{ "uniprot_canonical_ac": "A4Q9F0-1", "sequence": { "header": "sp|A4Q9F0-1|TTLL7_MOUSE Isoform 1 of Tubulin polyglutamylase TTLL7 OS=Mus musculus OX=10090 GN=Ttll7 PE=1 SV=1 CANONICAL=A4Q9F0-1", "length": 912, "sequence": "MPSLPQDGVIQGSSPVDLGTELPYQCTMKRKVRKKKKKGIITANVAGTKFEIVRLVIDEMGFMKTPDEDETSNLIWCDAAVQQEKITDLQNYQRINHFPGMGEICRKDFLARNMTKMIKSRPMDYTFVPRTWIFPSEYTQFQNYVKELKKKRKQKTFIVKPANGAMGHGISLIRNGDKVPSQDHLIVQEYIEKPFLMEGYKFDLRIYILVTSCDPLKIFLYHDGLVRMGTEKYIPPNESNLTQLYMHLTNYSVNKHNERFERNETEDKGSKRSIKWFTEFLQANQHDVTKFWSDISELVVKTLIVAEPHVLHAYRMCRPGQPPGSESVCFEVLGFDILLDRKLKPWLLEINRAPSFGTDQKIDYDVKRGVLLNALKLLNIRTSDKRKNLAKQKAEAQRRLYGQNPVRRLSPGSSDWEQQRHQLERRKEELKERLLQVRKQVSQEEHENRHMGNYRRIYPPEDKALLEKYEGLLAVAFQTFLSGRAASFQREMNNPLKKMREEDLLDLLEQCEIDDEKLMGKTGRVRGPKPLCCMPECAEVTKKQKYYGSSDSSYDSSSSSSNSELDENEKELCQKRLDQVPYSLKHTSHCKIIQQPSGSHNLIYSESPVYLTTLVFLSEFPDSMRRSVSCPRSISAHLPSRGDVRPFSSQQVIPLARPTSASRSHSLNRASSYARHLPHGSDTGSTNTLNESLRQLKTKEQEDDLTSQTLFVLKDMRIRFPGKSDAESELLIEDIMDNWKHYKTKVASYWLIKLDSVKQRKVLDIVKSSIRTVLPRIWRVPDAEELSLYRIFNRVFNRLLWSHGQGLWSCFCDSGSSWESIFSKSPEVVTPLQLQCCQRLVELCKQCLLVVYKYTTETRGPISGIGPDWGNSRYLLPGSTQFLMRSPLYNMKYNSPGMTRSNVLFTSRYGRL" }, "uniprot_id": "TTLL7_MOUSE", "enzyme_annotation": [ { "ec": "6.-.-.-", "activity": "" } ], "synonyms": { "protein": { "refseq": [ "tubulin polyglutamylase TTLL7 isoform Ttll7s", "tubulin polyglutamylase TTLL7; tubulin--tyrosine ligase-like protein 7" ], "uniprotkb": [ "Tubulin polyglutamylase TTLL7", "6.-.-.-", "Tubulin--tyrosine ligase-like protein 7", "mTTLL7" ] }, "gene": { "refseq": [ "Ttll7", "1110049N09Rik", "4921517B04Rik", "C630030B20", "mTTLL7" ], "uniprotkb": [ "Ttll7", "1110049N09Rik", "4921517B04Rik", "C630030B20", "mTTLL7" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F0", "id": "A4Q9F0", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Tubulin polyglutamylase TTLL7; 6.-.-.-; Tubulin--tyrosine ligase-like protein 7; mTTLL7." }, "publication": [ { "title": "Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/29593216", "journal": "Nature communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289887.1", "id": "NP_001289887.1", "database": "RefSeq" } ], "authors": "Ye B, Liu B, Hao L, Zhu X, Yang L, Wang S, Xia P, Du Y, Meng S, Huang G, Qin X, Wang Y, Yan X, Li C, Hao J, Zhu P, He L, Tian Y, Fan Z", "date": "2018", "pmid": "29593216" }, { "title": "Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-like Family Glutamylases.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/25959773", "journal": "Cell", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289887.1", "id": "NP_001289887.1", "database": "RefSeq" } ], "authors": "Garnham CP, Vemu A, Wilson-Kubalek EM, Yu I, Szyk A, Lander GC, Milligan RA, Roll-Mecak A", "date": "2015", "pmid": "25959773" }, { "title": "Recombinant mammalian tubulin polyglutamylase TTLL7 performs both initiation and elongation of polyglutamylation on beta-tubulin through a random sequential pathway.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/19152315", "journal": "Biochemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289887.1", "id": "NP_001289887.