{ "uniprot_canonical_ac": "A5YKK6-1", "sequence": { "header": "sp|A5YKK6-1|CNOT1_HUMAN Isoform 1 of CCR4-NOT transcription complex subunit 1 OS=Homo sapiens OX=9606 GN=CNOT1 PE=1 SV=2 CANONICAL=A5YKK6-1", "length": 2376, "sequence": "MNLDSLSLALSQISYLVDNLTKKNYRASQQEIQHIVNRHGPEADRHLLRCLFSHVDFSGDGKSSGKDFHQTQFLIQECALLITKPNFISTLSYAIDNPLHYQKSLKPAPHLFAQLSKVLKLSKVQEVIFGLALLNSSSSDLRGFAAQFIKQKLPDLLRSYIDADVSGNQEGGFQDIAIEVLHLLLSHLLFGQKGAFGVGQEQIDAFLKTLRRDFPQERCPVVLAPLLYPEKRDILMDRILPDSGGVAKTMMESSLADFMQEVGYGFCASIEECRNIIVQFGVREVTAAQVARVLGMMARTHSGLTDGIPLQSISAPGSGIWSDGKDKSDGAQAHTWNVEVLIDVLKELNPSLNFKEVTYELDHPGFQIRDSKGLHNVVYGIQRGLGMEVFPVDLIYRPWKHAEGQLSFIQHSLINPEIFCFADYPCHTVATDILKAPPEDDNREIATWKSLDLIESLLRLAEVGQYEQVKQLFSFPIKHCPDMLVLALLQINTSWHTLRHELISTLMPIFLGNHPNSAIILHYAWHGQGQSPSIRQLIMHAMAEWYMRGEQYDQAKLSRILDVAQDLKALSMLLNGTPFAFVIDLAALASRREYLKLDKWLTDKIREHGEPFIQACMTFLKRRCPSILGGLAPEKDQPKSAQLPPETLATMLACLQACAGSVSQELSETILTMVANCSNVMNKARQPPPGVMPKGRPPSASSLDAISPVQIDPLAGMTSLSIGGSAAPHTQSMQGFPPNLGSAFSTPQSPAKAFPPLSTPNQTTAFSGIGGLSSQLPVGGLGTGSLTGIGTGALGLPAVNNDPFVQRKLGTSGLNQPTFQQSKMKPSDLSQVWPEANQHFSKEIDDEANSYFQRIYNHPPHPTMSVDEVLEMLQRFKDSTIKREREVFNCMLRNLFEEYRFFPQYPDKELHITACLFGGIIEKGLVTYMALGLALRYVLEALRKPFGSKMYYFGIAALDRFKNRLKDYPQYCQHLASISHFMQFPHHLQEYIEYGQQSRDPPVKMQGSITTPGSIALAQAQAQAQVPAKAPLAGQVSTMVTTSTTTTVAKTVTVTRPTGVSFKKDVPPSINTTNIDTLLVATDQTERIVEPPENIQEKIAFIFNNLSQSNMTQKVEELKETVKEEFMPWVSQYLVMKRVSIEPNFHSLYSNFLDTLKNPEFNKMVLNETYRNIKVLLTSDKAAANFSDRSLLKNLGHWLGMITLAKNKPILHTDLDVKSLLLEAYVKGQQELLYVVPFVAKVLESSIRSVVFRPPNPWTMAIMNVLAELHQEHDLKLNLKFEIEVLCKNLALDINELKPGNLLKDKDRLKNLDEQLSAPKKDVKQPEELPPITTTTTSTTPATNTTCTATVPPQPQYSYHDINVYSLAGLAPHITLNPTIPLFQAHPQLKQCVRQAIERAVQELVHPVVDRSIKIAMTTCEQIVRKDFALDSEESRMRIAAHHMMRNLTAGMAMITCREPLLMSISTNLKNSFASALRTASPQQREMMDQAAAQLAQDNCELACCFIQKTAVEKAGPEMDKRLATEFELRKHARQEGRRYCDPVVLTYQAERMPEQIRLKVGGVDPKQLAVYEEFARNVPGFLPTNDLSQPTGFLAQPMKQAWATDDVAQIYDKCITELEQHLHAIPPTLAMNPQAQALRSLLEVVVLSRNSRDAIAALGLLQKAVEGLLDATSGADADLLLRYRECHLLVLKALQDGRAYGSPWCNKQITRCLIECRDEYKYNVEAVELLIRNHLVNMQQYDLHLAQSMENGLNYMAVAFAMQLVKILLVDERSVAHVTEADLFHTIETLMRINAHSRGNAPEGLPQLMEVVRSNYEAMIDRAHGGPNFMMHSGISQASEYDDPPGLREKAEYLLREWVNLYHSAAAGRDSTKAFSAFVGQMHQQGILKTDDLITRFFRLCTEMCVEISYRAQAEQQHNPAANPTMIRAKCYHNLDAFVRLIALLVKHSGEATNTVTKINLLNKVLGIVVGVLLQDHDVRQSEFQQLPYHRIFIMLLLELNAPEHVLETINFQTLTAFCNTFHILRPTKAPGFVYAWLELISHRIFIARMLAHTPQQKGWPMYAQLLIDLFKYLAPFLRNVELTKPMQILYKGTLRVLLVLLHDFPEFLCDYHYGFCDVIPPNCIQLRNLILSAFPRNMRLPDPFTPNLKVDMLSEINIAPRILTNFTGVMPPQFKKDLDSYLKTRSPVTFLSDLRSNLQVSNEPGNRYNLQLINALVLYVGTQAIAHIHNKGSTPSMSTITHSAHMDIFQNLAVDLDTEGRYLFLNAIANQLRYPNSHTHYFSCTMLYLFAEANTEAIQEQITRVLLERLIVNRPHPWGLLITFIELIKNPAFKFWNHEFVHCAPEIEKLFQSVAQCCMGQKQAQQVMEGTGAS" }, "uniprot_id": "CNOT1_HUMAN", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "CCR4-NOT transcription complex subunit 1 isoform c", "NOT1 (negative regulator of transcription 1, yeast) homolog; adrenal gland protein AD-005; CCR4-associated factor 1; negative regulator of transcription subunit 1 homolog" ], "uniprotkb": [ "CCR4-NOT transcription complex subunit 1", "Negative regulator of transcription subunit 1 homolog", "NOT1H", "hNOT1", "CCR4-associated factor 1" ] }, "gene": { "refseq": [ "CNOT1", "AD-005", "CDC39", "HPE12", "NOT1", "NOT1H" ], "uniprotkb": [ "CNOT1", "CDC39", "AD-005", "KIAA1007", "NOT1", "HPE12", "NOT1H" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5YKK6", "id": "A5YKK6", "database": "UniProtKB" } ], "name": "Homo sapiens", "taxid": 9606 } ], "recommendedname": { "full": "CCR4-NOT transcription complex subunit 1; Negative regulator of transcription subunit 1 homolog; NOT1H; hNOT1; CCR4-associated factor 1." }, "publication": [ { "title": "A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/30833792", "journal": "Nature immunology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001252541.1", "id": "NP_001252541.1", "database": "RefSeq" } ], "authors": "Hubel P, Urban C, Bergant V, Schneider WM, Knauer B, Stukalov A, Scaturro P, Mann A, Brunotte L, Hoffmann HH, Schoggins JW, Schwemmle M, Mann M, Rice CM, Pichlmair A", "date": "2019", "pmid": "30833792" }, { "title": "The central region of CNOT1 and CNOT9 stimulates deadenylation by the Ccr4-Not nuclease module.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/30309886", "journal": "The Biochemical journal", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001252541.1", "id": "NP_001252541.1", "database": "RefSeq" } ], "authors": "Pavanello L, Hall B, Airhihen B, Winkler GS", "date": "2018", "pmid": "30309886" }, { "title": "CNOT1 is involved in TTPmediated ICAM1 and IL8 mRNA decay.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/29956766", "journal": "Molecular medicine reports", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001252541.1", "id": "NP_001252541.1", "database": "RefSeq" } ], "authors": "Shi JX, Li JS, Hu R, Zhao XC, Liang CC, Li XM, Wang H, Shi Y, Su X", "date": "2018", "pmid": "29956766" }, { "title": "Molecular partners of hNOT/ALG3, the human counterpart of the Drosophila NOT and yeast ALG3 gene, suggest its involvement in distinct cellular processes relevant to congenital disorders of glycosylation, cancer, neurodegeneration and a variety of further pathologies.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/29547901", "journal": "Human molecular genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001252541.1", "id": "NP_001252541.1", "database": "RefSeq" } ], "authors": "Hacker B, Schultheiss C, Doring M, Kurzik-Dumke U", "date": "2018", "pmid": "29547901" }, { "title": "The CCR4-NOT complex contributes to repression of Major Histocompatibility Complex class II transcription.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/28615693", "journal": "Scientific reports", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001252541.1", "id": "NP_001252541.1", "database": "RefSeq" } ], "authors": "Rodriguez-Gil A, Ritter O, Saul VV, Wilhelm J, Yang CY, Grosschedl R, Imai Y, Kuba K, Kracht M, Schmitz ML", "date": "2017", "pmid": "28615693" }, { "title": "YTHDF2 destabilizes m(6)A-containing RNA through direct recruitment of the CCR4-NOT deadenylase complex.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/27558897", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5YKK6/publications", "id": "A5YKK6", "database": "UniProtKB" } ], "authors": "Du H., Liu M., Ma J., Wu L., Zhang Y., Zhao Y., He J., Xi H.", "date": "2016", "pmid": "27558897" }, { "title": "Structural basis for the recruitment of the human CCR4-NOT deadenylase complex by tristetraprolin.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/23644599", "journal": "Nat. Struct. Mol. Biol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5YKK6/publications", "id": "A5YKK6", "database": "UniProtKB" } ], "authors": "Nagar B., Sonenberg N., Fabian M.R., Frank F., Blackshear P.J., Karetnikov A., Lai W.S., Rouya C., Siddiqui N.", "date": "2013", "pmid": "23644599" }, { "title": "Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22367759", "journal": "Stem Cells", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5YKK6/publications", "id": "A5YKK6", "database": "UniProtKB" } ], "authors": "Hu G., Zheng X., Archer T.K., Dumitru R., Freudenberg J.M., Jothi R., Lackford B.L., Singh A.P.", "date": "2012", "pmid": "22367759" }, { "title": "The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22977175", "journal": "Nucleic Acids Res.