequency": "0.4", "annotation": "Filters passed (1/5): num. of cancers (5).", "sequence_org": "S", "disease": { "doid": "9256", "url": "http://disease-ontology.org/term/DOID:9256", "icd10": "", "name": "Colorectal cancer" }, "sequence_mut": "N", "subjects_tested": "254", "end_pos": 95, "type": "Point mutation" }, { "start_pos": 210, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A6BM72", "id": "A6BM72", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "Y", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "C", "subjects_tested": "50", "end_pos": 210, "type": "Point mutation" } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A6BM72#A6BM72-1", "isoform_ac": "A6BM72-1", "locus": { "end_pos": 65897937, "start_pos": 66128403, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000422354", "id": "ENST00000422354", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000414475", "id": "ENSP00000414475", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A6BM72-1|MEG11_HUMAN Isoform 1 of Multiple epidermal growth factor-like domains protein 11 OS=Homo sapiens OX=9606 GN=MEGF11 PE=2 SV=3 CANONICAL=A6BM72-1", "length": 1044, "sequence": "MVLSLTGLIAFSFLQATLALNPEDPNVCSHWESYAVTVQESYAHPFDQIYYTRCTDILNWFKCTRHRISYKTAYRRGLRTMYRRRSQCCPGYYESGDFCIPLCTEECVHGRCVSPDTCHCEPGWGGPDCSSGCDSDHWGPHCSNRCQCQNGALCNPITGACVCAAGFRGWRCEELCAPGTHGKGCQLPCQCRHGASCDPRAGECLCAPGYTGVYCEELCPPGSHGAHCELRCPCQNGGTCHHITGECACPPGWTGAVCAQPCPPGTFGQNCSQDCPCHHGGQCDHVTGQCHCTAGYMGDRCQEECPFGSFGFQCSQHCDCHNGGQCSPTTGACECEPGYKGPRCQERLCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPGWSGHHCNESCPVGYYGDGCQLPCTCQNGADCHSITGGCTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNNGGTCSPVDGSCTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDGSCSCTPGWLGDTCELPCPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSCENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVHSSRPCHHISGICECLPGFSGALCNQVCAGGYFGQDCAQLCSCANNGTCSPIDGSCQCFPGWIGKDCSQACPPGFWGPACFHACSCHNGASCSAEDGACHCTPGWTGLFCTQRCPAAFFGKDCGRVCQCQNGASCDHISGKCTCRTGFTGQHCEQRCAPGTFGYGCQQLCECMNNSTCDHVTGTCYCSPGFKGIRCDQAALMMEELNPYTKISPALGAERHSVGAVTGIMLLLFLIVVLLGLFAWHRRRQKEKGRDLAPRVSYTPAMRMTSTDYSLSGACGMDRRQNTYIMDKGFKDYMKESVCSSSTCSLNSSENPYATIKDPPILTCKLPESSYVEMKSPVHMGSPYTDVPSLSTSNKNIYEVEPTVSVVQEGCGHNSSYIQNAYDLPRNSHIPGHYDLLPVRQSPANGPSQDKQS" } }, { "url": "https://www.uniprot.org/uniprot/A6BM72#A0A0G2JLW8-1", "isoform_ac": "A0A0G2JLW8-1", "locus": { "end_pos": 65913738, "start_pos": 66136111, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000615866", "id": "ENST00000615866", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000478094", "id": "ENSP00000478094", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JLW8-1|MEG11_HUMAN Computationally mapped isoform of Multiple epidermal growth factor-like domains protein 11 OS=Homo sapiens OX=9606 GN=MEGF11 PE=2 SV=1 CANONICAL=A6BM72-1", "length": 828, "sequence": "MHTPSIRSITHDAQTSSTGSSAPGTALCTEECVHGRCVSPDTCHCEPGWGGPDCSSGCDSDHWGPHCSNRCQCQNGALCNPITGACVCAAGFRGWRCEELCAPGTHGKGCQLPCQCRHGASCDPRAGECLCAPGYTGVYCEELCPPGSHGAHCELRCPCQNGGTCHHITGECACPPGWTGAVCAQPCPPGTFGQNCSQDCPCHHGGQCDHVTGQCHCTAGYMGDRCQEECPFGSFGFQCSQHCDCHNGGQCSPTTGACECEPGYKGPRCQERLCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPGWSGHHCNESCPVGYYGDGCQLPCTCQNGADCHSITGGCTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNNGGTCSPVDGSCTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDGSCSCTPGWLGDTCELPCPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSCENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVHSSRPCHHISGICECLPGFSGALCNQVCAGGYFGQDCAQLCSCANNGTCSPIDGSCQCFPGWIGKDCSQACPPGFWGPACFHACSCHNGASCSAEDGACHCTPGWTGLFCTQRCPAAFFGKDCGRVCQCQNGASCDHISGKCTCRTGFTGQHCEQRCAPGTFGYGCQQLCECMNNSTCDHVTGTCYCSPGFKGIRCDQAALMMEELNPYTKISPALGAERHSVGAVTGIMLLLFLIVVLLGLFAWHRRRQKEKGRDLAPRVSYTPAMRMTSTDYSLS" } }, { "url": "https://www.uniprot.org/uniprot/A6BM72#A6BM72-2", "isoform_ac": "A6BM72-2", "locus": { "end_pos": 