{ "uniprot_canonical_ac": "A2BH40-1", "sequence": { "header": "sp|A2BH40-1|ARI1A_MOUSE Isoform 1 of AT-rich interactive domain-containing protein 1A OS=Mus musculus OX=10090 GN=Arid1a PE=1 SV=1 CANONICAL=A2BH40-1", "length": 2283, "sequence": "MAAQVAPAAASSLGNPPPPPSELKKAEQQQREEAGGEAAAAAAERGEMKAAAGQESEGPAVGPPQPLGKELQDGAESNGGGGGGGAGSGGGPGAEPDLKNSNGNAGPRPALNNNLPEPPGGGGGGGSSSSDGVGAPPHSAAAALPPPAYGFGQAYGRSPSAVAAAAAAVFHQQHGGQQSPGLAALQSGGGGGLEPYAGPQQNSHDHGFPNHQYNSYYPNRSAYPPPPQAYALSSPRGGTPGSGAAAAAGSKPPPSSSASASSSSSSFAQQRFGAMGGGGPSAAGGGTPQPTATPTLNQLLTSPSSARGYQGYPGGDYGGGPQDGGAGKGPADMASQCWGAAAAAAAAAAAVSGGAQQRSHHAPMSPGSSGGGGQPLARTPQSSSPMDQMGKMRPQPYGGTNPYSQQQGPPSGPQQGHGYPGQPYGSQTPQRYPMTMQGRAQSAMGSLSYAQQIPPYGQQGPSAYGQQGQTPYYNQQSPHPQQQPPYAQQPPSQTPHAQPSYQQQPQTQQPQLQSSQPPYSQQPSQPPHQQSPTPYPSQQSTTQQHPQSQPPYSQPQAQSPYQQQQPQQPASSSLSQQAAYPQPQPQQSQQTAYSQQRFPPPQELSQDSFGSQASSAPSMTSSKGGQEDMNLSLQSRPSSLPDLSGSIDDLPMGTEGALSPGVSTSGISSSQGEQSNPAQSPFSPHTSPHLPGIRGPSPSPVGSPASVAQSRSGPLSPAAVPGNQMPPRPPSGQSDSIMHPSMNQSSIAQDRGYMQRNPQMPQYTSPQPGSALSPRQPSGGQMHSGVGSYQQNSMGSYGPQGSQYGPQGGYPRQPNYNALPNANYPNAGMAGSMNPMGAGGQMHGQPGIPPYGTLPPGRMAHASMGNRPYGPNMANMPPQVGSGMCPPPGGMNRKTQESAVAMHVAANSIQNRPPGYPNMNQGGMMGTGPPYGQGINSMAGMINPQGPPYPMGGTMANNSAGMAASPEMMGLGDVKLTPATKMNNKADGTPKTESKSKKSSSSTTTNEKITKLYELGGEPERKMWVDRYLAFTEEKAMGMTNLPAVGRKPLDLYRLYVSVKEIGGLTQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQCLYAFECKIERGEDPPPDIFAAADSKKSQPKIQPPSPAGSGSMQGPQTPQSTSSSMAEGGDLKPPTPASTPHSQIPPLPGMSRSNSVGIQDAFPDGSDPTFQKRNSMTPNPGYQPSMNTSDMMGRMSYEPNKDPYGSMRKAPGSDPFMSSGQGPNGGMGDPYSRAAGPGLGSVAMGPRQHYPYGGPYDRVRTEPGIGPEGNMGTGAPQPNLMPSTPDSGMYSPSRYPPQQQQQQQQQHDSYGNQFSTQGTPSSSPFPSQQTTMYQQQQQNYKRPMDGTYGPPAKRHEGEMYSVPYSAGQGQPQQQQLPAAQSQPASQPQAAQPSPQQDVYNQYSNAYPASATAATDRRPAGGPQNQFPFQFGRDRVSAPPGSSAQQNMPPQMMGGPIQASAEVAQQGTMWQGRNDMTYNYANRQNTGSATQGPAYHGVNRTDEMLHTDQRANHEGPWPSHGTRQPPYGPSAPVPPMTRPPPSNYQPPPSMPNHIPQVSSPAPLPRPMENRTSPSKSPFLHSGMKMQKAGPPVPASHIAPTPVQPPMIRRDITFPPGSVEATQPVLKQRRRLTMKDIGTPEAWRVMMSLKSGLLAESTWALDTINILLYDDNSIMTFNLSQLPGLLELLVEYFRRCLIEIFGILKEYEVGDPGQRTLLDPGRFTKVYSPAHTEEEEEEHLDPKLEEEEEEGVGNDEEMAFLGKDKPSSENNEEKLVSKFDKLPVKIVQRNDPFVVDCSDKLGRVQEFDSGLLHWRIGGGDTTEHIQTHFESKIELLPSRPYVPCPTPPRKHLTTVEGTPGTTEQEGPPPDGLPEKRITATMDDMLSTRSSTLTDEGAKSAEATKESSKFPFGISPAQSHRNIKILEDEPHSKDETPLCTLLDWQDSLAKRCVCVSNTIRSLSFVPGNDFEMSKHPGLLLILGKLILLHHKHPERKQAPLTYEKEEEQDQGVSCDKVEWWWDCLEMLRENTLVTLANISGQLDLSPYPESICLPVLDGLLHWAVCPSAEAQDPFSTLGPNAVLSPQRLVLETLSKLSIQDNNVDLILATPPFSRLEKLYSTMVRFLSDRKNPVCREMAVVLLANLAQGDSLAARAIAVQKGSIGNLLGFLEDSLAATQFQQSQASLLHMQNPPFEPTSVDMMRRAARALLALAKVDENHSEFTLYESRLLDISVSPLMNSLVSQVICDVLFLIGQS" }, "uniprot_id": "ARI1A_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "AT-rich interactive domain-containing protein 1A isoform 1", "AT rich interactive domain 1A (Swi1 like); AT-rich interactive domain-containing protein 1A; BAF250; osa homolog 1; SWI-like protein; BRG1-associated factor 250a; ARID domain-containing protein 1A; SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1; SWI/SNF complex protein p270" ], "uniprotkb": [ "AT-rich interactive domain-containing protein 1A", "ARID domain-containing protein 1A", "BRG1-associated factor 250a", "BAF250A", "BRG1-associated factor 250", "BAF250", "SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1", "SNF complex protein p270", "Osa homolog 1", "SWI-like protein" ] }, "gene": { "refseq": [ "Arid1a", "1110030E03Rik", "BAF250a", "Osa1", "Smarcf1" ], "uniprotkb": [ "Arid1a", "Baf250", "Baf250a", "Osa1", "Smarcf1", "1110030E03Rik", "BAF250a" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40", "id": "A2BH40", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "AT-rich interactive domain-containing protein 1A; ARID domain-containing protein 1A; BRG1-associated factor 250a; BAF250A; BRG1-associated factor 250; BAF250; SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1; SNF complex protein p270; Osa homolog 1; SWI-like protein.", "short": "ARID domain-containing protein 1A" }, "publication": [ { "title": "Arid1a is essential for intestinal stem cells through Sox9 regulation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/30635419", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074288.1", "id": "NP_001074288.1", "database": "RefSeq" } ], "authors": "Hiramatsu Y, Fukuda A, Ogawa S, Goto N, Ikuta K, Tsuda M, Matsumoto Y, Kimura Y, Yoshioka T, Takada Y, Maruno T, Hanyu Y, Tsuruyama T, Wang Z, Akiyama H, Takaishi S, Miyoshi H, Taketo MM, Chiba T, Seno H", "date": "2019", "pmid": "30635419" }, { "title": "Antagonistic interaction between Ezh2 and Arid1a coordinates root patterning and development via Cdkn2a in mouse molars.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/31259687", "journal": "eLife", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074288.1", "id": "NP_001074288.1", "database": "RefSeq" } ], "authors": "Jing J, Feng J, Li J, Han X, He J, Ho TV, Du J, Zhou X, Urata M, Chai Y", "date": "2019", "pmid": "31259687" }, { "title": "A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/31271748", "journal": "Cell stem cell", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074288.1", "id": "NP_001074288.1", "database": "RefSeq" } ], "authors": "Li W, Yang L, He Q, Hu C, Zhu L, Ma X, Ma X, Bao S, Li L, Chen Y, Deng X, Zhang X, Cen J, Zhang L, Wang Z, Xie WF, Li H, Li Y, Hui L", "date": "2019", "pmid": "31271748" }, { "title": "Arid1a regulates insulin sensitivity and lipid metabolism.