{ "uniprot_canonical_ac": "A2RUC4-1", "sequence": { "header": "sp|A2RUC4-1|TYW5_HUMAN Isoform 1 of tRNA wybutosine-synthesizing protein 5 OS=Homo sapiens OX=9606 GN=TYW5 PE=1 SV=1 CANONICAL=A2RUC4-1", "length": 315, "sequence": "MAGQHLPVPRLEGVSREQFMQHLYPQRKPLVLEGIDLGPCTSKWTVDYLSQVGGKKEVKIHVAAVAQMDFISKNFVYRTLPFDQLVQRAAEEKHKEFFVSEDEKYYLRSLGEDPRKDVADIRKQFPLLKGDIKFPEFFKEEQFFSSVFRISSPGLQLWTHYDVMDNLLIQVTGKKRVVLFSPRDAQYLYLKGTKSEVLNIDNPDLAKYPLFSKARRYECSLEAGDVLFIPALWFHNVISEEFGVGVNIFWKHLPSECYDKTDTYGNKDPTAASRAAQILDRALKTLAELPEEYRDFYARRMVLHIQDKAYSKNSE" }, "uniprot_id": "TYW5_HUMAN", "enzyme_annotation": [ { "ec": "1.14.11.42", "activity": "7-(3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + 2-oxoglutarate + O(2) = 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + succinate + CO(2)." }, { "ec": "1.14.11.42", "activity": "" } ], "synonyms": { "protein": { "refseq": [ "tRNA wybutosine-synthesizing protein 5", "tRNA yW-synthesizing enzyme 5; jmjC domain-containing protein C2orf60; tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase" ], "uniprotkb": [ "tRNA wybutosine-synthesizing protein 5", "hTYW5", "1.14.11.42", "tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase" ] }, "gene": { "refseq": [ "TYW5", "C2orf60", "hTYW5" ], "uniprotkb": [ "TYW5", "C2orf60", "hTYW5" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUC4", "id": "A2RUC4", "database": "UniProtKB" } ], "name": "Homo sapiens", "taxid": 9606 } ], "recommendedname": { "full": "tRNA wybutosine-synthesizing protein 5; hTYW5; 1.14.11.42; tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase.", "short": "hTYW5" }, "publication": [ { "title": "Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/20972222", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034782.1", "id": "NP_001034782.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2RUC4/publications", "id": "A2RUC4", "database": "UniProtKB" } ], "authors": "Kato M, Araiso Y, Noma A, Nagao A, Suzuki T, Ishitani R, Nureki O", "date": "2011", "pmid": "20972222" }, { "title": "Expanding role of the jumonji C domain as an RNA hydroxylase.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/20739293", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034782.1", "id": "NP_001034782.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2RUC4/publications", "id": "A2RUC4", "database": "UniProtKB" } ], "authors": "Noma A, Ishitani R, Kato M, Nagao A, Nureki O, Suzuki T", "date": "2010", "pmid": "20739293" } ], "glycosylation": [], "mutation": [ { "start_pos": 163, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RUC4", "id": "A2RUC4", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "V", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "L", "subjects_tested": "50", "end_pos": 163, "type": "Point mutation" }, { "start_pos": 139, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RUC4", "id": "A2RUC4", "database": "BioMuta" } ], "frequency": "2.1", "annotation": "Filters passed (1/5): patient freq. (2.1%).", "sequence_org": "K", "disease": { "doid": "2531", "url": "http://disease-ontology.org/term/DOID:2531", "icd10": "", "name": "Hematologic cancer" }, "sequence_mut": "E", "subjects_tested": "48", "end_pos": 139, "type": "Point mutation" }, { "start_pos": 225, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RUC4", "id": "A2RUC4", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "D", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "G", "subjects_tested": "50", "end_pos": 225, "type": "Point mutation" }, { "start_pos": 158, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RUC4", "id": "A2RUC4", "database": "BioMuta" } ], "frequency": "2.0", "annotation": "Filters passed (1/5): patient freq. (2.0%).", "sequence_org": "W", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "Thyroid cancer" }, "sequence_mut": "C", "subjects_tested": "50", "end_pos": 158, "type": "Point mutation" }, { "start_pos": 