{ "uniprot_canonical_ac": "A4Q9E8-1", "sequence": { "header": "sp|A4Q9E8-1|TTLL6_MOUSE Isoform 1 of Tubulin polyglutamylase TTLL6 OS=Mus musculus OX=10090 GN=Ttll6 PE=2 SV=1 CANONICAL=A4Q9E8-1", "length": 822, "sequence": "MLQCLTSESEEGAEEREESSTEDLEELKEFVTLAFVRENTQKRLQNAQQHGKKKRKKKRLVINLSNCRYDSVRRAAQQYGLREAGDNDDWTLYWTDYSVSLERVMEMKSYQKINHFPGMSEICRKDLLARNMSRMLKLFPKDFHFFPRTWCLPADWGDLQTYSRTRKNKTYICKPDSGCQGRGIFITRSVKEIKPGEDMICQLYISKPFIIDGFKFDLRVYVLVTSCDPLRVFVYNEGLARFATTSYSHPNLDNLDEICMHLTNYSINKHSSNFVQDAFSGSKRKLSTFNSYMKTHGYDVEQIWRGIEDVIIKTLISAHPVIKHNYHTCFPSHTLNSACFEILGFDILLDRKLKPWLLEVNHSPSFSTDSKLDKEVKDSLLYDALVLINLGNCDKKKVLEEERQRGRFLQQCPNREIRLEEVKGFQAMRLQKTEEYEKKNCGGFRLIYPGLNLEKYDKFFQDNSSLFQNTVASRARELYARQLIQELRQKQEKKVFLKKARKEETQGESAGEQARDKVVRLQRQRQQPKCKTVATCPPKQSLHPVTLVSCTSGLLLNIRGLKKGEISESLEQKDTKEAMLIPCKPVSARNYSSVPDLRSANPSCFEPEFHVPNAKVKEVKSAFMVNIESTAQPITSVESSRDATAPISTSLESLASMSLSTSPECSSPESVHMVSYNHKQQKASFHKPMQEKKSKPLMFSKSRHLDLNCTSMKNDINRQYLMSEILQKVQMKKKRPLFPAPKSQYPTLSKERCPHSRSSSRKKEMNSPSVFVLQASHSRAESLNDLLVVATQARLDPRPSRSHSGTTTRDSSTQDPKHTATA" }, "uniprot_id": "TTLL6_MOUSE", "enzyme_annotation": [ { "ec": "6.-.-.-", "activity": "" } ], "synonyms": { "protein": { "refseq": [ "tubulin polyglutamylase TTLL6", "polyglutamylase; tubulin--tyrosine ligase-like protein 6; ttll6" ], "uniprotkb": [ "Tubulin polyglutamylase TTLL6", "6.-.-.-", "Tubulin--tyrosine ligase-like protein 6" ] }, "gene": { "refseq": [ "Ttll6", "4932418K24Rik", "D11Moh43e", "D11Moh44e", "t8130b59" ], "uniprotkb": [ "Ttll6", "4932418K24Rik", "D11Moh43e", "D11Moh44e", "t8130b59" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "id": "A4Q9E8", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Tubulin polyglutamylase TTLL6; 6.-.-.-; Tubulin--tyrosine ligase-like protein 6." }, "publication": [ { "title": "Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/29593216", "journal": "Nature communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766387.2", "id": "NP_766387.2", "database": "RefSeq" } ], "authors": "Ye B, Liu B, Hao L, Zhu X, Yang L, Wang S, Xia P, Du Y, Meng S, Huang G, Qin X, Wang Y, Yan X, Li C, Hao J, Zhu P, He L, Tian Y, Fan Z", "date": "2018", "pmid": "29593216" }, { "title": "IL-7Ralpha glutamylation and activation of transcription factor Sall3 promote group 3 ILC development.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/28794449", "journal": "Nature communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766387.2", "id": "NP_766387.2", "database": "RefSeq" } ], "authors": "Liu B, Ye B, Zhu X, Huang G, Yang L, Zhu P, Du Y, Wu J, Meng S, Tian Y, Fan Z", "date": "2017", "pmid": "28794449" }, { "title": "Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/26829768", "journal": "Nat. Immunol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8/publications", "id": "A4Q9E8", "database": "UniProtKB" } ], "authors": "Wang S., Zhu X., Fan Z., Tian Y., Xiong Z., Ye B., Du Y., Xia P.", "date": "2016", "pmid": "26829768" }, { "title": "High-throughput discovery of novel developmental phenotypes.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/27626380", "journal": "Nature", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766387.2", "id": "NP_766387.2", "database": "RefSeq" } ], "authors": "Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M, Murray SA", "date": "2016", "pmid": "27626380" }, { "title": "Amyloid-beta oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/24065130", "journal": "The EMBO journal", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766387.2", "id": "NP_766387.2", "database": "RefSeq" } ], "authors": "Zempel H, Luedtke J, Kumar Y, Biernat J, Dawson H, Mandelkow E, Mandelkow EM", "date": "2013", "pmid": "24065130" }, { "title": "CEP41 is mutated in Joubert syndrome and is required for tubulin glutamylation at the cilium.