65897937, "start_pos": 66123974, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000288745", "id": "ENST00000288745", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000288745", "id": "ENSP00000288745", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A6BM72-2|MEG11_HUMAN Isoform 2 of Multiple epidermal growth factor-like domains protein 11 OS=Homo sapiens OX=9606 GN=MEGF11 PE=2 SV=3 CANONICAL=A6BM72-1", "length": 969, "sequence": "MHTPSIRSITHDAQTSSTGSSAPGTALCTEECVHGRCVSPDTCHCEPGWGGPDCSSGCDSDHWGPHCSNRCQCQNGALCNPITGACVCAAGFRGWRCEELCAPGTHGKGCQLPCQCRHGASCDPRAGECLCAPGYTGVYCEELCPPGSHGAHCELRCPCQNGGTCHHITGECACPPGWTGAVCAQPCPPGTFGQNCSQDCPCHHGGQCDHVTGQCHCTAGYMGDRCQEECPFGSFGFQCSQHCDCHNGGQCSPTTGACECEPGYKGPRCQERLCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPGWSGHHCNESCPVGYYGDGCQLPCTCQNGADCHSITGGCTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNNGGTCSPVDGSCTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDGSCSCTPGWLGDTCELPCPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSCENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVHSSRPCHHISGICECLPGFSGALCNQVCAGGYFGQDCAQLCSCANNGTCSPIDGSCQCFPGWIGKDCSQACPPGFWGPACFHACSCHNGASCSAEDGACHCTPGWTGLFCTQRCPAAFFGKDCGRVCQCQNGASCDHISGKCTCRTGFTGQHCEQRCAPGTFGYGCQQLCECMNNSTCDHVTGTCYCSPGFKGIRCDQAALMMEELNPYTKISPALGAERHSVGAVTGIMLLLFLIVVLLGLFAWHRRRQKEKGRDLAPRVSYTPAMRMTSTDYSLSGACGMDRRQNTYIMDKGFKDYMKESVCSSSTCSLNSSENPYATIKDPPILTCKLPESSYVEMKSPVHMGSPYTDVPSLSTSNKNIYEVEPTVSVVQEGCGHNSSYIQNAYDLPRNSHIPGHYDLLPVRQSPANGPSQDKQS" } }, { "url": "https://www.uniprot.org/uniprot/A6BM72#A0A087WU24-1", "isoform_ac": "A0A087WU24-1", "locus": { "end_pos": 65906125, "start_pos": 65912200, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000489275", "id": "ENST00000489275", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000478311", "id": "ENSP00000478311", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A087WU24-1|MEG11_HUMAN Computationally mapped isoform of Multiple epidermal growth factor-like domains protein 11 OS=Homo sapiens OX=9606 GN=MEGF11 PE=2 SV=1 CANONICAL=A6BM72-1", "length": 117, "sequence": "XLSQSSSHAHCFSNSSYHALACGGPATSQASTLDRNSPTKLSNKSLDRDTAGWTPYSYVNVLDSHFQISALEARYPPEDFYIELRHLSRPAEPHSPDKPWIQERTDRTRAERCLWNG" } }, { "url": "https://www.uniprot.org/uniprot/A6BM72#A6BM72-3", "isoform_ac": "A6BM72-3", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A6BM72-3|MEG11_HUMAN Isoform 3 of Multiple epidermal growth factor-like domains protein 11 OS=Homo sapiens OX=9606 GN=MEGF11 PE=2 SV=3 CANONICAL=A6BM72-1", "length": 