149, "subjects_positive": "1", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RUC4", "id": "A2RUC4", "database": "BioMuta" } ], "frequency": "1.1", "annotation": "Filters passed (1/5): patient freq. (1.1%). In dbSNP: rs372920812.", "sequence_org": "R", "disease": { "doid": "9256", "url": "http://disease-ontology.org/term/DOID:9256", "icd10": "", "name": "Colorectal cancer" }, "sequence_mut": "Q", "subjects_tested": "94", "end_pos": 149, "type": "Point mutation" } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2RUC4#A2RUC4-1", "isoform_ac": "A2RUC4-1", "locus": { "end_pos": 199933070, "start_pos": 199955470, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000354611", "id": "ENST00000354611", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000346627", "id": "ENSP00000346627", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2RUC4-1|TYW5_HUMAN Isoform 1 of tRNA wybutosine-synthesizing protein 5 OS=Homo sapiens OX=9606 GN=TYW5 PE=1 SV=1 CANONICAL=A2RUC4-1", "length": 315, "sequence": "MAGQHLPVPRLEGVSREQFMQHLYPQRKPLVLEGIDLGPCTSKWTVDYLSQVGGKKEVKIHVAAVAQMDFISKNFVYRTLPFDQLVQRAAEEKHKEFFVSEDEKYYLRSLGEDPRKDVADIRKQFPLLKGDIKFPEFFKEEQFFSSVFRISSPGLQLWTHYDVMDNLLIQVTGKKRVVLFSPRDAQYLYLKGTKSEVLNIDNPDLAKYPLFSKARRYECSLEAGDVLFIPALWFHNVISEEFGVGVNIFWKHLPSECYDKTDTYGNKDPTAASRAAQILDRALKTLAELPEEYRDFYARRMVLHIQDKAYSKNSE" } }, { "url": "https://www.uniprot.org/uniprot/A2RUC4#A8KAJ9-1", "isoform_ac": "A8KAJ9-1", "locus": { "end_pos": 199939037, "start_pos": 199955470, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000441832", "id": "ENST00000441832", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000398447", "id": "ENSP00000398447", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A8KAJ9-1|TYW5_HUMAN Computationally mapped isoform of tRNA wybutosine-synthesizing protein 5 OS=Homo sapiens OX=9606 GN=TYW5 PE=1 SV=1 CANONICAL=A2RUC4-1", "length": 121, "sequence": "MAGQHLPVPRLEGVSREQFMQHLYPQRKPLVLEGIDLGPCTSKWTVDYLSQVGGKKEVKIHVAAVAQMDFIKLYLLTSWSRGQLKRNIKNSLFQRMRNTTYGHLEKTLERMLQISESSFLC" } }, { "url": "https://www.uniprot.org/uniprot/A2RUC4#A2RUC4-2", "isoform_ac": "A2RUC4-2", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A2RUC4-2|TYW5_HUMAN Isoform 2 of tRNA wybutosine-synthesizing protein 5 OS=Homo sapiens OX=9606 GN=TYW5 PE=1 SV=1 CANONICAL=A2RUC4-1", "length": 152, "sequence": "MDNLLIQVTGKKRVVLFSPRDAQYLYLKGTKSEVLNIDNPDLAKYPLFSKARRYECSLEAGDVLFIPALWFHNVISEEFGVGVNIFWKHLPSECYDKTDTYGNKDPTAASRAAQILDRALKTLAELPEEYRDFYARRMVLHIQDKAYSKNSE" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:129450", "resource": "KEGG Pathway", "id": "hsa:129450", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6782861", "resource": "Reactome", "id": "R-HSA-6782861", "name": "Synthesis of wybutosine at G37 of tRNA(Phe)" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2RUC4#function", "annotation": "tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUC4#function", "id": "A2RUC4", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "A2RSX7-1", "protein_name": "tRNA wybutosine-synthesizing protein 5; 1.14.11.42; tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase.", "sequence": { "length": 315, "sequence": "MAEQRLPVPRLRGVSREQFMEHLYPQRKPLVLEGLDLGSCTSKWTVDYLSQVGGTKEVKIHVAAVPQMDFISKNFVYRTLPFNKLVQRAAEETHKEFFISEDEKYYLRSLGEDPRKDVADIRQQFPSLGGDITFPMFFREEQFFSSVFRISSPGLQLWTHYDVMDNFLIQVTGKKRITLFNPRDAQYLYLSGSKSEVLNIDSPDLDKYPLFPKARRYECSLEAGDVLFIPALWFHNVVSEEFGVGVNIFWKHLPSECYDTTDTYGNKDPVAASRAVQILDRALKTLAELPEEYRDFYARQMVLRIQDKAYSKNFE" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/72085", "id": "72085", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2RUC4/", "id": "A2RUC4", "database": "OMA" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "D3ZY75-1", "protein_name": "tRNA-yW synthesizing protein 5.", "sequence": { "length": 