{ "uniprot_canonical_ac": "A2RUW1-1", "sequence": { "header": "sp|A2RUW1-1|TOLIP_RAT Isoform 1 of Toll-interacting protein OS=Rattus norvegicus OX=10116 GN=Tollip PE=1 SV=1 CANONICAL=A2RUW1-1", "length": 274, "sequence": "MATTVSTQRGPVYIGELPQDFLRITPTQQQQQIQLDAQAAQQLQYGGAVGTVGRLSITVVQAKLAKNYGMTRMDPYCRLRLGYAVYETPTAHNGAKNPRWNKVIQCTVPPGVDSFYLEIFDERAFSMDDRIAWTHITIPESLKQGQVEDEWYSLSGRQGDDKEGMINLVMSYTSLPAAMMMPPQPVVLMPTVYQQGVGYVPIAGMPAVCSPGMVPMAMPPPAVAPQPRCNEEDLKAIQDMFPNMDREVIRSVLEAQRGNKDAAINSLLQMGEES" }, "uniprot_id": "TOLIP_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "toll-interacting protein" ], "uniprotkb": [ "Toll-interacting protein" ] }, "gene": { "refseq": [ "Tollip" ], "uniprotkb": [ "Tollip" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUW1", "id": "A2RUW1", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Toll-interacting protein." }, "publication": [ { "title": "Hyaluronic acid 35 normalizes TLR4 signaling in Kupffer cells from ethanol-fed rats via regulation of microRNA291b and its target Tollip.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/29142263", "journal": "Scientific reports", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103138.1", "id": "NP_001103138.1", "database": "RefSeq" } ], "authors": "Saikia P, Roychowdhury S, Bellos D, Pollard KA, McMullen MR, McCullough RL, McCullough AJ, Gholam P, de la Motte C, Nagy LE", "date": "2017", "pmid": "29142263" }, { "title": "Bifidobacterium adolescentis protects against necrotizing enterocolitis and upregulates TOLLIP and SIGIRR in premature neonatal rats.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/28056921", "journal": "BMC pediatrics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103138.1", "id": "NP_001103138.1", "database": "RefSeq" } ], "authors": "Wu W, Wang Y, Zou J, Long F, Yan H, Zeng L, Chen Y", "date": "2017", "pmid": "28056921" }, { "title": "Tollip is a critical mediator of cerebral ischaemia-reperfusion injury.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/26011492", "journal": "The Journal of pathology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103138.1", "id": "NP_001103138.1", "database": "RefSeq" } ], "authors": "Li M, Feng B, Wang L, Guo S, Zhang P, Gong J, Zhang Y, Zheng A, Li H", "date": "2015", "pmid": "26011492" }, { "title": "Xuebijing exerts protective effects on lung permeability leakage and lung injury by upregulating Toll-interacting protein expression in rats with sepsis.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/25269519", "journal": "International journal of molecular medicine", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103138.1", "id": "NP_001103138.1", "database": "RefSeq" } ], "authors": "Liu MW, Wang YH, Qian CY, Li H", "date": "2014", "pmid": "25269519" }, { "title": "PPAR-gamma and tollip are associated with toll-like receptors in colitis rats.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/23656243", "journal": "Journal of immunoassay & immunochemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103138.1", "id": "NP_001103138.1", "database": "RefSeq" } ], "authors": "Xu N, Yu ZH, Yao QS, Wang ZQ, Qu HL, Sun Y, Liu J, Jin CZ", "date": "2013", "pmid": "23656243" }, { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUW1/publications", "id": "A2RUW1", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012", "pmid": "22673903" }, { "title": "TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a common theme.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/18535784", "journal": "Cellular and molecular life sciences : CMLS", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103138.1", "id": "NP_001103138.1", "database": "RefSeq" } ], "authors": "Verstrepen L, Bekaert T, Chau TL, Tavernier J, Chariot A, Beyaert R", "date": "2008", "pmid": "18535784" }, { "title": "Recruitment of clathrin onto endosomes by the Tom1-Tollip complex.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/16412388", "journal": "Biochemical and biophysical research communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103138.1", "id": "NP_001103138.1", "database": "RefSeq" } ], "authors": "Katoh Y, Imakagura H, Futatsumori M, Nakayama K", "date": "2006", "pmid": "16412388" }, { "title": "Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/11441107", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103138.1", "id": "NP_001103138.1", "database": "RefSeq" } ], "authors": "Bulut Y, Faure E, Thomas L, Equils O, Arditi M", "date": "2001", "pmid": "11441107" }, { "title": "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/10854325", "journal": "Nature cell biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103138.1", "id": "NP_001103138.1", "database": "RefSeq" } ], "authors": "Burns K, Clatworthy J, Martin L, Martinon F, Plumpton C, Maschera B, Lewis A, Ray K, Tschopp J, Volpe F", "date": "2000", "pmid": "10854325" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2RUW1#A2RUW1-1", "isoform_ac": "A2RUW1-1", "locus": { "end_pos": 