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22246503", "journal": "Nat. Genet.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8/publications", "id": "A4Q9E8", "database": "UniProtKB" } ], "authors": "Attie-Bitach T., Gleeson J.G., Johnson C.A., Logan C.V., Schroth J., Silhavy J.L., Zaki M.S., Boltshauser E., Nelson S.F., Brancati F., Hildebrandt F., Valente E.M., Lee J.H., Glass I.A., Louie C.M., Marsh S.E., Barbot C., Bielas S.L., Lee J.E., Doherty D.A., Setou M., Castroviejo I.P., Cluckey A., Iannicelli M., Ikegami K., Merriman B., Olvera J., Rapin I., Raynes H.R., Schlossman A.M.", "date": "2012", "pmid": "22246503" }, { "title": "A family of protein-deglutamylating enzymes associated with neurodegeneration.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/21074048", "journal": "Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8/publications", "id": "A4Q9E8", "database": "UniProtKB" } ], "authors": "Larroque C., Andrieux A., Bosc C., Janke C., Moutin M.J., Peris L., Magiera M.M., Deloulme J.C., Gold N.D., Lacroix B., Rogowski K., van Dijk J., Bec N., Bosson A., Desagher S., Grau M.B., Holzer M.", "date": "2010", "pmid": "21074048" }, { "title": "Tubulin polyglutamylation stimulates spastin-mediated microtubule severing.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/20530212", "journal": "J. Cell Biol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8/publications", "id": "A4Q9E8", "database": "UniProtKB" } ], "authors": "Gerlich D.W., Janke C., Guizetti J., Aldrian-Herrada G., Gold N.D., Lacroix B., Rogowski K., van Dijk J.", "date": "2010", "pmid": "20530212" }, { "title": "Tissue expression patterns identify mouse cilia genes.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17971504", "journal": "Physiological genomics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766387.2", "id": "NP_766387.2", "database": "RefSeq" } ], "authors": "McClintock TS, Glasser CE, Bose SC, Bergman DA", "date": "2008", "pmid": "17971504" }, { "title": "A targeted multienzyme mechanism for selective microtubule polyglutamylation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17499049", "journal": "Molecular cell", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766387.2", "id": "NP_766387.2", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A4Q9E8/publications", "id": "A4Q9E8", "database": "UniProtKB" } ], "authors": "van Dijk J, Rogowski K, Miro J, Lacroix B, Edde B, Janke C", "date": "2007", "pmid": "17499049" }, { "title": "Tubulin polyglutamylase enzymes are members of the TTL domain protein family.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/15890843", "journal": "Science (New York, N.Y.)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766387.2", "id": "NP_766387.2", "database": "RefSeq" } ], "authors": "Janke C, Rogowski K, Wloga D, Regnard C, Kajava AV, Strub JM, Temurak N, van Dijk J, Boucher D, van Dorsselaer A, Suryavanshi S, Gaertig J, Edde B", "date": "2005", "pmid": "15890843" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8#A4Q9E8-1", "isoform_ac": "A4Q9E8-1", "locus": { "end_pos": 96133786, "start_pos": 96158923, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000167258", "id": "ENSMUST00000167258", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000127778", "id": "ENSMUSP00000127778", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A4Q9E8-1|TTLL6_MOUSE Isoform 1 of Tubulin polyglutamylase TTLL6 OS=Mus musculus OX=10090 GN=Ttll6 PE=2 SV=1 CANONICAL=A4Q9E8-1", "length": 822, "sequence": "MLQCLTSESEEGAEEREESSTEDLEELKEFVTLAFVRENTQKRLQNAQQHGKKKRKKKRLVINLSNCRYDSVRRAAQQYGLREAGDNDDWTLYWTDYSVSLERVMEMKSYQKINHFPGMSEICRKDLLARNMSRMLKLFPKDFHFFPRTWCLPADWGDLQTYSRTRKNKTYICKPDSGCQGRGIFITRSVKEIKPGEDMICQLYISKPFIIDGFKFDLRVYVLVTSCDPLRVFVYNEGLARFATTSYSHPNLDNLDEICMHLTNYSINKHSSNFVQDAFSGSKRKLSTFNSYMKTHGYDVEQIWRGIEDVIIKTLISAHPVIKHNYHTCFPSHTLNSACFEILGFDILLDRKLKPWLLEVNHSPSFSTDSKLDKEVKDSLLYDALVLINLGNCDKKKVLEEERQRGRFLQQCPNREIRLEEVKGFQAMRLQKTEEYEKKNCGGFRLIYPGLNLEKYDKFFQDNSSLFQNTVASRARELYARQLIQELRQKQEKKVFLKKARKEETQGESAGEQARDKVVRLQRQRQQPKCKTVATCPPKQSLHPVTLVSCTSGLLLNIRGLKKGEISESLEQKDTKEAMLIPCKPVSARNYSSVPDLRSANPSCFEPEFHVPNAKVKEVKSAFMVNIESTAQPITSVESSRDATAPISTSLESLASMSLSTSPECSSPESVHMVSYNHKQQKASFHKPMQEKKSKPLMFSKSRHLDLNCTSMKNDINRQYLMSEILQKVQMKKKRPLFPAPKSQYPTLSKERCPHSRSSSRKKEMNSPSVFVLQASHSRAESLNDLLVVATQARLDPRPSRSHSGTTTRDSSTQDPKHTATA" } }, { "url": "https://www.uniprot.org/uniprot/A4Q9E8#A4Q9E8-2", "isoform_ac": "A4Q9E8-2", "locus": { "end_pos": 96135583, "start_pos": 96158923, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000107680", "id": "ENSMUST00000107680", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000103307", "id": "ENSMUSP00000103307", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A4Q9E8-2|TTLL6_MOUSE Isoform 2 of Tubulin polyglutamylase TTLL6 OS=Mus musculus OX=10090 GN=Ttll6 PE=2 SV=1 CANONICAL=A4Q9E8-1", "length": 718, "sequence": "MEMKSYQKINHFPGMSEICRKDLLARNMSRMLKLFPKDFHFFPRTWCLPADWGDLQTYSRTRKNKTYICKPDSGCQGRGIFITRSVKEIKPGEDMICQLYISKPFIIDGFKFDLRVYVLVTSCDPLRVFVYNEGLARFATTSYSHPNLDNLDEICMHLTNYSINKHSSNFVQDAFSGSKRKLSTFNSYMKTHGYDVEQIWRGIEDVIIKTLISAHPVIKHNYHTCFPSHTLNSACFEILGFDILLDRKLKPWLLEVNHSPSFSTDSKLDKEVKDSLLYDALVLINLGNCDKKKVLEEERQRGRFLQQCPNREIRLEEVKGFQAMRLQKTEEYEKKNCGGFRLIYPGLNLEKYDKFFQDNSSLFQNTVASRARELYARQLIQELRQKQEKKVFLKKARKEETQGESAGEQARDKVVRLQRQRQQPKCKTVATCPPKQSLHPVTLVSCTSGLLLNIRGLKKGEISESLEQKDTKEAMLIPCKPVSARNYSSVPDLRSANPSCFEPEFHVPNAKVKEVKSAFMVNIESTAQPITSVESSRDATAPISTSLESLASMSLSTSPECSSPESVHMVSYNHKQQKASFHKPMQEKKSKPLMFSKSRHLDLNCTSMKNDINRQYLMSEILQKVQMKKKRPLFPAPKSQYPTLSKERCPHSRSSSRKKEMNSPSVFVLQASHSRAESLNDLLVVATQARLDPRPSRSHSGTTTRDSSTQDPKHTATA" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:237930", "resource": "KEGG Pathway", "id": "mmu:237930", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8955332", "resource": "Reactome", "id": "R-MMU-8955332", "name": "Carboxyterminal post-translational modifications of tubulin" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8#function", "annotation": "Polyglutamylase which preferentially modifies alpha-tubulin (PubMed:17499049, PubMed:21074048). Mediates tubulin polyglutamylation in cilia (PubMed:22246503). Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step (PubMed:17499049, PubMed:21074048). Generates long side-chains (PubMed:20530212). Generates polyglutamylation of CGAS, leading to impair the DNA-binding activity of CGAS (PubMed:26829768).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8#function", "id": "A4Q9E8", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766387.2", "annotation": "Transgenic mice overexpressing Tau show TTLL6 translocalization into dendrites and decreased MT stability", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766387.2", "id": "NP_766387.