{
    "uniprot_canonical_ac": "A5D6W6-1", 
    "sequence": {
        "header": "sp|A5D6W6-1|FITM1_HUMAN Isoform 1 of Fat storage-inducing transmembrane protein 1  OS=Homo sapiens OX=9606 GN=FITM1 PE=2 SV=1 CANONICAL=A5D6W6-1", 
        "length": 292, 
        "sequence": "MERGPVVGAGLGAGARIQALLGCLLKVLLWVASALLYFGSEQAARLLGSPCLRRLYHAWLAAVVIFGPLLQFHVNPRTIFASHGNFFNIKFVNSAWGWTCTFLGGFVLLVVFLATRRVAVTARHLSRLVVGAAVWRGAGRAFLLIEDLTGSCFEPLPQGLLLHELPDRRSCLAAGHQWRGYTVSSHTFLLTFCCLLMAEEAAVFAKYLAHGLPAGAPLRLVFLLNVLLLGLWNFLLLCTVIYFHQYTHKVVGAAVGTFAWYLTYGSWYHQPWSPGSPGHGLFPRPHSSRKHN"
    }, 
    "uniprot_id": "FITM1_HUMAN", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [
                "fat storage-inducing transmembrane protein 1", 
                "fat-inducing transcript 1; fat-inducing protein 1"
            ], 
            "uniprotkb": [
                "Fat storage-inducing transmembrane protein 1", 
                "Fat-inducing protein 1"
            ]
        }, 
        "gene": {
            "refseq": [
                "FITM1", 
                "FIT1"
            ], 
            "uniprotkb": [
                "FITM1", 
                "FIT1"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A5D6W6", 
                    "id": "A5D6W6", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "recommendedname": {
        "full": "Fat storage-inducing transmembrane protein 1; Fat-inducing protein 1."
    }, 
    "publication": [
        {
            "title": "Evolutionarily conserved gene family important for fat storage.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/18160536", 
            "journal": "Proceedings of the National Academy of Sciences of the United States of America", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_981947.1", 
                    "id": "NP_981947.1", 
                    "database": "RefSeq"
                }, 
                {
                    "url": "https://www.uniprot.org/uniprot/A5D6W6/publications", 
                    "id": "A5D6W6", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Kadereit B, Kumar P, Wang WJ, Miranda D, Snapp EL, Severina N, Torregroza I, Evans T, Silver DL", 
            "date": "2008", 
            "pmid": "18160536"
        }
    ], 
    "glycosylation": [], 
    "mutation": [
        {
            "start_pos": 83, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5D6W6", 
                    "id": "A5D6W6", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "2.0", 
            "annotation": "Filters passed (1/5): patient freq. (2.0%).", 
            "sequence_org": "H", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "Y", 
            "subjects_tested": "50", 
            "end_pos": 83, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 64, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5D6W6", 
                    "id": "A5D6W6", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "2.0", 
            "annotation": "Filters passed (1/5): patient freq. (2.0%).", 
            "sequence_org": "V", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "I", 
            "subjects_tested": "50", 
            "end_pos": 64, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 106, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5D6W6", 
                    "id": "A5D6W6", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "2.0", 
            "annotation": "Filters passed (1/5): patient freq. (2.0%).", 
            "sequence_org": "F", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "I", 
            "subjects_tested": "50", 
            "end_pos": 106, 
            "type": "Point mutation"
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A5D6W6#A5D6W6-1", 
            "isoform_ac": "A5D6W6-1", 
            "locus": {
                "end_pos": 24131563, 
                "start_pos": 24132819, 
                "chromosome": "CHR_HG1_PATCH", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000644407", 
