{
    "uniprot_canonical_ac": "A4D256-1", 
    "sequence": {
        "header": "sp|A4D256-1|CC14C_HUMAN Isoform 1 of Dual specificity protein phosphatase CDC14C  OS=Homo sapiens OX=9606 GN=CDC14C PE=2 SV=3 CANONICAL=A4D256-1", 
        "length": 447, 
        "sequence": "MRSSTLQDPRRRDPQDDVYVDITDRLRFAILYSRPKSASNVHYFSIDNELEYENFSEDFGPLNLAMVYRYCCKINKKLKSITMLRKKIVHFTGSDQRKQANAAFLVGCYMVIYLGRTPEAAYRILIFGDTPYIPFRDAAYGSCNFYITLLDCFHAVKKAMQYGFLNFNSFNLDEYEHYEKAENGDLNWIIPDRFIAFCGPHSRARLESGYHQHSPETYIQYFKNHNVTTIIRLNKRMYDAKRFTDAGFDHHDLFFADGSTPTDAIVKRFLDICENAEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRICRPGLVIGPQQQFLVMKQTSLWLEGDYFRQRLKGQENGQHRAAFSKLLSGVDDISINGVENQDQQEPKPYSDDDEINGVTQGDRSRALKRRRQSKTNDILLPSPLAVLTFTLCSVVIWWIVCDYILPILLF"
    }, 
    "uniprot_id": "CC14C_HUMAN", 
    "enzyme_annotation": [
        {
            "ec": "3.1.3.16", 
            "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate."
        }, 
        {
            "ec": "3.1.3.48", 
            "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate."
        }, 
        {
            "ec": "3.1.3.16", 
            "activity": ""
        }, 
        {
            "ec": "3.1.3.48", 
            "activity": ""
        }
    ], 
    "synonyms": {
        "protein": {
            "refseq": [], 
            "uniprotkb": [
                "Dual specificity protein phosphatase CDC14C", 
                "3.1.3.48", 
                "3.1.3.16", 
                "CDC14 cell division cycle 14 homolog C"
            ]
        }, 
        "gene": {
            "refseq": [], 
            "uniprotkb": [
                "CDC14C", 
                "CDC14B2", 
                "CDC14Bretro"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A4D256", 
                    "id": "A4D256", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "recommendedname": {
        "full": "Dual specificity protein phosphatase CDC14C; 3.1.3.48; 3.1.3.16; CDC14 cell division cycle 14 homolog C."
    }, 
    "publication": [
        {
            "title": "Birth and rapid subcellular adaptation of a hominoid-specific CDC14 protein.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/18547142", 
            "journal": "PLoS Biol.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A4D256/publications", 
                    "id": "A4D256", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Kaessmann H., Marques A.C., Rosso L., Lambert N., Vanderhaeghen P., Lambot M.A., Weier M.", 
            "date": "2008", 
            "pmid": "18547142"
        }, 
        {
            "title": "Emergence of young human genes after a burst of retroposition in primates.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/16201836", 
            "journal": "PLoS Biol.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A4D256/publications", 
                    "id": "A4D256", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Reymond A., Kaessmann H., Dupanloup I., Marques A.C., Vinckenbosch N.", 
            "date": "2005", 
            "pmid": "16201836"
        }
    ], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A4D256#A4D256-1", 
            "isoform_ac": "A4D256-1", 
            "locus": {
                "end_pos": 48924673, 
                "start_pos": 48926013, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000650262", 
                        "id": "ENST00000650262", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000497792", 
                        "id": "ENSP00000497792", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A4D256-1|CC14C_HUMAN Isoform 1 of Dual specificity protein phosphatase CDC14C  OS=Homo sapiens OX=9606 GN=CDC14C PE=2 SV=3 CANONICAL=A4D256-1", 
                "length": 447, 
                "sequence": "MRSSTLQDPRRRDPQDDVYVDITDRLRFAILYSRPKSASNVHYFSIDNELEYENFSEDFGPLNLAMVYRYCCKINKKLKSITMLRKKIVHFTGSDQRKQANAAFLVGCYMVIYLGRTPEAAYRILIFGDTPYIPFRDAAYGSCNFYITLLDCFHAVKKAMQYGFLNFNSFNLDEYEHYEKAENGDLNWIIPDRFIAFCGPHSRARLESGYHQHSPETYIQYFKNHNVTTIIRLNKRMYDAKRFTDAGFDHHDLFFADGSTPTDAIVKRFLDICENAEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRICRPGLVIGPQQQFLVMKQTSLWLEGDYFRQRLKGQENGQHRAAFSKLLSGVDDISINGVENQDQQEPKPYSDDDEINGVTQGDRSRALKRRRQSKTNDILLPSPLAVLTFTLCSVVIWWIVCDYILPILLF"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4D256#A0A3B3ITA5-1", 
            "isoform_ac": "A0A3B3ITA5-1", 
            "locus": {
                "end_pos": 48919765, 
                "start_pos": 48926013, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000428251", 
                        "id": "ENST00000428251", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000497679", 
                        "id": "ENSP00000497679", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A3B3ITA5-1|CC14C_HUMAN Computationally mapped isoform of Dual specificity protein phosphatase CDC14C  OS=Homo sapiens OX=9606 GN=CDC14C PE=2 SV=1 CANONICAL=A4D256-1", 
                "length": 554, 
                "sequence": "MNEVSSECGKKCEPLGCSSTNGDLQGEAGAVVSIFLRMVPRIKSNEGYGYSNRNWRKENTMHSLDRNIVDGGQALGQWKRKSKGRSSWAAAPHCSPRCSLTSQGVKKMRSSTLQDPRRRDPQDDVYVDITDRLRFAILYSRPKSASNVHYFSIDNELEYENFSEDFGPLNLAMVYRYCCKINKKLKSITMLRKKIVHFTGSDQRKQANAAFLVGCYMVIYLGRTPEAAYRILIFGDTPYIPFRDAAYGSCNFYITLLDCFHAVKKAMQYGFLNFNSFNLDEYEHYEKAENGDLNWIIPDRFIAFCGPHSRARLESGYHQHSPETYIQYFKNHNVTTIIRLNKRMYDAKRFTDAGFDHHDLFFADGSTPTDAIVKRFLDICENAEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRICRPGLVIGPQQQFLVMKQTSLWLEGDYFRQRLKGQENGQHRAAFSKLLSGVDDISINGVENQDQQEPKPYSDDDEINGVTQGDRSRALKRRRQSKTNDILLPSPLAVLTFTLCSVVIWWIVCDYILPILLF"
            }
        }
    ], 
    "pathway": [], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A4D256#function", 
            "annotation": "Dual-specificity phosphatase. Preferentially dephosphorylates proteins modified by proline-directed kinases (By similarity).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A4D256#function", 
                    "id": "A4D256", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [], 
    "refseq": {
        "url": "", 
        "ac": "", 
        "name": "", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004722", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4D256", 
                                "id": "A4D256", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein serine/threonine phosphatase activity", 
                        "id": "GO:0004722"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004725", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4D256", 
