{ "uniprot_canonical_ac": "A2RRU3-1", "sequence": { "header": "sp|A2RRU3-1|UTP15_RAT Isoform 1 of U3 small nucleolar RNA-associated protein 15 homolog OS=Rattus norvegicus OX=10116 GN=Utp15 PE=2 SV=1 CANONICAL=A2RRU3-1", "length": 528, "sequence": "MAGYKPVVIQTYPVLGEKITQDTLYWNNYKTPVQIKEFGAVSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPVKTFSRFKDTAYCATFRQDGQLLVAGSEDGVVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLFVTGSYDHTVKMFDARTNKNVLCVEHGQPVESVLLFPSGGLLVSAGGRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKIYSTTSYKVVHSFDYAASILSLALSHQDETVVVGMTNGILSVKHRKSEAKKESLPRRRRPAYRTFIKGKIYTKQRDDIVVTRPAKKHLEWYDRDLKSFRISKALDRVLEPNCVIKTPEVTVSIIKELNRRGVLANALAGRDEKEITRVLNFLIRNLSQPRFAPVLINAAEIIIDIYLPVIGQSSVVDKKFIVLQGLVEKEIDYQRELLETLGMMDMLFATMTRNGSAPVWEHVPAELPEEKTESPRQPSDTDKNS" }, "uniprot_id": "UTP15_RAT", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "U3 small nucleolar RNA-associated protein 15 homolog", "UTP15, U3 small nucleolar ribonucleoprotein, homolog; UTP15 SSU processome component" ], "uniprotkb": [ "U3 small nucleolar RNA-associated protein 15 homolog" ] }, "gene": { "refseq": [ "Utp15", "RGD1310992" ], "uniprotkb": [ "Utp15", "RGD1310992" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU3", "id": "A2RRU3", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "U3 small nucleolar RNA-associated protein 15 homolog." }, "publication": [ { "title": "Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22658674", "journal": "Cell", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101117.1", "id": "NP_001101117.1", "database": "RefSeq" } ], "authors": "Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW", "date": "2012", "pmid": "22658674" }, { "title": "Recruitment of factors linking transcription and processing of pre-rRNA to NOR chromatin is UBF-dependent and occurs independent of transcription in human cells.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17699751", "journal": "Genes & development", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101117.1", "id": "NP_001101117.1", "database": "RefSeq" } ], "authors": "Prieto JL, McStay B", "date": "2007", "pmid": "17699751" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2RRU3#A2RRU3-1", "isoform_ac": "A2RRU3-1", "locus": { "end_pos": 28354714, "start_pos": 28367525, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000022259", "id": "ENSRNOT00000022259", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000022259", "id": "ENSRNOP00000022259", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2RRU3-1|UTP15_RAT Isoform 1 of U3 small nucleolar RNA-associated protein 15 homolog OS=Rattus norvegicus OX=10116 GN=Utp15 PE=2 SV=1 CANONICAL=A2RRU3-1", "length": 528, "sequence": "MAGYKPVVIQTYPVLGEKITQDTLYWNNYKTPVQIKEFGAVSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPVKTFSRFKDTAYCATFRQDGQLLVAGSEDGVVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLFVTGSYDHTVKMFDARTNKNVLCVEHGQPVESVLLFPSGGLLVSAGGRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKIYSTTSYKVVHSFDYAASILSLALSHQDETVVVGMTNGILSVKHRKSEAKKESLPRRRRPAYRTFIKGKIYTKQRDDIVVTRPAKKHLEWYDRDLKSFRISKALDRVLEPNCVIKTPEVTVSIIKELNRRGVLANALAGRDEKEITRVLNFLIRNLSQPRFAPVLINAAEIIIDIYLPVIGQSSVVDKKFIVLQGLVEKEIDYQRELLETLGMMDMLFATMTRNGSAPVWEHVPAELPEEKTESPRQPSDTDKNS" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:310019", "resource": "KEGG Pathway", "id": "rno:310019", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6791226", "resource": "Reactome", "id": "R-RNO-6791226", "name": "Major pathway of rRNA processing in the nucleolus and cytosol" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2RRU3#function", "annotation": "Involved in nucleolar processing of pre-18S ribosomal RNA.