                        "id": "ENST00000644407", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000493961", 
                        "id": "ENSP00000493961", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A5D6W6-1|FITM1_HUMAN Isoform 1 of Fat storage-inducing transmembrane protein 1  OS=Homo sapiens OX=9606 GN=FITM1 PE=2 SV=1 CANONICAL=A5D6W6-1", 
                "length": 292, 
                "sequence": "MERGPVVGAGLGAGARIQALLGCLLKVLLWVASALLYFGSEQAARLLGSPCLRRLYHAWLAAVVIFGPLLQFHVNPRTIFASHGNFFNIKFVNSAWGWTCTFLGGFVLLVVFLATRRVAVTARHLSRLVVGAAVWRGAGRAFLLIEDLTGSCFEPLPQGLLLHELPDRRSCLAAGHQWRGYTVSSHTFLLTFCCLLMAEEAAVFAKYLAHGLPAGAPLRLVFLLNVLLLGLWNFLLLCTVIYFHQYTHKVVGAAVGTFAWYLTYGSWYHQPWSPGSPGHGLFPRPHSSRKHN"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A5D6W6#A5D6W6-2", 
            "isoform_ac": "A5D6W6-2", 
            "locus": {
                "end_pos": 24132532, 
                "start_pos": 24132819, 
                "chromosome": "CHR_HG1_PATCH", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000642380", 
                        "id": "ENST00000642380", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000493481", 
                        "id": "ENSP00000493481", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A5D6W6-2|FITM1_HUMAN Isoform 2 of Fat storage-inducing transmembrane protein 1  OS=Homo sapiens OX=9606 GN=FITM1 PE=2 SV=1 CANONICAL=A5D6W6-1", 
                "length": 96, 
                "sequence": "MAEEAAVFAKYLAHGLPAGAPLRLVFLLNVLLLGLWNFLLLCTVIYFHQYTHKVVGAAVGTFAWYLTYGSWYHQPWSPGSPGHGLFPRPHSSRKHN"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:161247", 
            "resource": "KEGG Pathway", 
            "id": "hsa:161247", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8964572", 
            "resource": "Reactome", 
            "id": "R-HSA-8964572", 
            "name": "Lipid particle organization"
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A5D6W6#function", 
            "annotation": "Plays an important role in lipid droplet accumulation.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A5D6W6#function", 
                    "id": "A5D6W6", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "D3ZIQ3-1", 
            "protein_name": "Similar to CG10671-like (Predicted); Fat storage-inducing transmembrane protein 1.", 
            "sequence": {
                "length": 292, 
                "sequence": "MERGPMVGAGPGAGTRVRALLGCLVKVVLWVASALLYFGSEQAARLLGSPCLRRLYHAWLAAVVIFGPLLQFHVNSRTIFASHGNFFNIKFVNSAWGWTCTFLGGFVLLVVFLATRRVAVTARHLSRLVVGAAVWRGAGRAFLLIEDLTGSCFEPLPQGLLLHELPDRKSCLAAGHQWRGYTVSSHTFLLTFCCLLMAEEAAVFAKYLAHGLPAGAPLRLVFLLNVLLLGLWNFLLLCTVIYFHQYTHKVVGAAVGTFAWYLTYGSWYHQPWSPGIPGHGLFPRSRSIRKHN"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/41695", 
                    "id": "41695", 
                    "database": "MGI"
                }
            ], 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "Q91V79-1", 
            "protein_name": "Fat storage-inducing transmembrane protein 1; Fat-inducing protein 1.", 
            "sequence": {
                "length": 292, 
                "sequence": "MERGPTVGAGLGAGTRVRALLGCLVKVLLWVASALLYFGSEQAARLLGSPCLRRLYHAWLAAVVIFGPLLQFHVNSRTIFASHGNFFNIKFVNSAWGWTCTFLGGFVLLVVFLATRRVAVTARHLSRLVVGAAVWRGAGRAFLLIEDLTGSCFEPLPQGLLLHELPDRKSCLAAGHQWRGYTVSSHTFLLTFCCLLMAEEAAVFAKYLAHGLPAGAPLRLVFLLNVLLLGLWNFLLLCTVIYFHQYTHKVVGAAVGTFAWYLTYGSWYHQPWSPGIPGHGLFPRSRSMRKHN"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/41695", 
                    "id": "41695", 
                    "database": "MGI"
                }
            ], 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_981947.1", 
        "ac": "NP_981947.1", 
        "name": "fat storage-inducing transmembrane protein 1; fat-inducing transcript 1; fat-inducing protein 1.", 
        "summary": "FIT1 belongs to an evolutionarily conserved family of proteins involved in fat storage (Kadereit et al., 2008 [PubMed 18160536]).[supplied by OMIM, May 2008]."