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/30879920", "journal": "EBioMedicine", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074288.1", "id": "NP_001074288.1", "database": "RefSeq" } ], "authors": "Qu YL, Deng CH, Luo Q, Shang XY, Wu JX, Shi Y, Wang L, Han ZG", "date": "2019", "pmid": "30879920" }, { "title": "The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/30401838", "journal": "Nature", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074288.1", "id": "NP_001074288.1", "database": "RefSeq" } ], "authors": "Chang L, Azzolin L, Di Biagio D, Zanconato F, Battilana G, Lucon Xiccato R, Aragona M, Giulitti S, Panciera T, Gandin A, Sigismondo G, Krijgsveld J, Fassan M, Brusatin G, Cordenonsi M, Piccolo S", "date": "2018", "pmid": "30401838" }, { "title": "Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/26601204", "journal": "Sci. Adv.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40/publications", "id": "A2BH40", "database": "UniProtKB" } ], "authors": "Crabtree G.R., Kadoch C.", "date": "2015", "pmid": "26601204" }, { "title": "Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/24129315", "journal": "Mol. Cell. Proteomics", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40/publications", "id": "A2BH40", "database": "UniProtKB" } ], "authors": "Beausoleil S.A., Wang Y., Zhou J., Comb M.J., Guo A., Lee K.A., Aguiar M., Bedford M.T., Gu H., Jia X., Kornhauser J., Mulhern D., Ren J., Silva J.C., Vemulapalli V., Yang V.", "date": "2014", "pmid": "24129315" }, { "title": "SWI/SNF chromatin-remodeling factors: multiscale analyses and diverse functions.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22952240", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40/publications", "id": "A2BH40", "database": "UniProtKB" } ], "authors": "Auerbach R.K., Euskirchen G., Snyder M.", "date": "2012", "pmid": "22952240" }, { "title": "The phagosomal proteome in interferon-gamma-activated macrophages.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/19144319", "journal": "Immunity", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40/publications", "id": "A2BH40", "database": "UniProtKB" } ], "authors": "Thibault P., Trost M., Desjardins M., Courcelles M., English L., Lemieux S.", "date": "2009", "pmid": "19144319" }, { "title": "An essential switch in subunit composition of a chromatin remodeling complex during neural development.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17640523", "journal": "Neuron", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40/publications", "id": "A2BH40", "database": "UniProtKB" } ], "authors": "Aebersold R., Crabtree G.R., Wu H., Wan M., Lessard J., Ranish J.A., Graef I.A., Staahl B.T., Winslow M.M., Wu J.I.", "date": "2007", "pmid": "17640523" }, { "title": "Large-scale phosphorylation analysis of mouse liver.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17242355", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40/publications", "id": "A2BH40", "database": "UniProtKB" } ], "authors": "Beausoleil S.A., Gerber S.A., Gygi S.P., Villen J.", "date": "2007", "pmid": "17242355" }, { "title": "The p270 (ARID1A/SMARCF1) subunit of mammalian SWI/SNF-related complexes is essential for normal cell cycle arrest.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/16230384", "journal": "Cancer research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074288.1", "id": "NP_001074288.1", "database": "RefSeq" } ], "authors": "Nagl NG Jr, Patsialou A, Haines DS, Dallas PB, Beck GR Jr, Moran E", "date": "2005", "pmid": "16230384" }, { "title": "Cloning and characterization of hELD/OSA1, a novel BRG1 interacting protein.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/11988099", "journal": "The Biochemical journal", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074288.1", "id": "NP_001074288.1", "database": "RefSeq" } ], "authors": "Hurlstone AF, Olave IA, Barker N, van Noort M, Clevers H", "date": "2002", "pmid": "11988099" }, { "title": "Identification of a polymorphic, neuron-specific chromatin remodeling complex.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/12368262", "journal": "Genes & development", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074288.1", "id": "NP_001074288.1", "database": "RefSeq" } ], "authors": "Olave I, Wang W, Xue Y, Kuo A, Crabtree GR", "date": "2002", "pmid": "12368262" }, { "title": "Characterization of mammalian orthologues of the Drosophila osa gene: cDNA cloning, expression, chromosomal localization, and direct physical interaction with Brahma chromatin-remodeling complex.