875, "sequence": "MVLSLTGLIAFSFLQATLALNPEDPNVCSHWESYAVTVQESYAHPFDQIYYTRCTDILNWFKCTRHRISYKTAYRRGLRTMYRRRSQCCPGYYESGDFCIPLCTEECVHGRCVSPDTCHCEPGWGGPDCSSGCDSDHWGPHCSNRCQCQNGALCNPITGACVCAAGFRGWRCEELCAPGTHGKGCQLPCQCRHGASCDPRAGECLCAPGYTGVYCEELCPPGSHGAHCELRCPCQNGGTCHHITGECACPPGWTGAVCAQPCPPGTFGQNCSQDCPCHHGGQCDHVTGQCHCTAGYMGDRCQEECPFGSFGFQCSQHCDCHNGGQCSPTTGACECEPGYKGPRCQERLCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPGWSGHHCNESCPVGYYGDGCQLPCTCQNGADCHSITGGCTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNNGGTCSPVDGSCTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDGSCSCTPGWLGDTCELPCPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSCENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVHSSRPCHHISGICECLPGFSGALCNQVCAGGYFGQDCAQLCSCANNGTCSPIDGSCQCFPGWIGKDCSQACPPGFWGPACFHACSCHNGASCSAEDGACHCTPGWTGLFCTQRKPHLLASQPLRIPCCGLLATVGIVQTSREGGMQAAPGLVVPDSCPTRTEELCRGSSRPDWIQGIDKPKVLEGQGCKAAQQHFLGRTVGAYASVRMAPAVTTSVASAPAAQASPGNTVSRDVPQEPLAMGVSSYVSA" } }, { "url": "https://www.uniprot.org/uniprot/A6BM72#A0A087X003-1", "isoform_ac": "A0A087X003-1", "locus": { "end_pos": 65909076, "start_pos": 65909771, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000562154", "id": "ENST00000562154", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000483007", "id": "ENSP00000483007", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A087X003-1|MEG11_HUMAN Computationally mapped isoform of Multiple epidermal growth factor-like domains protein 11 OS=Homo sapiens OX=9606 GN=MEGF11 PE=2 SV=1 CANONICAL=A6BM72-1", "length": 26, "sequence": "XWTPYSYVNVLDQCPGGQVPARGLLH" } }, { "url": "https://www.uniprot.org/uniprot/A6BM72#A6BM72-4", "isoform_ac": "A6BM72-4", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A6BM72-4|MEG11_HUMAN Isoform 4 of Multiple epidermal growth factor-like domains protein 11 OS=Homo sapiens OX=9606 GN=MEGF11 PE=2 SV=3 CANONICAL=A6BM72-1", "length": 137, "sequence": "MMEELNPYTKISPALGAERHSVGAVTGIMLLLFLIVVLLGLFAWHRRRQKEKGRDLAPRVSYTPAMRMTSTDYSLSASTTPWWPVMEHLARPFSQRPRTQLSNKSLDRDTAGWTPYSYVNVLDQCPGGQVPARGLLH" } }, { "url": "https://www.uniprot.org/uniprot/A6BM72#C9JYE7-1", "isoform_ac": "C9JYE7-1", "locus": { "end_pos": 65929723, "start_pos": 65970563, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000455812", "id": "ENST00000455812", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000401400", "id": "ENSP00000401400", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|C9JYE7-1|MEG11_HUMAN Computationally mapped isoform of Multiple epidermal growth factor-like domains protein 11 OS=Homo sapiens OX=9606 GN=MEGF11 PE=2 SV=8 CANONICAL=A6BM72-1", "length": 227, "sequence": "MGDRCQEECPFGSFGFQCSQHCDCHNGGQCSPTTGACECEPGYKGPRCQERLCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPGWSGHHCNESCPVGYYGDGCQLPCTCQNGADCHSITGGCTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNNGGTCSPVDGSCTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDGSCSCTPGWLGDTCELPC" } }, { "url": "https://www.uniprot.org/uniprot/A6BM72#A0A0G2JN40-1", "isoform_ac": "A0A0G2JN40-1", "locus": { "end_pos": 65913738, "start_pos": 66140540, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000614717", "id": "ENST00000614717", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000480614", "id": "ENSP00000480614", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JN40-1|MEG11_HUMAN Computationally mapped isoform of Multiple epidermal growth factor-like domains protein 11 OS=Homo sapiens OX=9606 GN=MEGF11 PE=2 SV=1 CANONICAL=A6BM72-1", "length": 