{
    "uniprot_canonical_ac": "A2RU54-1", 
    "sequence": {
        "header": "sp|A2RU54-1|HMX2_HUMAN Isoform 1 of Homeobox protein HMX2  OS=Homo sapiens OX=9606 GN=HMX2 PE=2 SV=1 CANONICAL=A2RU54-1", 
        "length": 273, 
        "sequence": "MGSKEDAGKGCPAAGGVSSFTIQSILGGGPSEAPREPVGWPARKRSLSVSSEEEEPDDGWKAPACFCPDQHGPKEQGPKHHPPIPFPCLGTPKGSGGSGPGGLERTPFLSPSHSDFKEEKERLLPAGSPSPGSERPRDGGAERQAGAAKKKTRTVFSRSQVYQLESTFDMKRYLSSSERACLASSLQLTETQVKTWFQNRRNKWKRQLSAELEAANMAHASAQTLVSMPLVFRDSSLLRVPVPRSLAFPAPLYYPGSNLSALPLYNLYNKLDY"
    }, 
    "uniprot_id": "HMX2_HUMAN", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [
                "homeobox protein HMX2", 
                "homeobox protein H6 family member 2; homeo box (H6 family) 2"
            ], 
            "uniprotkb": [
                "Homeobox protein HMX2", 
                "Homeobox protein H6 family member 2"
            ]
        }, 
        "gene": {
            "refseq": [
                "HMX2", 
                "H6L", 
                "Nkx5-2"
            ], 
            "uniprotkb": [
                "HMX2", 
                "H6L", 
                "Nkx5-2"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2RU54", 
                    "id": "A2RU54", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "recommendedname": {
        "full": "Homeobox protein HMX2; Homeobox protein H6 family member 2."
    }, 
    "publication": [
        {
            "title": "Molecular (SNP) analyses of overlapping hemizygous deletions of 10q25.3 to 10qter in four patients: evidence for HMX2 and HMX3 as candidate genes in hearing and vestibular function.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/19253379", 
            "journal": "American journal of medical genetics. Part A", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005510.1", 
                    "id": "NP_005510.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Miller ND, Nance MA, Wohler ES, Hoover-Fong JE, Lisi E, Thomas GH, Pevsner J", 
            "date": "2009", 
            "pmid": "19253379"
        }, 
        {
            "title": "Phylogenetic conservation and physical mapping of members of the H6 homeobox gene family.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/7647458", 
            "journal": "Mammalian genome : official journal of the International Mammalian Genome Society", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005510.1", 
                    "id": "NP_005510.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Stadler HS, Murray JC, Leysens NJ, Goodfellow PJ, Solursh M", 
            "date": "1995", 
            "pmid": "7647458"
        }, 
        {
            "title": "A novel NK-related mouse homeobox gene: expression in central and peripheral nervous structures during embryonic development.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/7510254", 
            "journal": "Developmental biology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005510.1", 
                    "id": "NP_005510.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Bober E, Baum C, Braun T, Arnold HH", 
            "date": "1994", 
            "pmid": "7510254"
        }
    ], 
    "glycosylation": [], 
    "mutation": [
        {
            "start_pos": 260, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RU54", 
                    "id": "A2RU54", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "2.3", 
            "annotation": "Filters passed (1/5): patient freq. (2.3%).", 
            "sequence_org": "S", 
            "disease": {
                "doid": "11934", 
                "url": "http://disease-ontology.org/term/DOID:11934", 
                "icd10": "", 
                "name": "Head and neck cancer"
            }, 
            "sequence_mut": "*", 
            "subjects_tested": "44", 
            "end_pos": 260, 
            "type": "Point mutation"
        }, 
        {
            "start_pos": 61, 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RU54", 
                    "id": "A2RU54", 
                    "database": "BioMuta"
                }
            ], 
            "frequency": "2.0", 
            "annotation": "Filters passed (1/5): patient freq. (2.0%).", 