                                "id": "A4D256", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein tyrosine phosphatase activity", 
                        "id": "GO:0004725"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008138", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4D256", 
                                "id": "A4D256", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein tyrosine/serine/threonine phosphatase activity", 
                        "id": "GO:0008138"
                    }
                ], 
                "total": 3, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000922", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4D256", 
                                "id": "A4D256", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "spindle pole", 
                        "id": "GO:0000922"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4D256", 
                                "id": "A4D256", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nucleolus", 
                        "id": "GO:0005730"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4D256", 
                                "id": "A4D256", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytoplasm", 
                        "id": "GO:0005737"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4D256", 
                                "id": "A4D256", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "centrosome", 
                        "id": "GO:0005813"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072686", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4D256", 
                                "id": "A4D256", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "mitotic spindle", 
                        "id": "GO:0072686"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4D256", 
                                "id": "A4D256", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "integral component of membrane", 
                        "id": "GO:0016021"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4D256", 
                                "id": "A4D256", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "endoplasmic reticulum membrane", 
                        "id": "GO:0005789"
                    }
                ], 
                "total": 7, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000278", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4D256", 
                                "id": "A4D256", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "mitotic cell cycle", 
                        "id": "GO:0000278"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4D256", 
                                "id": "A4D256", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cilium assembly", 
                        "id": "GO:0060271"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000226", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4D256", 
                                "id": "A4D256", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "microtubule cytoskeleton organization", 
                        "id": "GO:0000226"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007096", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4D256", 
                                "id": "A4D256", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of exit from mitosis", 
                        "id": "GO:0007096"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071850", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4D256", 
                                "id": "A4D256", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "mitotic cell cycle arrest", 
                        "id": "GO:0071850"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032467", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4D256", 
                                "id": "A4D256", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of cytokinesis", 
                        "id": "GO:0032467"
                    }
                ], 
                "total": 6, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 56, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 54
        }, 
        {
            "end_pos": 228, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 226
        }
    ], 
    "crossref": [
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=22427", 
            "id": "22427", 
            "database": "HGNC"
        }, 
        {
            "url": "https://pharos.nih.gov/targets/A4D256", 
            "id": "A4D256", 
            "database": "PHAROS"
        }, 
        {
            "url": "https://www.nextprot.org/entry/NX_A4D256", 
            "id": "NX_A4D256", 
            "database": "neXtProt"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=CDC14C", 
            "id": "CDC14C", 
            "database": "GeneCards"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000340", 
            "id": "IPR000340", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000387", 
            "id": "IPR000387", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003595", 
            "id": "IPR003595", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR016130", 
            "id": "IPR016130", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR020422", 
            "id": "IPR020422", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR029260", 
            "id": "IPR029260", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR029021", 
            "id": "IPR029021", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00782", 
            "id": "PF00782", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF14671", 
            "id": "PF14671", 
            "database": "Pfam"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A4D256", 
            "id": "PR_A4D256", 
            "database": "PRO"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A4D256", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 51614.0, 
        "chemical_mass": 51614.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A4D256", 
            "name": "CDC14C; CDC14B2; CDC14Bretro.", 
            "locus": {
                "end_pos": 48927454, 
                "start_pos": 48919765, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSG00000218305", 
                        "id": "ENSG00000218305", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}