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766387.2", "annotation": "Ttll6 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766387.2", "id": "NP_766387.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZJ17-1", "protein_name": "Tubulin tyrosine ligase-like 6.", "sequence": { "length": 858, "sequence": "MLQCLTLESEEGAEEREESSTEDLEELKKLVALAFVRENTQKRLQNAQQHGKKKRKKKRLVINLSNCRYDSVRRAAQQYGLREAGDNDDWTLYWTDYSVSLERVMEMKSYQKINHFPGMSEICRKDLLARNMSRMLKLFPKDFHFFPRTWCLPADWGDLQTYSRTRKNKTYICKPDSGCQGRGIFITRSVKEIKPGEDMICQLYISKPFIIDGFKFDLRVYVLVTSCDPLRVFVYNEGLARFATTSYSHPNTENLDEICMHLTNYSINKHSSNFIQDAHSGSKRKLSTFNSYMKTHGYDVEQIWRAIEDVIIKTLISAHPVIKHNYHTCFPSHTLNSACFEILGFDILLDRKLKPWLLEVNHSPSFSTDSKLDKEVKDSLLYDALVLVNLGSCDKKKVLEEERQRGRFLQQCPNREIRMEEVKGFQAVRLQKTEEYEKKNCGGFRLIYPGQNLEKYEKFFQDNSSLFQNTVASRARELYARQLIQELRQKQQNKFFLKKERKEEMQGESAGEQARDKIVRLQRPRQQPKCKPATCPPKQSFHPVNLGSRASSLLLNIRGLKKSETARSLDQKDSKNEVVLIPCKPVSARNYSSVPDLRSSNPSYSELEFHMANSKVKEVKSAFSVNIVSSAQPTAEPSEQLSKVFGYCSQSQVKKTLSDAEFADHLSTSKPITPVETSPDATAPISTSLESLASSLSTTPECSSPESIHMASYNHKQQKASNKPTQEKKSKPLMFSKSRQLDLNCTSMKNDIKKQYLMSEILQKVQMKKKRPLFPVPKTQYPSLSKERYPHGRSSGRKKGMEAHSVVILQSSHSHAESLNDLLVVATQARLDPRPSRSHSGTTTRDSGTQDPKHTATA" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A4Q9E8/", "id": "A4Q9E8", "database": "OMA" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q8N841-1", "protein_name": "Tubulin polyglutamylase TTLL6; 6.-.-.-; Tubulin--tyrosine ligase-like protein 6.", "sequence": { "length": 843, "sequence": "MPQCPTLESQEGENSEEKGDSSKEDPKETVALAFVRENPGAQNGLQNAQQQGKKKRKKKRLVINLSSCRYESVRRAAQQYGFREGGEDDDWTLYWTDYSVSLERVMEMKSYQKINHFPGMSEICRKDLLARNMSRMLKMFPKDFRFFPRTWCLPADWGDLQTYSRSRKNKTYICKPDSGCQGKGIFITRTVKEIKPGEDMICQLYISKPFIIDGFKFDLRIYVLVTSCDPLRIFVYNEGLARFATTSYSRPCTDNLDDICMHLTNYSINKHSSNFSRDAHSGSKRKLSTFSAYLEDHSYNVEQIWRDIEDVIIKTLISAHPIIRHNYHTCFPNHTLNSACFEILGFDILLDHKLKPWLLEVNHSPSFSTDSRLDKEVKDGLLYDTLVLINLESCDKKKVLEEERQRGQFLQQCCSREMRIEEAKGFRAVQLKKTETYEKENCGGFRLIYPSLNSEKYEKFFQDNNSLFQNTVASRAREEYARQLIQELRLKREKKPFQMKKKVEMQGESAGEQVRKKGMRGWQQKQQQKDKAATQASKQYIQPLTLVSYTPDLLLSVRGERKNETDSSLNQEAPTEEASSVFPKLTSAKPFSSLPDLRNINLSSSKLEPSKPNFSIKEAKSASAVNVFTGTVHLTSVETTPESTTQLSISPKSPPTLAVTASSEYSGPETDRVVSFKCKKQQTPPHLTQKKMLKSFLPTKSKSFWESPNTNWTLLKSDMNKPHLISELLTKLQLSGKLSFFPAHYNPKLGMNNLSQNPSLPGECHSRSDSSGEKRQLDVSSLLLQSPQSYNVTLRDLLVIATPAQLDPRPCRSHASAMRDPCMQDQEAYSHCLISGQKGCERS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/18229", "id": "18229", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766387.2", "ac": "NP_766387.2", "name": "tubulin polyglutamylase TTLL6; polyglutamylase; tubulin--tyrosine ligase-like protein 6; ttll6.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015631", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "id": "A4Q9E8", "database": "UniProtKB" } ], "name": "tubulin binding", "id": "GO:0015631" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070739", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "id": "A4Q9E8", "database": "UniProtKB" } ], "name": "protein-glutamic acid ligase activity", "id": "GO:0070739" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "id": "A4Q9E8", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "id": "A4Q9E8", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "id": "A4Q9E8", "database": "UniProtKB" } ], "name": "microtubule", "id": "GO:0005874" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "id": "A4Q9E8", "database": "UniProtKB" } ], "name": "ciliary