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A4Q9F0/publications", "id": "A4Q9F0", "database": "UniProtKB" } ], "authors": "Mukai M, Ikegami K, Sugiura Y, Takeshita K, Nakagawa A, Setou M", "date": "2009", "pmid": "19152315" }, { "title": "Loss of alpha-tubulin polyglutamylation in ROSA22 mice is associated with abnormal targeting of KIF1A and modulated synaptic function.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17360631", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289887.1", "id": "NP_001289887.1", "database": "RefSeq" } ], "authors": "Ikegami K, Heier RL, Taruishi M, Takagi H, Mukai M, Shimma S, Taira S, Hatanaka K, Morone N, Yao I, Campbell PK, Yuasa S, Janke C, Macgregor GR, Setou M", "date": "2007", "pmid": "17360631" }, { "title": "A targeted multienzyme mechanism for selective microtubule polyglutamylation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17499049", "journal": "Molecular cell", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289887.1", "id": "NP_001289887.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A4Q9F0/publications", "id": "A4Q9F0", "database": "UniProtKB" } ], "authors": "van Dijk J, Rogowski K, Miro J, Lacroix B, Edde B, Janke C", "date": "2007", "pmid": "17499049" }, { "title": "TTLL7 is a mammalian beta-tubulin polyglutamylase required for growth of MAP2-positive neurites.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/16901895", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289887.1", "id": "NP_001289887.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A4Q9F0/publications", "id": "A4Q9F0", "database": "UniProtKB" } ], "authors": "Ikegami K, Mukai M, Tsuchida J, Heier RL, Macgregor GR, Setou M", "date": "2006", "pmid": "16901895" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F0#A4Q9F0-1", "isoform_ac": "A4Q9F0-1", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A4Q9F0-1|TTLL7_MOUSE Isoform 1 of Tubulin polyglutamylase TTLL7 OS=Mus musculus OX=10090 GN=Ttll7 PE=1 SV=1 CANONICAL=A4Q9F0-1", "length": 912, "sequence": "MPSLPQDGVIQGSSPVDLGTELPYQCTMKRKVRKKKKKGIITANVAGTKFEIVRLVIDEMGFMKTPDEDETSNLIWCDAAVQQEKITDLQNYQRINHFPGMGEICRKDFLARNMTKMIKSRPMDYTFVPRTWIFPSEYTQFQNYVKELKKKRKQKTFIVKPANGAMGHGISLIRNGDKVPSQDHLIVQEYIEKPFLMEGYKFDLRIYILVTSCDPLKIFLYHDGLVRMGTEKYIPPNESNLTQLYMHLTNYSVNKHNERFERNETEDKGSKRSIKWFTEFLQANQHDVTKFWSDISELVVKTLIVAEPHVLHAYRMCRPGQPPGSESVCFEVLGFDILLDRKLKPWLLEINRAPSFGTDQKIDYDVKRGVLLNALKLLNIRTSDKRKNLAKQKAEAQRRLYGQNPVRRLSPGSSDWEQQRHQLERRKEELKERLLQVRKQVSQEEHENRHMGNYRRIYPPEDKALLEKYEGLLAVAFQTFLSGRAASFQREMNNPLKKMREEDLLDLLEQCEIDDEKLMGKTGRVRGPKPLCCMPECAEVTKKQKYYGSSDSSYDSSSSSSNSELDENEKELCQKRLDQVPYSLKHTSHCKIIQQPSGSHNLIYSESPVYLTTLVFLSEFPDSMRRSVSCPRSISAHLPSRGDVRPFSSQQVIPLARPTSASRSHSLNRASSYARHLPHGSDTGSTNTLNESLRQLKTKEQEDDLTSQTLFVLKDMRIRFPGKSDAESELLIEDIMDNWKHYKTKVASYWLIKLDSVKQRKVLDIVKSSIRTVLPRIWRVPDAEELSLYRIFNRVFNRLLWSHGQGLWSCFCDSGSSWESIFSKSPEVVTPLQLQCCQRLVELCKQCLLVVYKYTTETRGPISGIGPDWGNSRYLLPGSTQFLMRSPLYNMKYNSPGMTRSNVLFTSRYGRL" } }, { "url": "https://www.uniprot.org/uniprot/A4Q9F0#A0A0G2LB90-1", "isoform_ac": "A0A0G2LB90-1", "locus": { "end_pos": 146894176, "start_pos": 146979748, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000037942", "id": "ENSMUST00000037942", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000043753", "id": "ENSMUSP00000043753", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2LB90-1|TTLL7_MOUSE