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5D6W6", 
                                "id": "A5D6W6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "endoplasmic reticulum membrane", 
                        "id": "GO:0005789"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030176", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5D6W6", 
                                "id": "A5D6W6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "integral component of endoplasmic reticulum membrane", 
                        "id": "GO:0030176"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010890", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5D6W6", 
                                "id": "A5D6W6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of sequestering of triglyceride", 
                        "id": "GO:0010890"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019915", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5D6W6", 
                                "id": "A5D6W6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "lipid storage", 
                        "id": "GO:0019915"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034389", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5D6W6", 
                                "id": "A5D6W6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "lipid droplet organization", 
                        "id": "GO:0034389"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008654", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5D6W6", 
                                "id": "A5D6W6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "phospholipid biosynthetic process", 
                        "id": "GO:0008654"
                    }
                ], 
                "total": 4, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_981947.1", 
            "id": "NP_981947.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=33714", 
            "id": "33714", 
            "database": "HGNC"
        }, 
        {
            "url": "https://pharos.nih.gov/targets/A5D6W6", 
            "id": "A5D6W6", 
            "database": "PHAROS"
        }, 
        {
            "url": "https://www.nextprot.org/entry/NX_A5D6W6", 
            "id": "NX_A5D6W6", 
            "database": "neXtProt"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=FITM1", 
            "id": "FITM1", 
            "database": "GeneCards"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8964572", 
            "id": "R-HSA-8964572", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:161247", 
            "id": "hsa:161247", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139914", 
            "id": "ENSG00000139914", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/SGWGWTC/", 
            "id": "SGWGWTC", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR019388", 
            "id": "IPR019388", 
            "database": "InterPro"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23129", 
            "id": "PTHR23129", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A5D6W6", 
            "id": "PR_A5D6W6", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/161247", 
            "id": "161247", 
            "database": "GeneID"
        }
    ], 
    "expression_disease": [
        {
            "trend": "Down", 
            "disease": {
                "doid": "3907", 
                "url": "http://disease-ontology.org/term/DOID:3907", 
                "icd10": "", 
                "name": "DOID:3907 / Lung squamous cell carcinoma"
            }, 
            "significant": "Yes", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5D6W6", 
                    "id": "A5D6W6", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "3571", 
                "url": "http://disease-ontology.org/term/DOID:3571", 
                "icd10": "", 
                "name": "DOID:3571 / Liver cancer [Livca]"
            }, 
            "significant": "Yes", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5D6W6", 
                    "id": "A5D6W6", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "DOID:1781 / Thyroid cancer [Thyca]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5D6W6", 
                    "id": "A5D6W6", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "3910", 
                "url": "http://disease-ontology.org/term/DOID:3910", 
                "icd10": "", 
                "name": "DOID:3910 / Lung adenocarcinoma"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5D6W6", 
                    "id": "A5D6W6", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "11054", 
                "url": "http://disease-ontology.org/term/DOID:11054", 
                "icd10": "", 
                "name": "DOID:11054 / Urinary bladder cancer [UBC]"
            }, 
            "significant": "Yes", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5D6W6", 
                    "id": "A5D6W6", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "5041", 
                "url": "http://disease-ontology.org/term/DOID:5041", 
                "icd10": "", 
                "name": "DOID:5041 / Esophageal cancer [EC]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5D6W6", 
                    "id": "A5D6W6", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "10283", 
                "url": "http://disease-ontology.org/term/DOID:10283", 
                "icd10": "", 
                "name": "DOID:10283 / Prostate cancer [PCa]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5D6W6", 
                    "id": "A5D6W6", 
                    "database": "BioXpress"
                }
            ]
        }
    ], 
    "uniprot_ac": "A5D6W6", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 32207.0, 
        "chemical_mass": 32207.0
    }, 
    "expression_tissue": [
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0009853", 
                "uberon": "0009853", 
                "name": "Body of uterus"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139914", 
                    "id": "ENSG00000139914", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000458", 
                "uberon": "0000458", 
                "name": "Endocervix"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139914", 
                    "id": "ENSG00000139914", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000948", 
                "uberon": "0000948", 
                "name": "Heart"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139914", 
                    "id": "ENSG00000139914", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000473", 
                "uberon": "0000473", 
                "name": "Testis"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139914", 
                    "id": "ENSG00000139914", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002369", 
                "uberon": "0002369", 
                "name": "Adrenal gland"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139914", 
                    "id": "ENSG00000139914", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000992", 
                "uberon": "0000992", 
                "name": "Ovary"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139914", 
                    "id": "ENSG00000139914", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000996", 
                "uberon": "0000996", 
                "name": "Vagina"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139914", 
                    "id": "ENSG00000139914", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001155", 
                "uberon": "0001155", 
                "name": "Colon"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139914", 
                    "id": "ENSG00000139914", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
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        {
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                    "id": "ENSG00000139914", 
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    ], 
    "gene": [
        {
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            "name": "FITM1; FIT1.", 
            "locus": {
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                "evidence": [
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                        "id": "ENSG00000139914", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}