{ "uniprot_canonical_ac": "A5D8V6-1", "sequence": { "header": "sp|A5D8V6-1|VP37C_HUMAN Isoform 1 of Vacuolar protein sorting-associated protein 37C OS=Homo sapiens OX=9606 GN=VPS37C PE=1 SV=2 CANONICAL=A5D8V6-1", "length": 355, "sequence": "METLKDKTLQELEELQNDSEAIDQLALESPEVQDLQLEREMALATNRSLAERNLEFQGPLEISRSNLSDRYQELRKLVERCQEQKAKLEKFSSALQPGTLLDLLQVEGMKIEEESEAMAEKFLEGEVPLETFLENFSSMRMLSHLRRVRVEKLQEVVRKPRASQELAGDAPPPRPPPPVRPVPQGTPPVVEEQPQPPLAMPPYPLPYSPSPSLPVGPTAHGALPPAPFPVVSQPSFYSGPLGPTYPAAQLGPRGAAGYSWSPQRSMPPRPGYPGTPMGASGPGYPLRGGRAPSPGYPQQSPYPATGGKPPYPIQPQLPSFPGQPQPSVPLQPPYPPGPAPPYGFPPPPGPAWPGY" }, "uniprot_id": "VP37C_HUMAN", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "vacuolar protein sorting-associated protein 37C", "hVps37C; ESCRT-I complex subunit VPS37C; vacuolar protein sorting 37C; vacuolar protein sorting 37 homolog C; VPS37C, ESCRT-I subunit" ], "uniprotkb": [ "Vacuolar protein sorting-associated protein 37C", "hVps37C", "ESCRT-I complex subunit VPS37C" ] }, "gene": { "refseq": [ "VPS37C" ], "uniprotkb": [ "VPS37C", "PML39" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5D8V6", "id": "A5D8V6", "database": "UniProtKB" } ], "name": "Homo sapiens", "taxid": 9606 } ], "recommendedname": { "full": "Vacuolar protein sorting-associated protein 37C; hVps37C; ESCRT-I complex subunit VPS37C.", "short": "hVps37C" }, "publication": [ { "title": "VPS37 isoforms differentially modulate the ternary complex formation of ALIX, ALG-2, and ESCRT-I.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/23924735", "journal": "Bioscience, biotechnology, and biochemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060436.4", "id": "NP_060436.4", "database": "RefSeq" } ], "authors": "Okumura M, Katsuyama AM, Shibata H, Maki M", "date": "2013", "pmid": "23924735" }, { "title": "The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22405001", "journal": "Structure (London, England : 1993)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060436.4", "id": "NP_060436.4", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A5D8V6/publications", "id": "A5D8V6", "database": "UniProtKB" } ], "authors": "Agromayor M, Soler N, Caballe A, Kueck T, Freund SM, Allen MD, Bycroft M, Perisic O, Ye Y, McDonald B, Scheel H, Hofmann K, Neil SJ, Martin-Serrano J, Williams RL", "date": "2012", "pmid": "22405001" }, { "title": "TANK-binding kinase 1 attenuates PTAP-dependent retroviral budding through targeting endosomal sorting complex required for transport-I.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/21270402", "journal": "J. Immunol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5D8V6/publications", "id": "A5D8V6", "database": "UniProtKB" } ], "authors": "Yang X., Gao G., Tang H., Xu Y., Cheng G., Da Q.", "date": "2011", "pmid": "21270402" }, { "title": "Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/19773279", "journal": "Occupational and environmental medicine", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060436.4", "id": "NP_060436.4", "database": "RefSeq" } ], "authors": "Hosgood HD 3rd, Zhang L, Shen M, Berndt SI, Vermeulen R, Li G, Yin S, Yeager M, Yuenger J, Rothman N, Chanock S, Smith M, Lan Q", "date": "2009", "pmid": "19773279" }, { "title": "Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/18005716", "journal": "Cell Host Microbe", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5D8V6/publications", "id": "A5D8V6", "database": "UniProtKB" } ], "authors": "Gygi S.P., Morita E., Eckert D.M., Sandrin V., Sundquist W.I., Alam S.L.", "date": "2007", "pmid": "18005716" }, { "title": "Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17853893", "journal": "The EMBO journal", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060436.4", "id": "NP_060436.4", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A5D8V6/publications", "id": "A5D8V6", "database": "UniProtKB" } ], "authors": "Morita E, Sandrin V, Chung HY, Morham SG, Gygi SP, Rodesch CK, Sundquist WI", "date": "2007", "pmid": "17853893" }, { "title": "Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/15509564", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060436.4", "id": "NP_060436.4", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A5D8V6/publications", "id": "A5D8V6", "database": "UniProtKB" } ], "authors": "Eastman SW, Martin-Serrano J, Chung W, Zang T, Bieniasz PD", "date": "2005", "pmid": "15509564" }, { "title": "The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/15218037", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060436.4", "id": "NP_060436.4", "database": "RefSeq" } ], "authors": "Stuchell MD, Garrus JE, Muller B, Stray KM, Ghaffarian S, McKinnon R, Krausslich HG, Morham SG, Sundquist WI", "date": "2004", "pmid": "15218037" }, { "title": "Secretory protein trafficking and organelle dynamics in living cells.