{ "uniprot_canonical_ac": "A4L9P5-1", "sequence": { "header": "sp|A4L9P5-1|HIPK1_RAT Isoform 1 of Homeodomain-interacting protein kinase 1 OS=Rattus norvegicus OX=10116 GN=Hipk1 PE=2 SV=1 CANONICAL=A4L9P5-1", "length": 1211, "sequence": "MASQLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQASSSHQVANFNIPAYDQGLLLQAPAVEHIVVTAADSSGSAATATFQSSQTLTHRSNVSLLEPYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRVTPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPSTSTNLTMSFSNQLSTVHNQASVLASSSTAAAATLSLANSDVSLLNYQSALYPPSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQTGLQATTKHSGFPVRMDNAVPLVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATITPQYAVPFTLSCAAGRPALVEQTAAVQQAWPGGTQQILLPSAWQQLPGVALHNSVQPTAVIPEAMGSSQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSSLPSRKNKQSAPVSSTSSLEVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPSPPVSVITIRSDTDEEEDNKFKPSSSSLKARSNVISYVTVNDSPDSDSSLSSPYPTDTLSALRGNSGTLLEGPGRTAADGIGTRTIIVPPLKTQLGDCTGATQASGLLSSSKTKPVASVSGQSSGCCITPTGYRAQRGGASAVQPLNLSQNQQSSSASTSQERSSNPAPRRQQAFVAPLSQAPYAFQHGSPLHSTGHPHLAPAPAHLPSQPHLYTYAAPTSAAALGSTSSIAHLFSPQGSSRHAAAYTTHPSTLVHQVPVSVGPSLLTSASVAPAQYQHQFATQSYIGSSRGSTIYTGYPLSPTKISQYSYL" }, "uniprot_id": "HIPK1_RAT", "enzyme_annotation": [ { "ec": "2.7.11.1", "activity": "ATP + a protein = ADP + a phosphoprotein." }, { "ec": "2.7.11.1", "activity": "" } ], "synonyms": { "protein": { "refseq": [], "uniprotkb": [ "Homeodomain-interacting protein kinase 1", "2.7.11.1" ] }, "gene": { "refseq": [], "uniprotkb": [ "Hipk1" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4L9P5", "id": "A4L9P5", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Homeodomain-interacting protein kinase 1; 2.7.11.1." }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A4L9P5#A4L9P5-1", "isoform_ac": "A4L9P5-1", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A4L9P5-1|HIPK1_RAT Isoform 1 of Homeodomain-interacting protein kinase 1 OS=Rattus norvegicus OX=10116 GN=Hipk1 PE=2 SV=1 CANONICAL=A4L9P5-1", "length": 1211, "sequence": "MASQLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQASSSHQVANFNIPAYDQGLLLQAPAVEHIVVTAADSSGSAATATFQSSQTLTHRSNVSLLEPYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRVTPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPSTSTNLTMSFSNQLSTVHNQASVLASSSTAAAATLSLANSDVSLLNYQSALYPPSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQTGLQATTKHSGFPVRMDNAVPLVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATITPQYAVPFTLSCAAGRPALVEQTAAVQQAWPGGTQQILLPSAWQQLPGVALHNSVQPTAVIPEAMGSSQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSSLPSRKNKQSAPVSSTSSLEVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPSPPVSVITIRSDTDEEEDNKFKPSSSSLKARSNVISYVTVNDSPDSDSSLSSPYPTDTLSALRGNSGTLLEGPGRTAADGIGTRTIIVPPLKTQLGDCTGATQASGLLSSSKTKPVASVSGQSSGCCITPTGYRAQRGGASAVQPLNLSQNQQSSSASTSQERSSNPAPRRQQAFVAPLSQAPYAFQHGSPLHSTGHPHLAPAPAHLPSQPHLYTYAAPTSAAALGSTSSIAHLFSPQGSSRHAAAYTTHPSTLVHQVPVSVGPSLLTSASVAPAQYQHQFATQSYIGSSRGSTIYTGYPLSPTKISQYSYL" } }, { "url": "https://www.uniprot.org/uniprot/A4L9P5#F1M8I6-1", "isoform_ac": "F1M8I6-1", "locus": { "end_pos": 206228191, "start_pos": 206261915, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000056079", "id": "ENSRNOT00000056079", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000061079", "id": "ENSRNOP00000061079", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F1M8I6-1|HIPK1_RAT Computationally mapped isoform of Homeodomain-interacting protein kinase 1 OS=Rattus norvegicus OX=10116 GN=Hipk1 PE=2 SV=3 CANONICAL=A4L9P5-1", "length": 1211, "sequence": "MASQLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQASSSHQVANFNIPAYDQGLLLQAPAVEHIVVTAADSSGSAATATFQSSQTLTHRSNVSLLEPYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRVTPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPSTSTNLTMSFSNQLSTVHNQASVLASSSTAAAATLSLANSDVSLLNYQSALYPPSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQTGLQATTKHSGFPVRMDNAVPLVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSAWQQLPGVALHNSVQPTAVIPEAMGSSQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSSLPSRKNKQSAPVSSTSSLEVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPSPPVSVITIRSDTDEEEDNKFKPSSSSLKARSNVISYVTVNDSPDSDSSLSSPYPTDTLSALRGNSGTLLEGPGRTAADGIGTRTIIVPPLKTQLGDCTGATQASGLLSSSKTKPVASVSGQSSGCCITPTGYRAQRGGASAVQPLNLSQNQQSSSASTSQERSSNPAPRRQQAFVAPLSQAPYAFQHGSPLHSTGHPHLAPAPAHLPSQPHLYTYAAPTSAAALGSTSSIAHLFSPQGSSRHAAAYTTHPSTLVHQVPVSVGPSLLTSASVAPAQYQHQFATQSYIGSSRGSTIYTGYPLSPTKISQYSYL" } }, { "url": "https://www.uniprot.org/uniprot/A4L9P5#A4L9P5-2", "isoform_ac": "A4L9P5-2", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A4L9P5-2|HIPK1_RAT Isoform 2 of Homeodomain-interacting protein kinase 1 OS=Rattus norvegicus OX=10116 GN=Hipk1 PE=2 SV=1 CANONICAL=A4L9P5-1", "length": 