Computationally mapped isoform of Tubulin polyglutamylase TTLL7 OS=Mus musculus OX=10090 GN=Ttll7 PE=1 SV=1 CANONICAL=A4Q9F0-1", "length": 912, "sequence": "MPSLPQDGVIQGSSPVDLGTELPYQCTMKRKVRKKKKKGIITANVAGTKFEIVRLVIDEMGFMKTPDEDETSNLIWCDAAVQQEKITDLQNYQRINHFPGMGEICRKDFLARNMTKMIKSRPMDYTFVPRTWIFPSEYTQFQNYVKELKKKRKQKTFIVKPANGAMGHGISLIRNGDKVPSQDHLIVQEYIEKPFLMEGYKFDLRIYILVTSCDPLKIFLYHDGLVRMGTEKYIPPNESNLTQLYMHLTNYSVNKHNERFERNETEDKGSKRSIKWFTEFLQANQHDVTKFWSDISELVVKTLIVAEPHVLHAYRMCRPGQPPGSESVCFEVLGFDILLDRKLKPWLLEINRAPSFGTDQKIDYDVKRGVLLNALKLLNIRTSDKRKNLAKQKAEAQRRLYGQNPVRRLSPGSSDWEQQRHQLERRKEELKERLLQVRKQVSQEEHENRHMGNYRRIYPPEDKALLEKYEGLLAVAFQTFLSGRAASFQREMNNPLKKMREEDLLDLLEQCEIDDEKLMGKTGRVRGPKPLCCMPECAEVTKKQKYYGSSDSSYDSSSSSSNSELDENEKELCQKRLDQVPYSLKHTSHCKIIQQSSGSHNLIYSESPVYLTTLVFLSEFPDSMRRSVSCPRSISAHLPSRGDVRPFSSQQVIPLARPTSASRSHSLNRASSYARHLPHGSDTGSTNTLNESLRQLKTKEQEDDLTSQTLFVLKDMRIRFPGKSDAESELLIEDIMDNWKHYKTKVASYWLIKLDSVKQRKVLDIVKSSIRTVLPRIWRVPDAEELSLYRIFNRVFNRLLWSHGQGLWSCFCDSGSSWESIFSKSPEVVTPLQLQCCQRLVELCKQCLLVVYKYTTETRGPISGIGPDWGNSRYLLPGSTQFLMRSPLYNMKYNSPGMTRSNVLFTSRYGRL" } }, { "url": "https://www.uniprot.org/uniprot/A4Q9F0#A4Q9F0-2", "isoform_ac": "A4Q9F0-2", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A4Q9F0-2|TTLL7_MOUSE Isoform 2 of Tubulin polyglutamylase TTLL7 OS=Mus musculus OX=10090 GN=Ttll7 PE=1 SV=1 CANONICAL=A4Q9F0-1", "length": 609, "sequence": "MPSLPQDGVIQGSSPVDLGTELPYQCTMKRKVRKKKKKGIITANVAGTKFEIVRLVIDEMGFMKTPDEDETSNLIWCDAAVQQEKITDLQNYQRINHFPGMGEICRKDFLARNMTKMIKSRPMDYTFVPRTWIFPSEYTQFQNYVKELKKKRKQKTFIVKPANGAMGHGISLIRNGDKVPSQDHLIVQEYIEKPFLMEGYKFDLRIYILVTSCDPLKIFLYHDGLVRMGTEKYIPPNESNLTQLYMHLTNYSVNKHNERFERNETEDKGSKRSIKWFTEFLQANQHDVTKFWSDISELVVKTLIVAEPHVLHAYRMCRPGQPPGSESVCFEVLGFDILLDRKLKPWLLEINRAPSFGTDQKIDYDVKRGVLLNALKLLNIRTSDKRKNLAKQKAEAQRRLYGQNPVRRLSPGSSDWEQQRHQLERRKEELKERLLQVRKQVSQEEHENRHMGNYRRIYPPEDKALLEKYEGLLAVAFQTFLSGRAASFQREMNNPLKKMREEDLLDLLEQCEIDDEKLMGKTGRVRGPKPLCCMPECAEVTKKQKYYGSSDSSYDSSSSSSNSELDENEKELCQKRLDQVPYSLKHTSHCKIIQQSSKSISPTSLEEEL" } }, { "url": "https://www.uniprot.org/uniprot/A4Q9F0#E9PWB8-1", "isoform_ac": "E9PWB8-1", "locus": { "end_pos": 146894176, "start_pos": 146979748, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000170055", "id": "ENSMUST00000170055", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000129369", "id": "ENSMUSP00000129369", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|E9PWB8-1|TTLL7_MOUSE Computationally mapped isoform of Tubulin polyglutamylase TTLL7 OS=Mus musculus OX=10090 GN=Ttll7 PE=1 SV=1 CANONICAL=A4Q9F0-1", "length": 892, "sequence": "MPSLPQDGVIQGSSPVDLGTELPYQCTMKRKVRKKKKKGIITANVAGTKFEIVRLVIDEMGFMKTPDEDETSNLIWCDAAVQQEKITDLQNYQRINHFPGMGEICRKDFLARNMTKMIKSRPMDYTFVPRTWIFPSEYTQFQNYVKELKKKRKQKTFIVKPANGAMGHGISLIRNGDKVPSQDHLIVQEYIEKPFLMEGYKFDLRIYILVTSCDPLKIFLYHDGLVRMGTEKYIPPNESNLTQLYMHLTNYSVNKHNERFERNETEDKGSKRSIKWFTEFLQANQHDVTKFWSDISELVVKTLIVAEPHVLHAYRMCRPGQPPGSESVCFEVLGFDILLDRKLKPWLLEINRAPSFGTDQKIDYDVKRGVLLNALKLLNIRTSDKRKNLAKQKAEAQRRLYGQNPVRRLSPGSSDWEQQRHQLERRKEELKERLLQVRKQVSQEEHENRHMGNYRRIYPPEDKALLEKYEGLLAVAFQTFLSGRAASFQREMNNPLKKMREEDLLDLLEQCEIDDEKLMGKTGRVRGPKPLCCMPECAEVTKKQKYYGSSDSSYDSSSSSSNSELDENEKELCQKRLDQVPYSLKHTSHCKIIQQSNSMRRSVSCPRSISAHLPSRGDVRPFSSQQVIPLARPTSASRSHSLNRASSYARHLPHGSDTGSTNTLVSYQWNESLRQLKTKEQEDDLTSQTLFVLKDMRIRFPGKSDAESELLIEDIMDNWKHYKTKVASYWLIKLDSVKQRKVLDIVKSSIRTVLPRIWRVPDAEELSLYRIFNRVFNRLLWSHGQGLWSCFCDSGSSWESIFSKSPEVVTPLQLQCCQRLVELCKQCLLVVYKYTTETRGPISGIGPDWGNSRYLLPGSTQFLMRSPLYNMKYNSPGMTRSNVLFTSRYGRL" } }, { "url": "https://www.uniprot.org/uniprot/A4Q9F0#A0A0G2JFF6-1", "isoform_ac": "A0A0G2JFF6-1", "locus": { "end_pos": 