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/11031247", "journal": "Annual review of cell and developmental biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060436.4", "id": "NP_060436.4", "database": "RefSeq" } ], "authors": "Lippincott-Schwartz J, Roberts TH, Hirschberg K", "date": "2000", "pmid": "11031247" } ], "glycosylation": [], "mutation": [ { "start_pos": 288, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5D8V6", "id": "A5D8V6", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "G", "disease": { "doid": "1612", "url": "http://disease-ontology.org/term/DOID:1612", "icd10": "", "name": "Breast cancer" }, "sequence_mut": "V", "subjects_tested": "50", "end_pos": 288, "type": "Point mutation" }, { "start_pos": 323, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5D8V6", "id": "A5D8V6", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "Q", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "H", "subjects_tested": "50", "end_pos": 323, "type": "Point mutation" }, { "start_pos": 342, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5D8V6", "id": "A5D8V6", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "Y", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "H", "subjects_tested": "50", "end_pos": 342, "type": "Point mutation" }, { "start_pos": 178, "subjects_positive": "10", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5D8V6", "id": "A5D8V6", "database": "BioMuta" } ], "frequency": "0.7", "annotation": "Filters passed (1/5): patient count (10/1514). In dbSNP: rs757821185.", "sequence_org": "P", "disease": { "doid": "1324", "url": "http://disease-ontology.org/term/DOID:1324", "icd10": "", "name": "Lung cancer" }, "sequence_mut": "S", "subjects_tested": "1514", "end_pos": 178, "type": "Point mutation" } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A5D8V6#A5D8V6-1", "isoform_ac": "A5D8V6-1", "locus": { "end_pos": 61131823, "start_pos": 61138829, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000301765", "id": "ENST00000301765", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000301765", "id": "ENSP00000301765", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A5D8V6-1|VP37C_HUMAN Isoform 1 of Vacuolar protein sorting-associated protein 37C OS=Homo sapiens OX=9606 GN=VPS37C PE=1 SV=2 CANONICAL=A5D8V6-1", "length": 355, "sequence": "METLKDKTLQELEELQNDSEAIDQLALESPEVQDLQLEREMALATNRSLAERNLEFQGPLEISRSNLSDRYQELRKLVERCQEQKAKLEKFSSALQPGTLLDLLQVEGMKIEEESEAMAEKFLEGEVPLETFLENFSSMRMLSHLRRVRVEKLQEVVRKPRASQELAGDAPPPRPPPPVRPVPQGTPPVVEEQPQPPLAMPPYPLPYSPSPSLPVGPTAHGALPPAPFPVVSQPSFYSGPLGPTYPAAQLGPRGAAGYSWSPQRSMPPRPGYPGTPMGASGPGYPLRGGRAPSPGYPQQSPYPATGGKPPYPIQPQLPSFPGQPQPSVPLQPPYPPGPAPPYGFPPPPGPAWPGY" } }, { "url": "https://www.uniprot.org/uniprot/A5D8V6#F5H4Q5-1", "isoform_ac": "F5H4Q5-1", "locus": { "end_pos": 61132444, "start_pos": 61138829, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000538036", "id": "ENST00000538036", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000446013", "id": "ENSP00000446013", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F5H4Q5-1|VP37C_HUMAN Computationally mapped isoform of Vacuolar protein sorting-associated protein 37C OS=Homo sapiens OX=9606 GN=VPS37C PE=1 SV=1 CANONICAL=A5D8V6-1", "length": 148, "sequence": "METLKDKTLQELEELQNDSEAIDQLALESPEVQDLQLEREMALATNRSLAERNLEFQGPLEISRSNLSDRYQELRKLVERCQEQKAKLEKFSSALQPGTLLDLLQVEGMKIEEESEAMAEKFLEGEVPLETFLENFSSMRMLSHLRRV" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:55048", "resource": "KEGG Pathway", "id": "hsa:55048", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174490", "resource": "Reactome", "id": "R-HSA-174490", "name": "Membrane binding and targetting of GAG