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/11318604", "journal": "Genomics", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40/publications", "id": "A2BH40", "database": "UniProtKB" } ], "authors": "Kozmik Z., Kralova J., Kreslova J., Machon O., Paces J., Vlcek C.", "date": "2001", "pmid": "11318604" } ], "glycosylation": [ { "residue": "Asn", "evidence": [ { "url": "https://glyconnect.expasy.org/browser/proteins/2144", "id": "2144", "database": "GlyConnect" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30899004", "id": "30899004", "database": "PubMed" } ], "relation": "attached", "position": 1598, "glytoucan_ac": "", "type": "N-linked" } ], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2BH40#A2BH40-1", "isoform_ac": "A2BH40-1", "locus": { "end_pos": 133680334, "start_pos": 133753611, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000105897", "id": "ENSMUST00000105897", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000101517", "id": "ENSMUSP00000101517", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2BH40-1|ARI1A_MOUSE Isoform 1 of AT-rich interactive domain-containing protein 1A OS=Mus musculus OX=10090 GN=Arid1a PE=1 SV=1 CANONICAL=A2BH40-1", "length": 2283, "sequence": "MAAQVAPAAASSLGNPPPPPSELKKAEQQQREEAGGEAAAAAAERGEMKAAAGQESEGPAVGPPQPLGKELQDGAESNGGGGGGGAGSGGGPGAEPDLKNSNGNAGPRPALNNNLPEPPGGGGGGGSSSSDGVGAPPHSAAAALPPPAYGFGQAYGRSPSAVAAAAAAVFHQQHGGQQSPGLAALQSGGGGGLEPYAGPQQNSHDHGFPNHQYNSYYPNRSAYPPPPQAYALSSPRGGTPGSGAAAAAGSKPPPSSSASASSSSSSFAQQRFGAMGGGGPSAAGGGTPQPTATPTLNQLLTSPSSARGYQGYPGGDYGGGPQDGGAGKGPADMASQCWGAAAAAAAAAAAVSGGAQQRSHHAPMSPGSSGGGGQPLARTPQSSSPMDQMGKMRPQPYGGTNPYSQQQGPPSGPQQGHGYPGQPYGSQTPQRYPMTMQGRAQSAMGSLSYAQQIPPYGQQGPSAYGQQGQTPYYNQQSPHPQQQPPYAQQPPSQTPHAQPSYQQQPQTQQPQLQSSQPPYSQQPSQPPHQQSPTPYPSQQSTTQQHPQSQPPYSQPQAQSPYQQQQPQQPASSSLSQQAAYPQPQPQQSQQTAYSQQRFPPPQELSQDSFGSQASSAPSMTSSKGGQEDMNLSLQSRPSSLPDLSGSIDDLPMGTEGALSPGVSTSGISSSQGEQSNPAQSPFSPHTSPHLPGIRGPSPSPVGSPASVAQSRSGPLSPAAVPGNQMPPRPPSGQSDSIMHPSMNQSSIAQDRGYMQRNPQMPQYTSPQPGSALSPRQPSGGQMHSGVGSYQQNSMGSYGPQGSQYGPQGGYPRQPNYNALPNANYPNAGMAGSMNPMGAGGQMHGQPGIPPYGTLPPGRMAHASMGNRPYGPNMANMPPQVGSGMCPPPGGMNRKTQESAVAMHVAANSIQNRPPGYPNMNQGGMMGTGPPYGQGINSMAGMINPQGPPYPMGGTMANNSAGMAASPEMMGLGDVKLTPATKMNNKADGTPKTESKSKKSSSSTTTNEKITKLYELGGEPERKMWVDRYLAFTEEKAMGMTNLPAVGRKPLDLYRLYVSVKEIGGLTQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQCLYAFECKIERGEDPPPDIFAAADSKKSQPKIQPPSPAGSGSMQGPQTPQSTSSSMAEGGDLKPPTPASTPHSQIPPLPGMSRSNSVGIQDAFPDGSDPTFQKRNSMTPNPGYQPSMNTSDMMGRMSYEPNKDPYGSMRKAPGSDPFMSSGQGPNGGMGDPYSRAAGPGLGSVAMGPRQHYPYGGPYDRVRTEPGIGPEGNMGTGAPQPNLMPSTPDSGMYSPSRYPPQQQQQQQQQHDSYGNQFSTQGTPSSSPFPSQQTTMYQQQQQNYKRPMDGTYGPPAKRHEGEMYSVPYSAGQGQPQQQQLPAAQSQPASQPQAAQPSPQQDVYNQYSNAYPASATAATDRRPAGGPQNQFPFQFGRDRVSAPPGSSAQQNMPPQMMGGPIQASAEVAQQGTMWQGRNDMTYNYANRQNTGSATQGPAYHGVNRTDEMLHTDQRANHEGPWPSHGTRQPPYGPSAPVPPMTRPPPSNYQPPPSMPNHIPQVSSPAPLPRPMENRTSPSKSPFLHSGMKMQKAGPPVPASHIAPTPVQPPMIRRDITFPPGSVEATQPVLKQRRRLTMKDIGTPEAWRVMMSLKSGLLAESTWALDTINILLYDDNSIMTFNLSQLPGLLELLVEYFRRCLIEIFGILKEYEVGDPGQRTLLDPGRFTKVYSPAHTEEEEEEHLDPKLEEEEEEGVGNDEEMAFLGKDKPSSENNEEKLVSKFDKLPVKIVQRNDPFVVDCSDKLGRVQEFDSGLLHWRIGGGDTTEHIQTHFESKIELLPSRPYVPCPTPPRKHLTTVEGTPGTTEQEGPPPDGLPEKRITATMDDMLSTRSSTLTDEGAKSAEATKESSKFPFGISPAQSHRNIKILEDEPHSKDETPLCTLLDWQDSLAKRCVCVSNTIRSLSFVPGNDFEMSKHPGLLLILGKLILLHHKHPERKQAPLTYEKEEEQDQGVSCDKVEWWWDCLEMLRENTLVTLANISGQLDLSPYPESICLPVLDGLLHWAVCPSAEAQDPFSTLGPNAVLSPQRLVLETLSKLSIQDNNVDLILATPPFSRLEKLYSTMVRFLSDRKNPVCREMAVVLLANLAQGDSLAARAIAVQKGSIGNLLGFLEDSLAATQFQQSQASLLHMQNPPFEPTSVDMMRRAARALLALAKVDENHSEFTLYESRLLDISVSPLMNSLVSQVICDVLFLIGQS" } }, { "url": "https://www.uniprot.org/uniprot/A2BH40#E9QAQ7-1", "isoform_ac": "E9QAQ7-1", "locus": { "end_pos": 133680334, "start_pos": 133753611, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000145664", "id": "ENSMUST00000145664", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000122354", "id": "ENSMUSP00000122354", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|E9QAQ7-1|ARI1A_MOUSE Computationally mapped isoform of AT-rich interactive domain-containing protein 1A OS=Mus musculus OX=10090 GN=Arid1a PE=1 SV=1 CANONICAL=A2BH40-1", "length": 2287, "sequence": "MAAQVAPAAASSLGNPPPPPSELKKAEQQQREEAGGEAAAAAAERGEMKAAAGQESEGPAVGPPQPLGKELQDGAESNGGGGGGGAGSGGGPGAEPDLKNSNGNAGPRPALNNNLPEPPGGGGGGGSSSSDGVGAPPHSAAAALPPPAYGFGQAYGRSPSAVAAAAAAVFHQQHGGQQSPGLAALQSGGGGGLEPYAGPQQNSHDHGFPNHQYNSYYPNRSAYPPPPQAYALSSPRGGTPGSGAAAAAGSKPPPSSSASASSSSSSFAQQRFGAMGGGGPSAAGGGTPQPTATPTLNQLLTSPSSARGYQGYPGGDYGGGPQDGGAGKGPADMASQCWGAAAAAAAAAAAVSGGAQQRSHHAPMSPGSSGGGGQPLARTPQSSSPMDQMGKMRPQPYGGTNPYSQQQGPPSGPQQGHGYPGQPYGSQTPQRYPMTMQGRAQSAMGSLSYAQQIPPYGQQGPSAYGQQGQTPYYNQQSPHPQQQPPYAQQPPSQTPHAQPSYQQQPQTQQPQLQSSQPPYSQQPSQPPHQQSPTPYPSQQSTTQQHPQSQPPYSQPQAQSPYQQQQPQQPASSSLSQQAAYPQPQPQQSQQTAYSQQRFPPPQELSQDSFGSQASSAPSMTSSKGGQEDMNLSLQSRPSSLPDLSGSIDDLPMGTEGALSPGVSTSGISSSQGEQSNPAQSPFSPHTSPHLPGIRGPSPSPVGSPASVAQSRSGPLSPAAVPGNQMPPRPPSGQSDSIMHPSMNQSSIAQDRGYMQRNPQMPQYTSPQPGSALSPRQPSGGQMHSGVGSYQQNSMGSYGPQGSQYGPQGGYPRQPNYNALPNANYPNAGMAGSMNPMGAGGQMHGQPGIPPYGTLPPGRMAHASMGNRPYGPNMANMPPQVGSGMCPPPGGMNRKTQESAVAMHVAANSIQNRPPGYPNMNQGGMMGTGPPYGQGINSMAGMINPQGPPYPMGGTMANNSAGMAASPEMMGLGDVKLTPATKMNNKADGTPKTESKSKKSSSSTTTNEKITKLYELGGEPERKMWVDRYLAFTEEKAMGMTNLPAVGRKPLDLYRLYVSVKEIGGLTQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQCLYAFECKIERGEDPPPDIFAAADSKKSQPKIQPPSPAGSGSMQGPQTPQSTSSSMAEGGDLKPPTPASTPHSQIPPLPGMRSNSVGIQDAFPDGSDPTFQKRNSMTPNPGYQPSMNTSDMMGRMSYEPNKDPYGSMRKAPGSDPFMSSGQGPNGGMGDPYSRAAGPGLGSVAMGPRQHYPYGGPYDRVRTEPGIGPEGNMGTGAPQPNLMPSTPDSGMYSPSRYPPQQQQQQQQQQQQQRHDSYGNQFSTQGTPSSSPFPSQQTTMYQQQQQNYKRPMDGTYGPPAKRHEGEMYSVPYSAGQGQPQQQQLPAAQSQPASQPQAAQPSPQQDVYNQYSNAYPASATAATDRRPAGGPQNQFPFQFGRDRVSAPPGSSAQQNMPPQMMGGPIQASAEVAQQGTMWQGRNDMTYNYANRQNTGSATQGPAYHGVNRTDEMLHTDQRANHEGPWPSHGTRQPPYGPSAPVPPMTRPPPSNYQPPPSMPNHIPQVSSPAPLPRPMENRTSPSKSPFLHSGMKMQKAGPPVPASHIAPTPVQPPMIRRDITFPPGSVEATQPVLKQRRRLTMKDIGTPEAWRVMMSLKSGLLAESTWALDTINILLYDDNSIMTFNLSQLPGLLELLVEYFRRCLIEIFGILKEYEVGDPGQRTLLDPGRFTKVYSPAHTEEEEEEHLDPKLEEEEEEGVGNDEEMAFLGKDKPSSENNEEKLVSKFDKLPVKIVQRNDPFVVDCSDKLGRVQEFDSGLLHWRIGGGDTTEHIQTHFESKIELLPSRPYVPCPTPPRKHLTTVEGTPGTTEQEGPPPDGLPEKRITATMDDMLSTRSSTLTDEGAKSAEATKESSKFPFGISPAQSHRNIKILEDEPHSKDETPLCTLLDWQDSLAKRCVCVSNTIRSLSFVPGNDFEMSKHPGLLLILGKLILLHHKHPERKQAPLTYEKEEEQDQGVSCDKVEWWWDCLEMLRENTLVTLANISGQLDLSPYPESICLPVLDGLLHWAVCPSAEAQDPFSTLGPNAVLSPQRLVLETLSKLSIQDNNVDLILATPPFSRLEKLYSTMVRFLSDRKNPVCREMAVVLLANLAQGDSLAARAIAVQKGSIGNLLGFLEDSLAATQFQQSQASLLHMQNPPFEPTSVDMMRRAARALLALAKVDENHSEFTLYESRLLDISVSPLMNSLVSQVICDVLFLIGQS" } }, { "url": "https://www.uniprot.org/uniprot/A2BH40#A2BH40-2", "isoform_ac": "A2BH40-2", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A2BH40-2|ARI1A_MOUSE Isoform 2 of AT-rich interactive domain-containing protein 1A OS=Mus musculus OX=10090 GN=Arid1a PE=1 SV=1 CANONICAL=A2BH40-1", "length": 1903, "sequence": "MDQMGKMRPQPYGGTNPYSQQQGPPSGPQQGHGYPGQPYGSQTPQRYPMTMQGRAQSAMGSLSYAQQIPPYGQQGPSAYGQQGQTPYYNQQSPHPQQQPPYAQQPPSQTPHAQPSYQQQPQTQQPQLQSSQPPYSQQPSQPPHQQSPTPYPSQQSTTQQHPQSQPPYSQPQAQSPYQQQQPQQPASSSLSQQAAYPQPQPQQSQQTAYSQQRFPPPQELSQDSFGSQASSAPSMTSSKGGQEDMNLSLQSRPSSLPDLSGSIDDLPMGTEGALSPGVSTSGISSSQGEQSNPAQSPFSPHTSPHLPGIRGPSPSPVGSPASVAQSRSGPLSPAAVPGNQMPPRPPSGQSDSIMHPSMNQSSIAQDRGYMQRNPQMPQYTSPQPGSALSPRQPSGGQMHSGVGSYQQNSMGSYGPQGSQYGPQGGYPRQPNYNALPNANYPNAGMAGSMNPMGAGGQMHGQPGIPPYGTLPPGRMAHASMGNRPYGPNMANMPPQVGSGMCPPPGGMNRKTQESAVAMHVAANSIQNRPPGYPNMNQGGMMGTGPPYGQGINSMAGMINPQGPPYPMGGTMANNSAGMAASPEMMGLGDVKLTPATKMNNKADGTPKTESKSKKSSSSTTTNEKITKLYELGGEPERKMWVDRYLAFTEEKAMGMTNLPAVGRKPLDLYRLYVSVKEIGGLTQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQCLYAFECKIERGEDPPPDIFAAADSKKSQPKIQPPSPAGSGSMQGPQTPQSTSSSMAEGGDLKPPTPASTPHSQIPPLPGMSRSNSVGIQDAFPDGSDPTFQKRNSMTPNPGYQPSMNTSDMMGRMSYEPNKDPYGSMRKAPGSDPFMSSGQGPNGGMGDPYSRAAGPGLGSVAMGPRQHYPYGGPYDRVRTEPGIGPEGNMGTGAPQPNLMPSTPDSGMYSPSRYPPQQQQQQQQQQQQQRHDSYGNQFSTQGTPSSSPFPSQQTTMYQQQQQNYKRPMDGTYGPPAKRHEGEMYSVPYSAGQGQPQQQQLPAAQSQPASQPQAAQPSPQQDVYNQYSNAYPASATAATDRRPAGGPQNQFPFQFGRDRVSAPPGSSAQQNMPPQMMGGPIQASAEVAQQGTMWQGRNDMTYNYANRQNTGSATQGPAYHGVNRTDEMLHTDQRANHEGPWPSHGTRQPPYGPSAPVPPMTRPPPSNYQPPPSMPNHIPQVSSPAPLPRPMENRTSPSKSPFLHSGMKMQKAGPPVPASHIAPTPVQPPMIRRDITFPPGSVEATQPVLKQRRRLTMKDIGTPEAWRVMMSLKSGLLAESTWALDTINILLYDDNSIMTFNLSQLPGLLELLVEYFRRCLIEIFGILKEYEVGDPGQRTLLDPGRFTKVYSPAHTEEEEEEHLDPKLEEEEEEGVGNDEEMAFLGKDKPSSENNEEKLVSKFDKLPVKIVQRNDPFVVDCSDKLGRVQEFDSGLLHWRIGGGDTTEHIQTHFESKIELLPSRPYVPCPTPPRKHLTTVEGTPGTTEQEGPPPDGLPEKRITATMDDMLSTRSSTLTDEGAKSAEATKESSKFPFGISPAQSHRNIKILEDEPHSKDETPLCTLLDWQDSLAKRCVCVSNTIRSLSFVPGNDFEMSKHPGLLLILGKLILLHHKHPERKQAPLTYEKEEEQDQGVSCDKVEWWWDCLEMLRENTLVTLANISGQLDLSPYPESICLPVLDGLLHWAVCPSAEAQDPFSTLGPNAVLSPQRLVLETLSKLSIQDNNVDLILATPPFSRLEKLYSTMVRFLSDRKNPVCREMAVVLLANLAQGDSLAARAIAVQKGSIGNLLGFLEDSLAATQFQQSQASLLHMQNPPFEPTSVDMMRRAARALLALAKVDENHSEFTLYESRLLDISVSPLMNSLVSQVICDVLFLIGQS" } }, { "url": "https://www.uniprot.org/uniprot/A2BH40#E9Q495-1", "isoform_ac": "E9Q495-1", "locus": { "end_pos": 133720781, "start_pos": 133723039, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000139709", "id": "ENSMUST00000139709", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000131950", "id": "ENSMUSP00000131950", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|E9Q495-1|ARI1A_MOUSE Computationally mapped isoform of AT-rich interactive domain-containing protein 1A OS=Mus musculus OX=10090 GN=Arid1a PE=1 SV=8 CANONICAL=A2BH40-1", "length": 140, "sequence": "MDQMGKMRPQPYGGTNPYSQQQGPPSGPQQGHGYPGQPYGSQTPQRYPMTMQGRAQSAMGSLSYAQQIPPYGQQGPSAYGQQGQTPYYNQQSPHPQQQPPYAQQPPSQTPHAQPSYQQQPQTQQPQLQSSQPPYSQQPSQ" } }, { "url": "https://www.uniprot.org/uniprot/A2BH40#A2BH40-3", "isoform_ac": "A2BH40-3", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A2BH40-3|ARI1A_MOUSE Isoform 3 of AT-rich interactive domain-containing protein 1A OS=Mus musculus OX=10090 GN=Arid1a PE=1 SV=1 CANONICAL=A2BH40-1", "length": 2066, "sequence": "MAAQVAPAAASSLGNPPPPPSELKKAEQQQREEAGGEAAAAAAERGEMKAAAGQESEGPAVGPPQPLGKELQDGAESNGGGGGGGAGSGGGPGAEPDLKNSNGNAGPRPALNNNLPEPPGGGGGGGSSSSDGVGAPPHSAAAALPPPAYGFGQAYGRSPSAVAAAAAAVFHQQHGGQQSPGLAALQSGGGGGLEPYAGPQQNSHDHGFPNHQYNSYYPNRSAYPPPPQAYALSSPRGGTPGSGAAAAAGSKPPPSSSASASSSSSSFAQQRFGAMGGGGPSAAGGGTPQPTATPTLNQLLTSPSSARGYQGYPGGDYGGGPQDGGAGKGPADMASQCWGAAAAAAAAAAAVSGGAQQRSHHAPMSPGSSGGGGQPLARTPQSSSPMDQMGKMRPQPYGGTNPYSQQQGPPSGPQQGHGYPGQPYGSQTPQRYPMTMQGRAQSAMGSLSYAQQIPPYGQQGPSAYGQQGQTPYYNQQSPHPQQQPPYAQQPPSQTPHAQPSYQQQPQTQQPQLQSSQPPYSQQPSQPPHQQSPTPYPSQQSTTQQHPQSQPPYSQPQAQSPYQQQQPQQPASSSLSQQAAYPQPQPQQSQQTAYSQQRFPPPQELSQDSFGSQASSAPSMTSSKGGQEDMNLSLQSRPSSLPDLSGSIDDLPMGTEGALSPGVSTSGISSSQGEQSNPAQSPFSPHTSPHLPGIRGPSPSPVGSPASVAQSRSGPLSPAAVPGNQMPPRPPSGQSDSIMHPSMNQSSIAQDRGYMQRNPQMPQYTSPQPGSALSPRQPSGGQMHSGVGSYQQNSMGSYGPQGSQYGPQGGYPRQPNYNALPNANYPNAGMAGSMNPMGAGGQMHGQPGIPPYGTLPPGRMAHASMGNRPYGPNMANMPPQVGSGMCPPPGGMNRKTQESAVAMHVAANSIQNRPPGYPNMNQGGMMGTGPPYGQGINSMAGMINPQGPPYPMGGTMANNSAGMAASPEMMGLGDVKLTPATKMNNKADGTPKTESKSKKSSSSTTTNEKITKLYELGGEPERKMWVDRYLAFTEEKAMGMTNLPAVGRKPLDLYRLYVSVKEIGGLTQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQCLYAFECKIERGEDPPPDIFAAADSKKSQPKIQPPSPAGSGSMQGPQTPQSTSSSMAEGGDLKPPTPASTPHSQIPPLPGMSRSNSVGIQDAFPDGSDPTFQKRNSMTPNPGYQPSMNTSDMMGRMSYEPNKDPYGSMRKAPGSDPFMSSGQGPNGGMGDPYSRAAGPGLGSVAMGPRQHYPYGGPYDRVRTEPGIGPEGNMGTGAPQPNLMPSTPDSGMYSPSRYPPQQQQQQQQQHDSYGNQFSTQGTPSSSPFPSQQTTMYQQQPQVSSPAPLPRPMENRTSPSKSPFLHSGMKMQKAGPPVPASHIAPTPVQPPMIRRDITFPPGSVEATQPVLKQRRRLTMKDIGTPEAWRVMMSLKSGLLAESTWALDTINILLYDDNSIMTFNLSQLPGLLELLVEYFRRCLIEIFGILKEYEVGDPGQRTLLDPGRFTKVYSPAHTEEEEEEHLDPKLEEEEEEGVGNDEEMAFLGKDKPSSENNEEKLVSKFDKLPVKIVQRNDPFVVDCSDKLGRVQEFDSGLLHWRIGGGDTTEHIQTHFESKIELLPSRPYVPCPTPPRKHLTTVEGTPGTTEQEGPPPDGLPEKRITATMDDMLSTRSSTLTDEGAKSAEATKESSKFPFGISPAQSHRNIKILEDEPHSKDETPLCTLLDWQDSLAKRCVCVSNTIRSLSFVPGNDFEMSKHPGLLLILGKLILLHHKHPERKQAPLTYEKEEEQDQGVSCDKVEWWWDCLEMLRENTLVTLANISGQLDLSPYPESICLPVLDGLLHWAVCPSAEAQDPFSTLGPNAVLSPQRLVLETLSKLSIQDNNVDLILATPPFSRLEKLYSTMVRFLSDRKNPVCREMAVVLLANLAQGDSLAARAIAVQKGSIGNLLGFLEDSLAATQFQQSQASLLHMQNPPFEPTSVDMMRRAARALLALAKVDENHSEFTLYESRLLDISVSPLMNSLVSQVICDVLFLIGQS" } }, { "url": "https://www.uniprot.org/uniprot/A2BH40#A2BH40-4", "isoform_ac": "A2BH40-4", "locus": { "end_pos": 133680334, "start_pos": 133723039, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000008024", "id": "ENSMUST00000008024", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000008024", "id": "ENSMUSP00000008024", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2BH40-4|ARI1A_MOUSE Isoform 4 of AT-rich interactive domain-containing protein 1A OS=Mus musculus OX=10090 GN=Arid1a PE=1 SV=1 CANONICAL=A2BH40-1", "length": 1902, "sequence": "MDQMGKMRPQPYGGTNPYSQQQGPPSGPQQGHGYPGQPYGSQTPQRYPMTMQGRAQSAMGSLSYAQQIPPYGQQGPSAYGQQGQTPYYNQQSPHPQQQPPYAQQPPSQTPHAQPSYQQQPQTQQPQLQSSQPPYSQQPSQPPHQQSPTPYPSQQSTTQQHPQSQPPYSQPQAQSPYQQQQPQQPASSSLSQQAAYPQPQPQQSQQTAYSQQRFPPPQELSQDSFGSQASSAPSMTSSKGGQEDMNLSLQSRPSSLPDLSGSIDDLPMGTEGALSPGVSTSGISSSQGEQSNPAQSPFSPHTSPHLPGIRGPSPSPVGSPASVAQSRSGPLSPAAVPGNQMPPRPPSGQSDSIMHPSMNQSSIAQDRGYMQRNPQMPQYTSPQPGSALSPRQPSGGQMHSGVGSYQQNSMGSYGPQGSQYGPQGGYPRQPNYNALPNANYPNAGMAGSMNPMGAGGQMHGQPGIPPYGTLPPGRMAHASMGNRPYGPNMANMPPQVGSGMCPPPGGMNRKTQESAVAMHVAANSIQNRPPGYPNMNQGGMMGTGPPYGQGINSMAGMINPQGPPYPMGGTMANNSAGMAASPEMMGLGDVKLTPATKMNNKADGTPKTESKSKKSSSSTTTNEKITKLYELGGEPERKMWVDRYLAFTEEKAMGMTNLPAVGRKPLDLYRLYVSVKEIGGLTQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQCLYAFECKIERGEDPPPDIFAAADSKKSQPKIQPPSPAGSGSMQGPQTPQSTSSSMAEGGDLKPPTPASTPHSQIPPLPGMRSNSVGIQDAFPDGSDPTFQKRNSMTPNPGYQPSMNTSDMMGRMSYEPNKDPYGSMRKAPGSDPFMSSGQGPNGGMGDPYSRAAGPGLGSVAMGPRQHYPYGGPYDRVRTEPGIGPEGNMGTGAPQPNLMPSTPDSGMYSPSRYPPQQQQQQQQQQQQQRHDSYGNQFSTQGTPSSSPFPSQQTTMYQQQQQNYKRPMDGTYGPPAKRHEGEMYSVPYSAGQGQPQQQQLPAAQSQPASQPQAAQPSPQQDVYNQYSNAYPASATAATDRRPAGGPQNQFPFQFGRDRVSAPPGSSAQQNMPPQMMGGPIQASAEVAQQGTMWQGRNDMTYNYANRQNTGSATQGPAYHGVNRTDEMLHTDQRANHEGPWPSHGTRQPPYGPSAPVPPMTRPPPSNYQPPPSMPNHIPQVSSPAPLPRPMENRTSPSKSPFLHSGMKMQKAGPPVPASHIAPTPVQPPMIRRDITFPPGSVEATQPVLKQRRRLTMKDIGTPEAWRVMMSLKSGLLAESTWALDTINILLYDDNSIMTFNLSQLPGLLELLVEYFRRCLIEIFGILKEYEVGDPGQRTLLDPGRFTKVYSPAHTEEEEEEHLDPKLEEEEEEGVGNDEEMAFLGKDKPSSENNEEKLVSKFDKLPVKIVQRNDPFVVDCSDKLGRVQEFDSGLLHWRIGGGDTTEHIQTHFESKIELLPSRPYVPCPTPPRKHLTTVEGTPGTTEQEGPPPDGLPEKRITATMDDMLSTRSSTLTDEGAKSAEATKESSKFPFGISPAQSHRNIKILEDEPHSKDETPLCTLLDWQDSLAKRCVCVSNTIRSLSFVPGNDFEMSKHPGLLLILGKLILLHHKHPERKQAPLTYEKEEEQDQGVSCDKVEWWWDCLEMLRENTLVTLANISGQLDLSPYPESICLPVLDGLLHWAVCPSAEAQDPFSTLGPNAVLSPQRLVLETLSKLSIQDNNVDLILATPPFSRLEKLYSTMVRFLSDRKNPVCREMAVVLLANLAQGDSLAARAIAVQKGSIGNLLGFLEDSLAATQFQQSQASLLHMQNPPFEPTSVDMMRRAARALLALAKVDENHSEFTLYESRLLDISVSPLMNSLVSQVICDVLFLIGQS" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:93760", "resource": "KEGG Pathway", "id": "mmu:93760", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-3214858", "resource": "Reactome", "id": "R-MMU-3214858", "name": "RMTs methylate histone arginines" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8939243", "resource": "Reactome", "id": "R-MMU-8939243", "name": "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2BH40#function", "annotation": "Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (PubMed:17640523).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40#function", "id": "A2BH40", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074288.1", "annotation": "This study demonstrates that hepatocyte-specific inactivation of Arid1a reduced fatty acid oxidation, and aggravated diet-induced steatosis and insulin resistance in mice.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074288.1", "id": "NP_001074288.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074288.1", "annotation": "Deletion of Arid1a concomitant with Sox9 overexpression in Lgr5(+) ISCs restores self-renewal in Arid1a-deleted Lgr5(+) ISCs.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074288.1", "id": "NP_001074288.