903, "sequence": "MVLSLTGLIAFSFLQATLALNPEDPNVCSHWESYAVTVQESYAHPFDQIYYTRCTDILNWFKCTRHRISYKTAYRRGLRTMYRRRSQCCPGYYESGDFCIPLCTEECVHGRCVSPDTCHCEPGWGGPDCSSGCDSDHWGPHCSNRCQCQNGALCNPITGACVCAAGFRGWRCEELCAPGTHGKGCQLPCQCRHGASCDPRAGECLCAPGYTGVYCEELCPPGSHGAHCELRCPCQNGGTCHHITGECACPPGWTGAVCAQPCPPGTFGQNCSQDCPCHHGGQCDHVTGQCHCTAGYMGDRCQEECPFGSFGFQCSQHCDCHNGGQCSPTTGACECEPGYKGPRCQERLCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPGWSGHHCNESCPVGYYGDGCQLPCTCQNGADCHSITGGCTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNNGGTCSPVDGSCTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDGSCSCTPGWLGDTCELPCPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSCENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVHSSRPCHHISGICECLPGFSGALCNQVCAGGYFGQDCAQLCSCANNGTCSPIDGSCQCFPGWIGKDCSQACPPGFWGPACFHACSCHNGASCSAEDGACHCTPGWTGLFCTQRCPAAFFGKDCGRVCQCQNGASCDHISGKCTCRTGFTGQHCEQRCAPGTFGYGCQQLCECMNNSTCDHVTGTCYCSPGFKGIRCDQAALMMEELNPYTKISPALGAERHSVGAVTGIMLLLFLIVVLLGLFAWHRRRQKEKGRDLAPRVSYTPAMRMTSTDYSLS" } }, { "url": "https://www.uniprot.org/uniprot/A6BM72#H3BR81-1", "isoform_ac": "H3BR81-1", "locus": { "end_pos": 65915548, "start_pos": 65970563, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000490495", "id": "ENST00000490495", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000456118", "id": "ENSP00000456118", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|H3BR81-1|MEG11_HUMAN Computationally mapped isoform of Multiple epidermal growth factor-like domains protein 11 OS=Homo sapiens OX=9606 GN=MEGF11 PE=2 SV=1 CANONICAL=A6BM72-1", "length": 579, "sequence": "MGDRCQEECPFGSFGFQCSQHCDCHNGGQCSPTTGACECEPGYKGPRCQERLCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPGWSGHHCNESCPVGYYGDGCQLPCTCQNGADCHSITGGCTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNNGGTCSPVDGSCTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDGSCSCTPGWLGDTCELPCPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSCENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVHSSRPCHHISGICECLPGFSGALCNQVCAGGYFGQDCAQLCSCANNGTCSPIDGSCQCFPGWIGKDCSQACPPGFWGPACFHACSCHNGASCSAEDGACHCTPGWTGLFCTQRKPHLLASQPLRIPCCGLLATVGIVQTSREGGMQAAPGLVVPDSCPTRTEELCRGSSRPDWIQGIDKPKVLEGQGCKAAQQHFLGRTVGAYASVRMAPAVTTSVASAPAAQASPGNTVSRDVPQEPLAMGVSSYVSA" } }, { "url": "https://www.uniprot.org/uniprot/A6BM72#A0A0A0MS64-1", "isoform_ac": "A0A0A0MS64-1", "locus": { "end_pos": 65897937, "start_pos": 66128403, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000395614", "id": "ENST00000395614", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000378976", "id": "ENSP00000378976", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0A0MS64-1|MEG11_HUMAN Computationally mapped isoform of Multiple epidermal growth factor-like domains protein 11 OS=Homo sapiens OX=9606 GN=MEGF11 PE=2 SV=1 CANONICAL=A6BM72-1", "length": 1140, "sequence": "MVLSLTGLIAFSFLQATLALNPEDPNVCSHWESYAVTVQESYAHPFDQIYYTRCTDILNWFKCTRHRISYKTAYRRGLRTMYRRRSQCCPGYYESGDFCIPLCTEECVHGRCVSPDTCHCEPGWGGPDCSSGCDSDHWGPHCSNRCQCQNGALCNPITGACVCAAGFRGWRCEELCAPGTHGKGCQLPCQCRHGASCDPRAGECLCAPGYTGVYCEELCPPGSHGAHCELRCPCQNGGTCHHITGECACPPGWTGAVCAQPCPPGTFGQNCSQDCPCHHGGQCDHVTGQCHCTAGYMGDRCQEECPFGSFGFQCSQHCDCHNGGQCSPTTGACECEPGYKGPRCQERLCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPGWSGHHCNESCPVGYYGDGCQLPCTCQNGADCHSITGGCTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNNGGTCSPVDGSCTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDGSCSCTPGWLGDTCELPCPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSCENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVHSSRPCHHISGICECLPGFSGALCNQVCAGGYFGQDCAQLCSCANNGTCSPIDGSCQCFPGWIGKDCSQACPPGFWGPACFHACSCHNGASCSAEDGACHCTPGWTGLFCTQRCPAAFFGKDCGRVCQCQNGASCDHISGKCTCRTGFTGQHCEQRCAPGTFGYGCQQLCECMNNSTCDHVTGTCYCSPGFKGIRCDQAALMMEELNPYTKISPALGAERHSVGAVTGIMLLLFLIVVLLGLFAWHRRRQKEKGRDLAPRVSYTPAMRMTSTDYSLSDLSQSSSHAHCFSNSSYHALACGGPATSQASTLDRNSPTKLSNKSLDRDTAGWTPYSYVNVLDSHFQISALEARYPPEDFYIELRHLSRPAEPHSPGACGMDRRQNTYIMDKGFKDYMKESVCSSSTCSLNSSENPYATIKDPPILTCKLPESSYVEMKSPVHMGSPYTDVPSLSTSNKNIYEVEPTVSVVQEGCGHNSSYIQNAYDLPRNSHIPGHYDLLPVRQSPANGPSQDKQS" } }, { "url": "https://www.uniprot.org/uniprot/A6BM72#A0A0G2JMV8-1", "isoform_ac": "A0A0G2JMV8-1", "locus": { "end_pos": 