{ "uniprot_canonical_ac": "A2RRU4-1", "sequence": { "header": "sp|A2RRU4-1|SCAP_RAT Isoform 1 of Sterol regulatory element-binding protein cleavage-activating protein OS=Rattus norvegicus OX=10116 GN=Scap PE=2 SV=1 CANONICAL=A2RRU4-1", "length": 1276, "sequence": "MTLTERLREKISQAFYNHGLLCASYPIPIILFTGLCILACCYPLLKLPLPGTGPVEFSTPVKGYSPPPADSDHKQGEPSEQPEWYVGAPVAYIQQIFVKSSVSPWHRNLLAVDVFRSPLSRAFQLVEEIRNHVLRDSSGTKSLEEVCLQVTDLLPGLRKLRSLLPEHGCLLLSPGNFWQNDWERFHADPDIIGTIHQHEPKTLQTSATLKDLLFGVPGKYSGVSLYTRKRMVSYTITLVFQRYHAKFLSSLRARLMLLHPSPNCSLRAENLVHVHFKEEIGIAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNVATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPESCLPSAKPVGRPARYERQLAVRPSTPHTITLQPSSFRNLRLPKRLRVIYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLRTYLAAQVTEQSPLGEGSLGPMPVPSGVLPASHPDPAFSIFPPDAPKLPENQTLPGELPEHAVPAEGVQDSRAPEVTWGPEDEELWRKLSFRHWPTLFNYYNITLAKRYISLLPVIPVTLHLNPREALEGRHPQDGRTAWAPPEPLPAGLWETGPKGPGGTQTHGDITLYKVAALGLAAGIVLVLLLLCLYRVLCPRNYGQPGGGAGRRRRGELPCDDYGYAPPETEIVPLVLRGHLMDIECLASDGMLLVSCCLAGQVCVWDAQTGDCLTRIPRPGPRRDSCGGGAFEAQENWERLSDGGKASPEEPGDSPPLRRRPRGPPPPSLFGDQPDLTCLIDTNFSVQLPPEPTQPEPRHRAGCGRSRDSGYDFSRLVQRVYQEEGLAAVHMSALRPPSPGPPLPQASQEEGTAPEKGSPPLAWAPSTAGSIWSLELQGSLIVVGRSSGRLEVWDAIEGVLCCSNEEISSGITALVFLDRRIVAARLNGSLDFFSLETHTSLSPLQFRGTPGRGSSPSSPVYSSSNTVACHLTHTVPCAHQKPITALRAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDGAICLWDVLTGSRVSHTFAHRGDVTSLTCTTSCVISSGLDDFINIWDRSTGIKLYSIQQDLGCGASLGVISDNLLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVCNFGSELSLVYVPSVLEKLD" }, "uniprot_id": "SCAP_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "sterol regulatory element-binding protein cleavage-activating protein", "SREBP cleavage activating protein" ], "uniprotkb": [ "Sterol regulatory element-binding protein cleavage-activating protein", "SCAP", "SREBP cleavage-activating protein" ] }, "gene": { "refseq": [ "Scap" ], "uniprotkb": [ "Scap" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Sterol regulatory element-binding protein cleavage-activating protein; SCAP; SREBP cleavage-activating protein.", "short": "SCAP" }, "publication": [ { "title": "Aging of myelinating glial cells predominantly affects lipid metabolism and immune response pathways.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22337502", "journal": "Glia", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094436.1", "id": "NP_001094436.1", "database": "RefSeq" } ], "authors": "Verdier V, Csardi G, de Preux-Charles AS, Medard JJ, Smit AB, Verheijen MH, Bergmann S, Chrast R", "date": "2012", "pmid": "22337502" }, { "title": "Differential gene expression pattern of diabetic rat retinas after intravitreal injection of erythropoietin.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/20973890", "journal": "Clinical & experimental ophthalmology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094436.1", "id": "NP_001094436.1", "database": "RefSeq" } ], "authors": "Chu Q, Zhang J, Wu Y, Zhang Y, Xu G, Li W, Xu GT", "date": "2011", "pmid": "20973890" }, { "title": "Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/19933148", "journal": "Genes & development", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094436.1", "id": "NP_001094436.1", "database": "RefSeq" } ], "authors": "Osborne TF, Espenshade PJ", "date": "2009", "pmid": "19933148" }, { "title": "Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/19158095", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094436.1", "id": "NP_001094436.1", "database": "RefSeq" } ], "authors": "Yellaturu