315, "sequence": "MAEQRLPVPRLRGVSREQFMEHLYPQRKPLVLEGLDLGSCTSKWTVDYLSQVGGTKEVKIHVAAVAQMDFISKNFVYRTLPFNKLVQRAAEETHKEFFISQDERYYLRSLGEDPRKDIADIRQQFPSLGEDITFPMFFREEQFFSSVFRISSPGLQLWTHYDVMDNFLIQVTGKKRITLFSPRDAQYLYLSGSKSEVLNIDSPDLDKYPLFPKARRYECSLEAGDVLFIPALWFHNVVSEEFGVGVNVFLKHLPSECYDTTDTYGNKDPVAASRAMQILDRALKTLAELPEEYRDFYARQMVLRIQDKAYSKNSE" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/72085", "id": "72085", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2RUC4/", "id": "A2RUC4", "database": "OMA" } ], "organism": "Rattus norvegicus", "tax_id": 10116 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034782.1", "ac": "NP_001034782.1", "name": "tRNA wybutosine-synthesizing protein 5; tRNA yW-synthesizing enzyme 5; jmjC domain-containing protein C2orf60; tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUC4", "id": "A2RUC4", "database": "UniProtKB" } ], "name": "iron ion binding", "id": "GO:0005506" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUC4", "id": "A2RUC4", "database": "UniProtKB" } ], "name": "protein homodimerization activity", "id": "GO:0042803" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000049", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUC4", "id": "A2RUC4", "database": "UniProtKB" } ], "name": "tRNA binding", "id": "GO:0000049" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016706", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUC4", "id": "A2RUC4", "database": "UniProtKB" } ], "name": "2-oxoglutarate-dependent dioxygenase activity", "id": "GO:0016706" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016706", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUC4", "id": "A2RUC4", "database": "UniProtKB" } ], "name": "2-oxoglutarate-dependent dioxygenase activity", "id": "GO:0016706" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0102524", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUC4", "id": "A2RUC4", "database": "UniProtKB" } ], "name": "tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity", "id": "GO:0102524" } ], "total": 6, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUC4", "id": "A2RUC4", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031591", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUC4", "id": "A2RUC4", "database": "UniProtKB" } ], "name": "wybutosine biosynthetic process", "id": "GO:0031591" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031591", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUC4", "id": "A2RUC4", "database": "UniProtKB" } ], "name": "wybutosine biosynthetic process", "id": "GO:0031591" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006400", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUC4", "id": "A2RUC4", "database": "UniProtKB" } ], "name": "tRNA modification", "id": "GO:0006400" } ], "total": 3, "name": "Biological Process" } ] }, "site_annotation": [], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034782.1", "id": "NP_001034782.1", "database": "RefSeq" }, { "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=26754", "id": "26754", "database": "HGNC" }, { "url": "https://pharos.nih.gov/targets/A2RUC4", "id": "A2RUC4", "database": "PHAROS" }, { "url": "https://www.nextprot.org/entry/NX_A2RUC4", "id": "NX_A2RUC4", "database": "neXtProt" }, { "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=TYW5", "id": "TYW5", "database": "GeneCards" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6782861", "id": "R-HSA-6782861", "database": "Reactome" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:129450", "id": "hsa:129450", "database": "KEGG Pathway" }, { "url": "https://www.rcsb.org/structure/3AL5", "id": "3AL5", "database": "PDB" }, { "url": "https://www.rcsb.org/structure/3AL6", "id": "3AL6", "database": "PDB" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162971", "id": "ENSG00000162971", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/PLYDDRP/", "id": "PLYDDRP", "database": "OMA" }, { "url": "N/A", "id": "1.14.11.42", "database": "BRENDA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR003347", "id": "IPR003347", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR029612", "id": "IPR029612", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR041667", "id": "IPR041667", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF13621", "id": "PF13621", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12461:SF50", "id": "PTHR12461:SF50", "database": "PANTHER" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2RUC4", "id": "PR_A2RUC4", "database": "PRO" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2RUC4*", "id": "A2RUC4", "database": "IntAct" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/129450", "id": "129450", "database": "GeneID" } ], "expression_disease": [ { "trend": "Up", "disease": { "doid": "3910", "url": "http://disease-ontology.org/term/DOID:3910", "icd10": "", "name": "DOID:3910 / Lung adenocarcinoma" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2RUC4", "id": "A2RUC4", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "11054", "url": "http://disease-ontology.org/term/DOID:11054", "icd10": "", "name": "DOID:11054 / Urinary bladder cancer [UBC]" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2RUC4", "id": "A2RUC4", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "3571", "url": "http://disease-ontology.org/term/DOID:3571", "icd10": "", "name": "DOID:3571 / Liver cancer [Livca]" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2RUC4", "id": "A2RUC4", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "3907", "url": "http://disease-ontology.org/term/DOID:3907", "icd10": "", "name": "DOID:3907 / Lung squamous cell carcinoma" }, "significant": "Yes", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2RUC4", "id": "A2RUC4", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "5041", "url": "http://disease-ontology.org/term/DOID:5041", "icd10": "", "name": "DOID:5041 / Esophageal cancer [EC]" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2RUC4", "id": "A2RUC4", "database": "BioXpress" } ] }, { "trend": "Up", "disease": { "doid": "10283", "url": "http://disease-ontology.org/term/DOID:10283", "icd10": "", "name": "DOID:10283 / Prostate cancer [PCa]" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2RUC4", "id": "A2RUC4", "database": "BioXpress" } ] }, { "trend": "Down", "disease": { "doid": "1781", "url": "http://disease-ontology.org/term/DOID:1781", "icd10": "", "name": "DOID:1781 / Thyroid cancer [Thyca]" }, "significant": "No", "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2RUC4", "id": "A2RUC4", "database": "BioXpress" } ] } ], "uniprot_ac": "A2RUC4", "disease": [], "mass": { "monoisotopic_mass": 36548.0, "chemical_mass": 36548.0 }, "expression_tissue": [ { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0009853", "uberon": "0009853", "name": "Body of uterus" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162971", "id": "ENSG00000162971", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000458", "uberon": "0000458", "name": "Endocervix" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162971", "id": "ENSG00000162971", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000948", "uberon": "0000948", "name": "Heart" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162971", "id": "ENSG00000162971", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000473", "uberon": "0000473", "name": "Testis" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162971", "id": "ENSG00000162971", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002369", "uberon": "0002369", "name": "Adrenal gland" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162971", "id": "ENSG00000162971", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000992", "uberon": "0000992", "name": "Ovary" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162971", "id": "ENSG00000162971", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000996", "uberon": "0000996", "name": "Vagina" }, "present": "yes", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162971", "id": "ENSG00000162971", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001155", "uberon": "0001155", "name": "Colon" }, 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