{
    "uniprot_canonical_ac": "A4V8B4-1", 
    "sequence": {
        "header": "sp|A4V8B4-1|SAV1_RAT Isoform 1 of Protein salvador homolog 1  OS=Rattus norvegicus OX=10116 GN=Sav1 PE=2 SV=1 CANONICAL=A4V8B4-1", 
        "length": 387, 
        "sequence": "MLSRKKTKNEVSKPAEVQGKYVKKETSPLLRNLMPSFIRHGPTIPRRTDLCLPESSASAFSASGDGVVSRNQSFLRTPVQRTPHEVMRRESNRLSAPSSYLVRSLADVPREYGSSQSFLTEVNFAVENGDSGSRYFYSDNFFDGQRRRPLGDRAQEDYRYYEYNHDLFQRMPQNQGRHTSGIGRVTATSLGNLTNHGSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKRAQYRHPCAPSVPRYDQPPPITYQPQQTERNQSLLVPANPYHTAEIPDWLQVYARAPVKYDHILKWELFQLADLDTYQGMLKLLFMKELEQIVKLYEAYRQALVTELENRKQRQQWYAQHHGKKFLS"
    }, 
    "uniprot_id": "SAV1_RAT", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [
                "protein salvador homolog 1", 
                "Salvador homolog 1 protein; rWW45; 45 kDa WW domain protein"
            ], 
            "uniprotkb": [
                "Protein salvador homolog 1", 
                "45 kDa WW domain protein", 
                "rWW45"
            ]
        }, 
        "gene": {
            "refseq": [
                "Sav1"
            ], 
            "uniprotkb": [
                "Sav1", 
                "Ww45"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A4V8B4", 
                    "id": "A4V8B4", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "recommendedname": {
        "full": "Protein salvador homolog 1; 45 kDa WW domain protein; rWW45."
    }, 
    "publication": [
        {
            "title": "Mammalian ste20-like kinase and SAV1 promote 3T3-L1 adipocyte differentiation by activation of PPARgamma.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/22292086", 
            "journal": "PloS one", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091050.1", 
                    "id": "NP_001091050.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Park BH, Kim DS, Won GW, Jeon HJ, Oh BC, Lee Y, Kim EG, Lee YH", 
            "date": "2012", 
            "pmid": "22292086"
        }, 
        {
            "title": "Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/20080689", 
            "journal": "Proceedings of the National Academy of Sciences of the United States of America", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091050.1", 
                    "id": "NP_001091050.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Lu L, Li Y, Kim SM, Bossuyt W, Liu P, Qiu Q, Wang Y, Halder G, Finegold MJ, Lee JS, Johnson RL", 
            "date": "2010", 
            "pmid": "20080689"
        }, 
        {
            "title": "A crucial role of WW45 in developing epithelial tissues in the mouse.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/18369314", 
            "journal": "The EMBO journal", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091050.1", 
                    "id": "NP_001091050.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Lee JH, Kim TS, Yang TH, Koo BK, Oh SP, Lee KP, Oh HJ, Lee SH, Kong YY, Kim JM, Lim DS", 
            "date": "2008", 
            "pmid": "18369314"
        }, 
        {
            "title": "Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/16930133", 
            "journal": "The FEBS journal", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091050.1", 
                    "id": "NP_001091050.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Callus BA, Verhagen AM, Vaux DL", 
            "date": "2006", 
            "pmid": "16930133"
        }
    ], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A4V8B4#A4V8B4-1", 
            "isoform_ac": "A4V8B4-1", 
            "locus": {
                "end_pos": 92377185, 
                "start_pos": 92398507, 
                "chromosome": "6", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000007314", 
                        "id": "ENSRNOT00000007314", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000007314", 
                        "id": "ENSRNOP00000007314", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A4V8B4-1|SAV1_RAT Isoform 1 of Protein salvador homolog 1  OS=Rattus norvegicus OX=10116 GN=Sav1 PE=2 SV=1 CANONICAL=A4V8B4-1", 
                "length": 387, 
                "sequence": "MLSRKKTKNEVSKPAEVQGKYVKKETSPLLRNLMPSFIRHGPTIPRRTDLCLPESSASAFSASGDGVVSRNQSFLRTPVQRTPHEVMRRESNRLSAPSSYLVRSLADVPREYGSSQSFLTEVNFAVENGDSGSRYFYSDNFFDGQRRRPLGDRAQEDYRYYEYNHDLFQRMPQNQGRHTSGIGRVTATSLGNLTNHGSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKRAQYRHPCAPSVPRYDQPPPITYQPQQTERNQSLLVPANPYHTAEIPDWLQVYARAPVKYDHILKWELFQLADLDTYQGMLKLLFMKELEQIVKLYEAYRQALVTELENRKQRQQWYAQHHGKKFLS"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?rno:299116", 
            "resource": "KEGG Pathway", 
            "id": "rno:299116", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2028269", 
            "resource": "Reactome", 
            "id": "R-RNO-2028269", 
            "name": "Signaling by Hippo"
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A4V8B4#function", 
            "annotation": "Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation (By similarity).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A4V8B4#function", 
