{ "uniprot_canonical_ac": "A2RRU1-1", "sequence": { "header": "sp|A2RRU1-1|GYS1_RAT Isoform 1 of Glycogen [starch] synthase, muscle OS=Rattus norvegicus OX=10116 GN=Gys1 PE=1 SV=1 CANONICAL=A2RRU1-1", "length": 738, "sequence": "MPLSRSLSMSSLPGLEDWEDEFDPENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYYLVGPYTEQGVRTQVELLEPPTPELKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQNEEKPYVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADIFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALAKAFPDHFTYEPHEVDATQGYRYPRPASVPPSPSLSRHSSPHQSEDEEEPRDGPLREDSERYDEEEEAAKDRRNIRAPEWPRRASCSSSTGGSKRSNSVDTGPSSSLSTPTEPLSPTSSLGEERN" }, "uniprot_id": "GYS1_RAT", "enzyme_annotation": [ { "ec": "2.4.1.11", "activity": "UDP-alpha-D-glucose + ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha-D-glucosyl)(n+1)." }, { "ec": "2.4.1.11", "activity": "" } ], "synonyms": { "protein": { "refseq": [ "glycogen [starch] synthase, muscle", "glycogen synthase 1, muscle" ], "uniprotkb": [ "Glycogen [starch] synthase, muscle", "2.4.1.11" ] }, "gene": { "refseq": [ "Gys1" ], "uniprotkb": [ "Gys1" ] } }, "keywords": [ "glycosyltransferase-activity" ], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU1", "id": "A2RRU1", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "recommendedname": { "full": "Glycogen [starch] synthase, muscle; 2.4.1.11." }, "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU1/publications", "id": "A2RRU1", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012", "pmid": "22673903" }, { "title": "Phosphate incorporation during glycogen synthesis and Lafora disease.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/21356517", "journal": "Cell metabolism", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103085.1", "id": "NP_001103085.1", "database": "RefSeq" } ], "authors": "Tagliabracci VS, Heiss C, Karthik C, Contreras CJ, Glushka J, Ishihara M, Azadi P, Hurley TD, DePaoli-Roach AA, Roach PJ", "date": "2011", "pmid": "21356517" }, { "title": "Insulin-stimulated glycogen synthesis and glycogen synthase activation after electrical stimulation of epitrochlearis muscles with different initial glycogen contents.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/20597590", "journal": "Archives of physiology and biochemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103085.1", "id": "NP_001103085.1", "database": "RefSeq" } ], "authors": "Lai YC, Stuenaes JT, Kuo CH, Jensen J", "date": "2010", "pmid": "20597590" }, { "title": "Identification of a novel mutation in GYS1 (muscle-specific glycogen synthase) resulting in sudden cardiac death, that is diagnosable from skin fibroblasts.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/19699667", "journal": "Molecular genetics and metabolism", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103085.1", "id": "NP_001103085.1", "database": "RefSeq" } ], "authors": "Cameron JM, Levandovskiy V, MacKay N, Utgikar R, Ackerley C, Chiasson D, Halliday W, Raiman J, Robinson BH", "date": "2009", "pmid": "19699667" }, { "title": "Glycogen content regulates insulin- but not contraction-mediated glycogen synthase activation in the rat slow-twitch soleus muscles.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/19432592", "journal": "Acta physiologica (Oxford, England)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103085.1", "id": "NP_001103085.1", "database": "RefSeq" } ], "authors": "Lai YC, Lin FC, Jensen J", "date": "2009", "pmid": "19432592" }, { "title": "Glycogen synthesis in the astrocyte: from glycogenin to proglycogen to glycogen.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/8224611", "journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103085.1", "id": "NP_001103085.1", "database": "RefSeq" } ], "authors": "Lomako J, Lomako WM, Whelan WJ, Dombro RS, Neary JT, Norenberg MD", "date": "1993", "pmid": "8224611" }, { "title": "Epinephrine regulation of skeletal muscle glycogen metabolism. Studies utilizing the perfused rat hindlimb preparation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/6244274", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103085.1", "id": "NP_001103085.1", "database": "RefSeq" } ], "authors": "Dietz MR, Chiasson JL, Soderling TR, Exton JH", "date": "1980", "pmid": "6244274" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2RRU1#A2RRU1-1", "isoform_ac": "A2RRU1-1", "locus": { "end_pos": 101427410, "start_pos": 101445830, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000028271", "id": "ENSRNOT00000028271", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000028271", "id": "ENSRNOP00000028271", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2RRU1-1|GYS1_RAT Isoform 1 of Glycogen [starch] synthase, muscle OS=Rattus norvegicus OX=10116 GN=Gys1 PE=1 SV=1 CANONICAL=A2RRU1-1", "length": 738, "sequence": "MPLSRSLSMSSLPGLEDWEDEFDPENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYYLVGPYTEQGVRTQVELLEPPTPELKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQNEEKPYVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADIFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALAKAFPDHFTYEPHEVDATQGYRYPRPASVPPSPSLSRHSSPHQSEDEEEPRDGPLREDSERYDEEEEAAKDRRNIRAPEWPRRASCSSSTGGSKRSNSVDTGPSSSLSTPTEPLSPTSSLGEERN" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:690987", "resource": "KEGG Pathway", "id": "rno:690987", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3322077", "resource": "Reactome", "id": "R-RNO-3322077", "name": "Glycogen synthesis" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2RRU1#function", "annotation": "Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU1#function", "id": "A2RRU1", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103085.1", "annotation": "After contraction insulin-stimulated glycogen synthesis was increased by rather similar magnitude at all glycogen contents in concert with increased glycogen synthase activation.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103085.1", "id": "NP_001103085.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103085.1", "annotation": "After contraction, glycogen synthase (GS) was increased to similar levels in muscles with low, normal and high glycogen content; rate of glycogen synthesis after contraction was also similar; insulin increased GS activation at all glycogen contents.