{
    "uniprot_canonical_ac": "A2RT62-1", 
    "sequence": {
        "header": "sp|A2RT62-1|FXL16_MOUSE Isoform 1 of F-box/LRR-repeat protein 16  OS=Mus musculus OX=10090 GN=Fbxl16 PE=1 SV=1 CANONICAL=A2RT62-1", 
        "length": 479, 
        "sequence": "MSSPGIDGDPKPPCLPRNGLVKLPGQPNGLGAASITKGTPAAKNRPCQPPPPPTLPPPSLATPLSRVALAGGPCPPASGPASGPVSGPPVERPPLATDEKILNGLFWYFSACEKCILAQVCKAWRRVLYQPKFWAGLTPVLHAKELYNVLPGGEKEFVNLQGFAARGFEGFCLVGVSDLDICEFIDNYSLSKKGVKAMSLKRSTITDAGLEVMLEQMQGVVRLELSGCNDFTEAGLWSSLSARITSLSVSDCINVADDAIAAISQLLPNLAELSLQAYHVTDTALAYFTARQGHSTHTLRLLSCWEITNHGVVNVVHSLPNLTSLSLSGCSKVTDDGVELVAENLRKLRSLDLSWCPRITDMALEYVACDLHRLEELVLDRCVRITDTGLSYLSTMSSLRSLYLRWCCQVQDFGLKHLLAMRNLRLLSLAGCPLLTTTGLSGLVQLQELEELELTNCPGATPELFKYFSQHLPRCLVIE"
    }, 
    "uniprot_id": "FXL16_MOUSE", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [
                "F-box/LRR-repeat protein 16"
            ], 
            "uniprotkb": [
                "F-box/LRR-repeat protein 16", 
                "F-box and leucine-rich repeat protein 16"
            ]
        }, 
        "gene": {
            "refseq": [
                "Fbxl16", 
                "BC042620", 
                "Scirr1"
            ], 
            "uniprotkb": [
                "Fbxl16", 
                "BC042620", 
                "Scirr1"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2RT62", 
                    "id": "A2RT62", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "recommendedname": {
        "full": "F-box/LRR-repeat protein 16; F-box and leucine-rich repeat protein 16."
    }, 
    "publication": [
        {
            "title": "High-throughput discovery of novel developmental phenotypes.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/27626380", 
            "journal": "Nature", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157697.1", 
                    "id": "NP_001157697.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M, Murray SA", 
            "date": "2016", 
            "pmid": "27626380"
        }, 
        {
            "title": "Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/24129315", 
            "journal": "Mol. Cell. Proteomics", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2RT62/publications", 
                    "id": "A2RT62", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Beausoleil S.A., Wang Y., Zhou J., Comb M.J., Guo A., Lee K.A., Aguiar M., Bedford M.T., Gu H., Jia X., Kornhauser J., Mulhern D., Ren J., Silva J.C., Vemulapalli V., Yang V.", 
            "date": "2014", 
            "pmid": "24129315"
        }, 
        {
            "title": "The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/24194600", 
            "journal": "Nucleic acids research", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157697.1", 
                    "id": "NP_001157697.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H", 
            "date": "2014", 
            "pmid": "24194600"
        }, 
        {
            "title": "F-box protein FBXL16 binds PP2A-B55alpha and regulates differentiation of embryonic stem cells along the FLK1+ lineage.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/24390425", 
            "journal": "Molecular & cellular proteomics : MCP", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157697.1", 
                    "id": "NP_001157697.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Honarpour N, Rose CM, Brumbaugh J, Anderson J, Graham RL, Sweredoski MJ, Hess S, Coon JJ, Deshaies RJ", 
            "date": "2014", 
            "pmid": "24390425"
        }, 
        {
            "title": "Identification and characterization of scirr1, a novel gene up-regulated after spinal cord injury.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/17603280", 
            "journal": "Experimental & molecular medicine", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157697.1", 
                    "id": "NP_001157697.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Liu T, Ma Z, Que H, Li X, Ni Y, Jing S, Liu S", 
            "date": "2007", 
            "pmid": "17603280"
        }
    ], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2RT62#A2RT62-1", 
            "isoform_ac": "A2RT62-1", 
            "locus": {
                "end_pos": 25816431, 
                "start_pos": 25819519, 
                "chromosome": "17", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000045692", 
