{ "uniprot_canonical_ac": "A3KG59-1", "sequence": { "header": "sp|A3KG59-1|P20D2_MOUSE Isoform 1 of Peptidase M20 domain-containing protein 2 OS=Mus musculus OX=10090 GN=Pm20d2 PE=1 SV=1 CANONICAL=A3KG59-1", "length": 431, "sequence": "MGPVVERPAEPGTSSAAELELLKRRAAERIDEAAERLGALSRAIWSAPELAYEEHRAHGELTRFFECEPPAASWAVQPHFGLPTAFRAEWAPPESAAGPRALQVAFLCEYDALPALGHACGHNLIAEVGVAAALGLRAALESIAAPPPVKVIVLGTPAEEDGGGKIDLIEAGAFENLDVVFMAHPSQENAAYLPDVAEHDVTVKYYGKASHAAAYPWEGVNALDAAVLAYTNLSVLRQQMKPTWRVHGIIKNGGVKPNIIPSYSELVYYFRAPSMKELQVLTKKAEDCFRAAALATGCTVDIESEAHDYYNVIPNKTLCSAYTENGKKLGMEFISEDAVLNGPSGSTDFGNVSFVVPGIHPYFYIGTDALNHTEQYTEAAGSQAAQLYTLRTAKALAMTALDVIFKPALLEGVRKEFKCKLQEEQLLNTAA" }, "uniprot_id": "P20D2_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "peptidase M20 domain-containing protein 2", "aminoacylase-1-like protein 2; aminoacylase 1-like 2" ], "uniprotkb": [ "Peptidase M20 domain-containing protein 2", "Aminoacylase-1-like protein 2" ] }, "gene": { "refseq": [ "Pm20d2", "Acy1l2", "Gm424" ], "uniprotkb": [ "Pm20d2", "Acy1l2", "Gm424" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KG59", "id": "A3KG59", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Peptidase M20 domain-containing protein 2; Aminoacylase-1-like protein 2." }, "publication": [ { "title": "Metabolite proofreading in carnosine and homocarnosine synthesis: molecular identification of PM20D2 as beta-alanyl-lysine dipeptidase.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/24891507", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030039.2", "id": "NP_001030039.2", "database": "RefSeq" } ], "authors": "Veiga-da-Cunha M, Chevalier N, Stroobant V, Vertommen D, Van Schaftingen E", "date": "2014", "pmid": "24891507" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A3KG59#A3KG59-1", "isoform_ac": "A3KG59-1", "locus": { "end_pos": 33174329, "start_pos": 33189380, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000098181", "id": "ENSMUST00000098181", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000095783", "id": "ENSMUSP00000095783", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A3KG59-1|P20D2_MOUSE Isoform 1 of Peptidase M20 domain-containing protein 2 OS=Mus musculus OX=10090 GN=Pm20d2 PE=1 SV=1 CANONICAL=A3KG59-1", "length": 431, "sequence": "MGPVVERPAEPGTSSAAELELLKRRAAERIDEAAERLGALSRAIWSAPELAYEEHRAHGELTRFFECEPPAASWAVQPHFGLPTAFRAEWAPPESAAGPRALQVAFLCEYDALPALGHACGHNLIAEVGVAAALGLRAALESIAAPPPVKVIVLGTPAEEDGGGKIDLIEAGAFENLDVVFMAHPSQENAAYLPDVAEHDVTVKYYGKASHAAAYPWEGVNALDAAVLAYTNLSVLRQQMKPTWRVHGIIKNGGVKPNIIPSYSELVYYFRAPSMKELQVLTKKAEDCFRAAALATGCTVDIESEAHDYYNVIPNKTLCSAYTENGKKLGMEFISEDAVLNGPSGSTDFGNVSFVVPGIHPYFYIGTDALNHTEQYTEAAGSQAAQLYTLRTAKALAMTALDVIFKPALLEGVRKEFKCKLQEEQLLNTAA" } }, { "url": "https://www.uniprot.org/uniprot/A3KG59#A3KG59-2", "isoform_ac": "A3KG59-2", "locus": { "end_pos": 33181687, "start_pos": 33189380, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000119167", "id": "ENSMUST00000119167", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000113669", "id": "ENSMUSP00000113669", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A3KG59-2|P20D2_MOUSE Isoform 2 of Peptidase M20 domain-containing protein 2 OS=Mus musculus OX=10090 GN=Pm20d2 PE=1 SV=1 CANONICAL=A3KG59-1", "length": 305, "sequence": "MGPVVERPAEPGTSSAAELELLKRRAAERIDEAAERLGALSRAIWSAPELAYEEHRAHGELTRFFECEPPAASWAVQPHFGLPTAFRAEWAPPESAAGPRALQVAFLCEYDALPALGHACGHNLIAEVGVAAALGLRAALESIAAPPPVKVIVLGTPAEEDGGGKIDLIEAGAFENLDVVFMAHPSQENAAYLPDVAEHDVTVKYYGKASHAAAYPWEGVNALDAAVLAYTNLSVLRQQMKPTWRVHGIIKNGGVKPNIIPSYSELVYYFRAPSMKELQVLTKKAEDCFRAAALATGCTVRAFQN" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:242377", "resource": "KEGG Pathway", "id": "mmu:242377", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030039.2", "annotation": "PM20D2 hydrolyzed beta-alanyl-lysine, beta-alanyl-ornithine, gamma-aminobutyryl-lysine, and gamma-aminobutyryl-ornithine as its best substrates.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030039.2", "id": "NP_001030039.