214826775, "start_pos": 214844668, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000046344", "id": "ENSRNOT00000046344", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000049498", "id": "ENSRNOP00000049498", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2RUW1-1|TOLIP_RAT Isoform 1 of Toll-interacting protein OS=Rattus norvegicus OX=10116 GN=Tollip PE=1 SV=1 CANONICAL=A2RUW1-1", "length": 274, "sequence": "MATTVSTQRGPVYIGELPQDFLRITPTQQQQQIQLDAQAAQQLQYGGAVGTVGRLSITVVQAKLAKNYGMTRMDPYCRLRLGYAVYETPTAHNGAKNPRWNKVIQCTVPPGVDSFYLEIFDERAFSMDDRIAWTHITIPESLKQGQVEDEWYSLSGRQGDDKEGMINLVMSYTSLPAAMMMPPQPVVLMPTVYQQGVGYVPIAGMPAVCSPGMVPMAMPPPAVAPQPRCNEEDLKAIQDMFPNMDREVIRSVLEAQRGNKDAAINSLLQMGEES" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:361677", "resource": "KEGG Pathway", "id": "rno:361677", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6798695", "resource": "Reactome", "id": "R-RNO-6798695", "name": "Neutrophil degranulation" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9020702", "resource": "Reactome", "id": "R-RNO-9020702", "name": "Interleukin-1 signaling" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2RUW1#function", "annotation": "Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUW1#function", "id": "A2RUW1", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103138.1", "annotation": "We have identified miR291b as a critical miRNA up-regulated by ethanol. Normalization of the miR291b --> Tollip pathway by HA35 ameliorated ethanol-induced sensitization of TLR4 signaling in macrophages/monocytes, suggesting that HA35 may be a novel therapeutic agent in the treatment of Alcoholic liver disease. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103138.1", "id": "NP_001103138.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103138.1", "annotation": "This study demonstrated B. adolescentis prevents NEC in preterm neonatal rats and that the mechanism for this action might be associated with the alteration of TLR4, TOLLIP, and SIGIRR expression. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103138.1", "id": "NP_001103138.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103138.1", "annotation": "Tollip acts as a novel modulator of I/R injury by promoting neuronal apoptosis and ischaemic inflammation, which are largely mediated by suppression of Akt signalling.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103138.1", "id": "NP_001103138.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103138.1", "annotation": "Daata indicate that Xuebijing (XBJ) significantly reduced ligation and puncture (CLP)-induced lung permeability by upregulating Toll-interacting protein (Tollip) expression.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103138.1", "id": "NP_001103138.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103138.1", "annotation": "The disbalance between TLRs and their negative regulating factors PPAR-gamma and Tollip was closely associated with the course of colitis.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103138.1", "id": "NP_001103138.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q9QZ06-1", "protein_name": "Toll-interacting protein.", "sequence": { "length": 274, "sequence": "MATTVSTQRGPVYIGELPQDFLRITPTQQQQQIQLDAQAAQQLQYGGTVGTVGRLSITVVQAKLAKNYGMTRMDPYCRLRLGYAVYETPTAHNGAKNPRWNKVIQCTVPPGVDSFYLEIFDERAFSMDDRIAWTHITIPESLKQGQVEDEWYSLSGRQGDDKEGMINLVMSYTSLPAAMMMPPQPVVLMPTVYQQGVGYVPIAGMPAVCSPGMVPMAMPPPAVAPQPRCNEEDLKAIQDMFPNMDREVIRSVLEAQRGNKDAAINSLLQMGEES" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/10375", "id": "10375", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2RUW1/", "id": "A2RUW1", "database": "OMA" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q9H0E2-1", "protein_name": "Toll-interacting protein.", "sequence": { "length": 274, "sequence": "MATTVSTQRGPVYIGELPQDFLRITPTQQQRQVQLDAQAAQQLQYGGAVGTVGRLNITVVQAKLAKNYGMTRMDPYCRLRLGYAVYETPTAHNGAKNPRWNKVIHCTVPPGVDSFYLEIFDERAFSMDDRIAWTHITIPESLRQGKVEDKWYSLSGRQGDDKEGMINLVMSYALLPAAMVMPPQPVVLMPTVYQQGVGYVPITGMPAVCSPGMVPVALPPAAVNAQPRCSEEDLKAIQDMFPNMDQEVIRSVLEAQRGNKDAAINSLLQMGEEP" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/10375", "id": "10375", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2RUW1/", "id": "A2RUW1", "database": "OMA" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103138.1", "ac": "NP_001103138.1", "name": "toll-interacting protein.