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5YKK6/publications", "id": "A5YKK6", "database": "UniProtKB" } ], "authors": "Izaurralde E., Schmidt S., Huntzinger E., Wohlbold L., Bawankar P., Petit A.P., Weichenrieder O.", "date": "2012", "pmid": "22977175" }, { "title": "GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/21981923", "journal": "Mol. Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5YKK6/publications", "id": "A5YKK6", "database": "UniProtKB" } ], "authors": "Izaurralde E., Braun J.E., Fauser M., Huntzinger E.", "date": "2011", "pmid": "21981923" }, { "title": "Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/21278420", "journal": "Nucleic Acids Res.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5YKK6/publications", "id": "A5YKK6", "database": "UniProtKB" } ], "authors": "Stoecklin G., Timmers H.T., Kreth J., Sandler H.", "date": "2011", "pmid": "21278420" }, { "title": "miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/21984185", "journal": "Nat. Struct. Mol. Biol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5YKK6/publications", "id": "A5YKK6", "database": "UniProtKB" } ], "authors": "Yamamoto T., Nagar B., Raught B., Sonenberg N., Morita M., Green J., Fabian M.R., Frank F., Srikumar T., Cieplak M.K., Duchaine T.F.", "date": "2011", "pmid": "21984185" }, { "title": "The role of the CNOT1 subunit of the CCR4-NOT complex in mRNA deadenylation and cell viability.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/21976065", "journal": "Protein Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5YKK6/publications", "id": "A5YKK6", "database": "UniProtKB" } ], "authors": "Suzuki T., Yamamoto T., Ito K., Takahashi A., Morita M.", "date": "2011", "pmid": "21976065" }, { "title": "Human Ccr4-Not complexes contain variable deadenylase subunits.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/19558367", "journal": "Biochem. J.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5YKK6/publications", "id": "A5YKK6", "database": "UniProtKB" } ], "authors": "Heck A.J., Pijnappel W.W., Timmers H.T., Kolkman A., Lau N.C., Mulder K.W., van Schaik F.M.", "date": "2009", "pmid": "19558367" }, { "title": "Interaction of antiproliferative protein Tob with the CCR4-NOT deadenylase complex.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/18377426", "journal": "Cancer Sci.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5YKK6/publications", "id": "A5YKK6", "database": "UniProtKB" } ], "authors": "Suzuki T., Takeda S., Yamamoto T., Ito K., Morita M., Semba K., Inoue J., Fukuda H., Miyasaka T.", "date": "2008", "pmid": "18377426" }, { "title": "Human Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcription.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/16778766", "journal": "EMBO J.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5YKK6/publications", "id": "A5YKK6", "database": "UniProtKB" } ], "authors": "Bardwell V.J., Timmers H.T., Winkler G.S., Kalkhoven E., Mulder K.W.", "date": "2006", "pmid": "16778766" }, { "title": "Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/11733989", "journal": "Journal of molecular biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001252541.1", "id": "NP_001252541.1", "database": "RefSeq" } ], "authors": "Chen J, Rappsilber J, Chiang YC, Russell P, Mann M, Denis CL", "date": "2001", "pmid": "11733989" }, { "title": "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/10637334", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001252541.1", "id": "NP_001252541.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A5YKK6/publications", "id": "A5YKK6", "database": "UniProtKB" } ], "authors": "Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT", "date": "2000", "pmid": "10637334" }, { "title": "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/10931946", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5YKK6/publications", "id": "A5YKK6", "database": "UniProtKB" } ], "authors": "Chen J.-L., Chen M.-D., Chen Z., Dai M., Fu G., Gao G.-F., Gu B.-W., Gu J., Gu Y.-J., Han Z.-G., Hu R.-M., Huang C.-H., Huang G.-Y., Huang Q.-H., Jiang C.-L., Jin W.-R., Li Y.-B., Mao Y.-F., Peng Y.-D., Ren S.-X., Rong R., Shi J.-X., Song H.-D., Wu T.-M., Xu S.-H., Ye M., Zhang C.-K., Zhang Q.-H., Zhou J.", "date": "2000", "pmid": "10931946" } ], "glycosylation": [ { "residue": "Thr", "evidence": [ { "url": "https://data.glygen.org/GLYDS000142", "id": "GLYDS000142", "database": "GlyGen" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/29351928", "id": "29351928", "database": "PubMed" } ], "relation": "attached", "position": 1051, "glytoucan_ac": "G70994MS", "type": "O-linked" } ], "mutation": [ { "start_pos": 347, "subjects_positive": "36", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "2.4", "annotation": "Filters passed (2/5): patient freq. (2.4%); patient count (36/1514).", "sequence_org": "E", "disease": { "doid": "1324", "url": "http://disease-ontology.org/term/DOID:1324", "icd10": "", "name": "Lung cancer" }, "sequence_mut": "D", "subjects_tested": "1514", "end_pos": 347, "type": "Point mutation" }, { "start_pos": 1189, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (2/5): patient freq. (2.0%); num. of cancers (3).", "sequence_org": "R", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "H", "subjects_tested": "50", "end_pos": 1189, "type": "Point mutation" }, { "start_pos": 2197, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "0.2", "annotation": "Filters passed (1/5): num. of cancers (3).", "sequence_org": "R", "disease": { "doid": "363", "url": "http://disease-ontology.org/term/DOID:363", "icd10": "", "name": "Uterine cancer" }, "sequence_mut": "H", "subjects_tested": "558", "end_pos": 2197, "type": "Point mutation" }, { "start_pos": 2055, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "T", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "A", "subjects_tested": "50", "end_pos": 2055, "type": "Point mutation" }, { "start_pos": 660, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "1.5", "annotation": "Filters passed (1/5): patient freq. (1.5%).", "sequence_org": "G", "disease": { "doid": "1324", "url": "http://disease-ontology.org/term/DOID:1324", "icd10": "", "name": "Lung cancer" }, "sequence_mut": "A", "subjects_tested": "66", "end_pos": 660, "type": "Point mutation" }, { "start_pos": 2045, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "0.1", "annotation": "Filters passed (1/5): num. of cancers (3).", "sequence_org": "R", "disease": { "doid": "11054", "url": "http://disease-ontology.org/term/DOID:11054", "icd10": "", "name": "Urinary bladder cancer" }, "sequence_mut": "W", "subjects_tested": "742", "end_pos": 2045, "type": "Point mutation" }, { "start_pos": 1189, "subjects_positive": "2", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "0.2", "annotation": "Filters passed (1/5): num. of cancers (3).", "sequence_org": "R", "disease": { "doid": "10534", "url": "http://disease-ontology.org/term/DOID:10534", "icd10": "", "name": "Stomach cancer" }, "sequence_mut": "H", "subjects_tested": "1044", "end_pos": 1189, "type": "Point mutation" }, { "start_pos": 1196, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "G", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "*", "subjects_tested": "50", "end_pos": 1196, "type": "Point mutation" }, { "start_pos": 2208, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "N", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "D", "subjects_tested": "50", "end_pos": 2208, "type": "Point mutation" }, { "start_pos": 158, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "0.1", "annotation": "Filters passed (1/5): num. of cancers (3).", "sequence_org": "R", "disease": { "doid": "10534", "url": "http://disease-ontology.org/term/DOID:10534", "icd10": "", "name": "Stomach cancer" }, "sequence_mut": "H", "subjects_tested": "1044", "end_pos": 158, "type": "Point mutation" }, { "start_pos": 369, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "0.1", "annotation": "Filters passed (1/5): num. of cancers (3). In dbSNP: rs371890421.", "sequence_org": "R", "disease": { "doid": "10283", "url": "http://disease-ontology.org/term/DOID:10283", "icd10": "", "name": "Prostate cancer" }, "sequence_mut": "C", "subjects_tested": "1118", "end_pos": 369, "type": "Point mutation" }, { "start_pos": 1068, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "P", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "S", "subjects_tested": "50", "end_pos": 1068, "type": "Point mutation" }, { "start_pos": 2197, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "0.2", "annotation": "Filters passed (1/5): num. of cancers (3).", "sequence_org": "R", "disease": { "doid": "9256", "url": "http://disease-ontology.org/term/DOID:9256", "icd10": "", "name": "Colorectal cancer" }, "sequence_mut": "H", "subjects_tested": "456", "end_pos": 2197, "type": "Point mutation" }, { "start_pos": 2045, "subjects_positive": "2", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "0.4", "annotation": "Filters passed (1/5): num. of cancers (3).", "sequence_org": "R", "disease": { "doid": "363", "url": "http://disease-ontology.org/term/DOID:363", "icd10": "", "name": "Uterine cancer" }, "sequence_mut": "W", "subjects_tested": "558", "end_pos": 2045, "type": "Point mutation" }, { "start_pos": 299, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "1.1", "annotation": "Filters passed (1/5): patient freq. (1.1%). In dbSNP: rs34830321.", "sequence_org": "R", "disease": { "doid": "9256", "url": "http://disease-ontology.org/term/DOID:9256", "icd10": "", "name": "Colorectal cancer" }, "sequence_mut": "Q", "subjects_tested": "94", "end_pos": 299, "type": "Point mutation" }, { "start_pos": 2230, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "I", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "T", "subjects_tested": "50", "end_pos": 2230, "type": "Point mutation" }, { "start_pos": 1640, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "0.1", "annotation": "Filters passed (1/5): num. of cancers (3).", "sequence_org": "R", "disease": { "doid": "1324", "url": "http://disease-ontology.org/term/DOID:1324", "icd10": "", "name": "Lung cancer" }, "sequence_mut": "*", "subjects_tested": "689", "end_pos": 1640, "type": "Point mutation" }, { "start_pos": 1376, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "1.3", "annotation": "Filters passed (1/5): patient freq. (1.3%).", "sequence_org": "L", "disease": { "doid": "1319", "url": "http://disease-ontology.org/term/DOID:1319", "icd10": "", "name": "Brain cancer" }, "sequence_mut": "V", "subjects_tested": "78", "end_pos": 1376, "type": "Point mutation" }, { "start_pos": 369, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "0.2", "annotation": "Filters passed (1/5): num. of cancers (3). In dbSNP: rs371890421.", "sequence_org": "R", "disease": { "doid": "363", "url": "http://disease-ontology.org/term/DOID:363", "icd10": "", "name": "Uterine cancer" }, "sequence_mut": "C", "subjects_tested": "558", "end_pos": 369, "type": "Point mutation" }, { "start_pos": 1154, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "1.1", "annotation": "Filters passed (1/5): patient freq. (1.1%).", "sequence_org": "D", "disease": { "doid": "2394", "url": "http://disease-ontology.org/term/DOID:2394", "icd10": "", "name": "Ovarian cancer" }, "sequence_mut": "H", "subjects_tested": "93", "end_pos": 1154, "type": "Point mutation" }, { "start_pos": 1189, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "0.3", "annotation": "Filters passed (1/5): num. of cancers (3).", "sequence_org": "R", "disease": { "doid": "1793", "url": "http://disease-ontology.org/term/DOID:1793", "icd10": "", "name": "Pancreatic cancer" }, "sequence_mut": "H", "subjects_tested": "399", "end_pos": 1189, "type": "Point mutation" }, { "start_pos": 158, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "0.1", "annotation": "Filters passed (1/5): num. of cancers (3).", "sequence_org": "R", "disease": { "doid": "1319", "url": "http://disease-ontology.org/term/DOID:1319", "icd10": "", "name": "Brain cancer" }, "sequence_mut": "H", "subjects_tested": "678", "end_pos": 158, "type": "Point mutation" }, { "start_pos": 499, "subjects_positive": "3", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "0.5", "annotation": "Filters passed (1/5): num. of cancers (3). In dbSNP: rs763930906.", "sequence_org": "R", "disease": { "doid": "363", "url": "http://disease-ontology.org/term/DOID:363", "icd10": "", "name": "Uterine cancer" }, "sequence_mut": "H", "subjects_tested": "558", "end_pos": 499, "type": "Point mutation" }, { "start_pos": 1640, "subjects_positive": "2", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "1.2", "annotation": "Filters passed (1/5): patient freq. (1.2%). In dbSNP: rs181822641.", "sequence_org": "R", "disease": { "doid": "9256", "url": "http://disease-ontology.org/term/DOID:9256", "icd10": "", "name": "Colorectal cancer" }, "sequence_mut": "Q", "subjects_tested": "162", "end_pos": 1640, "type": "Point mutation" }, { "start_pos": 499, "subjects_positive": "2", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "0.4", "annotation": "Filters passed (1/5): num. of cancers (3). In dbSNP: rs763930906.", "sequence_org": "R", "disease": { "doid": "9256", "url": "http://disease-ontology.org/term/DOID:9256", "icd10": "", "name": "Colorectal cancer" }, "sequence_mut": "H", "subjects_tested": "456", "end_pos": 499, "type": "Point mutation" }, { "start_pos": 130, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "G", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "V", "subjects_tested": "50", "end_pos": 130, "type": "Point mutation" }, { "start_pos": 158, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "0.2", "annotation": "Filters passed (1/5): num. of cancers (3).", "sequence_org": "R", "disease": { "doid": "363", "url": "http://disease-ontology.org/term/DOID:363", "icd10": "", "name": "Uterine cancer" }, "sequence_mut": "H", "subjects_tested": "558", "end_pos": 158, "type": "Point mutation" }, { "start_pos": 1640, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "0.2", "annotation": "Filters passed (1/5): num. of cancers (3).", "sequence_org": "R", "disease": { "doid": "9256", "url": "http://disease-ontology.org/term/DOID:9256", "icd10": "", "name": "Colorectal cancer" }, "sequence_mut": "*", "subjects_tested": "456", "end_pos": 1640, "type": "Point mutation" }, { "start_pos": 2045, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "0.2", "annotation": "Filters passed (1/5): num. of cancers (3).", "sequence_org": "R", "disease": { "doid": "9256", "url": "http://disease-ontology.org/term/DOID:9256", "icd10": "", "name": "Colorectal cancer" }, "sequence_mut": "W", "subjects_tested": "456", "end_pos": 2045, "type": "Point mutation" }, { "start_pos": 1640, "subjects_positive": "2", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "0.4", "annotation": "Filters passed (1/5): num. of cancers (3).", "sequence_org": "R", "disease": { "doid": "363", "url": "http://disease-ontology.org/term/DOID:363", "icd10": "", "name": "Uterine cancer" }, "sequence_mut": "*", "subjects_tested": "558", "end_pos": 1640, "type": "Point mutation" }, { "start_pos": 499, "subjects_positive": "2", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "0.2", "annotation": "Filters passed (1/5): num. of cancers (3). In dbSNP: rs763930906.", "sequence_org": "R", "disease": { "doid": "10534", "url": "http://disease-ontology.org/term/DOID:10534", "icd10": "", "name": "Stomach cancer" }, "sequence_mut": "H", "subjects_tested": "1044", "end_pos": 499, "type": "Point mutation" }, { "start_pos": 1065, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "D", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "Y", "subjects_tested": "50", "end_pos": 1065, "type": "Point mutation" }, { "start_pos": 204, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "D", "disease": { "doid": "1612", "url": "http://disease-ontology.org/term/DOID:1612", "icd10": "", "name": "Breast cancer" }, "sequence_mut": "G", "subjects_tested": "50", "end_pos": 204, "type": "Point mutation" }, { "start_pos": 369, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "0.2", "annotation": "Filters passed (1/5): num. of cancers (3). In dbSNP: rs371890421.", "sequence_org": "R", "disease": { "doid": "9256", "url": "http://disease-ontology.org/term/DOID:9256", "icd10": "", "name": "Colorectal cancer" }, "sequence_mut": "C", "subjects_tested": "456", "end_pos": 369, "type": "Point mutation" }, { "start_pos": 1713, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "C", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "Y", "subjects_tested": "50", "end_pos": 1713, "type": "Point mutation" }, { "start_pos": 2177, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "1.0", "annotation": "Filters passed (1/5): patient freq. (1.0%).", "sequence_org": "K", "disease": { "doid": "11054", "url": "http://disease-ontology.org/term/DOID:11054", "icd10": "", "name": "Urinary bladder cancer" }, "sequence_mut": "R", "subjects_tested": "103", "end_pos": 2177, "type": "Point mutation" }, { "start_pos": 1399, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "R", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "L", "subjects_tested": "50", "end_pos": 1399, "type": "Point mutation" }, { "start_pos": 583, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "1.0", "annotation": "Filters passed (1/5): patient freq. (1.0%). In dbSNP: rs757514797.", "sequence_org": "I", "disease": { "doid": "11054", "url": "http://disease-ontology.org/term/DOID:11054", "icd10": "", "name": "Urinary bladder cancer" }, "sequence_mut": "T", "subjects_tested": "103", "end_pos": 583, "type": "Point mutation" }, { "start_pos": 1096, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "Q", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "L", "subjects_tested": "50", "end_pos": 1096, "type": "Point mutation" }, { "start_pos": 2197, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "0.1", "annotation": "Filters passed (1/5): num. of cancers (3).", "sequence_org": "R", "disease": { "doid": "1319", "url": "http://disease-ontology.org/term/DOID:1319", "icd10": "", "name": "Brain cancer" }, "sequence_mut": "H", "subjects_tested": "678", "end_pos": 2197, "type": "Point mutation" }, { "start_pos": 525, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5YKK6", "id": "A5YKK6", "database": "BioMuta" } ], "frequency": "1.1", "annotation": "Filters passed (1/5): patient freq. (1.1%).", "sequence_org": "W", "disease": { "doid": "9256", "url": "http://disease-ontology.org/term/DOID:9256", "icd10": "", "name": "Colorectal cancer" }, "sequence_mut": "*", "subjects_tested": "94", "end_pos": 525, "type": "Point mutation" } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A5YKK6#A5YKK6-1", "isoform_ac": "A5YKK6-1", "locus": { "end_pos": 58520961, "start_pos": 58599337, "chromosome": "16", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000317147", "id": "ENST00000317147", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000320949", "id": "ENSP00000320949", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A5YKK6-1|CNOT1_HUMAN Isoform 1 of CCR4-NOT transcription complex subunit 1 OS=Homo sapiens OX=9606 GN=CNOT1 PE=1 SV=2 CANONICAL=A5YKK6-1", "length": 2376, "sequence": "MNLDSLSLALSQISYLVDNLTKKNYRASQQEIQHIVNRHGPEADRHLLRCLFSHVDFSGDGKSSGKDFHQTQFLIQECALLITKPNFISTLSYAIDNPLHYQKSLKPAPHLFAQLSKVLKLSKVQEVIFGLALLNSSSSDLRGFAAQFIKQKLPDLLRSYIDADVSGNQEGGFQDIAIEVLHLLLSHLLFGQKGAFGVGQEQIDAFLKTLRRDFPQERCPVVLAPLLYPEKRDILMDRILPDSGGVAKTMMESSLADFMQEVGYGFCASIEECRNIIVQFGVREVTAAQVARVLGMMARTHSGLTDGIPLQSISAPGSGIWSDGKDKSDGAQAHTWNVEVLIDVLKELNPSLNFKEVTYELDHPGFQIRDSKGLHNVVYGIQRGLGMEVFPVDLIYRPWKHAEGQLSFIQHSLINPEIFCFADYPCHTVATDILKAPPEDDNREIATWKSLDLIESLLRLAEVGQYEQVKQLFSFPIKHCPDMLVLALLQINTSWHTLRHELISTLMPIFLGNHPNSAIILHYAWHGQGQSPSIRQLIMHAMAEWYMRGEQYDQAKLSRILDVAQDLKALSMLLNGTPFAFVIDLAALASRREYLKLDKWLTDKIREHGEPFIQACMTFLKRRCPSILGGLAPEKDQPKSAQLPPETLATMLACLQACAGSVSQELSETILTMVANCSNVMNKARQPPPGVMPKGRPPSASSLDAISPVQIDPLAGMTSLSIGGSAAPHTQSMQGFPPNLGSAFSTPQSPAKAFPPLSTPNQTTAFSGIGGLSSQLPVGGLGTGSLTGIGTGALGLPAVNNDPFVQRKLGTSGLNQPTFQQSKMKPSDLSQVWPEANQHFSKEIDDEANSYFQRIYNHPPHPTMSVDEVLEMLQRFKDSTIKREREVFNCMLRNLFEEYRFFPQYPDKELHITACLFGGIIEKGLVTYMALGLALRYVLEALRKPFGSKMYYFGIAALDRFKNRLKDYPQYCQHLASISHFMQFPHHLQEYIEYGQQSRDPPVKMQGSITTPGSIALAQAQAQAQVPAKAPLAGQVSTMVTTSTTTTVAKTVTVTRPTGVSFKKDVPPSINTTNIDTLLVATDQTERIVEPPENIQEKIAFIFNNLSQSNMTQKVEELKETVKEEFMPWVSQYLVMKRVSIEPNFHSLYSNFLDTLKNPEFNKMVLNETYRNIKVLLTSDKAAANFSDRSLLKNLGHWLGMITLAKNKPILHTDLDVKSLLLEAYVKGQQELLYVVPFVAKVLESSIRSVVFRPPNPWTMAIMNVLAELHQEHDLKLNLKFEIEVLCKNLALDINELKPGNLLKDKDRLKNLDEQLSAPKKDVKQPEELPPITTTTTSTTPATNTTCTATVPPQPQYSYHDINVYSLAGLAPHITLNPTIPLFQAHPQLKQCVRQAIERAVQELVHPVVDRSIKIAMTTCEQIVRKDFALDSEESRMRIAAHHMMRNLTAGMAMITCREPLLMSISTNLKNSFASALRTASPQQREMMDQAAAQLAQDNCELACCFIQKTAVEKAGPEMDKRLATEFELRKHARQEGRRYCDPVVLTYQAERMPEQIRLKVGGVDPKQLAVYEEFARNVPGFLPTNDLSQPTGFLAQPMKQAWATDDVAQIYDKCITELEQHLHAIPPTLAMNPQAQALRSLLEVVVLSRNSRDAIAALGLLQKAVEGLLDATSGADADLLLRYRECHLLVLKALQDGRAYGSPWCNKQITRCLIECRDEYKYNVEAVELLIRNHLVNMQQYDLHLAQSMENGLNYMAVAFAMQLVKILLVDERSVAHVTEADLFHTIETLMRINAHSRGNAPEGLPQLMEVVRSNYEAMIDRAHGGPNFMMHSGISQASEYDDPPGLREKAEYLLREWVNLYHSAAAGRDSTKAFSAFVGQMHQQGILKTDDLITRFFRLCTEMCVEISYRAQAEQQHNPAANPTMIRAKCYHNLDAFVRLIALLVKHSGEATNTVTKINLLNKVLGIVVGVLLQDHDVRQSEFQQLPYHRIFIMLLLELNAPEHVLETINFQTLTAFCNTFHILRPTKAPGFVYAWLELISHRIFIARMLAHTPQQKGWPMYAQLLIDLFKYLAPFLRNVELTKPMQILYKGTLRVLLVLLHDFPEFLCDYHYGFCDVIPPNCIQLRNLILSAFPRNMRLPDPFTPNLKVDMLSEINIAPRILTNFTGVMPPQFKKDLDSYLKTRSPVTFLSDLRSNLQVSNEPGNRYNLQLINALVLYVGTQAIAHIHNKGSTPSMSTITHSAHMDIFQNLAVDLDTEGRYLFLNAIANQLRYPNSHTHYFSCTMLYLFAEANTEAIQEQITRVLLERLIVNRPHPWGLLITFIELIKNPAFKFWNHEFVHCAPEIEKLFQSVAQCCMGQKQAQQVMEGTGAS" } }, { "url": "https://www.uniprot.org/uniprot/A5YKK6#H3BNB1-1", "isoform_ac": "H3BNB1-1", "locus": { "end_pos": 58543607, "start_pos": 58546702, "chromosome": "16", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000567133", "id": "ENST00000567133", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000454763", "id": "ENSP00000454763", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|H3BNB1-1|CNOT1_HUMAN Computationally mapped isoform of CCR4-NOT transcription complex subunit 1 OS=Homo sapiens OX=9606 GN=CNOT1 PE=1 SV=1 CANONICAL=A5YKK6-1", "length": 185, "sequence": "XAELHQEHDLKDKDRLKNLDEQLSAPKKDVKQPEELPPITTTTTSTTPATNTTCTATVPPQPQYSYHDINVYSLAGLAPHITLNPTIPLFQAHPQLKQCVRQAIERAVQELVHPVVDRSIKIAMTTCEQIVRKDFALDSEESRMRIAAHHMMRNLTAGMAMITCREPLLMSISTNLKNSFASALR" } }, { "url": "https://www.uniprot.org/uniprot/A5YKK6#A5YKK6-2", "isoform_ac": "A5YKK6-2", "locus": { "end_pos": 58520961, "start_pos": 58599337, "chromosome": "16", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000569240", "id": "ENST00000569240", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000455635", "id": "ENSP00000455635", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A5YKK6-2|CNOT1_HUMAN Isoform 2 of CCR4-NOT transcription complex subunit 1 OS=Homo sapiens OX=9606 GN=CNOT1 PE=1 SV=2 CANONICAL=A5YKK6-1", "length": 2371, "sequence": "MNLDSLSLALSQISYLVDNLTKKNYRASQQEIQHIVNRHGPEADRHLLRCLFSHVDFSGDGKSSGKDFHQTQFLIQECALLITKPNFISTLSYAIDNPLHYQKSLKPAPHLFAQLSKVLKLSKVQEVIFGLALLNSSSSDLRGFAAQFIKQKLPDLLRSYIDADVSGNQEGGFQDIAIEVLHLLLSHLLFGQKGAFGVGQEQIDAFLKTLRRDFPQERCPVVLAPLLYPEKRDILMDRILPDSGGVAKTMMESSLADFMQEVGYGFCASIEECRNIIVQFGVREVTAAQVARVLGMMARTHSGLTDGIPLQSISAPGSGIWSDGKDKSDGAQAHTWNVEVLIDVLKELNPSLNFKEVTYELDHPGFQIRDSKGLHNVVYGIQRGLGMEVFPVDLIYRPWKHAEGQLSFIQHSLINPEIFCFADYPCHTVATDILKAPPEDDNREIATWKSLDLIESLLRLAEVGQYEQVKQLFSFPIKHCPDMLVLALLQINTSWHTLRHELISTLMPIFLGNHPNSAIILHYAWHGQGQSPSIRQLIMHAMAEWYMRGEQYDQAKLSRILDVAQDLKALSMLLNGTPFAFVIDLAALASRREYLKLDKWLTDKIREHGEPFIQACMTFLKRRCPSILGGLAPEKDQPKSAQLPPETLATMLACLQACAGSVSQELSETILTMVANCSNVMNKARQPPPGVMPKGRPPSASSLDAISPVQIDPLAGMTSLSIGGSAAPHTQSMQGFPPNLGSAFSTPQSPAKAFPPLSTPNQTTAFSGIGGLSSQLPVGGLGTGSLTGIGTGALGLPAVNNDPFVQRKLGTSGLNQPTFQQTDLSQVWPEANQHFSKEIDDEANSYFQRIYNHPPHPTMSVDEVLEMLQRFKDSTIKREREVFNCMLRNLFEEYRFFPQYPDKELHITACLFGGIIEKGLVTYMALGLALRYVLEALRKPFGSKMYYFGIAALDRFKNRLKDYPQYCQHLASISHFMQFPHHLQEYIEYGQQSRDPPVKMQGSITTPGSIALAQAQAQAQVPAKAPLAGQVSTMVTTSTTTTVAKTVTVTRPTGVSFKKDVPPSINTTNIDTLLVATDQTERIVEPPENIQEKIAFIFNNLSQSNMTQKVEELKETVKEEFMPWVSQYLVMKRVSIEPNFHSLYSNFLDTLKNPEFNKMVLNETYRNIKVLLTSDKAAANFSDRSLLKNLGHWLGMITLAKNKPILHTDLDVKSLLLEAYVKGQQELLYVVPFVAKVLESSIRSVVFRPPNPWTMAIMNVLAELHQEHDLKLNLKFEIEVLCKNLALDINELKPGNLLKDKDRLKNLDEQLSAPKKDVKQPEELPPITTTTTSTTPATNTTCTATVPPQPQYSYHDINVYSLAGLAPHITLNPTIPLFQAHPQLKQCVRQAIERAVQELVHPVVDRSIKIAMTTCEQIVRKDFALDSEESRMRIAAHHMMRNLTAGMAMITCREPLLMSISTNLKNSFASALRTASPQQREMMDQAAAQLAQDNCELACCFIQKTAVEKAGPEMDKRLATEFELRKHARQEGRRYCDPVVLTYQAERMPEQIRLKVGGVDPKQLAVYEEFARNVPGFLPTNDLSQPTGFLAQPMKQAWATDDVAQIYDKCITELEQHLHAIPPTLAMNPQAQALRSLLEVVVLSRNSRDAIAALGLLQKAVEGLLDATSGADADLLLRYRECHLLVLKALQDGRAYGSPWCNKQITRCLIECRDEYKYNVEAVELLIRNHLVNMQQYDLHLAQSMENGLNYMAVAFAMQLVKILLVDERSVAHVTEADLFHTIETLMRINAHSRGNAPEGLPQLMEVVRSNYEAMIDRAHGGPNFMMHSGISQASEYDDPPGLREKAEYLLREWVNLYHSAAAGRDSTKAFSAFVGQMHQQGILKTDDLITRFFRLCTEMCVEISYRAQAEQQHNPAANPTMIRAKCYHNLDAFVRLIALLVKHSGEATNTVTKINLLNKVLGIVVGVLLQDHDVRQSEFQQLPYHRIFIMLLLELNAPEHVLETINFQTLTAFCNTFHILRPTKAPGFVYAWLELISHRIFIARMLAHTPQQKGWPMYAQLLIDLFKYLAPFLRNVELTKPMQILYKGTLRVLLVLLHDFPEFLCDYHYGFCDVIPPNCIQLRNLILSAFPRNMRLPDPFTPNLKVDMLSEINIAPRILTNFTGVMPPQFKKDLDSYLKTRSPVTFLSDLRSNLQVSNEPGNRYNLQLINALVLYVGTQAIAHIHNKGSTPSMSTITHSAHMDIFQNLAVDLDTEGRYLFLNAIANQLRYPNSHTHYFSCTMLYLFAEANTEAIQEQITRVLLERLIVNRPHPWGLLITFIELIKNPAFKFWNHEFVHCAPEIEKLFQSVAQCCMGQKQAQQVMEGTGAS" } }, { "url": "https://www.uniprot.org/uniprot/A5YKK6#H3BU44-1", "isoform_ac": "H3BU44-1", "locus": { "end_pos": 58576468, "start_pos": 58599337, "chromosome": "16", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000628857", "id": "ENST00000628857", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000485782", "id": "ENSP00000485782", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|H3BU44-1|CNOT1_HUMAN Computationally mapped isoform of CCR4-NOT transcription complex subunit 1 OS=Homo sapiens OX=9606 GN=CNOT1 PE=1 SV=1 CANONICAL=A5YKK6-1", "length": 96, "sequence": "MNLDSLSLALSQISYLVDNLTKKNYRASQQEIQHIVNRHGPEADRHLLRCLFSHVDFSGDGKSSGKDFHQTQFLIQECALLITKPNCLEYLMWPRT" } }, { "url": "https://www.uniprot.org/uniprot/A5YKK6#A5YKK6-3", "isoform_ac": "A5YKK6-3", "locus": { "end_pos": 58528094, "start_pos": 58599337, "chromosome": "16", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000567188", "id": "ENST00000567188", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000456649", "id": "ENSP00000456649", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A5YKK6-3|CNOT1_HUMAN Isoform 3 of CCR4-NOT transcription complex subunit 1 OS=Homo sapiens OX=9606 GN=CNOT1 PE=1 SV=2 CANONICAL=A5YKK6-1", "length": 