basal body", "id": "GO:0036064" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051013", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "id": "A4Q9E8", "database": "UniProtKB" } ], "name": "microtubule severing", "id": "GO:0051013" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018095", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "id": "A4Q9E8", "database": "UniProtKB" } ], "name": "protein polyglutamylation", "id": "GO:0018095" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018095", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "id": "A4Q9E8", "database": "UniProtKB" } ], "name": "protein polyglutamylation", "id": "GO:0018095" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001578", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "id": "A4Q9E8", "database": "UniProtKB" } ], "name": "microtubule bundle formation", "id": "GO:0001578" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003353", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "id": "A4Q9E8", "database": "UniProtKB" } ], "name": "positive regulation of cilium movement", "id": "GO:0003353" } ], "total": 5, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 65, "annotation": "n_glycosylation_sequon", "start_pos": 63 }, { "end_pos": 133, "annotation": "n_glycosylation_sequon", "start_pos": 131 }, { "end_pos": 170, "annotation": "n_glycosylation_sequon", "start_pos": 168 }, { "end_pos": 266, "annotation": "n_glycosylation_sequon", "start_pos": 264 }, { "end_pos": 363, "annotation": "n_glycosylation_sequon", "start_pos": 361 }, { "end_pos": 465, "annotation": "n_glycosylation_sequon", "start_pos": 463 }, { "end_pos": 592, "annotation": "n_glycosylation_sequon", "start_pos": 590 }, { "end_pos": 710, "annotation": "n_glycosylation_sequon", "start_pos": 708 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766387.2", "id": "NP_766387.2", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8955332", "id": "R-MMU-8955332", "database": "Reactome" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:237930", "id": "mmu:237930", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000038756", "id": "ENSMUSG00000038756", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/KGFQAVW/", "id": "KGFQAVW", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013815", "id": "IPR013815", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR004344", "id": "IPR004344", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027754", "id": "IPR027754", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF03133", "id": "PF03133", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12241:SF96", "id": "PTHR12241:SF96", "database": "PANTHER" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A4Q9E8", "id": "PR_A4Q9E8", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/237930", "id": "237930", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:2683461", "id": "2683461", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A4Q9E8", "disease": [], "mass": { "monoisotopic_mass": 94507.0, "chemical_mass": 94507.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "name": "Ttll6; 4932418K24Rik; D11Moh43e; D11Moh44e; t8130b59.", "locus": { "end_pos": 96165451, "start_pos": 96133786, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000038756", "id": "ENSMUSG00000038756", "database": "Ensembl Gene" } ] } } ] }