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU3#function", "id": "A2RRU3", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q8C7V3-1", "protein_name": "U3 small nucleolar RNA-associated protein 15 homolog; Src-associated protein SAW.", "sequence": { "length": 528, "sequence": "MAGYKPVAIQTYPVLGEKITQDTLYWNNYKTPVQIKEFGAVSKVDFSPQLPYNYAVTASSRIHIYGRYSQEPVKTFSRFKDTAYCATFRQDGQLLVAGSEDGVVQLFDINGRAPLRQFEGHTKAVHTVDFTADNYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLFVTGSYDHTVKIFDARTNKNVLCVEHGQPVESVLLFPSGGLLVSAGGRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSFDYAASILSLALSHQDETIVVGMTNGILSVKHRKSEAKKTSLPRRRRPAYRTFIKGKNYLKQRDDIMVSRPAKKHLEGYDKDLKSFRVSQALDRVLEPKCVIRTPEVTVSIIKELTRRGVLANALAGRDEKEVTRVLNFLIRNLSQPRFAPVLINAAEIIIDIYLPVIGQSSVVDKKFIVLQELVEKEIDYQRELLETLGMMDMLFATMTRNDSDPVPEHVPAELPEEKTESPTQPSDTDKNS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/6629", "id": "6629", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2RRU3/", "id": "A2RRU3", "database": "OMA" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q8TED0-1", "protein_name": "U3 small nucleolar RNA-associated protein 15 homolog.", "sequence": { "length": 518, "sequence": "MAGYKPVAIQTYPILGEKITQDTLYWNNYKTPVQIKEFGAVSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESVLSVEHGQPVESVLLFPSGGLLVSAGGRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSFDYAASILSLALAHEDETIVVGMTNGILSVKHRKSEAKKESLPRRRRPAYRTFIKGKNYMKQRDDILINRPAKKHLELYDRDLKHFRISKALDRVLDPTCTIKTPEITVSIIKELNRRGVLANALAGRDEKEISHVLNFLIRNLSQPRFAPVLINAAEIIIDIYLPVIGQSPVVDKKFLLLQGLVEKEIDYQRELLETLGMMDMLFATMRRKEGTSVLEHTSDGFPENKKIES" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/6629", "id": "6629", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101117.1", "ac": "NP_001101117.1", "name": "U3 small nucleolar RNA-associated protein 15 homolog; UTP15, U3 small nucleolar ribonucleoprotein, homolog; UTP15 SSU processome component.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU3", "id": "A2RRU3", "database": "UniProtKB" } ], "name": "nucleolus", "id": "GO:0005730" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU3", "id": "A2RRU3", "database": "UniProtKB" } ], "name": "endoplasmic reticulum", "id": "GO:0005783" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001650", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU3", "id": "A2RRU3", "database": "UniProtKB" } ], "name": "fibrillar center", "id": "GO:0001650" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU3", "id": "A2RRU3", "database": "UniProtKB" } ], "name": "rRNA processing", "id": "GO:0006364" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045943", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU3", "id": "A2RRU3", "database": "UniProtKB" } ], "name": "positive regulation of transcription by RNA polymerase I", "id": "GO:0045943" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000234", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU3", "id": "A2RRU3", "database": "UniProtKB" } ], "name": "positive regulation of rRNA processing", "id": "GO:2000234" } ], "total": 3, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 430, "annotation": "n_glycosylation_sequon", "start_pos": 428 }, { "end_pos": 499, "annotation": "n_glycosylation_sequon", "start_pos": 497 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101117.1", "id": "NP_001101117.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6791226", "id": "R-RNO-6791226", "database": "Reactome" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:310019", "id": "rno:310019", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000016591", "id": "ENSRNOG00000016591", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/QEPVKTF/", "id": "QEPVKTF", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR018983", "id": "IPR018983", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "id": "IPR001680", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "id": "IPR015943", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017986", "id": "IPR017986", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "id": "IPR019775", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "id": "IPR036322", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF09384", "id": "PF09384", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00400", "id": "PF00400", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2RRU3", "id": "PR_A2RRU3", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/310019", "id": "310019", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1310992", "id": "1310992", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A2RRU3", "disease": [], "mass": { "monoisotopic_mass": 59515.0, "chemical_mass": 59515.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2RRU3", "name": "Utp15; RGD1310992.", "locus": { "end_pos": 28353854, "start_pos": 28370261, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000016591", "id": "ENSRNOG00000016591", "database": "Ensembl Gene" } ] } } ] }