            "sequence_org": "K", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "Thyroid cancer"
            }, 
            "sequence_mut": "M", 
            "subjects_tested": "50", 
            "end_pos": 61, 
            "type": "Point mutation"
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2RU54#A2RU54-1", 
            "isoform_ac": "A2RU54-1", 
            "locus": {
                "end_pos": 123148379, 
                "start_pos": 123150120, 
                "chromosome": "10", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000339992", 
                        "id": "ENST00000339992", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000341108", 
                        "id": "ENSP00000341108", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2RU54-1|HMX2_HUMAN Isoform 1 of Homeobox protein HMX2  OS=Homo sapiens OX=9606 GN=HMX2 PE=2 SV=1 CANONICAL=A2RU54-1", 
                "length": 273, 
                "sequence": "MGSKEDAGKGCPAAGGVSSFTIQSILGGGPSEAPREPVGWPARKRSLSVSSEEEEPDDGWKAPACFCPDQHGPKEQGPKHHPPIPFPCLGTPKGSGGSGPGGLERTPFLSPSHSDFKEEKERLLPAGSPSPGSERPRDGGAERQAGAAKKKTRTVFSRSQVYQLESTFDMKRYLSSSERACLASSLQLTETQVKTWFQNRRNKWKRQLSAELEAANMAHASAQTLVSMPLVFRDSSLLRVPVPRSLAFPAPLYYPGSNLSALPLYNLYNKLDY"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:3167", 
            "resource": "KEGG Pathway", 
            "id": "hsa:3167", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A2RU54#function", 
            "annotation": "Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2RU54#function", 
                    "id": "A2RU54", 
                    "database": "UniProtKB"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005510.1", 
            "annotation": "Propose that hemizygous deletions of HMX2 and HMX3 are responsible for inner ear malformations, vestibular dysfunction, and congenital sensorineural hearing loss", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005510.1", 
                    "id": "NP_005510.1", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "D4A578-1", 
            "protein_name": "H6 family homeobox 2; Similar to Hmx2 protein (Predicted), isoform CRA_b.", 
            "sequence": {
                "length": 273, 
                "sequence": "MGSKEDVGKGCPAAGGVSSFTIQSILGGGPSEAPREPAGWPARKRSLSVSSEEEEPEEGWKAPACYCPDPHGPKEPSPKHHPPIPFPCLGTPKGSGGAGPAASERTPFLSPSHPDFKEEKERLLPAGSPSPGPERPRDGGAERQAGAAKKKTRTVFSRSQVYQLESTFDMKRYLSSSERACLASSLQLTETQVKTWFQNRRNKWKRQLSAELEAANMAHASAQTLVGMPLVFRDSSLLRVPVPRSLAFPAPLYYPSSNLSALPLYNLYNKLDY"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/24625", 
                    "id": "24625", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A2RU54/", 
                    "id": "A2RU54", 
                    "database": "OMA"
                }
            ], 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "P43687-1", 
            "protein_name": "Homeobox protein HMX2; Homeobox protein Nkx-5.2.", 
            "sequence": {
                "length": 273, 
                "sequence": "MGSKEDVGKGCPAAGGVSSFTIQSILGGGPSEAPREPAGWPARKRSLSVSSEEEEPEEGWKAPACFCPDPHGPKEPSPKHHTPIPFPCLGTPKGSGGAGPAASERTPFLSPSHPDFKEEKERLLPAGSPSPGPERPRDGGAERQTGAAKKKTRTVFSRSQVYQLESTFDMKRYLSSSERACLASSLQLTETQVKTWFQNRRNKWKRQLSAELEAANMAHASAQTLVGMPLVFRDSSLLRVPVPRSLAFPAPLYYPSSNLSALPLYNLYNKLDY"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/24625", 
                    "id": "24625", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A2RU54/", 
                    "id": "A2RU54", 
                    "database": "OMA"
                }
            ], 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005510.1", 
        "ac": "NP_005510.1", 
        "name": "homeobox protein HMX2; homeobox protein H6 family member 2; homeo box (H6 family) 2.", 
        "summary": "The protein encoded by this gene is a member of the NKL homeobox family of transcription factors. Members in this family are of ancient origin and play an important role in organ development during embryogenesis. A related mouse protein plays a role in patterning of inner ear structures. In humans, variations in a region containing this gene have been associated with inner ear malformations, vestibular dysfunction, and hearing loss. [provided by RefSeq, Aug 2012]."