146896656, "start_pos": 146897815, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000124743", "id": "ENSMUST00000124743", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000143151", "id": "ENSMUSP00000143151", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JFF6-1|TTLL7_MOUSE Computationally mapped isoform of Tubulin polyglutamylase TTLL7 OS=Mus musculus OX=10090 GN=Ttll7 PE=1 SV=1 CANONICAL=A4Q9F0-1", "length": 47, "sequence": "ETSNLIWCDAAVQQEKITDLQNYQRINHFPGMGEICRKDFLARNMTK" } }, { "url": "https://www.uniprot.org/uniprot/A4Q9F0#E9Q6C6-1", "isoform_ac": "E9Q6C6-1", "locus": { "end_pos": 146894176, "start_pos": 146979748, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000106134", "id": "ENSMUST00000106134", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000101740", "id": "ENSMUSP00000101740", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|E9Q6C6-1|TTLL7_MOUSE Computationally mapped isoform of Tubulin polyglutamylase TTLL7 OS=Mus musculus OX=10090 GN=Ttll7 PE=1 SV=1 CANONICAL=A4Q9F0-1", "length": 887, "sequence": "MPSLPQDGVIQGSSPVDLGTELPYQCTMKRKVRKKKKKGIITANVAGTKFEIVRLVIDEMGFMKTPDEDETSNLIWCDAAVQQEKITDLQNYQRINHFPGMGEICRKDFLARNMTKMIKSRPMDYTFVPRTWIFPSEYTQFQNYVKELKKKRKQKTFIVKPANGAMGHGISLIRNGDKVPSQDHLIVQEYIEKPFLMEGYKFDLRIYILVTSCDPLKIFLYHDGLVRMGTEKYIPPNESNLTQLYMHLTNYSVNKHNERFERNETEDKGSKRSIKWFTEFLQANQHDVTKFWSDISELVVKTLIVAEPHVLHAYRMCRPGQPPGSESVCFEVLGFDILLDRKLKPWLLEINRAPSFGTDQKIDYDVKRGVLLNALKLLNIRTSDKRKNLAKQKAEAQRRLYGQNPVRRLSPGSSDWEQQRHQLERRKEELKERLLQVRKQVSQEEHENRHMGNYRRIYPPEDKALLEKYEGLLAVAFQTFLSGRAASFQREMNNPLKKMREEDLLDLLEQCEIDDEKLMGKTGRVRGPKPLCCMPECAEVTKKQKYYGSSDSSYDSSSSSSNSELDENEKELCQKRLDQVPYSLKHTSHCKIIQQSNSMRRSVSCPRSISAHLPSRGDVRPFSSQQVIPLARPTSASRSHSLNRASSYARHLPHGSDTGSTNTLNESLRQLKTKEQEDDLTSQTLFVLKDMRIRFPGKSDAESELLIEDIMDNWKHYKTKVASYWLIKLDSVKQRKVLDIVKSSIRTVLPRIWRVPDAEELSLYRIFNRVFNRLLWSHGQGLWSCFCDSGSSWESIFSKSPEVVTPLQLQCCQRLVELCKQCLLVVYKYTTETRGPISGIGPDWGNSRYLLPGSTQFLMRSPLYNMKYNSPGMTRSNVLFTSRYGRL" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:70892", "resource": "KEGG Pathway", "id": "mmu:70892", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8955332", "resource": "Reactome", "id": "R-MMU-8955332", "name": "Carboxyterminal post-translational modifications of tubulin" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F0#function", "annotation": "Polyglutamylase which preferentially modifies beta-tubulin (PubMed:16901895, PubMed:17499049, PubMed:19152315). Mediates both ATP-dependent initiation and elongation of polyglutamylation of microtubules (PubMed:16901895, PubMed:19152315). Required for neurite growth; responsible for the strong increase in tubulin polyglutamylation during postnatal neuronal maturation (PubMed:16901895).