65915548, "start_pos": 65970689, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000614417", "id": "ENST00000614417", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000480105", "id": "ENSP00000480105", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JMV8-1|MEG11_HUMAN Computationally mapped isoform of Multiple epidermal growth factor-like domains protein 11 OS=Homo sapiens OX=9606 GN=MEGF11 PE=2 SV=1 CANONICAL=A6BM72-1", "length": 621, "sequence": "GAVCAQPCPPGTFGQNCSQDCPCHHGGQCDHVTGQCHCTAGYMGDRCQEECPFGSFGFQCSQHCDCHNGGQCSPTTGACECEPGYKGPRCQERLCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPGWSGHHCNESCPVGYYGDGCQLPCTCQNGADCHSITGGCTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNNGGTCSPVDGSCTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDGSCSCTPGWLGDTCELPCPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSCENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVHSSRPCHHISGICECLPGFSGALCNQVCAGGYFGQDCAQLCSCANNGTCSPIDGSCQCFPGWIGKDCSQACPPGFWGPACFHACSCHNGASCSAEDGACHCTPGWTGLFCTQRKPHLLASQPLRIPCCGLLATVGIVQTSREGGMQAAPGLVVPDSCPTRTEELCRGSSRPDWIQGIDKPKVLEGQGCKAAQQHFLGRTVGAYASVRMAPAVTTSVASAPAAQASPGNTVSRDVPQEPLAMGVSSYVSA" } }, { "url": "https://www.uniprot.org/uniprot/A6BM72#A0A087WT97-1", "isoform_ac": "A0A087WT97-1", "locus": { "end_pos": 65922056, "start_pos": 65922375, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000564573", "id": "ENST00000564573", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000477691", "id": "ENSP00000477691", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A087WT97-1|MEG11_HUMAN Computationally mapped isoform of Multiple epidermal growth factor-like domains protein 11 OS=Homo sapiens OX=9606 GN=MEGF11 PE=2 SV=1 CANONICAL=A6BM72-1", "length": 30, "sequence": "XCLPGFSGALCNQASKWQKQILIPTCMLKG" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:84465", "resource": "KEGG Pathway", "id": "hsa:84465", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A6BM72#function", "annotation": "May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6BM72#function", "id": "A6BM72", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_115821.2", "annotation": "Observational study of gene-disease association. (HuGE Navigator)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_115821.2", "id": "NP_115821.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q80T91-1", "protein_name": "Multiple epidermal growth factor-like domains protein 11; Multiple EGF-like domains protein 11.", "sequence": { "length": 