CR, Deng X, Cagen LM, Wilcox HG, Mansbach CM 2nd, Siddiqi SA, Park EA, Raghow R, Elam MB", "date": "2009", "pmid": "19158095" }, { "title": "Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/12242332", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094436.1", "id": "NP_001094436.1", "database": "RefSeq" } ], "authors": "Yabe D, Brown MS, Goldstein JL", "date": "2002", "pmid": "12242332" }, { "title": "A new feature on the cholesterol-lowering landscape.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/11726962", "journal": "Nature medicine", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094436.1", "id": "NP_001094436.1", "database": "RefSeq" } ], "authors": "Rader DJ", "date": "2001", "pmid": "11726962" }, { "title": "SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/11358865", "journal": "Genes & development", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094436.1", "id": "NP_001094436.1", "database": "RefSeq" } ], "authors": "Matsuda M, Korn BS, Hammer RE, Moon YA, Komuro R, Horton JD, Goldstein JL, Brown MS, Shimomura I", "date": "2001", "pmid": "11358865" } ], "glycosylation": [ { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 590, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 263, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 641, "glytoucan_ac": "", "type": "N-linked" } ], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4#A2RRU4-1", "isoform_ac": "A2RRU4-1", "locus": { "end_pos": 118596844, "start_pos": 118628485, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000090238", "id": "ENSRNOT00000090238", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000072003", "id": "ENSRNOP00000072003", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2RRU4-1|SCAP_RAT Isoform 1 of Sterol regulatory element-binding protein cleavage-activating protein OS=Rattus norvegicus OX=10116 GN=Scap PE=2 SV=1 CANONICAL=A2RRU4-1", "length": 1276, "sequence": "MTLTERLREKISQAFYNHGLLCASYPIPIILFTGLCILACCYPLLKLPLPGTGPVEFSTPVKGYSPPPADSDHKQGEPSEQPEWYVGAPVAYIQQIFVKSSVSPWHRNLLAVDVFRSPLSRAFQLVEEIRNHVLRDSSGTKSLEEVCLQVTDLLPGLRKLRSLLPEHGCLLLSPGNFWQNDWERFHADPDIIGTIHQHEPKTLQTSATLKDLLFGVPGKYSGVSLYTRKRMVSYTITLVFQRYHAKFLSSLRARLMLLHPSPNCSLRAENLVHVHFKEEIGIAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNVATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPESCLPSAKPVGRPARYERQLAVRPSTPHTITLQPSSFRNLRLPKRLRVIYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLRTYLAAQVTEQSPLGEGSLGPMPVPSGVLPASHPDPAFSIFPPDAPKLPENQTLPGELPEHAVPAEGVQDSRAPEVTWGPEDEELWRKLSFRHWPTLFNYYNITLAKRYISLLPVIPVTLHLNPREALEGRHPQDGRTAWAPPEPLPAGLWETGPKGPGGTQTHGDITLYKVAALGLAAGIVLVLLLLCLYRVLCPRNYGQPGGGAGRRRRGELPCDDYGYAPPETEIVPLVLRGHLMDIECLASDGMLLVSCCLAGQVCVWDAQTGDCLTRIPRPGPRRDSCGGGAFEAQENWERLSDGGKASPEEPGDSPPLRRRPRGPPPPSLFGDQPDLTCLIDTNFSVQLPPEPTQPEPRHRAGCGRSRDSGYDFSRLVQRVYQEEGLAAVHMSALRPPSPGPPLPQASQEEGTAPEKGSPPLAWAPSTAGSIWSLELQGSLIVVGRSSGRLEVWDAIEGVLCCSNEEISSGITALVFLDRRIVAARLNGSLDFFSLETHTSLSPLQFRGTPGRGSSPSSPVYSSSNTVACHLTHTVPCAHQKPITALRAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDGAICLWDVLTGSRVSHTFAHRGDVTSLTCTTSCVISSGLDDFINIWDRSTGIKLYSIQQDLGCGASLGVISDNLLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVCNFGSELSLVYVPSVLEKLD" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:301024", "resource": "KEGG