{
    "uniprot_canonical_ac": "A2RSX7-1", 
    "sequence": {
        "header": "sp|A2RSX7-1|TYW5_MOUSE Isoform 1 of tRNA wybutosine-synthesizing protein 5  OS=Mus musculus OX=10090 GN=Tyw5 PE=2 SV=2 CANONICAL=A2RSX7-1", 
        "length": 315, 
        "sequence": "MAEQRLPVPRLRGVSREQFMEHLYPQRKPLVLEGLDLGSCTSKWTVDYLSQVGGTKEVKIHVAAVPQMDFISKNFVYRTLPFNKLVQRAAEETHKEFFISEDEKYYLRSLGEDPRKDVADIRQQFPSLGGDITFPMFFREEQFFSSVFRISSPGLQLWTHYDVMDNFLIQVTGKKRITLFNPRDAQYLYLSGSKSEVLNIDSPDLDKYPLFPKARRYECSLEAGDVLFIPALWFHNVVSEEFGVGVNIFWKHLPSECYDTTDTYGNKDPVAASRAVQILDRALKTLAELPEEYRDFYARQMVLRIQDKAYSKNFE"
    }, 
    "uniprot_id": "TYW5_MOUSE", 
    "enzyme_annotation": [
        {
            "ec": "1.14.11.42", 
            "activity": "7-(3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + 2-oxoglutarate + O(2) = 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + succinate + CO(2)."
        }, 
        {
            "ec": "1.14.11.42", 
            "activity": ""
        }
    ], 
    "synonyms": {
        "protein": {
            "refseq": [
                "tRNA wybutosine-synthesizing protein 5 isoform 1", 
                "jmjC domain-containing protein C2orf60 homolog; tRNA yW-synthesizing enzyme 5; tRNA wybutosine-synthesizing protein 5; tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase"
            ], 
            "uniprotkb": [
                "tRNA wybutosine-synthesizing protein 5", 
                "1.14.11.42", 
                "tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase"
            ]
        }, 
        "gene": {
            "refseq": [
                "Tyw5", 
                "1110034B05Rik"
            ], 
            "uniprotkb": [
                "Tyw5", 
                "1110034B05Rik"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2RSX7", 
                    "id": "A2RSX7", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "recommendedname": {
        "full": "tRNA wybutosine-synthesizing protein 5; 1.14.11.42; tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase."
    }, 
    "publication": [
        {
            "title": "Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/26073538", 
            "journal": "American journal of reproductive immunology (New York, N.Y. : 1989)", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032831.2", 
                    "id": "NP_001032831.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Pan J, Mor G, Ju W, Zhong J, Luo X, Aldo PB, Zhong M, Yu Y, Jenkins EC, Brown WT, Zhong N", 
            "date": "2015", 
            "pmid": "26073538"
        }, 
        {
            "title": "Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/20972222", 
            "journal": "Nucleic acids research", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032831.2", 
                    "id": "NP_001032831.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Kato M, Araiso Y, Noma A, Nagao A, Suzuki T, Ishitani R, Nureki O", 
            "date": "2011", 
            "pmid": "20972222"
        }, 
        {
            "title": "BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/12520002", 
            "journal": "Nucleic acids research", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032831.2", 
                    "id": "NP_001032831.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE", 
            "date": "2003", 
            "pmid": "12520002"
        }
    ], 
    "glycosylation": [], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2RSX7#A2RSX7-1", 
            "isoform_ac": "A2RSX7-1", 
            "locus": {
                "end_pos": 57388499, 
                "start_pos": 57406461, 
                "chromosome": "1", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000162686", 
                        "id": "ENSMUST00000162686", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000125427", 
                        "id": "ENSMUSP00000125427", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2RSX7-1|TYW5_MOUSE Isoform 1 of tRNA wybutosine-synthesizing protein 5  OS=Mus musculus OX=10090 GN=Tyw5 PE=2 SV=2 CANONICAL=A2RSX7-1", 
                "length": 315, 
                "sequence": "MAEQRLPVPRLRGVSREQFMEHLYPQRKPLVLEGLDLGSCTSKWTVDYLSQVGGTKEVKIHVAAVPQMDFISKNFVYRTLPFNKLVQRAAEETHKEFFISEDEKYYLRSLGEDPRKDVADIRQQFPSLGGDITFPMFFREEQFFSSVFRISSPGLQLWTHYDVMDNFLIQVTGKKRITLFNPRDAQYLYLSGSKSEVLNIDSPDLDKYPLFPKARRYECSLEAGDVLFIPALWFHNVVSEEFGVGVNIFWKHLPSECYDTTDTYGNKDPVAASRAVQILDRALKTLAELPEEYRDFYARQMVLRIQDKAYSKNFE"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RSX7#E0CZH0-1", 