1091, "sequence": "MAPSAVGLLVFLLQAALALNPEDPNVCSHWESYAVTVQESYAHPFDQIYYTRCADILNWFKCTRHRISYKTAYRRGLRTMYRRRSQCCPGYYENGDFCIPLCTEECMHGRCVSPDTCHCEPGWGGPDCSSGCDSEHWGPHCSNRCQCQNGALCNPITGACVCAPGFRGWRCEELCAPGTHGKGCQLLCQCHHGASCDPRTGECLCAPGYTGVYCEELCPPGSHGAHCELRCPCQNGGTCHHITGECACPPGWTGAVCAQPCPPGTFGQNCSQDCPCHHGGQCDHVTGQCHCTAGYMGDRCQEECPFGTFGFLCSQRCDCHNGGQCSPATGACECEPGYKGPSCQERLCPEGLHGPGCTLPCPCDTENTISCHPVTGACTCQPGWSGHYCNESCPAGYYGNGCQLPCTCQNGADCHSITGSCTCAPGFMGEVCAVPCAAGTYGPNCSSVCSCSNGGTCSPVDGSCTCREGWQGLDCSLPCPSGTWGLNCNETCICANGAACSPFDGSCACTPGWLGDSCELPCPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSCENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVHSRGPCHHISGICECLPGFSGALCNQVCAGGHFGQDCAQLCSCANNGTCSPIDGSCQCFPGWIGKDCSQACPSGFWGSACFHTCSCHNGASCSAEDGACHCTPGWTGLFCTQRCPSAFFGKDCGHICQCQNGASCDHITGKCTCRTGFSGRHCEQRCAPGTFGYGCQQLCECMNNATCDHVTGTCYCSPGFKGIRCDQAALMMDELNPYTKISPALGAERHSVGAVTGIVLLLFLVVVLLGLFAWRRRRQKEKGRDLAPRVSYTPAMRMTSTDYSLSDLSQSSSHAQCFSNASYHTLACGGPATSQASTLDRNSPTKLSNKSLDRDTAGWTPYSYVNVLDSHFQISALEARYPPEDFYIELRHLSRHAEPHSPGTCGMDRRQNTYIMDKGFKDYMKESVCSSSTCSLNSSENPYATIKDPPILTCKLPESSYVEMKSPVHLGSPYTDVPSLSTSNKNIYEVGRCLT" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/13031", "id": "13031", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_115821.2", "ac": "NP_115821.2", "name": "multiple epidermal growth factor-like domains protein 11 precursor; multiple epidermal growth factor-like domains protein 11; multiple EGF-like domains protein 11.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6BM72", "id": "A6BM72", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6BM72", "id": "A6BM72", "database": "UniProtKB" } ], "name": "basolateral plasma membrane", "id": "GO:0016323" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034109", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6BM72", "id": "A6BM72", "database": "UniProtKB" } ], "name": "homotypic cell-cell adhesion", "id": "GO:0034109" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010842", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6BM72", "id": "A6BM72", "database": "UniProtKB" } ], "name": "retina layer formation", "id": "GO:0010842" } ], "total": 2, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 272, "annotation": "n_glycosylation_sequon", "start_pos": 270 }, { "end_pos": 393, "annotation": "n_glycosylation_sequon", "start_pos": 391 }, { "end_pos": 447, "annotation": "n_glycosylation_sequon", "start_pos": 445 }, { "end_pos": 492, "annotation": "n_glycosylation_sequon", "start_pos": 490 }, { "end_pos": 533, "annotation": "n_glycosylation_sequon", "start_pos": 531 }, { "end_pos": 576, "annotation": "n_glycosylation_sequon", "start_pos": 574 }, { "end_pos": 674, "annotation": "n_glycosylation_sequon", "start_pos": 672 }, { "end_pos": 802, "annotation": "n_glycosylation_sequon", "start_pos": 800 }, { "end_pos": 803, "annotation": "n_glycosylation_sequon", "start_pos": 801 }, { "end_pos": 940, "annotation": "n_glycosylation_sequon", "start_pos": 938 }, { "end_pos": 1007, "annotation": "n_glycosylation_sequon", "start_pos": 1005 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_115821.2", "id": "NP_115821.2", "database": "RefSeq" }, { "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=29635", "id": "29635", "database": "HGNC" }, { "url": "https://pharos.nih.gov/targets/A6BM72", "id": "A6BM72", "database": "PHAROS" }, { "url": "https://www.nextprot.org/entry/NX_A6BM72", "id": "NX_A6BM72", "database": "neXtProt" }, { "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=MEGF11", "id": "MEGF11", "database": "GeneCards" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:84465", "id": "hsa:84465", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157890", "id": "ENSG00000157890", "database": "Bgee" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "id": "IPR000742", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013032", "id": "IPR013032", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002049", "id": "IPR002049", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011489", "id": "IPR011489", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00053", "id": "PF00053", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF12661", "id": "PF12661", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A6BM72", "id": "PR_A6BM72", "database": "PRO" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A6BM72*", "id": "A6BM72", "database": "IntAct" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/84465", "id": "84465", "database": "GeneID" } ], "expression_disease": [ { "trend": "Down", "disease": { "doid": "3910", "url": "http://disease-ontology.org/term/DOID:3910", "icd10": "", "name": "DOID:3910 / Lung adenocarcinoma" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6BM72", "id": "A6BM72", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "3571", "url": "http://disease-ontology.org/term/DOID:3571", "icd10": "", "name": "DOID:3571 / Liver cancer [Livca]" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6BM72", "id": "A6BM72", "database": "BioXpress" } ] }, { "trend": "Down", "disease": { "doid": "5041", "url": "http://disease-ontology.org/term/DOID:5041", "icd10": "", "name": "DOID:5041 / Esophageal cancer [EC]" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6BM72", "id": "A6BM72", "database": "BioXpress" } ] }, { "trend": "Down", "disease": { "doid": "10283", "url": "http://disease-ontology.org/term/DOID:10283", "icd10": "", "name": "DOID:10283 / Prostate cancer [PCa]" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6BM72", "id": "A6BM72", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "11054", "url": "http://disease-ontology.org/term/DOID:11054", "icd10": "", "name": "DOID:11054 / Urinary bladder cancer [UBC]" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6BM72", "id": "A6BM72", "database": "BioXpress" } ] }, { "trend": "Down", "disease": { "doid": "3907", "url": "http://disease-ontology.org/term/DOID:3907", "icd10": "", "name": "DOID:3907 / Lung squamous cell carcinoma" }, "significant": "Yes", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6BM72", "id": "A6BM72", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "DOID:1781 / Thyroid cancer [Thyca]" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6BM72", "id": "A6BM72", "database": "BioXpress" } ] } ], "uniprot_ac": "A6BM72", "disease": [], "mass": { "monoisotopic_mass": 110844.0, "chemical_mass": 110844.0 }, "expression_tissue": [ { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0009853", "uberon": "0009853", "name": "Body of uterus" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157890", "id": "ENSG00000157890", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000458", "uberon": "0000458", "name": "Endocervix" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157890", "id": "ENSG00000157890", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000948", "uberon": "0000948", "name": "Heart" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157890", "id": "ENSG00000157890", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000473", "uberon": "0000473", "name": "Testis" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157890", "id": "ENSG00000157890", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002369", "uberon": "0002369", "name": "Adrenal