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F0#function", "id": "A4Q9F0", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289887.1", "annotation": "TTLL7, the most abundant neuronal glutamylase, adds glutamates preferentially to the beta-tubulin tail; coupled with ensemble and single-molecule biochemistry, the hybrid X-ray and cryo-electron microscopy structure of TTLL7 bound to the microtubule delineates a tripartite microtubule recognition strategy.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289887.1", "id": "NP_001289887.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289887.1", "annotation": "TTLL7 performs both the initiation and elongation of polyglutamylation on beta-tubulin; the mechanism of binding of three substrates glutamate, ATP, and tubulin to the enzyme is a random sequential pathway.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289887.1", "id": "NP_001289887.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289887.1", "annotation": "TTLL7 is a mammalian beta-tubulin polyglutamylase required for growth of MAP2-positive neurites", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289887.1", "id": "NP_001289887.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q6ZT98-1", "protein_name": "Tubulin polyglutamylase TTLL7; 6.-.-.-; Tubulin--tyrosine ligase-like protein 7; Testis development protein NYD-SP30.", "sequence": { "length": 887, "sequence": "MPSLPQEGVIQGPSPLDLNTELPYQSTMKRKVRKKKKKGTITANVAGTKFEIVRLVIDEMGFMKTPDEDETSNLIWCDSAVQQEKISELQNYQRINHFPGMGEICRKDFLARNMTKMIKSRPLDYTFVPRTWIFPAEYTQFQNYVKELKKKRKQKTFIVKPANGAMGHGISLIRNGDKLPSQDHLIVQEYIEKPFLMEGYKFDLRIYILVTSCDPLKIFLYHDGLVRMGTEKYIPPNESNLTQLYMHLTNYSVNKHNEHFERDETENKGSKRSIKWFTEFLQANQHDVAKFWSDISELVVKTLIVAEPHVLHAYRMCRPGQPPGSESVCFEVLGFDILLDRKLKPWLLEINRAPSFGTDQKIDYDVKRGVLLNALKLLNIRTSDKRRNLAKQKAEAQRRLYGQNSIKRLLPGSSDWEQQRHQLERRKEELKERLAQVRKQISREEHENRHMGNYRRIYPPEDKALLEKYENLLAVAFQTFLSGRAASFQRELNNPLKRMKEEDILDLLEQCEIDDEKLMGKTTKTRGPKPLCSMPESTEIMKRPKYCSSDSSYDSSSSSSESDENEKEEYQNKKREKQVTYNLKPSNHYKLIQQPSSIRRSVSCPRSISAQSPSSGDTRPFSAQQMISVSRPTSASRSHSLNRASSYMRHLPHSNDACSTNSQVSESLRQLKTKEQEDDLTSQTLFVLKDMKIRFPGKSDAESELLIEDIIDNWKYHKTKVASYWLIKLDSVKQRKVLDIVKTSIRTVLPRIWKVPDVEEVNLYRIFNRVFNRLLWSRGQGLWNCFCDSGSSWESIFNKSPEVVTPLQLQCCQRLVELCKQCLLVVYKYATDKRGSLSGIGPDWGNSRYLLPGSTQFFLRTPTYNLKYNSPGMTRSNVLFTSRYGHL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/41578", "id": "41578", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289887.1", "ac": "NP_001289887.1", "name": "tubulin polyglutamylase TTLL7 isoform Ttll7s; tubulin polyglutamylase TTLL7; tubulin--tyrosine ligase-like protein 7.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070740", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F0", "id": "A4Q9F0", "database": "UniProtKB" } ], "name": "tubulin-glutamic acid ligase activity", "id": "GO:0070740" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F0", "id": "A4Q9F0", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048487", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F0", "id": "A4Q9F0", "database": "UniProtKB" } ], "name": "beta-tubulin binding", "id": "GO:0048487" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043014", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F0", "id": "A4Q9F0", "database": "UniProtKB" } ], "name": "alpha-tubulin