                    "id": "A4V8B4", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q8VEB2-1", 
            "protein_name": "Protein salvador homolog 1; 45 kDa WW domain protein; mWW45.", 
            "sequence": {
                "length": 386, 
                "sequence": "MLSRKKTKNEVSKPAEVQGKYVKKETSPLLRNLMPSFIRHGPTIPRRTDLCLPDSSATAFSASGDGVVSRNQSFLRTAIQRTPHEVMRRESHRLSAPSYLVRSLADVPRECGSSQSFLTEVNFAVENGDSGSRYFFSDNFFDGQRRRPLGDRAQEDYRYYEYNHDLFQRMPQSQGRHTSGIGRVTATSLGNLTNHGSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKRAQYRHPCAPSVPRYDQPPPITYQPQQTERNQSLLVPANPYHTAEIPDWLQVYARAPVKYDHILKWELFQLADLDTYQGMLKLLFMKELEQIVKLYEAYRQALLTELENRKQRQQWYAQQHGKTFLS"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A4V8B4/", 
                    "id": "A4V8B4", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/32517", 
                    "id": "32517", 
                    "database": "MGI"
                }
            ], 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }, 
        {
            "uniprot_canonical_ac": "Q9H4B6-1", 
            "protein_name": "Protein salvador homolog 1; 45 kDa WW domain protein; hWW45.", 
            "sequence": {
                "length": 383, 
                "sequence": "MLSRKKTKNEVSKPAEVQGKYVKKETSPLLRNLMPSFIRHGPTIPRRTDICLPDSSPNAFSTSGDVVSRNQSFLRTPIQRTPHEIMRRESNRLSAPSYLARSLADVPREYGSSQSFVTEVSFAVENGDSGSRYYYSDNFFDGQRKRPLGDRAHEDYRYYEYNHDLFQRMPQNQGRHASGIGRVAATSLGNLTNHGSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHPCAPSVPRYDQPPPVTYQPQQTERNQSLLVPANPYHTAEIPDWLQVYARAPVKYDHILKWELFQLADLDTYQGMLKLLFMKELEQIVKMYEAYRQALLTELENRKQRQQWYAQQHGKNF"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A4V8B4/", 
                    "id": "A4V8B4", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/32517", 
                    "id": "32517", 
                    "database": "MGI"
                }
            ], 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091050.1", 
        "ac": "NP_001091050.1", 
        "name": "protein salvador homolog 1; Salvador homolog 1 protein; rWW45; 45 kDa WW domain protein.", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060090", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4V8B4", 
                                "id": "A4V8B4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "molecular adaptor activity", 
                        "id": "GO:0060090"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4V8B4", 
                                "id": "A4V8B4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "identical protein binding", 
                        "id": "GO:0042802"
                    }
                ], 
                "total": 2, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4V8B4", 
                                "id": "A4V8B4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nucleus", 
                        "id": "GO:0005634"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4V8B4", 
                                "id": "A4V8B4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytoplasm", 
                        "id": "GO:0005737"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4V8B4", 
                                "id": "A4V8B4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytosol", 
                        "id": "GO:0005829"
                    }
                ], 
                "total": 3, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4V8B4", 
                                "id": "A4V8B4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "signal transduction", 
                        "id": "GO:0007165"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4V8B4", 
                                "id": "A4V8B4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of apoptotic process", 
                        "id": "GO:0043065"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045600", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4V8B4", 
                                "id": "A4V8B4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of fat cell differentiation", 
                        "id": "GO:0045600"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051091", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4V8B4", 
                                "id": "A4V8B4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of DNA-binding transcription factor activity", 
                        "id": "GO:0051091"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4V8B4", 
                                "id": "A4V8B4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "apoptotic process", 
                        "id": "GO:0006915"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035329", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4V8B4", 
                                "id": "A4V8B4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "hippo signaling", 
                        "id": "GO:0035329"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050680", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4V8B4", 