2150, "sequence": "MNLDSLSLALSQISYLVDNLTKKNYRASQQEIQHIVNRHGPEADRHLLRCLFSHVDFSGDGKSSGKDFHQTQFLIQECALLITKPNFISTLSYAIDNPLHYQKSLKPAPHLFAQLSKVLKLSKVQEVIFGLALLNSSSSDLRGFAAQFIKQKLPDLLRSYIDADVSGNQEGGFQDIAIEVLHLLLSHLLFGQKGAFGVGQEQIDAFLKTLRRDFPQERCPVVLAPLLYPEKRDILMDRILPDSGGVAKTMMESSLADFMQEVGYGFCASIEECRNIIVQFGVREVTAAQVARVLGMMARTHSGLTDGIPLQSISAPGSGIWSDGKDKSDGAQAHTWNVEVLIDVLKELNPSLNFKEVTYELDHPGFQIRDSKGLHNVVYGIQRGLGMEVFPVDLIYRPWKHAEGQLSFIQHSLINPEIFCFADYPCHTVATDILKAPPEDDNREIATWKSLDLIESLLRLAEVGQYEQVKQLFSFPIKHCPDMLVLALLQINTSWHTLRHELISTLMPIFLGNHPNSAIILHYAWHGQGQSPSIRQLIMHAMAEWYMRGEQYDQAKLSRILDVAQDLKALSMLLNGTPFAFVIDLAALASRREYLKLDKWLTDKIREHGEPFIQACMTFLKRRCPSILGGLAPEKDQPKSAQLPPETLATMLACLQACAGSVSQELSETILTMVANCSNVMNKARQPPPGVMPKGRPPSASSLDAISPVQIDPLAGMTSLSIGGSAAPHTQSMQGFPPNLGSAFSTPQSPAKAFPPLSTPNQTTAFSGIGGLSSQLPVGGLGTGSLTGIGTGALGLPAVNNDPFVQRKLGTSGLNQPTFQQTDLSQVWPEANQHFSKEIDDEANSYFQRIYNHPPHPTMSVDEVLEMLQRFKDSTIKREREVFNCMLRNLFEEYRFFPQYPDKELHITACLFGGIIEKGLVTYMALGLALRYVLEALRKPFGSKMYYFGIAALDRFKNRLKDYPQYCQHLASISHFMQFPHHLQEYIEYGQQSRDPPVKMQGSITTPGSIALAQAQAQAQVPAKAPLAGQVSTMVTTSTTTTVAKTVTVTRPTGVSFKKDVPPSINTTNIDTLLVATDQTERIVEPPENIQEKIAFIFNNLSQSNMTQKVEELKETVKEEFMPWVSQYLVMKRVSIEPNFHSLYSNFLDTLKNPEFNKMVLNETYRNIKVLLTSDKAAANFSDRSLLKNLGHWLGMITLAKNKPILHTDLDVKSLLLEAYVKGQQELLYVVPFVAKVLESSIRSVVFRPPNPWTMAIMNVLAELHQEHDLKLNLKFEIEVLCKNLALDINELKPGNLLKDKDRLKNLDEQLSAPKKDVKQPEELPPITTTTTSTTPATNTTCTATVPPQPQYSYHDINVYSLAGLAPHITLNPTIPLFQAHPQLKQCVRQAIERAVQELVHPVVDRSIKIAMTTCEQIVRKDFALDSEESRMRIAAHHMMRNLTAGMAMITCREPLLMSISTNLKNSFASALRTASPQQREMMDQAAAQLAQDNCELACCFIQKTAVEKAGPEMDKRLATEFELRKHARQEGRRYCDPVVLTYQAERMPEQIRLKVGGVDPKQLAVYEEFARNVPGFLPTNDLSQPTGFLAQPMKQAWATDDVAQIYDKCITELEQHLHAIPPTLAMNPQAQALRSLLEVVVLSRNSRDAIAALGLLQKAVEGLLDATSGADADLLLRYRECHLLVLKALQDGRAYGSPWCNKQITRCLIECRDEYKYNVEAVELLIRNHLVNMQQYDLHLAQSMENGLNYMAVAFAMQLVKILLVDERSVAHVTEADLFHTIETLMRINAHSRGNAPEGLPQLMEVVRSNYEAMIDRAHGGPNFMMHSGISQASEYDDPPGLREKAEYLLREWVNLYHSAAAGRDSTKAFSAFVGQMHQQGILKTDDLITRFFRLCTEMCVEISYRAQAEQQHNPAANPTMIRAKCYHNLDAFVRLIALLVKHSGEATNTVTKINLLNKVLGIVVGVLLQDHDVRQSEFQQLPYHRIFIMLLLELNAPEHVLETINFQTLTAFCNTFHILRPTKAPGFVYAWLELISHRIFIARMLAHTPQQKGWPMYAQLLIDLFKYLAPFLRNVELTKPMQILYKGTLRVLLVLLHDFPEFLCDYHYGFCDVIPPNCIQLRNLILSAFPRNMRLPDPFTPNLKSLTL" } }, { "url": "https://www.uniprot.org/uniprot/A5YKK6#H3BT18-1", "isoform_ac": "H3BT18-1", "locus": { "end_pos": 58588823, "start_pos": 58599337, "chromosome": "16", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000564557", "id": "ENST00000564557", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000456975", "id": "ENSP00000456975", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|H3BT18-1|CNOT1_HUMAN Computationally mapped isoform of CCR4-NOT transcription complex subunit 1 OS=Homo sapiens OX=9606 GN=CNOT1 PE=1 SV=1 CANONICAL=A5YKK6-1", "length": 62, "sequence": "MNLDSLSLALSQISYLVDNLTKKNYRASQQEIQHIVNRHGPEADRHLLRCLFSHVDFSGDGK" } }, { "url": "https://www.uniprot.org/uniprot/A5YKK6#A5YKK6-4", "isoform_ac": "A5YKK6-4", "locus": { "end_pos": 58543388, "start_pos": 58599337, "chromosome": "16", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000441024", "id": "ENST00000441024", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000413113", "id": "ENSP00000413113", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A5YKK6-4|CNOT1_HUMAN Isoform 4 of CCR4-NOT transcription complex subunit 1 OS=Homo sapiens OX=9606 GN=CNOT1 PE=1 SV=2 CANONICAL=A5YKK6-1", "length": 1551, "sequence": "MNLDSLSLALSQISYLVDNLTKKNYRASQQEIQHIVNRHGPEADRHLLRCLFSHVDFSGDGKSSGKDFHQTQFLIQECALLITKPNFISTLSYAIDNPLHYQKSLKPAPHLFAQLSKVLKLSKVQEVIFGLALLNSSSSDLRGFAAQFIKQKLPDLLRSYIDADVSGNQEGGFQDIAIEVLHLLLSHLLFGQKGAFGVGQEQIDAFLKTLRRDFPQERCPVVLAPLLYPEKRDILMDRILPDSGGVAKTMMESSLADFMQEVGYGFCASIEECRNIIVQFGVREVTAAQVARVLGMMARTHSGLTDGIPLQSISAPGSGIWSDGKDKSDGAQAHTWNVEVLIDVLKELNPSLNFKEVTYELDHPGFQIRDSKGLHNVVYGIQRGLGMEVFPVDLIYRPWKHAEGQLSFIQHSLINPEIFCFADYPCHTVATDILKAPPEDDNREIATWKSLDLIESLLRLAEVGQYEQVKQLFSFPIKHCPDMLVLALLQINTSWHTLRHELISTLMPIFLGNHPNSAIILHYAWHGQGQSPSIRQLIMHAMAEWYMRGEQYDQAKLSRILDVAQDLKALSMLLNGTPFAFVIDLAALASRREYLKLDKWLTDKIREHGEPFIQACMTFLKRRCPSILGGLAPEKDQPKSAQLPPETLATMLACLQACAGSVSQELSETILTMVANCSNVMNKARQPPPGVMPKGRPPSASSLDAISPVQIDPLAGMTSLSIGGSAAPHTQSMQGFPPNLGSAFSTPQSPAKAFPPLSTPNQTTAFSGIGGLSSQLPVGGLGTGSLTGIGTGALGLPAVNNDPFVQRKLGTSGLNQPTFQQSKMKPSDLSQVWPEANQHFSKEIDDEANSYFQRIYNHPPHPTMSVDEVLEMLQRFKDSTIKREREVFNCMLRNLFEEYRFFPQYPDKELHITACLFGGIIEKGLVTYMALGLALRYVLEALRKPFGSKMYYFGIAALDRFKNRLKDYPQYCQHLASISHFMQFPHHLQEYIEYGQQSRDPPVKMQGSITTPGSIALAQAQAQAQVPAKAPLAGQVSTMVTTSTTTTVAKTVTVTRPTGVSFKKDVPPSINTTNIDTLLVATDQTERIVEPPENIQEKIAFIFNNLSQSNMTQKVEELKETVKEEFMPWVSQYLVMKRVSIEPNFHSLYSNFLDTLKNPEFNKMVLNETYRNIKVLLTSDKAAANFSDRSLLKNLGHWLGMITLAKNKPILHTDLDVKSLLLEAYVKGQQELLYVVPFVAKVLESSIRSVVFRPPNPWTMAIMNVLAELHQEHDLKLNLKFEIEVLCKNLALDINELKPGNLLKDKDRLKNLDEQLSAPKKDVKQPEELPPITTTTTSTTPATNTTCTATVPPQPQYSYHDINVYSLAGLAPHITLNPTIPLFQAHPQLKQCVRQAIERAVQELVHPVVDRSIKIAMTTCEQIVRKDFALDSEESRMRIAAHHMMRNLTAGMAMITCREPLLMSISTNLKNSFASALRVSWLFPWYRYKTYYCLSVIIFFFVYIWHWALPLILNNHHICLMSSIILDCNSVRQSIMSVCFFFFLLYSQHDV" } }, { "url": "https://www.uniprot.org/uniprot/A5YKK6#H3BR89-1", "isoform_ac": "H3BR89-1", "locus": { "end_pos": 58551790, "start_pos": 58558490, "chromosome": "16", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000562046", "id": "ENST00000562046", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000456131", "id": "ENSP00000456131", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|H3BR89-1|CNOT1_HUMAN Computationally mapped isoform of CCR4-NOT transcription complex subunit 1 OS=Homo sapiens OX=9606 GN=CNOT1 PE=1 SV=1 CANONICAL=A5YKK6-1", "length": 193, "sequence": "XSSQLPVGGLGTGSLTGIGTGALGLPAVNNDPFVQRKLGTSGLNQPTFQQSKMKPSDLSQVWPEANQHFSKEIDDEANSYFQRIYNHPPHPTMSVDEYPDKELHITACLFGGIIEKGLVTYMALGLALRYVLEALRKPFGSKMYYFGIAALDRFKNRLKDYPQYCQHLASISHFMQFPHHLQEYIEYGQQSRD" } }, { "url": "https://www.uniprot.org/uniprot/A5YKK6#H3BVC9-1", "isoform_ac": "H3BVC9-1", "locus": { "end_pos": 58546465, "start_pos": 58551766, "chromosome": "16", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000567285", "id": "ENST00000567285", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000458057", "id": "ENSP00000458057", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|H3BVC9-1|CNOT1_HUMAN Computationally mapped isoform of CCR4-NOT transcription complex subunit 1 OS=Homo sapiens OX=9606 GN=CNOT1 PE=1 SV=1 CANONICAL=A5YKK6-1", "length": 241, "sequence": "XITTPGSIALAQAQAQAQVPAKAPLAGQVSTMVTTSTTTTVAKTVTVTRPTGVSFKKDVPPSINTTNIDTLLVATDQTERIVEPPENIQEKIAFIFNNLSQSNMTQKVEELKETVKEEFMPWVSQYLVMKRVSIEPNFHSLYSNFLDTLKNPEFNKMVLNETYRNIKDLDVKSLLLEAYVKGQQELLYVVPFVAKVLESSIRSVVFRPPNPWTMAIMNVLAELHQEHDLKLNLKFEIEVLC" } }, { "url": "https://www.uniprot.org/uniprot/A5YKK6#H3BMZ2-1", "isoform_ac": "H3BMZ2-1", "locus": { "end_pos": 58531958, "start_pos": 58539878, "chromosome": "16", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000568917", "id": "ENST00000568917", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000454611", "id": "ENSP00000454611", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|H3BMZ2-1|CNOT1_HUMAN Computationally mapped isoform of CCR4-NOT transcription complex subunit 1 OS=Homo sapiens OX=9606 GN=CNOT1 PE=1 SV=1 CANONICAL=A5YKK6-1", "length": 439, "sequence": "PTLAMNPQAQALRSLLEVVVLSRNSRDAIAALGLLQKAVEGLLDATSGADADLLLRYRECHLLVLKALQDGRAYGSPWCNKQITRCLIECRDEYKYNVEAVELLIRNHLVNMQQYDLHLAQSMENGLNYMAVAFAMQLVKILLVDERSVAHVTEADLFHTIETLMRINAHSRGNAPEGLPQLMEVVRSNYEAMIDRAHGGPNFMMHSGISQASEYDDPPGLREKAEYLLREWVNLYHSAAAGRDSTKAFSAFVGQVELLERKMHQQGILKTDDLITRFFRLCTEMCVEISYRAQAEQQHNPAANPTMIRAKCYHNLDAFVRLIALLVKHSGEATNTVTKINLLNKVLGIVVGVLLQDHDVRQSEFQQLPYHRIFIMLLLELNAPEHVLETINFQTLTAFCNTFHILRPTKAPGFVYAWLELISHRIFIARMLAHTPQQK" } }, { "url": "https://www.uniprot.org/uniprot/A5YKK6#H3BTH2-1", "isoform_ac": "H3BTH2-1", "locus": { "end_pos": 