proteins" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-162588", "resource": "Reactome", "id": "R-HSA-162588", "name": "Budding and maturation of HIV virion" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-917729", "resource": "Reactome", "id": "R-HSA-917729", "name": "Endosomal Sorting Complex Required For Transport (ESCRT)" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9615710", "resource": "Reactome", "id": "R-HSA-9615710", "name": "Microautophagy" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A5D8V6#function", "annotation": "Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5D8V6#function", "id": "A5D8V6", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060436.4", "annotation": "VPS37B and appeared to interact with ALG-2 in a stronger manner than TSG101 does", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060436.4", "id": "NP_060436.4", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060436.4", "annotation": "Observational study of gene-disease association. (HuGE Navigator)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060436.4", "id": "NP_060436.4", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060436.4", "annotation": "VPS37C as a functional component of mammalian endosomal sorting complex required for transport-I", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060436.4", "id": "NP_060436.4", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "B5DFF4-1", "protein_name": "VPS37C subunit of ESCRT-I; Vacuolar protein sorting 37C (Yeast) (Predicted); Vps37c protein.", "sequence": { "length": 353, "sequence": "MEGLKDKTLQELEEMQNDPEAIARLALESPEVQDLQLEREMALATNRSLAEQNLEFQGPLEISRSNLSDKYQELRKLVERCQEQKAKLEKFSSALQPGTLLDLLQIEGMKIEEESEAMAEKFLEGEVPLETFLESFSSMRTLLHLRRVRVEKLQDVVRRPRALPELAGDAPPKRPPPPRPAPQAAPPETEEQTPQPSVVTPYPLPYSPSPGLPVGPTAQGALQPAPFPVVTQPSSYGGPLGPSYPSPQPGPRAMVGYSWSPQRSGPPRPGYPVAPTSTSGPGYPLVGGQTPGPGYPQQSPYFPSGSKPPYPTQPQLPGFPGQPPPPVPPQPPYPSGVTPPYGFHPPGSAWPRY" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A5D8V6/", "id": "A5D8V6", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/45637", "id": "45637", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q8R105-1", "protein_name": "Vacuolar protein sorting-associated protein 37C; ESCRT-I complex subunit VPS37C.", "sequence": { "length": 352, "sequence": "MEGLKDKTLQELEEMQNDPEAIARLALESPEVQDLQLEREMALATNRSLAEQNLEFQGPLEISRSNLSDKYQELRKLVERCQEQKAKLEKFSSALQPGTLLDLLQIEGMKIEEESEAMAEKFLEGEVPLETFLESFSSMRTLLHLRRVRVEKLQDVVRRPRALPELAGDVPPKRPPPPRPVPQATPPETEEQPPQPSVVTPYPLPYSPSPGLPVGPTAQGALQPAPFPVVAQPSSYGGPLGPYPSPHPGPRAMVGYSWSPQRSGPPQPGYPTAPTSTSGPGYPLVGGRTPGPGYPQQSPYLPSGNKPPYPTQPQLPGFPGQPQPPVPPQPPYPPGTTPSYGFHPPGPAWPRY" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A5D8V6/", "id": "A5D8V6", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/45637", "id": "45637", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060436.4", "ac": "NP_060436.4", "name": "vacuolar protein sorting-associated protein 37C; hVps37C; ESCRT-I complex subunit VPS37C; vacuolar protein sorting 37C; vacuolar protein sorting 37 homolog C; VPS37C, ESCRT-I subunit.", "summary": "VPS37C is a subunit of ESCRT-I (endosomal sorting complex required for transport I), a complex in the class E vacuolar protein sorting (VPS) pathway required for sorting ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies (Eastman et al., 2005 [PubMed 15509564]).[supplied by OMIM, Mar 2008]." }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048306", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5D8V6", "id": "A5D8V6", "database": "UniProtKB" } ], "name": "calcium-dependent protein binding", "id": "GO:0048306" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5D8V6", "id": "A5D8V6", "database": "UniProtKB" } ], "name": "intracellular membrane-bounded organelle", "id": "GO:0043231" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5D8V6", "id": "A5D8V6", "database": "UniProtKB" } ], "name": "extracellular exosome", "id": "GO:0070062" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5D8V6", "id": "A5D8V6", "database": "UniProtKB" } ], "name": "extracellular exosome", "id": "GO:0070062" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000813", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5D8V6", "id": "A5D8V6", "database": "UniProtKB" } ], "name": "ESCRT I