                        "id": "ENSMUST00000045692", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000048562", 
                        "id": "ENSMUSP00000048562", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2RT62-1|FXL16_MOUSE Isoform 1 of F-box/LRR-repeat protein 16  OS=Mus musculus OX=10090 GN=Fbxl16 PE=1 SV=1 CANONICAL=A2RT62-1", 
                "length": 479, 
                "sequence": "MSSPGIDGDPKPPCLPRNGLVKLPGQPNGLGAASITKGTPAAKNRPCQPPPPPTLPPPSLATPLSRVALAGGPCPPASGPASGPVSGPPVERPPLATDEKILNGLFWYFSACEKCILAQVCKAWRRVLYQPKFWAGLTPVLHAKELYNVLPGGEKEFVNLQGFAARGFEGFCLVGVSDLDICEFIDNYSLSKKGVKAMSLKRSTITDAGLEVMLEQMQGVVRLELSGCNDFTEAGLWSSLSARITSLSVSDCINVADDAIAAISQLLPNLAELSLQAYHVTDTALAYFTARQGHSTHTLRLLSCWEITNHGVVNVVHSLPNLTSLSLSGCSKVTDDGVELVAENLRKLRSLDLSWCPRITDMALEYVACDLHRLEELVLDRCVRITDTGLSYLSTMSSLRSLYLRWCCQVQDFGLKHLLAMRNLRLLSLAGCPLLTTTGLSGLVQLQELEELELTNCPGATPELFKYFSQHLPRCLVIE"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RT62#A0A494B9I8-1", 
            "isoform_ac": "A0A494B9I8-1", 
            "locus": {
                "end_pos": 25818059, 
                "start_pos": 25819520, 
                "chromosome": "17", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000235694", 
                        "id": "ENSMUST00000235694", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000157669", 
                        "id": "ENSMUSP00000157669", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A494B9I8-1|FXL16_MOUSE Computationally mapped isoform of F-box/LRR-repeat protein 16  OS=Mus musculus OX=10090 GN=Fbxl16 PE=1 SV=1 CANONICAL=A2RT62-1", 
                "length": 122, 
                "sequence": "XELVAENLRKLRSLDLSWCPRITDMALEYVACDLHRLEELVLDSLYLRWCCQVQDFGLKHLLAMRNLRLLSLAGCPLLTTTGLSGLVQLQELEELELTNCPGATPELFKYFSQHLPRCLVIE"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:214931", 
            "resource": "KEGG Pathway", 
            "id": "mmu:214931", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8951664", 
            "resource": "Reactome", 
            "id": "R-MMU-8951664", 
            "name": "Neddylation"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983168", 
            "resource": "Reactome", 
            "id": "R-MMU-983168", 
            "name": "Antigen processing: Ubiquitination & Proteasome degradation"
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A2RT62#function", 
            "annotation": "Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2RT62#function", 
                    "id": "A2RT62", 
                    "database": "UniProtKB"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157697.1", 
            "annotation": "FBXL16 negatively regulates the activity of B55alpha-PP2A to modulate the genesis of FLK1+ progenitor cells.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157697.1", 
                    "id": "NP_001157697.1", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157697.1", 
            "annotation": "SCIRR1 ise involved in the succeeding injury and/or repair processes of the injured spinal cord.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157697.1", 
                    "id": "NP_001157697.1", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q8N461-1", 
            "protein_name": "F-box/LRR-repeat protein 16; F-box and leucine-rich repeat protein 16.", 
            "sequence": {
                "length": 479, 
                "sequence": "MSSPGIDGDPKPPCLPRNGLVKLPGQPNGLGAASITKGTPATKNRPCQPPPPPTLPPPSLAAPLSRAALAGGPCTPAGGPASALAPGHPAERPPLATDEKILNGLFWYFSACEKCVLAQVCKAWRRVLYQPKFWAGLTPVLHAKELYNVLPGGEKEFVNLQGFAARGFEGFCLVGVSDLDICEFIDNYALSKKGVKAMSLKRSTITDAGLEVMLEQMQGVVRLELSGCNDFTEAGLWSSLSARITSLSVSDCINVADDAIAAISQLLPNLAELSLQAYHVTDTALAYFTARQGHSTHTLRLLSCWEITNHGVVNVVHSLPNLTALSLSGCSKVTDDGVELVAENLRKLRSLDLSWCPRITDMALEYVACDLHRLEELVLDRCVRITDTGLSYLSTMSSLRSLYLRWCCQVQDFGLKHLLALGSLRLLSLAGCPLLTTTGLSGLVQLQELEELELTNCPGATPELFKYFSQHLPRCLVIE"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A2RT62/", 
                    "id": "A2RT62", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/17732", 
                    "id": "17732", 
                    "database": "MGI"
                }
            ], 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }, 
        {
            "uniprot_canonical_ac": "Q5MJ12-1", 
            "protein_name": "F-box/LRR-repeat protein 16; F-box and leucine-rich repeat protein 16; Spinal cord injury and regeneration-related protein 1.", 
            "sequence": {
                "length": 479, 