Pathway", "id": "rno:301024", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1655829", "resource": "Reactome", "id": "R-RNO-1655829", "name": "Regulation of cholesterol biosynthesis by SREBP (SREBF)" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4#function", "annotation": "Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4#function", "id": "A2RRU4", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094436.1", "annotation": "Insulin selectively stimulates the processing of SREBP-1c in rat hepatocytes by enhancing the association between the SCAP-SREBP-1c complex and COPII proteins and subsequent ER to Golgi transport and proteolytic cleavage.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094436.1", "id": "NP_001094436.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q12770-1", "protein_name": "Sterol regulatory element-binding protein cleavage-activating protein; SCAP; SREBP cleavage-activating protein.", "sequence": { "length": 1279, "sequence": "MTLTERLREKISRAFYNHGLLCASYPIPIILFTGFCILACCYPLLKLPLPGTGPVEFTTPVKDYSPPPVDSDRKQGEPTEQPEWYVGAPVAYVQQIFVKSSVFPWHKNLLAVDVFRSPLSRAFQLVEEIRNHVLRDSSGIRSLEELCLQVTDLLPGLRKLRNLLPEHGCLLLSPGNFWQNDWERFHADPDIIGTIHQHEPKTLQTSATLKDLLFGVPGKYSGVSLYTRKRMVSYTITLVFQHYHAKFLGSLRARLMLLHPSPNCSLRAESLVHVHFKEEIGVAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPEACLPSAKPVGQPTRYERQLAVRPSTPHTITLQPSSFRNLRLPKRLRVVYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLRNYLAAQVTEQSPLGEGALAPMPVPSGMLPPSHPDPAFSIFPPDAPKLPENQTSPGESPERGGPAEVVHDSPVPEVTWGPEDEELWRKLSFRHWPTLFSYYNITLAKRYISLLPVIPVTLRLNPREALEGRHPQDGRSAWPPPGPIPAGHWEAGPKGPGGVQAHGDVTLYKVAALGLATGIVLVLLLLCLYRVLCPRNYGQLGGGPGRRRRGELPCDDYGYAPPETEIVPLVLRGHLMDIECLASDGMLLVSCCLAGHVCVWDAQTGDCLTRIPRPGRQRRDSGVGSGLEAQESWERLSDGGKAGPEEPGDSPPLRHRPRGPPPPSLFGDQPDLTCLIDTNFSAQPRSSQPTQPEPRHRAVCGRSRDSPGYDFSCLVQRVYQEEGLAAVCTPALRPPSPGPVLSQAPEDEGGSPEKGSPSLAWAPSAEGSIWSLELQGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLDKRIVAARLNGSLDFFSLETHTALSPLQFRGTPGRGSSPASPVYSSSDTVACHLTHTVPCAHQKPITALKAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTTSCVISSGLDDLISIWDRSTGIKFYSIQQDLGCGASLGVISDNLLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVCNFGSELSLVYVPSVLEKLD" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/8160", "id": "8160", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q6GQT6-1", "protein_name": "Sterol regulatory element-binding protein cleavage-activating protein; SCAP; SREBP cleavage-activating protein.", "sequence": { "length": 1276, "sequence": "MTLTERLREKISQAFYNHGLLCASYPIPIILFTGLCILACCYPLLKLPLPGTGPVEFSTPVKGYSPPPADSDHKQGEPSEQPEWYVGAPVAYIQQIFVKSSVSPWHRNLLAVDVFRSPLSRAFQLVEEIRNHVLRDSSGTKSLEEVCLQVTDLLPGLRKLRSLLPEHGCLLLSPGNFWQNDWERFHADPDIIGTIHQHEPKTLQTSATLKDLLFGVPGKYSGVSLYTRKRMVSYTITLVFQRYHAKFLSSLRARLMLLHPSPNCSLRAENLVHVHFKEEIGIAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNAATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPESCLPSAKPVGRPARYERQQAVRPSTPHTITLQPSSFRNLRLPKRLRVIYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLRTYLAAQVTEQSPLGEGSLGPMPVPSGVLPASHPDPAFSIFPPDAPKLPENQTLPGELPEHAGPAEGVHDSRAPEVTWGPEDEELWRKLSFRHWPTLFNYYNITLAKRYISLLPVIPVTLHLNPREALEGRHPQDGRSAWAPQEPLPAGLWESGPKGPGGTQTHGDITLYKVAALGLAAGIVLVLLLLCLYRVLCPRNYGQPGGGPGRRRRGELPCDDYGYAPPETEIVPLVLRGHLMDIECLASDGMLLVSCCLAGQVCVWDAQTGDCLTRIPRPGPRRDSCGGGAFETQENWERLSDGGKASPEEPGDSPPLRRRPRGPPPPSLFGDQPDLTCLIDTNFSVQLPPEPTQPEPRHRVGCGRSRDSGYDFSRLVQRVYQEEGLAAMRMPALRPPSPGPPLPQASQEEGTAPEKGSPPLAWTPSTAGSIWSLELQGNLIVVGRSSGRLEVWDAIEGVLCCSNEEISSGITALVFLDRRIVAARLNGSLDFFSLETHTSLSPLQFRGTPGRGSSPSSSVYSSSNTVTCHRTHTVPCAHQKPITALRAAAGRLVTGSQDHTLRVFRLDDSCCLFTLKGHSGAITAVYIDQTMVLASGGQDGAICLWDVLTGSRVSQTFAHRGDVTSLTCTASCVISSGLDDFISIWDRSTGIKLYSIQQDLGCGASLGVISDNLLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVCNFGSELSLVYVPSVLEKLD" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/8160", "id": "8160", "database": "MGI" } ], "organism": "Mus