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074288.1", "annotation": "ARID1A-containing SWI/SNF complex (ARID1A-SWI/SNF) operates as an inhibitor of the pro-oncogenic transcriptional coactivators YAP and TAZ", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074288.1", "id": "NP_001074288.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074288.1", "annotation": "Results provide a direct biological basis to support the implication from tumor tissue screens that deficiency of p270 plays a causative role in carcinogenesis.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074288.1", "id": "NP_001074288.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "D4A3E3-1", "protein_name": "AT-rich interaction domain 1A.", "sequence": { "length": 2021, "sequence": "MGGGGPSAAGGGTPQPTATPTLNQLLTSPSSARGYQGYPGGDYGGGPQDGGAGKGPADMASQCWGAAAAAAAAAAASGGAQQRSHHAPMSPGSSGGGGQPLARTPQSSSPMDQMGKMRPQPYGGTNPYSQQQGPPSGPQQGHGYPGQPYGSQTPQRYPMTMQGRAQSAMGSLSYAQQIPPYGQQGPSAYGQQGQTPYYNQQSPHPQQQQQPPYSQQPPSQTPHAQPSYQQQPQTQQPQLQSSQPPYSQQPSQPPHQQSQTPYPSQQSTTQQHPQSQPPYSQPQAQAPYQQQQPQQPASSTLSQQAAYPQPQPQQSQQTAYSQQRFPPPQELSQDSFGSQASSAPSMTSSKGGQEDMNLSLQSRPSSLPDLSGSIDDLPMGTEGALSPGVSTSGISSSQGEQSNPAQSPFSPHTSPHLPGIRGPSPSPVGSPASVAQSRSGPLSPAAVPGNQMPPRPPSGQSDSIMHPSMNQSSIAQDRGYMQRNPQMPQYTSPQPGSALSPRQPSGGQMHSGMGSYQQNSMGSYGPQGSQYGPQGGYPRQPNYNALPNANYPSAGMAGSMNPLGAGGQMHGQPGIPPYGTLPPGRMTHASMGNRPYGPNMANMPPQVGSGMCPPPGGMNRKTQESAVAMHVAANSIQNRPPGYPNMNQGGIMGTGPPYGQGINSMAGMINPQGPPYPMGGTMANNSAGMAASPEMMGLGDVKLTPATKMNNKADGTPKTESKSKKSSSSTTTNEKITKLYELGGEPERKMWVDRYLAFTEEKAMGMTNLPAVGRKPLDLYRLYVSVKEIGGLTQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQCLYAFECKIERGEDPPPDIFAAADSKKSQPKIQPPSPAGSGSMQGPQTPQSTSSSMAEGGDLKPPTPASTPHSQIPPLPGMRSNSVGIQDAFPDGSEPTFQKRNSMTPNPGYQPSMNTSDMMGRMSYEPNKDPYGGMRKAPGSDPFMSSGQGPNGGMGDPYSRAAGPGLGNVAMGPRQHYPYGGPYDRVRTEPGIGPEGNMGTGAPQPNLMPSTPDSGMYSPSRYPPQQQQQQQQQQQQQQQQQQRHDSYGNQFSTQGTPSSSPFPSQQTTMYQQQQQQNYKRPMDGTYGPPAKRHEGELYSVPYSTGQGQPQQQQLPAAQSQSASQPQAAQPSPQQDVYNQYSNAYPATATAATERRPAGGPQNQFPFQFGRDRVSAPPGSNAQQNMPPQMMGGPIQASAEVAQQGTMWQGRNDMTYNYANRQNTGSAPQGPAYHGVNRTDEMLHTDQRANHEGPWPSHGTRQPPYGPSAPVPPMTRPPPSNYQPPPSMQNHIPQVSSPAPLPRPMENRTSPSKSPFLHSGMKMQKAGPPVPASHIAPTPVQPPMIRRDITFPPGSVEATQPVLKQRRRLTMKDIGTPEAWRVMMSLKSGLLAESTWALDTINILLYDDNSIMTFNLSQLPGLLELLVEYFRRCLIEIFGILKEYEVGDPGQRTLLDPGRLTKVSSPAPTEEEEEEEHVDPKLEEEEEEGVENDEEMAFLGKDKPPSEKSEEKLVSKFDKLPVKIVQKNDPFVVDCSDKLGRVQEFDSGLLHWRIGGGDTTEHIQTHFESKIELLPSRPCVPSPVPPRKHVTTVEGTPGTTEQEGPPPDGLPEKRITATMDDMLSTRSSTLTDEGTKSTEANKESSKFPFGISPAQSHRNIKILEDEPHSKDETPLCTLLDWQDSLAKRCVCVSNAIRSLSFVPGNDFEMSKHPGLLLILGKLILLHHKHPERKQAPLTYEKEEEQDQGVSCDKVEWWWDCLEMLRENTLVTLANISGQLDLSPYPESICLPVLDGLLHWAVCPSAEAQDPFSTLGPNAVLSPQRLVLETLSKLSIQDNNVDLILATPPFSRLEKLYSTMVRFLSDRKNPVCREMAVVLLANLAQGDSLAARAIAVQKGSIGNLLGFLEDSLAATQFQQSQASLLHMQSPPFEPTSVDMMRRAARALLALAKVDENHSEFTLYESRLLDISVSPLMNSLVSQVICDVLFLIGQS" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2BH40/", "id": "A2BH40", "database": "OMA" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "O14497-1", "protein_name": "AT-rich interactive domain-containing protein 1A; ARID domain-containing protein 1A; BRG1-associated factor 250a; BAF250A; BRG1-associated factor 250; BAF250; Osa homolog 1; hOSA1; SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1; SNF complex protein p270; B120; SWI-like protein; hELD.", "sequence": { "length": 2285, "sequence": "MAAQVAPAAASSLGNPPPPPPSELKKAEQQQREEAGGEAAAAAAAERGEMKAAAGQESEGPAVGPPQPLGKELQDGAESNGGGGGGGAGSGGGPGAEPDLKNSNGNAGPRPALNNNLTEPPGGGGGGSSDGVGAPPHSAAAALPPPAYGFGQPYGRSPSAVAAAAAAVFHQQHGGQQSPGLAALQSGGGGGLEPYAGPQQNSHDHGFPNHQYNSYYPNRSAYPPPAPAYALSSPRGGTPGSGAAAAAGSKPPPSSSASASSSSSSFAQQRFGAMGGGGPSAAGGGTPQPTATPTLNQLLTSPSSARGYQGYPGGDYSGGPQDGGAGKGPADMASQCWGAAAAAAAAAAASGGAQQRSHHAPMSPGSSGGGGQPLARTPQPSSPMDQMGKMRPQPYGGTNPYSQQQGPPSGPQQGHGYPGQPYGSQTPQRYPMTMQGRAQSAMGGLSYTQQIPPYGQQGPSGYGQQGQTPYYNQQSPHPQQQQPPYSQQPPSQTPHAQPSYQQQPQSQPPQLQSSQPPYSQQPSQPPHQQSPAPYPSQQSTTQQHPQSQPPYSQPQAQSPYQQQQPQQPAPSTLSQQAAYPQPQSQQSQQTAYSQQRFPPPQELSQDSFGSQASSAPSMTSSKGGQEDMNLSLQSRPSSLPDLSGSIDDLPMGTEGALSPGVSTSGISSSQGEQSNPAQSPFSPHTSPHLPGIRGPSPSPVGSPASVAQSRSGPLSPAAVPGNQMPPRPPSGQSDSIMHPSMNQSSIAQDRGYMQRNPQMPQYSSPQPGSALSPRQPSGGQIHTGMGSYQQNSMGSYGPQGGQYGPQGGYPRQPNYNALPNANYPSAGMAGGINPMGAGGQMHGQPGIPPYGTLPPGRMSHASMGNRPYGPNMANMPPQVGSGMCPPPGGMNRKTQETAVAMHVAANSIQNRPPGYPNMNQGGMMGTGPPYGQGINSMAGMINPQGPPYSMGGTMANNSAGMAASPEMMGLGDVKLTPATKMNNKADGTPKTESKSKKSSSSTTTNEKITKLYELGGEPERKMWVDRYLAFTEEKAMGMTNLPAVGRKPLDLYRLYVSVKEIGGLTQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQCLYAFECKIERGEDPPPDIFAAADSKKSQPKIQPPSPAGSGSMQGPQTPQSTSSSMAEGGDLKPPTPASTPHSQIPPLPGMSRSNSVGIQDAFNDGSDSTFQKRNSMTPNPGYQPSMNTSDMMGRMSYEPNKDPYGSMRKAPGSDPFMSSGQGPNGGMGDPYSRAAGPGLGNVAMGPRQHYPYGGPYDRVRTEPGIGPEGNMSTGAPQPNLMPSNPDSGMYSPSRYPPQQQQQQQQRHDSYGNQFSTQGTPSGSPFPSQQTTMYQQQQQNYKRPMDGTYGPPAKRHEGEMYSVPYSTGQGQPQQQQLPPAQPQPASQQQAAQPSPQQDVYNQYGNAYPATATAATERRPAGGPQNQFPFQFGRDRVSAPPGTNAQQNMPPQMMGGPIQASAEVAQQGTMWQGRNDMTYNYANRQSTGSAPQGPAYHGVNRTDEMLHTDQRANHEGSWPSHGTRQPPYGPSAPVPPMTRPPPSNYQPPPSMQNHIPQVSSPAPLPRPMENRTSPSKSPFLHSGMKMQKAGPPVPASHIAPAPVQPPMIRRDITFPPGSVEATQPVLKQRRRLTMKDIGTPEAWRVMMSLKSGLLAESTWALDTINILLYDDNSIMTFNLSQLPGLLELLVEYFRRCLIEIFGILKEYEVGDPGQRTLLDPGRFSKVSSPAPMEGGEEEEELLGPKLEEEEEEEVVENDEEIAFSGKDKPASENSEEKLISKFDKLPVKIVQKNDPFVVDCSDKLGRVQEFDSGLLHWRIGGGDTTEHIQTHFESKTELLPSRPHAPCPPAPRKHVTTAEGTPGTTDQEGPPPDGPPEKRITATMDDMLSTRSSTLTEDGAKSSEAIKESSKFPFGISPAQSHRNIKILEDEPHSKDETPLCTLLDWQDSLAKRCVCVSNTIRSLSFVPGNDFEMSKHPGLLLILGKLILLHHKHPERKQAPLTYEKEEEQDQGVSCNKVEWWWDCLEMLRENTLVTLANISGQLDLSPYPESICLPVLDGLLHWAVCPSAEAQDPFSTLGPNAVLSPQRLVLETLSKLSIQDNNVDLILATPPFSRLEKLYSTMVRFLSDRKNPVCREMAVVLLANLAQGDSLAARAIAVQKGSIGNLLGFLEDSLAATQFQQSQASLLHMQNPPFEPTSVDMMRRAARALLALAKVDENHSEFTLYESRLLDISVSPLMNSLVSQVICDVLFLIGQS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/21216", "id": "21216", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2BH40/", "id": "A2BH40", "database": "OMA" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074288.1", "ac": "NP_001074288.1", "name": "AT-rich