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "D4AAB5-1", "protein_name": "Peptidase M20 domain-containing protein 2.", "sequence": { "length": 431, "sequence": "MGPVVERPAERCTSSATELELLKQRAAERIDEAAERLGALSRAIWSAPELAYEEHRAHGELTRFFEREPPAASWAVQPHFGLPTAFRAEWAPPEAAAGPGALQLAFLCEYDALPALGHACGHNLIAEVGAAAALGLRAALESIAAPPPVKVIVLGTPAEEEGGGKIDLIKAGAFENLDVVFMAHPSQENAAYLPDVAEHDVTVKYYGKASHAAAYPWEGVNALDAAVLAYNNLSALRQQMKPTWRVHGIIKNGGVKPNIIPSYSELLYYFRAPSMKELHVLTKKAEDSFRAAALATGCTVEIKSEAHDYYNVIPNKTLCSAYMENGKKLGVEFISEDAVLNGPSGSTDFGNVSFVVPGIHPYFYIGTDALNHTEEYTEAAGSQAAQWYTLRTAKALAMTALDVIFKPQLLEGIRKEFKSKLQEEQLLNTPA" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A3KG59/", "id": "A3KG59", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/19025", "id": "19025", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q8IYS1-1", "protein_name": "Peptidase M20 domain-containing protein 2; Aminoacylase-1-like protein 2.", "sequence": { "length": 436, "sequence": "MRPGGERPVEGGACNGRSELELLKLRSAECIDEAAERLGALSRAIWSQPELAYEEHHAHRVLTHFFEREPPAASWAVQPHYQLPTAFRAEWEPPEARAPSATPRPLHLGFLCEYDALPGIGHACGHNLIAEVGAAAALGVRGALEGLPRPPPPVKVVVLGTPAEEDGGGKIDLIEAGAFTNLDVVFMAHPSQENAAYLPDMAEHDVTVKYYGKASHSASYPWEGLNALDAAVLAYNNLSVFRQQMKPTWRVHGIIKNGGVKPNIIPSYSELIYYFRAPSMKELQVLTKKAEDCFRAAALASGCTVEIKGGAHDYYNVLPNKSLWKAYMENGRKLGIEFISEDTMLNGPSGSTDFGNVSFVVPGIHPYFHIGSNALNHTEQYTEAAGSQEAQFYTLRTAKALAMTALDVIFKPELLEGIREDFKLKLQEEQFVNAVE" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A3KG59/", "id": "A3KG59", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/19025", "id": "19025", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030039.2", "ac": "NP_001030039.2", "name": "peptidase M20 domain-containing protein 2; aminoacylase-1-like protein 2; aminoacylase 1-like 2.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016805", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KG59", "id": "A3KG59", "database": "UniProtKB" } ], "name": "dipeptidase activity", "id": "GO:0016805" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KG59", "id": "A3KG59", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032268", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KG59", "id": "A3KG59", "database": "UniProtKB" } ], "name": "regulation of cellular protein metabolic process", "id": "GO:0032268" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KG59", "id": "A3KG59", "database": "UniProtKB" } ], "name": "proteolysis", "id": "GO:0006508" } ], "total": 2, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 234, "annotation": "n_glycosylation_sequon", "start_pos": 232 }, { "end_pos": 317, "annotation": "n_glycosylation_sequon", "start_pos": 315 }, { "end_pos": 353, "annotation": "n_glycosylation_sequon", "start_pos": 351 }, { "end_pos": 373, "annotation": "n_glycosylation_sequon", "start_pos": 371 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030039.2", "id": "NP_001030039.2", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:242377", "id": "mmu:242377", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000054659", "id": "ENSMUSG00000054659", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/HYAITDT/", "id": "HYAITDT", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002933", "id": "IPR002933", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011650", "id": "IPR011650", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036264", "id": "IPR036264", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017439", "id": "IPR017439", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017144", "id": "IPR017144", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF01546", "id": "PF01546", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF07687", "id": "PF07687", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A3KG59", "id": "PR_A3KG59", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/242377", "id": "242377", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:2685270", "id": "2685270", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A3KG59", "disease": [], "mass": { "monoisotopic_mass": 46482.0, "chemical_mass": 46482.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A3KG59", "name": "Pm20d2; Acy1l2; Gm424.", "locus": { "end_pos": 33174230, "start_pos": 33189737, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000054659", "id": "ENSMUSG00000054659", "database": "Ensembl Gene" } ] } } ] }