{ "uniprot_canonical_ac": "A4GW50-1", "sequence": { "header": "tr|A4GW50-1|A4GW50_RAT Isoform 1 of Non-specific serine/threonine protein kinase OS=Rattus norvegicus OX=10116 GN=Stk38l PE=1 SV=1 CANONICAL=A4GW50-1", "length": 464, "sequence": "MAMTAGATTTFPMSSHTRERVTVAKLTLENFYSNLILQHEERETRQKKLEVAMEEEGLADEEKKLRRSQHARKETEFLRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKADMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGFPPFCSETPQETYRKVMSWKETLAFPPEVPVSEKAKDLILRFCTDSENRIGNGGVEEIKGHPFFEGVDWGHIRERPAAIPIEIRSIDDTSNFDDFPESDILQPVPNTTEPDYKSKDWVFLNYTYKRFEGLTQRGSIPTYMKAGKL" }, "uniprot_id": "A4GW50_RAT", "enzyme_annotation": [ { "ec": "2.7.11.1", "activity": "ATP + a protein = ADP + a phosphoprotein." }, { "ec": "2.7.11.1", "activity": "" } ], "synonyms": { "protein": { "refseq": [ "serine/threonine-protein kinase 38-like" ], "uniprotkb": [ "Non-specific serine/threonine protein kinase", "2.7.11.1" ] }, "gene": { "refseq": [ "Stk38l", "RGD1564793" ], "uniprotkb": [ "Stk38l", "rCG_29601", "RGD1564793" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GW50", "id": "A4GW50", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Non-specific serine/threonine protein kinase; 2.7.11.1." }, "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GW50/publications", "id": "A4GW50", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012", "pmid": "22673903" }, { "title": "MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/21730291", "journal": "Molecular and cellular biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076805.1", "id": "NP_001076805.1", "database": "RefSeq" } ], "authors": "Zhou Y, Adolfs Y, Pijnappel WW, Fuller SJ, Van der Schors RC, Li KW, Sugden PH, Smit AB, Hergovich A, Pasterkamp RJ", "date": "2011", "pmid": "21730291" }, { "title": "Nuclear Dbf2-related protein kinases (NDRs) in isolated cardiac myocytes and the myocardium: activation by cellular stresses and by phosphoprotein serine-/threonine-phosphatase inhibitors.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/18555663", "journal": "Cell. Signal.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GW50/publications", "id": "A4GW50", "database": "UniProtKB" } ], "authors": "Hemmings B.A., Molkentin J.D., Cullingford T.E., Fuller S.J., Sugden P.H., Hergovich A., Clerk A., Cornils H., Pikkarainen S., Tham el L.", "date": "2008", "pmid": "18555663" }, { "title": "Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/15067004", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076805.1", "id": "NP_001076805.1", "database": "RefSeq" } ], "authors": "Devroe E, Erdjument-Bromage H, Tempst P, Silver PA", "date": "2004", "pmid": "15067004" }, { "title": "Neuronal functions of the novel serine/threonine kinase Ndr2.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/15308672", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076805.1", "id": "NP_001076805.1", "database": "RefSeq" } ], "authors": "Stork O, Zhdanov A, Kudersky A, Yoshikawa T, Obata K, Pape HC", "date": "2004", "pmid": "15308672" }, { "title": "Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/15037617", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076805.1", "id": "NP_001076805.1", "database": "RefSeq" } ], "authors": "Stegert MR, Tamaskovic R, Bichsel SJ, Hergovich A, Hemmings BA", "date": "2004", "pmid": "15037617" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A4GW50#A4GW50-1", "isoform_ac": "A4GW50-1", "locus": { "end_pos": 181069905, "start_pos": 181086666, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000002502", "id": "ENSRNOT00000002502", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000002502", "id": "ENSRNOP00000002502", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A4GW50-1|A4GW50_RAT Isoform 1 of Non-specific serine/threonine protein kinase OS=Rattus norvegicus OX=10116 GN=Stk38l PE=1 SV=1 CANONICAL=A4GW50-1", "length": 464, "sequence": "MAMTAGATTTFPMSSHTRERVTVAKLTLENFYSNLILQHEERETRQKKLEVAMEEEGLADEEKKLRRSQHARKETEFLRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKADMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGFPPFCSETPQETYRKVMSWKETLAFPPEVPVSEKAKDLILRFCTDSENRIGNGGVEEIKGHPFFEGVDWGHIRERPAAIPIEIRSIDDTSNFDDFPESDILQPVPNTTEPDYKSKDWVFLNYTYKRFEGLTQRGSIPTYMKAGKL" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:691337", "resource": "KEGG Pathway", "id": "rno:691337", "name": "" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q7TSE6-1", "protein_name": "Serine/threonine-protein kinase 38-like; 2.7.11.1; NDR2 protein kinase; Nuclear Dbf2-related kinase 2.", "sequence": { "length": 