1177, "sequence": "MASQLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQASSSHQVANFNIPAYDQGLLLQAPAVEHIVVTAADSSGSAATATFQSSQTLTHRSNVSLLEPYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRVTPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKRRVHMYDTASVLASSSTAAAATLSLANSDVSLLNYQSALYPPSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQTGLQATTKHSGFPVRMDNAVPLVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATITPQYAVPFTLSCAAGRPALVEQTAAVQQAWPGGTQQILLPSAWQQLPGVALHNSVQPTAVIPEAMGSSQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSSLPSRKNKQSAPVSSTSSLEVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPSPPVSVITIRSDTDEEEDNKFKPSSSSLKARSNVISYVTVNDSPDSDSSLSSPYPTDTLSALRGNSGTLLEGPGRTAADGIGTRTIIVPPLKTQLGDCTGATQASGLLSSSKTKPVASVSGQSSGCCITPTGYRAQRGGASAVQPLNLSQNQQSSSASTSQERSSNPAPRRQQAFVAPLSQAPYAFQHGSPLHSTGHPHLAPAPAHLPSQPHLYTYAAPTSAAALGSTSSIAHLFSPQGSSRHAAAYTTHPSTLVHQVPVSVGPSLLTSASVAPAQYQHQFATQSYIGSSRGSTIYTGYPLSPTKISQYSYL" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804756", "resource": "Reactome", "id": "R-RNO-6804756", "name": "Regulation of TP53 Activity through Phosphorylation" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A4L9P5#function", "annotation": "Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation (By similarity). Phosphorylates PAGE4 at 'Thr-51' which is critical for the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4L9P5#function", "id": "A4L9P5", "database": "UniProtKB" } ] } ], "orthologs": [], "refseq": { "url": "", "ac": "", "name": "", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4L9P5", "id": "A4L9P5", "database": "UniProtKB" } ], "name": "protein serine/threonine kinase activity", "id": "GO:0004674" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004713", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4L9P5", "id": "A4L9P5", "database": "UniProtKB" } ], "name": "protein tyrosine kinase activity", "id": "GO:0004713" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4L9P5", "id": "A4L9P5", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4L9P5", "id": "A4L9P5", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4L9P5", "id": "A4L9P5", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016605", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4L9P5", "id": "A4L9P5", "database": "UniProtKB" } ], "name": "PML body", "id": "GO:0016605" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4L9P5", "id": "A4L9P5", "database": "UniProtKB" } ], "name": "nuclear speck", "id": "GO:0016607" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042771", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4L9P5", "id": "A4L9P5", "database": "UniProtKB" } ], "name": "intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator", "id": "GO:0042771" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018107", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4L9P5", "id": "A4L9P5", "database": "UniProtKB" } ], "name": "peptidyl-threonine phosphorylation", "id": "GO:0018107" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018105", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4L9P5", "id": "A4L9P5", "database": "UniProtKB" } ], "name": "peptidyl-serine phosphorylation", "id": "GO:0018105" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007224", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4L9P5", "id": "A4L9P5", "database": "UniProtKB" } ], "name": "smoothened signaling pathway", "id": "GO:0007224" } ], "total": 4, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 113, "annotation": "n_glycosylation_sequon", "start_pos": 111 }, { "end_pos": 135, "annotation": "n_glycosylation_sequon", "start_pos": 133 }, { "end_pos": 151, "annotation": "n_glycosylation_sequon", "start_pos": 149 }, { "end_pos": 264, "annotation": "n_glycosylation_sequon", "start_pos": 262 }, { "end_pos": 473, "annotation": "n_glycosylation_sequon", "start_pos": 471 }, { "end_pos": 572, "annotation": "n_glycosylation_sequon", "start_pos": 570 }, { "end_pos": 942, "annotation": "n_glycosylation_sequon", "start_pos": 940 }, { "end_pos": 1048, "annotation": "n_glycosylation_sequon", "start_pos": 1046 } ], "crossref": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804756", "id": "R-RNO-6804756", "database": "Reactome" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "id": "IPR000719", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "id": "IPR011009", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "id": "IPR017441", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "id": "IPR008271", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00069", "id": "PF00069", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A4L9P5", "id": "PR_A4L9P5", "database": "PRO" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A4L9P5*", "id": "A4L9P5", "database": "IntAct" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1304941", "id": "1304941", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A4L9P5", "disease": [], "mass": { "monoisotopic_mass": 130801.0, "chemical_mass": 130801.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A4L9P5", "name": "Hipk1.", "locus": { "end_pos": 206224015, "start_pos": 206274079, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000019333", "id": "ENSRNOG00000019333", "database": "Ensembl Gene" } ] } } ] }