interactive domain-containing protein 1A isoform 1; AT rich interactive domain 1A (Swi1 like); AT-rich interactive domain-containing protein 1A; BAF250; osa homolog 1; SWI-like protein; BRG1-associated factor 250a; ARID domain-containing protein 1A; SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1; SWI/SNF complex protein p270.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40", "id": "A2BH40", "database": "UniProtKB" } ], "name": "DNA binding", "id": "GO:0003677" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016922", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40", "id": "A2BH40", "database": "UniProtKB" } ], "name": "nuclear receptor binding", "id": "GO:0016922" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000790", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40", "id": "A2BH40", "database": "UniProtKB" } ], "name": "nuclear chromatin", "id": "GO:0000790" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016514", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40", "id": "A2BH40", "database": "UniProtKB" } ], "name": "SWI/SNF complex", "id": "GO:0016514" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016514", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40", "id": "A2BH40", "database": "UniProtKB" } ], "name": "SWI/SNF complex", "id": "GO:0016514" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071564", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40", "id": "A2BH40", "database": "UniProtKB" } ], "name": "npBAF complex", "id": "GO:0071564" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071565", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40", "id": "A2BH40", "database": "UniProtKB" } ], "name": "nBAF complex", "id": "GO:0071565" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40", "id": "A2BH40", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035060", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40", "id": "A2BH40", "database": "UniProtKB" } ], "name": "brahma complex", "id": "GO:0035060" } ], "total": 7, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40", "id": "A2BH40", "database": "UniProtKB" } ], "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40", "id": "A2BH40", "database": "UniProtKB" } ], "name": "chromatin remodeling", "id": "GO:0006338" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030900", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40", "id": "A2BH40", "database": "UniProtKB" } ], "name": "forebrain development", "id": "GO:0030900" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043044", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40", "id": "A2BH40", "database": "UniProtKB" } ], "name": "ATP-dependent chromatin remodeling", "id": "GO:0043044" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001843", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40", "id": "A2BH40", "database": "UniProtKB" } ], "name": "neural tube closure", "id": "GO:0001843" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006325", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40", "id": "A2BH40", "database": "UniProtKB" } ], "name": "chromatin organization", "id": "GO:0006325" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019827", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40", "id": "A2BH40", "database": "UniProtKB" } ], "name": "stem cell population maintenance", "id": "GO:0019827" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055007", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40", "id": "A2BH40", "database": "UniProtKB" } ], "name": "cardiac muscle cell differentiation", "id": "GO:0055007" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007369", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40", "id": "A2BH40", "database": "UniProtKB" } ], "name": "gastrulation", "id": "GO:0007369" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901998", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40", "id": "A2BH40", "database": "UniProtKB" } ], "name": "toxin transport", "id": "GO:1901998" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001704", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40", "id": "A2BH40", "database": "UniProtKB" } ], "name": "formation of primary germ layer", "id": "GO:0001704" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003205", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40", "id": "A2BH40", "database": "UniProtKB" } ], "name": "cardiac chamber