464, "sequence": "MAMTAGATTTFPMSNHTRERVTVAKLTLENFYSNLILQHEERETRQKKLEVAMEEEGLADEEKKLRRSQHARKETEFLRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKADMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLGFIHRDVKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGFPPFCSETPQETYRKVMSWKETLAFPPEVPVSEKAKDLILRFCTDSENRIGNGGVEEIKGHPFFEGVDWGHIRERPAAIPIEIRSIDDTSNFDDFPESDILQPVPNTTEPDYKSKDWVFLNYTYKRFEGLTQRGSIPTYMKAGKL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/56299", "id": "56299", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A4GW50/", "id": "A4GW50", "database": "OMA" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q9Y2H1-1", "protein_name": "Serine/threonine-protein kinase 38-like; 2.7.11.1; NDR2 protein kinase; Nuclear Dbf2-related kinase 2.", "sequence": { "length": 464, "sequence": "MAMTAGTTTTFPMSNHTRERVTVAKLTLENFYSNLILQHEERETRQKKLEVAMEEEGLADEEKKLRRSQHARKETEFLRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEVPISEKAKDLILRFCIDSENRIGNSGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKSIDDTSNFDDFPESDILQPVPNTTEPDYKSKDWVFLNYTYKRFEGLTQRGSIPTYMKAGKL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/56299", "id": "56299", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A4GW50/", "id": "A4GW50", "database": "OMA" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076805.1", "ac": "NP_001076805.1", "name": "serine/threonine-protein kinase 38-like.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GW50", "id": "A4GW50", "database": "UniProtKB" } ], "name": "magnesium ion binding", "id": "GO:0000287" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GW50", "id": "A4GW50", "database": "UniProtKB" } ], "name": "protein serine/threonine kinase activity", "id": "GO:0004674" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GW50", "id": "A4GW50", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GW50", "id": "A4GW50", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GW50", "id": "A4GW50", "database": "UniProtKB" } ], "name": "actin cytoskeleton", "id": "GO:0015629" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GW50", "id": "A4GW50", "database": "UniProtKB" } ], "name": "intracellular signal transduction", "id": "GO:0035556" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018105", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GW50", "id": "A4GW50", "database": "UniProtKB" } ], "name": "peptidyl-serine phosphorylation", "id": "GO:0018105" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051128", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4GW50", "id": "A4GW50", "database": "UniProtKB" } ], "name": "regulation of cellular component organization", "id": "GO:0051128" } ], "total": 3, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 251, "annotation": "n_glycosylation_sequon", "start_pos": 249 }, { "end_pos": 427, "annotation": "n_glycosylation_sequon", "start_pos": 425 }, { "end_pos": 442, "annotation": "n_glycosylation_sequon", "start_pos": 440 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076805.1", "id": "NP_001076805.1", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:691337", "id": "rno:691337", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000001828", "id": "ENSRNOG00000001828", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/ANFIGYT/", "id": "ANFIGYT", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "id": "IPR000719", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "id": "IPR011009", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "id": "IPR017441", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "id": "IPR008271", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000961", "id": "IPR000961", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017892", "id": "IPR017892", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00069", "id": "PF00069", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00433", "id": "PF00433", "database": "Pfam" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A4GW50*", "id": "A4GW50", "database": "IntAct" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/691337", "id": "691337", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1564793", "id": "1564793", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A4GW50", "disease": [], "mass": { "monoisotopic_mass": 53759.0, "chemical_mass": 53759.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A4GW50", "name": "Stk38l; rCG_29601; RGD1564793.", "locus": { "end_pos": 181089740, "start_pos": 181027212, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000001828", "id": "ENSRNOG00000001828", "database": "Ensembl Gene" } ] } } ] }