58543285, "start_pos": 58543802, "chromosome": "16", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000566240", "id": "ENST00000566240", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000457173", "id": "ENSP00000457173", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|H3BTH2-1|CNOT1_HUMAN Computationally mapped isoform of CCR4-NOT transcription complex subunit 1 OS=Homo sapiens OX=9606 GN=CNOT1 PE=1 SV=1 CANONICAL=A5YKK6-1", "length": 68, "sequence": "XKIAMTTCEQIVRKDFALDSEESRMRIAAHHMMRNLTAGMAMITCREPLLMSISTNLKNSFASALREG" } }, { "url": "https://www.uniprot.org/uniprot/A5YKK6#H3BMH0-1", "isoform_ac": "H3BMH0-1", "locus": { "end_pos": 58555784, "start_pos": 58575063, "chromosome": "16", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000569882", "id": "ENST00000569882", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000454377", "id": "ENSP00000454377", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|H3BMH0-1|CNOT1_HUMAN Computationally mapped isoform of CCR4-NOT transcription complex subunit 1 OS=Homo sapiens OX=9606 GN=CNOT1 PE=1 SV=1 CANONICAL=A5YKK6-1", "length": 277, "sequence": "RREYLKLDKWLTDKIREHGEPFIQACMTFLKRRCPSILGGLAPEKDQPKSAQLPPETLATMLACLQACAGSVSQELSETILTMVANCSNVMNKARQPPPGVMPKGRPPSASSLDAISPVQIDPLAGMTSLSIGGSAAPHTQSMQGFPPNLGSAFSTPQSPAKAFPPLSTPNQTTAFSGIGGLSSQLPGGLGTGSLTGIGTGALGLPAVNNDPFVQRKLGTSGLNQPTFQQSKMKPSDLSQVWPEANQHFSKEIDDEANSYFQRIYNHPPHPTMSVDE" } }, { "url": "https://www.uniprot.org/uniprot/A5YKK6#H3BPF1-1", "isoform_ac": "H3BPF1-1", "locus": { "end_pos": 58599263, "start_pos": 58599337, "chromosome": "16", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000565697", "id": "ENST00000565697", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000455289", "id": "ENSP00000455289", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|H3BPF1-1|CNOT1_HUMAN Computationally mapped isoform of CCR4-NOT transcription complex subunit 1 OS=Homo sapiens OX=9606 GN=CNOT1 PE=1 SV=8 CANONICAL=A5YKK6-1", "length": 25, "sequence": "MNLDSLSLALSQISYLVDNLTKKNY" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:23019", "resource": "KEGG Pathway", "id": "hsa:23019", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-429947", "resource": "Reactome", "id": "R-HSA-429947", "name": "Deadenylation of mRNA" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804115", "resource": "Reactome", "id": "R-HSA-6804115", "name": "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A5YKK6#function", "annotation": "Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5YKK6#function", "id": "A5YKK6", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001252541.1", "annotation": "Data suggest that the CCR4-NOT transcription complex subunit 1 (CNOT1)-CCR4-NOT transcription complex subunit 9 (CNOT9) components stimulate deadenylation by the nuclease module. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001252541.1", "id": "NP_001252541.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001252541.1", "annotation": "These results together with the authors' previous study, have identified that CNOT1 provides a platform for the recruitment of TTP and CNOT7, and is involved in TTPmediated ICAM1 and IL8 mRNA decay.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001252541.1", "id": "NP_001252541.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001252541.1", "annotation": "Our data suggest the involvement of hNOT-1/ALG3-1 in various molecular contexts determining essential processes associated with distinct cellular machineries and related to various pathologies, such as cancer, viral infections, neuronal and immunological disorders and Congenital Disorders of Glycosylation.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001252541.1", "id": "NP_001252541.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001252541.1", "annotation": "Increased expression of MHC II genes after knock-down or knock-out of either CNOT1, CNOT2, or CNOT3 subunit was seen in a variety of cell systems and also in naive macrophages from CNOT3 conditional knock-out mice. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001252541.1", "id": "NP_001252541.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001252541.1", "annotation": "Purification and characterization of 1.0 MDa yeast CCR4-NOT complex identifies two novel components, CAF40 and CAF130: yeast CAF40 binds human NOT1", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001252541.1", "id": "NP_001252541.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "G3V7M0-1", "protein_name": "RCG39079; CCR4-NOT transcription complex, subunit 1.", "sequence": { "length": 2376, "sequence": "MNLDSLSLALSQISYLVDNLTKKNYRASQQEIQHIVNRHGPEADRHLLRCLFSHVDFSGDGKSSGKDFHQTQFLIQECASLITKPNFISTLSYAIDNPLHYQKSLKPAPHLFAQLSKVLKLSKVQEVIFGLALLNSSSPDLRGFAAQFIKQKLPDLLRSYIDADVSGNQEGGFQDIAIEVLHLLLSHLLFGQKGAFGVGQEQIDAFLKTLRRDFPQERCPVVLAPLLYPEKRDILMDRILPDSGGVAKTMMESSLADFMQEVGYGFCASIEECRNIIMQFGVREVTAAQVARVLGMMARTHSGLTDGIPLQSISAPGSGIWSDGKDKSEGAQAHTWNVEVLIDVLKELNPSLNFKEVTYELDHPGFQIRDSKGLHNVVYGIQRGLGMEVFPVDFIYRPWKHAEGQLSFIQHSLINPEVFCFADYPCHTVATDILKAPPEDDNREIATWKSLDLIESLLRLAEVGQYEQVKQLFSFPIKHCPDMLVLALLQINTSWHTLRHELISTLMPIFLGNHPNSAIILHYAWHGQGQSPSIRQLIMHAMAEWYMRGEQYDQAKLSRILDVAQDLKALSMLLNGTPFAFVIDLAALASRREYLKLDKWLTDKIREHGEPFIQACMTFLKRRCPSILGGLAPEKDQPKSAQLPAETLATMLACLQACAGSVSQELSETILTMVANCSNVMNKARQPPPGVMPKGRPPSASSLDAISPVQIDPLAGMASLSIGGSAAPHTQSMQGFPPNLGSAFSTPQSPAKAFPPLSTPNQTTAFSGIGGLSSQLPVGGLGTGSLTGIGTGALGLPAVNSDPFVQRKLGTSGLNQPTFQQSKMKPSDLSQVWPEANQHFSKEIDDEANSYFQRIYNHPPHPTMSVDEVLEMLQRFKDSTIKREREVFNCMLRNLFEEYRFFPQYPDKELHITACLFGGIIEKGLVTYMALGLALRYVLEALRKPFGSKMYYFGIAALDRFKNRLKDYPQYCQHLASISHFMQFPHHLQEYIEYGQQSRDPPVKMQGSITTPGSIALAQAQAQAQVPAKAPLAGQVNTMVTTSTTTTVAKTVTVTKPTGVSFKKDVPPSINTTNIDTLLVATDQTERIVEPPENIQEKIAFIFNNLSQSNMTQKVEELKETVKEEFMPWVSQYLVMKRVSIEPNFHSLYSNFLDTLKNPEFNKMVLNETYRNIKVLLTSDKAAANFSDRSLLKNLGHWLGMITLAKNKPILHTDLDVKSLLLEAYVKGQQELLYVVPFVAKVLESSIRSLVFRPPNPWTMAIMNVLAELHQEHDLKLNLKFEIEVLCKNLALDINELKPGNLLKDKDRLKNLDEQLSAPKKDVKQPEELPAITTTTTSTTPATSTTCTATVPPQPQYSYHDINVYSLAGLAPHITLNPTIPLFQAHPQLKQCVRQAIERAVQELVHPVVDRSIKIAMTTCEQIVRKDFALDSEESRMRIAAHHMMRNLTAGMAMITCREPLLMSISTNLKNSFASALRTASPQQREMMDQAAAQLAQDNCELACCFIQKTAVEKAGPEMDKRLATEFELRKHARQEGRRYCDPVVLTYQAERMPEQIRLKVGGVDPKQLAVYEEFARNVPGFLPTNDLSQPTGFLAQPMKQAWATDDVAQIYDKCITELEQHLHAIPPTLAMNPQAQALRSLLEVVVLSRNSRDAIAALGLLQKAVEGLLDATSGADADLLLRYRECHLLVLKGLQDGRAYGSPWCNKQITRCLIECRDEYKYNVEAVELLIRNHLVNMQQYDLHLAQSMENGLNYMAVAFAMQLVKILLVDERSVAHITEADLFHTIETLMRINAHSRGNAPEGLPQLMEVVRSNYEAMIDRAHGGPNFMMHSGISQASEYDDPPGLREKAEYLLREWVNLYHSAAAGRDSTKAFSAFVGQMHQQGILKTDDLITRFFRLCTEMCVEISYRAQAEQQHNPAANPTMIRAKCYHNLDAFVRLIALLVKHSGEATNTVTKINLLNKVLGIVVGVLLQDHDVRQSEFQQLPYHRIFIMLLLELNAPEHVLETINFQTLTAFCNTFHILRPTKAPGFVYAWLELISHRIFIARMLAHTPQQKGWPMYAQLLIDLFKYLAPFLRNVELTKPMQILYKGTLRVLLVLLHDFPEFLCDYHYGFCDVIPPNCIQLRNLILSAFPRNMRLPDPFTPNLKVDMLSEINIAPRILTNFTGVMPPQFKKDLDSYLKTRSPVTFLSDLRSNLQVSNEPGNRYNLQLINALVLYVGTQAIAHIHNKGSTPSMSTITHSAHMDIFQNLAVDLDTEGRYLFLNAIANQLRYPNSHTHYFSCTMLYLFAEANTEAIQEQITRVLLERLIVNRPHPWGLLITFIELIKNPAFKFWNHEFVHCAPEIEKLFQSVAQCCMGQKQAQQVMEGTGAS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/9453", "id": "9453", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A5YKK6/", "id": "A5YKK6", "database": "OMA" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q6ZQ08-1", "protein_name": "CCR4-NOT