            "isoform_ac": "E0CZH0-1", 
            "locus": {
                "end_pos": 57393631, 
                "start_pos": 57406461, 
                "chromosome": "1", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000160118", 
                        "id": "ENSMUST00000160118", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000125386", 
                        "id": "ENSMUSP00000125386", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|E0CZH0-1|TYW5_MOUSE Computationally mapped isoform of tRNA wybutosine-synthesizing protein 5  OS=Mus musculus OX=10090 GN=Tyw5 PE=2 SV=1 CANONICAL=A2RSX7-1", 
                "length": 131, 
                "sequence": "MAEQRLPVPRLRGVSREQFMEHLYPQRKPLVLEGLDLGSCTSKWTVDYLSQVGGTKEVKIHVAAVPQMDFIKLYLLTSWSREQPKKHIKNSSFQRMRNTTYGHLEKTQGSRKNSFTGKVGCCCWAFPIIGL"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RSX7#A2RSX7-2", 
            "isoform_ac": "A2RSX7-2", 
            "locus": {
                "end_pos": 57393454, 
                "start_pos": 57406461, 
                "chromosome": "1", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000079998", 
                        "id": "ENSMUST00000079998", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000078912", 
                        "id": "ENSMUSP00000078912", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2RSX7-2|TYW5_MOUSE Isoform 2 of tRNA wybutosine-synthesizing protein 5  OS=Mus musculus OX=10090 GN=Tyw5 PE=2 SV=2 CANONICAL=A2RSX7-1", 
                "length": 121, 
                "sequence": "MAEQRLPVPRLRGVSREQFMEHLYPQRKPLVLEGLDLGSCTSKWTVDYLSQVGGTKEVKIHVAAVPQMDFIKLYLLTSWSREQPKKHIKNSSFQRMRNTTYGHLEKTQGRMLQTSDSSSHH"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RSX7#G3UW53-1", 
            "isoform_ac": "G3UW53-1", 
            "locus": {
                "end_pos": 57388667, 
                "start_pos": 57406443, 
                "chromosome": "1", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000160837", 
                        "id": "ENSMUST00000160837", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000128576", 
                        "id": "ENSMUSP00000128576", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|G3UW53-1|TYW5_MOUSE Computationally mapped isoform of tRNA wybutosine-synthesizing protein 5  OS=Mus musculus OX=10090 GN=Tyw5 PE=2 SV=1 CANONICAL=A2RSX7-1", 
                "length": 255, 
                "sequence": "PVPRLRGVSREQFMEHLYPQRKPLVLEGLDLGSCTSKWTVDYLSQVGGTKEVKIHVAAVPQMDFIKLYLLTSWSREQPKKHIKNSSFQRMRNTTYGHLEKTQGSRKNSFTGKDVADIRQQFPSLGGDITFPMFFREEQFFSSVFRISSPGLQLWTHYDVMDNFLIQVTGKKRITLFNPRDAQYLYLSGSKSEVLNIDSPDLDKYPLFPKARRYECSLEAGDVLFIPALWFHNVVSEEFGVGVNIFWKHLPSECYD"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:68736", 
            "resource": "KEGG Pathway", 
            "id": "mmu:68736", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A2RSX7#function", 
            "annotation": "tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes (By similarity).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2RSX7#function", 
                    "id": "A2RSX7", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "A2RUC4-1", 
            "protein_name": "tRNA wybutosine-synthesizing protein 5; hTYW5; 1.14.11.42; tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase.", 
            "sequence": {
                "length": 315, 
                "sequence": "MAGQHLPVPRLEGVSREQFMQHLYPQRKPLVLEGIDLGPCTSKWTVDYLSQVGGKKEVKIHVAAVAQMDFISKNFVYRTLPFDQLVQRAAEEKHKEFFVSEDEKYYLRSLGEDPRKDVADIRKQFPLLKGDIKFPEFFKEEQFFSSVFRISSPGLQLWTHYDVMDNLLIQVTGKKRVVLFSPRDAQYLYLKGTKSEVLNIDNPDLAKYPLFSKARRYECSLEAGDVLFIPALWFHNVISEEFGVGVNIFWKHLPSECYDKTDTYGNKDPTAASRAAQILDRALKTLAELPEEYRDFYARRMVLHIQDKAYSKNSE"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/72085", 
                    "id": "72085", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A2RSX7/", 
                    "id": "A2RSX7", 
                    "database": "OMA"
                }
            ], 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }, 
        {
            "uniprot_canonical_ac": "D3ZY75-1", 
            "protein_name": "tRNA-yW synthesizing protein 5.", 
            "sequence": {
                "length": 315, 