complex", "id": "GO:0000813" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000813", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5D8V6", "id": "A5D8V6", "database": "UniProtKB" } ], "name": "ESCRT I complex", "id": "GO:0000813" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043657", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5D8V6", "id": "A5D8V6", "database": "UniProtKB" } ], "name": "host cell", "id": "GO:0043657" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031902", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5D8V6", "id": "A5D8V6", "database": "UniProtKB" } ], "name": "late endosome membrane", "id": "GO:0031902" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010008", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5D8V6", "id": "A5D8V6", "database": "UniProtKB" } ], "name": "endosome membrane", "id": "GO:0010008" } ], "total": 8, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036258", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5D8V6", "id": "A5D8V6", "database": "UniProtKB" } ], "name": "multivesicular body assembly", "id": "GO:0036258" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0039702", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5D8V6", "id": "A5D8V6", "database": "UniProtKB" } ], "name": "viral budding via host ESCRT complex", "id": "GO:0039702" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006612", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5D8V6", "id": "A5D8V6", "database": "UniProtKB" } ], "name": "protein targeting to membrane", "id": "GO:0006612" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016236", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5D8V6", "id": "A5D8V6", "database": "UniProtKB" } ], "name": "macroautophagy", "id": "GO:0016236" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006623", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5D8V6", "id": "A5D8V6", "database": "UniProtKB" } ], "name": "protein targeting to vacuole", "id": "GO:0006623" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043162", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5D8V6", "id": "A5D8V6", "database": "UniProtKB" } ], "name": "ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway", "id": "GO:0043162" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019058", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5D8V6", "id": "A5D8V6", "database": "UniProtKB" } ], "name": "viral life cycle", "id": "GO:0019058" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0075733", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5D8V6", "id": "A5D8V6", "database": "UniProtKB" } ], "name": "intracellular transport of virus", "id": "GO:0075733" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016197", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5D8V6", "id": "A5D8V6", "database": "UniProtKB" } ], "name": "endosomal transport", "id": "GO:0016197" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032509", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5D8V6", "id": "A5D8V6", "database": "UniProtKB" } ], "name": "endosome transport via multivesicular body sorting pathway", "id": "GO:0032509" } ], "total": 10, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 19, "annotation": "n_glycosylation_sequon", "start_pos": 17 }, { "end_pos": 48, "annotation": "n_glycosylation_sequon", "start_pos": 46 }, { "end_pos": 68, "annotation": "n_glycosylation_sequon", "start_pos": 66 }, { "end_pos": 137, "annotation": "n_glycosylation_sequon", "start_pos": 135 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060436.4", "id": "NP_060436.4", "database": "RefSeq" }, { "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=26097", "id": "26097", "database": "HGNC" }, { "url": "https://pharos.nih.gov/targets/A5D8V6", "id": "A5D8V6", "database": "PHAROS" }, { "url": "https://www.nextprot.org/entry/NX_A5D8V6", "id": "NX_A5D8V6", "database": "neXtProt" }, { "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=VPS37C", "id": "VPS37C", "database": "GeneCards" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174490", "id": "R-HSA-174490", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-162588", "id": "R-HSA-162588", "database": "Reactome" }, { 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