musculus", "tax_id": 10090 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094436.1", "ac": "NP_001094436.1", "name": "sterol regulatory element-binding protein cleavage-activating protein; SREBP cleavage activating protein.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044877", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "protein-containing complex binding", "id": "GO:0044877" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032934", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "sterol binding", "id": "GO:0032934" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "intracellular membrane-bounded organelle", "id": "GO:0043231" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "protein-containing complex", "id": "GO:0032991" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "Golgi membrane", "id": "GO:0000139" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "endoplasmic reticulum membrane", "id": "GO:0005789" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012507", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "ER to Golgi transport vesicle membrane", "id": "GO:0012507" } ], "total": 6, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007568", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "aging", "id": "GO:0007568" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "immune response", "id": "GO:0006955" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008203", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "cholesterol metabolic process", "id": "GO:0008203" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044255", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "cellular lipid metabolic process", "id": "GO:0044255" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001666", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "response to hypoxia", "id": "GO:0001666" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042304", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "regulation of fatty acid biosynthetic process", "id": "GO:0042304" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045540", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "regulation of cholesterol biosynthetic process", "id": "GO:0045540" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032868", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "response to insulin", "id": "GO:0032868" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032933", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "SREBP signaling pathway", "id": "GO:0032933" } ], "total": 9, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 265, "annotation": "n_glycosylation_sequon", "start_pos": 263 }, { "end_pos": 592, "annotation": "n_glycosylation_sequon", "start_pos": 590 }, { "end_pos": 643, "annotation": "n_glycosylation_sequon", "start_pos": 641 }, { "end_pos": 881, "annotation": "n_glycosylation_sequon", "start_pos": 879 }, { "end_pos": 1025, "annotation": "n_glycosylation_sequon", "start_pos": 1023 } ], "crossref": [ { "url": 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