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RU54", 
                                "id": "A2RU54", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", 
                        "id": "GO:0000981"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RU54", 
                                "id": "A2RU54", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "sequence-specific DNA binding", 
                        "id": "GO:0043565"
                    }
                ], 
                "total": 2, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000790", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RU54", 
                                "id": "A2RU54", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nuclear chromatin", 
                        "id": "GO:0000790"
                    }
                ], 
                "total": 1, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048026", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RU54", 
                                "id": "A2RU54", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of mRNA splicing, via spliceosome", 
                        "id": "GO:0048026"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RU54", 
                                "id": "A2RU54", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of cell population proliferation", 
                        "id": "GO:0008284"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RU54", 
                                "id": "A2RU54", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cell differentiation", 
                        "id": "GO:0030154"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042472", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RU54", 
                                "id": "A2RU54", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "inner ear morphogenesis", 
                        "id": "GO:0042472"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007420", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RU54", 
                                "id": "A2RU54", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "brain development", 
                        "id": "GO:0007420"
                    }
                ], 
                "total": 5, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 260, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 258
        }
    ], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005510.1", 
            "id": "NP_005510.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=5018", 
            "id": "5018", 
            "database": "HGNC"
        }, 
        {
            "url": "https://pharos.nih.gov/targets/A2RU54", 
            "id": "A2RU54", 
            "database": "PHAROS"
        }, 
        {
            "url": "https://www.nextprot.org/entry/NX_A2RU54", 
            "id": "NX_A2RU54", 
            "database": "neXtProt"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=HMX2", 
            "id": "HMX2", 
            "database": "GeneCards"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?hsa:3167", 
            "id": "hsa:3167", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188816", 
            "id": "ENSG00000188816", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/FPTPLYY/", 
            "id": "FPTPLYY", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", 
            "id": "cd00086", 
            "database": "CDD"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", 
            "id": "IPR001356", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", 
            "id": "IPR009057", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", 
            "id": "IPR017970", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR020479", 
            "id": "IPR020479", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00046", 
            "id": "PF00046", 
            "database": "Pfam"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2RU54", 
            "id": "PR_A2RU54", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ebi.ac.uk/intact/interactors/id:A2RU54*", 
            "id": "A2RU54", 
            "database": "IntAct"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/3167", 
            "id": "3167", 
            "database": "GeneID"
        }
    ], 
    "expression_disease": [
        {
            "trend": "Down", 
            "disease": {
                "doid": "3571", 
                "url": "http://disease-ontology.org/term/DOID:3571", 
                "icd10": "", 
                "name": "DOID:3571 / Liver cancer [Livca]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2RU54", 
                    "id": "A2RU54", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "3907", 
                "url": "http://disease-ontology.org/term/DOID:3907", 
                "icd10": "", 
                "name": "DOID:3907 / Lung squamous cell carcinoma"
            }, 
            "significant": "Yes", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2RU54", 
                    "id": "A2RU54", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "10283", 
                "url": "http://disease-ontology.org/term/DOID:10283", 
                "icd10": "", 
                "name": "DOID:10283 / Prostate cancer [PCa]"
            }, 
            "significant": "Yes", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2RU54", 
                    "id": "A2RU54", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "5041", 
                "url": "http://disease-ontology.org/term/DOID:5041", 
                "icd10": "", 
                "name": "DOID:5041 / Esophageal cancer [EC]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2RU54", 
                    "id": "A2RU54", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "3910", 
                "url": "http://disease-ontology.org/term/DOID:3910", 
                "icd10": "", 
                "name": "DOID:3910 / Lung adenocarcinoma"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2RU54", 
                    "id": "A2RU54", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Down", 
            "disease": {
                "doid": "1781", 
                "url": "http://disease-ontology.org/term/DOID:1781", 
                "icd10": "", 
                "name": "DOID:1781 / Thyroid cancer [Thyca]"
            }, 
            "significant": "No", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2RU54", 
                    "id": "A2RU54", 
                    "database": "BioXpress"
                }
            ]
        }, 
        {
            "trend": "Up", 
            "disease": {
                "doid": "11054", 
                "url": "http://disease-ontology.org/term/DOID:11054", 
                "icd10": "", 
                "name": "DOID:11054 / Urinary bladder cancer [UBC]"
            }, 
            "significant": "Yes", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A2RU54", 
                    "id": "A2RU54", 
                    "database": "BioXpress"
                }
            ]
        }
    ], 
    "uniprot_ac": "A2RU54", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 29598.0, 
        "chemical_mass": 29598.0
    }, 
    "expression_tissue": [
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0009853", 
                "uberon": "0009853", 
                "name": "Body of uterus"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188816", 