                                "id": "A4V8B4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of epithelial cell proliferation", 
                        "id": "GO:0050680"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030216", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4V8B4", 
                                "id": "A4V8B4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "keratinocyte differentiation", 
                        "id": "GO:0030216"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050821", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4V8B4", 
                                "id": "A4V8B4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein stabilization", 
                        "id": "GO:0050821"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001942", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4V8B4", 
                                "id": "A4V8B4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "hair follicle development", 
                        "id": "GO:0001942"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060412", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4V8B4", 
                                "id": "A4V8B4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ventricular septum morphogenesis", 
                        "id": "GO:0060412"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060487", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4V8B4", 
                                "id": "A4V8B4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "lung epithelial cell differentiation", 
                        "id": "GO:0060487"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060044", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4V8B4", 
                                "id": "A4V8B4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of cardiac muscle cell proliferation", 
                        "id": "GO:0060044"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000036", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4V8B4", 
                                "id": "A4V8B4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of stem cell population maintenance", 
                        "id": "GO:2000036"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060575", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4V8B4", 
                                "id": "A4V8B4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "intestinal epithelial cell differentiation", 
                        "id": "GO:0060575"
                    }
                ], 
                "total": 15, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 73, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 71
        }, 
        {
            "end_pos": 194, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 192
        }, 
        {
            "end_pos": 227, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 225
        }, 
        {
            "end_pos": 293, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 291
        }
    ], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091050.1", 
            "id": "NP_001091050.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2028269", 
            "id": "R-RNO-2028269", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?rno:299116", 
            "id": "rno:299116", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000005264", 
            "id": "ENSRNOG00000005264", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/RRESHRM/", 
            "id": "RRESHRM", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00201", 
            "id": "cd00201", 
            "database": "CDD"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001202", 
            "id": "IPR001202", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036020", 
            "id": "IPR036020", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011524", 
            "id": "IPR011524", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR030030", 
            "id": "IPR030030", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00397", 
            "id": "PF00397", 
            "database": "Pfam"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10316:SF70", 
            "id": "PTHR10316:SF70", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A4V8B4", 
            "id": "PR_A4V8B4", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/299116", 
            "id": "299116", 
            "database": "GeneID"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1307253", 
            "id": "1307253", 
            "database": "RGD"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A4V8B4", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 45046.0, 
        "chemical_mass": 45046.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A4V8B4", 
            "name": "Sav1; Ww45.", 
            "locus": {
                "end_pos": 92376093, 
                "start_pos": 92398525, 
                "chromosome": "6", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000005264", 
                        "id": "ENSRNOG00000005264", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}