                "sequence": "MSSPGIDGDPKPSCLPRNGLVKLPGQPNGLGAASITKGTPAAKNRPCQPPPPPTLPPPSLATPLSRVALAGGPCPPASGPASGPVPGPPVERPPLATDEKILNGLFWYFSACEKCILAQVCKAWRRVLYQPKFWAGLTPVLHAKELYNVLPGGEKEFVNLQGFAARGFEGFCLVGVSDLDICEFIDNYSLSKKGVKAMSLKRSTITDAGLEVMLEQMQGVVRLELSGCNDFTEAGLWSSLSARITSLSVSDCINVADDAIAAISQLLPNLAELSLQAYHVTDTALAYFTARQGHSTHTLRLLSCWEITNHGVVNVVHSLPNLTSLSLSGCSKVTDDGVELVAENLRKLRSLDLSWCPRITDMALEYVACDLHRLEELVLDRCVRITDTGLSYLSTMSSLRSLYLRWCCQVQDFGLKHLLAMRSLRLLSLAGCPLLTTTGLSGLVQLQELEELELTNCPGATPELFKYFSQHLPRCLVIE"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A2RT62/", 
                    "id": "A2RT62", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/17732", 
                    "id": "17732", 
                    "database": "MGI"
                }
            ], 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157697.1", 
        "ac": "NP_001157697.1", 
        "name": "F-box/LRR-repeat protein 16.", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019005", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RT62", 
                                "id": "A2RT62", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "SCF ubiquitin ligase complex", 
                        "id": "GO:0019005"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RT62", 
                                "id": "A2RT62", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytoplasm", 
                        "id": "GO:0005737"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RT62", 
                                "id": "A2RT62", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ubiquitin-dependent protein catabolic process", 
                        "id": "GO:0006511"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031146", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RT62", 
                                "id": "A2RT62", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", 
                        "id": "GO:0031146"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RT62", 
                                "id": "A2RT62", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein ubiquitination", 
                        "id": "GO:0016567"
                    }
                ], 
                "total": 3, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 189, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 187
        }, 
        {
            "end_pos": 323, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 321
        }
    ], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157697.1", 
            "id": "NP_001157697.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8951664", 
            "id": "R-MMU-8951664", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983168", 
            "id": "R-MMU-983168", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:214931", 
            "id": "mmu:214931", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000025738", 
            "id": "ENSMUSG00000025738", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/RGFQSFC/", 
            "id": "RGFQSFC", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", 
            "id": "IPR001611", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", 
            "id": "IPR032675", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR006553", 
            "id": "IPR006553", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", 
            "id": "IPR036047", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF13516", 
            "id": "PF13516", 
            "database": "Pfam"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2RT62", 
            "id": "PR_A2RT62", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/214931", 
            "id": "214931", 
            "database": "GeneID"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:2448488", 
            "id": "2448488", 
            "database": "MGI"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A2RT62", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 51878.0, 
        "chemical_mass": 51878.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2RT62", 
            "name": "Fbxl16; BC042620; Scirr1.", 
            "locus": {
                "end_pos": 25821244, 
                "start_pos": 25809085, 
                "chromosome": "17", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000025738", 
                        "id": "ENSMUSG00000025738", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}