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103085.1", "id": "NP_001103085.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q9Z1E4-1", "protein_name": "Glycogen [starch] synthase, muscle; 2.4.1.11.", "sequence": { "length": 738, "sequence": "MPLSRSLSVSSLPGLEDWEDEFDPENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYYLVGPYTEQGVRTQVELLEPPTPELKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQNEEKPYVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALAKAFPDHFTYEPHEVDATQGYRYPRPASVPPSPSLSRHSSPHQSEDEEEPRDGPLGEDSERYDEEEEAAKDRRNIRAPEWPRRASCSSSTGGSKRSNSVDTGPSSSLSTPTEPLSPTSSLGEERN" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/113557", "id": "113557", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2RRU1/", "id": "A2RRU1", "database": "OMA" } ], "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "P13807-1", "protein_name": "Glycogen [starch] synthase, muscle; 2.4.1.11.", "sequence": { "length": 737, "sequence": "MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/113557", "id": "113557", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2RRU1/", "id": "A2RRU1", "database": "OMA" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103085.1", "ac": "NP_001103085.1", "name": "glycogen [starch] synthase, muscle; glycogen synthase 1, muscle.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004373", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU1", "id": "A2RRU1", "database": "UniProtKB" } ], "name": "glycogen (starch) synthase activity", "id": "GO:0004373" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004373", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU1", "id": "A2RRU1", "database": "UniProtKB" } ], "name": "glycogen (starch) synthase activity", "id": "GO:0004373" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004373", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU1", "id": "A2RRU1", "database": "UniProtKB" } ], "name": "glycogen (starch) synthase activity", "id": "GO:0004373" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004373", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU1", "id": "A2RRU1", "database": "UniProtKB" } ], "name": "glycogen (starch) synthase activity", "id": "GO:0004373" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004373", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU1", "id": "A2RRU1", "database": "UniProtKB" } ], "name": "glycogen (starch) synthase activity", "id": "GO:0004373" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005536", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU1", "id": "A2RRU1", "database": "UniProtKB" } ], "name": "glucose binding", "id": "GO:0005536" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005536", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU1", "id": "A2RRU1", "database": "UniProtKB" } ], "name": "glucose binding", "id": "GO:0005536" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU1", "id": "A2RRU1", "database": "UniProtKB" } ], "name": "protein kinase binding", "id": "GO:0019901" } ], "total": 8, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU1", "id": "A2RRU1", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016234", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU1", "id": "A2RRU1", "database": "UniProtKB" } ], "name": "inclusion body", "id": "GO:0016234" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005977", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU1", "id": "A2RRU1", "database": "UniProtKB" } ], "name": "glycogen metabolic process", "id": "GO:0005977" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005977", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU1", "id": "A2RRU1", "database": "UniProtKB" } ], "name": "glycogen metabolic process", "id": "GO:0005977" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005978", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU1", "id": "A2RRU1", "database": "UniProtKB" } ], "name": "glycogen biosynthetic process", "id": "GO:0005978" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005978", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU1", "id": "A2RRU1", "database": "UniProtKB" } ], "name": "glycogen biosynthetic process", "id": "GO:0005978" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU1", "id": "A2RRU1", "database": "UniProtKB" } ], "name": "heart development", "id": "GO:0007507" } ], "total": 5, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 358, "annotation": "n_glycosylation_sequon", "start_pos": 356 }, { "end_pos": 469, "annotation": "n_glycosylation_sequon", "start_pos": 467 }, { "end_pos": 532, "annotation": "n_glycosylation_sequon", "start_pos": 530 }, { "end_pos": 589, "annotation": "n_glycosylation_sequon", "start_pos": 587 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103085.1", "id": "NP_001103085.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3322077", "id": "R-RNO-3322077", "database": "Reactome" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?rno:690987", "id": "rno:690987", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000020812", "id": "ENSRNOG00000020812", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/VFHPDFL/", "id": "VFHPDFL", "database": "OMA" }, { "url": "http://www.cazy.org/fam/GT3.html", "id": "GT3", "database": "CAZy" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03793", "id": "cd03793", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR008631", "id": "IPR008631", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF05693", "id": "PF05693", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10176", "id": "PTHR10176", "database": "PANTHER" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2RRU1", "id": "PR_A2RRU1", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/690987", "id": "690987", "database": "GeneID" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1589798", "id": "1589798", "database": "RGD" } ], "expression_disease": [], "uniprot_ac": "A2RRU1", "disease": [], "mass": { "monoisotopic_mass": 84072.0, "chemical_mass": 84072.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2RRU1", "name": "Gys1.", "locus": { "end_pos": 101447092, "start_pos": 101427195, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000020812", "id": "ENSRNOG00000020812", "database": "Ensembl Gene" } ] } } ] }