gland" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157890", "id": "ENSG00000157890", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000992", "uberon": "0000992", "name": "Ovary" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157890", "id": "ENSG00000157890", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000996", "uberon": "0000996", "name": "Vagina" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157890", "id": "ENSG00000157890", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001155", "uberon": "0001155", "name": "Colon" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157890", "id": "ENSG00000157890", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001987", "uberon": "0001987", "name": "Placenta" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157890", "id": "ENSG00000157890", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000955", "uberon": "0000955", "name": "Brain" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157890", "id": "ENSG00000157890", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001160", "uberon": "0001160", "name": "Fundus of stomach" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157890", "id": "ENSG00000157890", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001150", "uberon": "0001150", "name": "Body of pancreas" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157890", "id": "ENSG00000157890", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002048", "uberon": "0002048", "name": "Lung" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157890", "id": "ENSG00000157890", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000007", "uberon": "0000007", "name": "Pituitary gland" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157890", "id": "ENSG00000157890", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002107", "uberon": "0002107", "name": "Liver" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157890", "id": "ENSG00000157890", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002046", "uberon": "0002046", "name": "Thyroid gland" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157890", "id": "ENSG00000157890", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000178", "uberon": "0000178", "name": "Blood" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157890", "id": "ENSG00000157890", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001043", "uberon": "0001043", "name": "Esophagus" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157890", "id": "ENSG00000157890", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002367", "uberon": "0002367", "name": "Prostate gland" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157890", "id": "ENSG00000157890", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001161", "uberon": "0001161", "name": "Body of stomach" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157890", "id": "ENSG00000157890", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001255", "uberon": "0001255", "name": "Urinary bladder" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157890", "id": "ENSG00000157890", "database": "Bgee" } ] } ], "gene": [ { "url": "https://www.uniprot.org/uniprot/A6BM72", "name": "MEGF11; KIAA1781; PRO4432.", "locus": { "end_pos": 65895079, "start_pos": 66253747, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENSG00000157890", "id": "ENSG00000157890", "database": "Ensembl Gene" } ] } } ] }