                "sequence": "MAEQRLPVPRLRGVSREQFMEHLYPQRKPLVLEGLDLGSCTSKWTVDYLSQVGGTKEVKIHVAAVAQMDFISKNFVYRTLPFNKLVQRAAEETHKEFFISQDERYYLRSLGEDPRKDIADIRQQFPSLGEDITFPMFFREEQFFSSVFRISSPGLQLWTHYDVMDNFLIQVTGKKRITLFSPRDAQYLYLSGSKSEVLNIDSPDLDKYPLFPKARRYECSLEAGDVLFIPALWFHNVVSEEFGVGVNVFLKHLPSECYDTTDTYGNKDPVAASRAMQILDRALKTLAELPEEYRDFYARQMVLRIQDKAYSKNSE"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/72085", 
                    "id": "72085", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A2RSX7/", 
                    "id": "A2RSX7", 
                    "database": "OMA"
                }
            ], 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032831.2", 
        "ac": "NP_001032831.2", 
        "name": "tRNA wybutosine-synthesizing protein 5 isoform 1; jmjC domain-containing protein C2orf60 homolog; tRNA yW-synthesizing enzyme 5; tRNA wybutosine-synthesizing protein 5; tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase.", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RSX7", 
                                "id": "A2RSX7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "iron ion binding", 
                        "id": "GO:0005506"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RSX7", 
                                "id": "A2RSX7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein homodimerization activity", 
                        "id": "GO:0042803"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000049", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RSX7", 
                                "id": "A2RSX7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "tRNA binding", 
                        "id": "GO:0000049"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016706", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RSX7", 
                                "id": "A2RSX7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "2-oxoglutarate-dependent dioxygenase activity", 
                        "id": "GO:0016706"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0102524", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RSX7", 
                                "id": "A2RSX7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity", 
                        "id": "GO:0102524"
                    }
                ], 
                "total": 5, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031591", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RSX7", 
                                "id": "A2RSX7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "wybutosine biosynthetic process", 
                        "id": "GO:0031591"
                    }
                ], 
                "total": 1, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032831.2", 
            "id": "NP_001032831.2", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:68736", 
            "id": "mmu:68736", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000048495", 
            "id": "ENSMUSG00000048495", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/PLYDDRP/", 
            "id": "PLYDDRP", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003347", 
            "id": "IPR003347", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR029612", 
            "id": "IPR029612", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR041667", 
            "id": "IPR041667", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF13621", 
            "id": "PF13621", 
            "database": "Pfam"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12461:SF50", 
            "id": "PTHR12461:SF50", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2RSX7", 
            "id": "PR_A2RSX7", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/68736", 
            "id": "68736", 
            "database": "GeneID"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:1915986", 
            "id": "1915986", 
            "database": "MGI"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A2RSX7", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 36633.0, 
        "chemical_mass": 36633.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2RSX7", 
            "name": "Tyw5; 1110034B05Rik.", 
            "locus": {
                "end_pos": 57388237, 
                "start_pos": 57407101, 
                "chromosome": "1", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000048495", 
                        "id": "ENSMUSG00000048495", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}