development", "id": "GO:0003205" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003408", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40", "id": "A2BH40", "database": "UniProtKB" } ], "name": "optic cup formation involved in camera-type eye development", "id": "GO:0003408" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006344", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40", "id": "A2BH40", "database": "UniProtKB" } ], "name": "maintenance of chromatin silencing", "id": "GO:0006344" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007566", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40", "id": "A2BH40", "database": "UniProtKB" } ], "name": "embryo implantation", "id": "GO:0007566" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060674", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40", "id": "A2BH40", "database": "UniProtKB" } ], "name": "placenta blood vessel development", "id": "GO:0060674" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042921", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40", "id": "A2BH40", "database": "UniProtKB" } ], "name": "glucocorticoid receptor signaling pathway", "id": "GO:0042921" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40", "id": "A2BH40", "database": "UniProtKB" } ], "name": "positive regulation of transcription, DNA-templated", "id": "GO:0045893" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030521", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40", "id": "A2BH40", "database": "UniProtKB" } ], "name": "androgen receptor signaling pathway", "id": "GO:0030521" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006337", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40", "id": "A2BH40", "database": "UniProtKB" } ], "name": "nucleosome disassembly", "id": "GO:0006337" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030520", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BH40", "id": "A2BH40", "database": "UniProtKB" } ], "name": "intracellular estrogen receptor signaling pathway", "id": "GO:0030520" } ], "total": 21, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 221, "annotation": "n_glycosylation_sequon", "start_pos": 219 }, { "end_pos": 632, "annotation": "n_glycosylation_sequon", "start_pos": 630 }, { "end_pos": 745, "annotation": "n_glycosylation_sequon", "start_pos": 743 }, { "end_pos": 959, "annotation": "n_glycosylation_sequon", "start_pos": 957 }, { "end_pos": 1219, "annotation": "n_glycosylation_sequon", "start_pos": 1217 }, { "end_pos": 1530, "annotation": "n_glycosylation_sequon", "start_pos": 1528 }, { "end_pos": 1600, "annotation": "n_glycosylation_sequon", "start_pos": 1598 }, { "end_pos": 1708, "annotation": "n_glycosylation_sequon", "start_pos": 1706 }, { "end_pos": 2066, "annotation": "n_glycosylation_sequon", "start_pos": 2064 }, { "end_pos": 2247, "annotation": "n_glycosylation_sequon", "start_pos": 2245 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074288.1", "id": "NP_001074288.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-3214858", "id": "R-MMU-3214858", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8939243", "id": "R-MMU-8939243", "database": "Reactome" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:93760", "id": "mmu:93760", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000007880", "id": "ENSMUSG00000007880", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/PMDQVGK/", "id": "PMDQVGK", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "id": "IPR011989", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "id": "IPR016024", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001606", "id": "IPR001606", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036431", "id": "IPR036431", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR021906", "id": "IPR021906", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR033388", "id": "IPR033388", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR030094", "id": "IPR030094", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF01388", "id": "PF01388", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF12031", "id": "PF12031", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12656", "id": "PTHR12656", "database": "PANTHER" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12656:SF12", "id": "PTHR12656:SF12", "database": "PANTHER" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2BH40", "id": "PR_A2BH40", "database": "PRO" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2BH40*", "id": "A2BH40", "database": "IntAct" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/93760", "id": "93760", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:1935147", "id": "1935147", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A2BH40", "disease": [], "mass": { "monoisotopic_mass": 242092.0, "chemical_mass": 242092.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2BH40", "name": "Arid1a; Baf250; Baf250a; Osa1; Smarcf1; 1110030E03Rik; BAF250a.", "locus": { "end_pos": 133679008, "start_pos": 133756769, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000007880", "id": "ENSMUSG00000007880", "database": "Ensembl Gene" } ] } } ] }