                    "id": "ENSG00000188816", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000458", 
                "uberon": "0000458", 
                "name": "Endocervix"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188816", 
                    "id": "ENSG00000188816", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000948", 
                "uberon": "0000948", 
                "name": "Heart"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188816", 
                    "id": "ENSG00000188816", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000473", 
                "uberon": "0000473", 
                "name": "Testis"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188816", 
                    "id": "ENSG00000188816", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002369", 
                "uberon": "0002369", 
                "name": "Adrenal gland"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188816", 
                    "id": "ENSG00000188816", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000992", 
                "uberon": "0000992", 
                "name": "Ovary"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188816", 
                    "id": "ENSG00000188816", 
                    "database": "Bgee"
                }
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                "name": "Vagina"
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            "evidence": [
                {
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                    "id": "ENSG00000188816", 
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        {
            "tissue": {
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                "name": "Colon"
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            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188816", 
                    "id": "ENSG00000188816", 
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        }, 
        {
            "tissue": {
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                "uberon": "0001987", 
                "name": "Placenta"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188816", 
                    "id": "ENSG00000188816", 
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        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000955", 
                "uberon": "0000955", 
                "name": "Brain"
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            "present": "no", 
            "evidence": [
                {
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                    "id": "ENSG00000188816", 
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        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001160", 
                "uberon": "0001160", 
                "name": "Fundus of stomach"
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            "evidence": [
                {
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                    "id": "ENSG00000188816", 
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            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001150", 
                "uberon": "0001150", 
                "name": "Body of pancreas"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188816", 
                    "id": "ENSG00000188816", 
                    "database": "Bgee"
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        }, 
        {
            "tissue": {
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                "uberon": "0002048", 
                "name": "Lung"
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            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188816", 
                    "id": "ENSG00000188816", 
                    "database": "Bgee"
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        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000007", 
                "uberon": "0000007", 
                "name": "Pituitary gland"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188816", 
                    "id": "ENSG00000188816", 
                    "database": "Bgee"
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            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002107", 
                "uberon": "0002107", 
                "name": "Liver"
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            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188816", 
                    "id": "ENSG00000188816", 
                    "database": "Bgee"
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        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002046", 
                "uberon": "0002046", 
                "name": "Thyroid gland"
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            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188816", 
                    "id": "ENSG00000188816", 
                    "database": "Bgee"
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            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178", 
                "uberon": "0000178", 
                "name": "Blood"
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            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188816", 
                    "id": "ENSG00000188816", 
                    "database": "Bgee"
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            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001043", 
                "uberon": "0001043", 
                "name": "Esophagus"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188816", 
                    "id": "ENSG00000188816", 
                    "database": "Bgee"
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            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002367", 
                "uberon": "0002367", 
                "name": "Prostate gland"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188816", 
                    "id": "ENSG00000188816", 
                    "database": "Bgee"
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            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001161", 
                "uberon": "0001161", 
                "name": "Body of stomach"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188816", 
                    "id": "ENSG00000188816", 
                    "database": "Bgee"
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            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001255", 
                "uberon": "0001255", 
                "name": "Urinary bladder"
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            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188816", 
                    "id": "ENSG00000188816", 
                    "database": "Bgee"
                }
            ]
        }
    ], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2RU54", 
            "name": "HMX2; H6L; Nkx5-2.", 
            "locus": {
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                "start_pos": 123148122, 
                "chromosome": "10", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSG00000188816", 
                        "id": "ENSG00000188816", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}