binding", "id": "GO:0043014" } ], "total": 4, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F0", "id": "A4Q9F0", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F0", "id": "A4Q9F0", "database": "UniProtKB" } ], "name": "microtubule", "id": "GO:0005874" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F0", "id": "A4Q9F0", "database": "UniProtKB" } ], "name": "cilium", "id": "GO:0005929" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F0", "id": "A4Q9F0", "database": "UniProtKB" } ], "name": "dendrite", "id": "GO:0030425" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043204", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F0", "id": "A4Q9F0", "database": "UniProtKB" } ], "name": "perikaryon", "id": "GO:0043204" } ], "total": 5, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018095", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F0", "id": "A4Q9F0", "database": "UniProtKB" } ], "name": "protein polyglutamylation", "id": "GO:0018095" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F0", "id": "A4Q9F0", "database": "UniProtKB" } ], "name": "nervous system development", "id": "GO:0007399" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F0", "id": "A4Q9F0", "database": "UniProtKB" } ], "name": "cell differentiation", "id": "GO:0030154" } ], "total": 3, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 115, "annotation": "n_glycosylation_sequon", "start_pos": 113 }, { "end_pos": 239, "annotation": "n_glycosylation_sequon", "start_pos": 237 }, { "end_pos": 242, "annotation": "n_glycosylation_sequon", "start_pos": 240 }, { "end_pos": 252, "annotation": "n_glycosylation_sequon", "start_pos": 250 }, { "end_pos": 265, "annotation": "n_glycosylation_sequon", "start_pos": 263 }, { "end_pos": 692, "annotation": "n_glycosylation_sequon", "start_pos": 690 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289887.1", "id": "NP_001289887.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8955332", "id": "R-MMU-8955332", "database": "Reactome" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:70892", "id": "mmu:70892", "database": "KEGG Pathway" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013815", "id": "IPR013815", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR004344", "id": "IPR004344", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF03133", "id": "PF03133", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A4Q9F0", "id": "PR_A4Q9F0", "database": "PRO" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A4Q9F0*", "id": "A4Q9F0", "database": "IntAct" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/70892", "id": "70892", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:1918142", "id": "1918142", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A4Q9F0", "disease": [], "mass": { "monoisotopic_mass": 105501.0, "chemical_mass": 105501.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F0", "name": "Ttll7; 1110049N09Rik; 4921517B04Rik; C630030B20; mTTLL7.", "locus": { "end_pos": 146984009, "start_pos": 146852367, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000036745", "id": "ENSMUSG00000036745", "database": "Ensembl Gene" } ] } } ] }