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005150", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUW1", "id": "A2RUW1", "database": "UniProtKB" } ], "name": "interleukin-1, type I receptor binding", "id": "GO:0005150" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUW1", "id": "A2RUW1", "database": "UniProtKB" } ], "name": "ubiquitin protein ligase binding", "id": "GO:0031625" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031624", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUW1", "id": "A2RUW1", "database": "UniProtKB" } ], "name": "ubiquitin conjugating enzyme binding", "id": "GO:0031624" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043130", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUW1", "id": "A2RUW1", "database": "UniProtKB" } ], "name": "ubiquitin binding", "id": "GO:0043130" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032183", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUW1", "id": "A2RUW1", "database": "UniProtKB" } ], "name": "SUMO binding", "id": "GO:0032183" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019900", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUW1", "id": "A2RUW1", "database": "UniProtKB" } ], "name": "kinase binding", "id": "GO:0019900" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035325", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUW1", "id": "A2RUW1", "database": "UniProtKB" } ], "name": "Toll-like receptor binding", "id": "GO:0035325" } ], "total": 7, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUW1", "id": "A2RUW1", "database": "UniProtKB" } ], "name": "perinuclear region of cytoplasm", "id": "GO:0048471" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUW1", "id": "A2RUW1", "database": "UniProtKB" } ], "name": "nuclear body", "id": "GO:0016604" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUW1", "id": "A2RUW1", "database": "UniProtKB" } ], "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033235", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUW1", "id": "A2RUW1", "database": "UniProtKB" } ], "name": "positive regulation of protein sumoylation", "id": "GO:0033235" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUW1", "id": "A2RUW1", "database": "UniProtKB" } ], "name": "inflammatory response", "id": "GO:0006954" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUW1", "id": "A2RUW1", "database": "UniProtKB" } ], "name": "signal transduction", "id": "GO:0007165" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030855", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUW1", "id": "A2RUW1", "database": "UniProtKB" } ], "name": "epithelial cell differentiation", "id": "GO:0030855" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUW1", "id": "A2RUW1", "database": "UniProtKB" } ], "name": "innate immune response", "id": "GO:0045087" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006914", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUW1", "id": "A2RUW1", "database": "UniProtKB" } ], "name": "autophagy", "id": "GO:0006914" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016310", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUW1", "id": "A2RUW1", "database": "UniProtKB" } ], "name": "phosphorylation", "id": "GO:0016310" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036010", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUW1", "id": "A2RUW1", "database": "UniProtKB" } ], "name": "protein localization to endosome", "id": "GO:0036010" } ], "total": 9, "name": "Biological Process" } ] }, "site_annotation": [], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103138.1", "id": "NP_001103138.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6798695", "id": "R-RNO-6798695", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9020702", "id": "R-RNO-9020702", "database": "Reactome" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:361677", "id": "rno:361677", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000019861", "id": "ENSRNOG00000019861", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/YNQGMVP/", "id": "YNQGMVP", "database": "OMA" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04016", "id": "cd04016", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14363", "id": "cd14363", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "id": "IPR000008", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "id": "IPR035892", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR003892", "id": "IPR003892", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR009060", "id": "IPR009060", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR037301", "id": "IPR037301", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR041799", "id": "IPR041799", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00168", "id": "PF00168", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF02845", "id": "PF02845", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2RUW1", "id": "PR_A2RUW1", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/361677", "id": "361677", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1304676", "id": "1304676", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A2RUW1", "disease": [], "mass": { "monoisotopic_mass": 30315.0, "chemical_mass": 30315.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2RUW1", "name": "Tollip.", "locus": { "end_pos": 214823978, "start_pos": 214844858, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000019861", "id": "ENSRNOG00000019861", "database": "Ensembl Gene" } ] } } ] }