transcription complex subunit 1; CCR4-associated factor 1.", "sequence": { "length": 2375, "sequence": "MNLDSLSLALSQISYLVDNLTKKNYRASQQEIQHIVNRHGPEADRHLLRCLFSHVDFSGDGKSSGKDFHQTQFLIQECASLITKPNFISTLSYAIDNPLHYQKSLKPAPHLFAQLSKVLKLSKVQEVIFGLALLNSSSPDLRGFAAQFIKQKLPDLLRSYIDADVSGNQEGGFQDIAIEVLHLLLSHLLFGQKGAFGVGQEQIDAFLKTLRRDFPQERCPVVLAPLLYPEKRDILMDRILPDSGGVAKTMMESSLADFMQEVGYGFCASIEECRNIIMQFGVREVTAAQVARVLGMMARTHSGLTDGIPLQSISAPGSGIWSDGKDKSEGAQAHTWNVEVLIDVLKELNPSLNFKEVTYELDHPGFQIRDSKGLHNVVYGIQRGLGMEVFPVDFIYRPWKHAEGQLSFIQHSLINPEVFCFADYPCHTVATDILKAPPEDDNREIATWKSLDLIESLLRLAEVGQYEQVKQLFSFPIKHCPDMLVLALLQINTSWHTLRHELISTLMPIFLGNHPNSAIILHYAWHGQGQSPSIRQLIMHAMAEWYMRGEQYDQAKLSRILDVAQDLKALSMLLNGTPFAFVIDLAALASRREYLKLDKWLTDKIREHGEPFIQACMTFLKRRCPSILGGLAPEKDQPKSAQLPAETLATMLACLQACAGSVSQELSETILTMVANCSNVMNKARQPPPGVMPKGRPPSASSLDAISPVQIDPLAGMASLSIGGSAAPHTQSMQGFPPNLGSAFSTPQSPAKAFPPLSTPNQTTAFSGIGGLSSQLPGGLGTGSLTGIGTGALGLPAVNNDPFVQRKLGTSGLNQPTFQQSKMKPSDLSQVWPEANQHFSKEIDDEANSYFQRIYNHPPHPTMSVDEVLEMLQRFKDSTIKREREVFNCMLRNLFEEYRFFPQYPDKELHITACLFGGIIEKGLVTYMALGLALRYVLEALRKPFGSKMYYFGIAALDRFKNRLKDYPQYCQHLASISHFMQFPHHLQEYIEYGQQSRDPPVKMQGSITTPGSIALAQAQAQAQVPAKAPLAGQVNTMVTTSTTTTVAKTVTVTKPTGVSFKKDVPPSINTTNIDTLLVATDQTERIVEPPENIQEKIAFIFNNLSQSNMTQKVEELKETVKEEFMPWVSQYLVMKRVSIEPNFHSLYSNFLDTLKNPEFNKMVLNETYRNIKVLLTSDKAAANFSDRSLLKNLGHWLGMITLAKNKPILHTDLDVKSLLLEAYVKGQQELLYVVPFVAKVLESSIRSLVFRPPNPWTMAIMNVLAELHQEHDLKLNLKFEIEVLCKNLALDINELKPGNLLKDKDRLKNLDEQLSAPKKDVKQPEELPAITTTTTSTTPATSTTCTATVPPQPQYSYHDINVYSLAGLAPHITLNPTIPLFQAHPQLKQCVRQAIERAVQELVHPVVDRSIKIAMTTCEQIVRKDFALDSEESRMRIAAHHMMRNLTAGMAMITCREPLLMSISTNLKNSFASALRTASPQQREMMDQAAAQLAQDNCELACCFIQKTAVEKAGPEMDKRLATEFELRKHARQEGRRYCDPVVLTYQAERMPEQIRLKVGGVDPKQLAVYEEFARNVPGFLPTNDLSQPTGFLAQPMKQAWATDDVAQIYDKCITELEQHLHAIPPTLAMNPQAQALRSLLEVVVLSRNSRDAIAALGLLQKAVEGLLDATSGADADLLLRYRECHLLVLKALQDGRAYGSPWCNKQITRCLIECRDEYKYNVEAVELLIRNHLVNMQQYDLHLAQSMENGLNYMAVAFAMQLVKILLVDERSVAHITEADLFHTIETLMRINAHSRGNAPEGLPQLMEVVRSNYEAMIDRAHGGPNFMMHSGISQASEYDDPPGLREKAEYLLREWVNLYHSAAAGRDSTKAFSAFVGQMHQQGILKTDDLITRFFRLCTEMCVEISYRAQAEQQHNPAANPTMIRAKCYHNLDAFVRLIALLVKHSGEATNTVTKINLLNKVLGIVVGVLLQDHDVRQSEFQQLPYHRIFIMLLLELNAPEHVLETINFQTLTAFCNTFHILRPTKAPGFVYAWLELISHRIFIARMLAHTPQQKGWPMYAQLLIDLFKYLAPFLRNVELTKPMQILYKGTLRVLLVLLHDFPEFLCDYHYGFCDVIPPNCIQLRNLILSAFPRNMRLPDPFTPNLKVDMLSEINIAPRILTNFTGVMPPQFKKDLDSYLKTRSPVTFLSDLRSNLQVSNEPGNRYNLQLINALVLYVGTQAIAHIHNKGSTPSMSTITHSAHMDIFQNLAVDLDTEGRYLFLNAIANQLRYPNSHTHYFSCTMLYLFAEANTEAIQEQITRVLLERLIVNRPHPWGLLITFIELIKNPAFKFWNHEFVHCAPEIEKLFQSVAQCCMGQKQAQQVMEGTGAS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/9453", "id": "9453", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001252541.1", "ac": "NP_001252541.1", "name": "CCR4-NOT transcription complex subunit 1 isoform c; NOT1 (negative regulator of transcription 1, yeast) homolog; adrenal gland protein AD-005; CCR4-associated factor 1; negative regulator of transcription subunit 1 homolog.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060090", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5YKK6", "id": "A5YKK6", "database": "UniProtKB" } ], "name": "molecular adaptor activity", "id": "GO:0060090" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5YKK6", "id": "A5YKK6", "database": "UniProtKB" } ], "name": "RNA binding", "id": "GO:0003723" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5YKK6", "id": "A5YKK6", "database": "UniProtKB" } ], "name": "RNA binding", "id": "GO:0003723" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5YKK6", "id": "A5YKK6", "database": "UniProtKB" } ], "name": "protein domain specific binding", "id": "GO:0019904" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030331", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5YKK6", "id": "A5YKK6", "database": "UniProtKB" } ], "name": "estrogen receptor binding", "id": "GO:0030331" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042974", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5YKK6", "id": "A5YKK6", "database": "UniProtKB" } ], "name": "retinoic acid receptor binding", "id": "GO:0042974" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070016", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5YKK6", "id": "A5YKK6", "database": "UniProtKB" } ], "name": "armadillo repeat domain binding", "id": "GO:0070016" } ], "total": 7, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5YKK6", "id": "A5YKK6", "database": "UniProtKB" } ], "name": "extracellular space", "id": "GO:0005615" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005778", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5YKK6", "id": "A5YKK6", "database": "UniProtKB" } ], "name": "peroxisomal membrane", "id": "GO:0005778" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5YKK6", "id": "A5YKK6", "database": "UniProtKB" } ], "name": "membrane", "id": "GO:0016020" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000932", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5YKK6", "id": "A5YKK6", "database": "UniProtKB" } ], "name": "P-body", "id": "GO:0000932" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030014", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5YKK6", "id": "A5YKK6", "database": "UniProtKB" } ], "name": "CCR4-NOT complex", "id": "GO:0030014" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030015", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5YKK6", "id": "A5YKK6", "database": "UniProtKB" } ], "name": "CCR4-NOT core complex", "id": "GO:0030015" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5YKK6", "id": "A5YKK6", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5YKK6", "id": "A5YKK6", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" } ], "total": 8, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5YKK6", "id": "A5YKK6", "database": "UniProtKB" } ], "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017148", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5YKK6", "id": "A5YKK6", "database": "UniProtKB" } ], "name": "negative regulation of translation", "id": "GO:0017148" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060213", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5YKK6", "id": "A5YKK6", "database": "UniProtKB" } ], "name": "positive regulation of nuclear-transcribed mRNA poly(A) tail shortening", "id": "GO:0060213" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900153", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5YKK6", "id": "A5YKK6", "database": "UniProtKB" } ], "name": "positive regulation of nuclear-transcribed mRNA 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