{
    "uniprot_canonical_ac": "A2BGH0-1", 
    "sequence": {
        "header": "sp|A2BGH0-1|BPIB4_MOUSE Isoform 1 of BPI fold-containing family B member 4  OS=Mus musculus OX=10090 GN=Bpifb4 PE=2 SV=1 CANONICAL=A2BGH0-1", 
        "length": 617, 
        "sequence": "MWTAWCVAALSVAAVCGIRQDTTTVLRVTKDVLGNAISGTIQKSDAFRSALREVPVGVGGVPYNDFHVREPPPKYTNGRQLGGNYKYGHIKANDNRAQLGGKYRYGEILDSDGSLRDLRHEDYRPPDSAYHRGSGRYRSAADSSSVGRLYRRELRPGEIPAGVATGALGPGGLLGTGGMLANEGILAGQGGLLGGGGLLGDGGLLGGGGVLGVLGEGGILSTVQGITGLRIVELTLPRVSVRLLPGVGVYLSLYTRVAINGRSLIGFLDIAVEVNITAKVRLTMDRTGYPRLVIERCDTLLGGIKVKLLRGLLPNLVDNLVNRVLANVLPDLLCPIVDVVLGLVNDQLGLVDSLVPLGILGSVQYTFSSLPLVTGEFLELDLNTLVGEAGGDLIDYPLGRPAILPRPQMPELPPMGDNTNSQLAISANFLSSVLTMLQKQGAMDIDITDGMFEDLPPLTTSTLGALIPKVFQQYPESRPLTIRIQVPNPPTVTLQKDKALVKVFATSEVVVSQPNDVETTICLIDVDTDLLASFSVEGDKLMIDAKLDKTSLNLRTSNVGNFDVFILEMLVEKIFDLAFMPAMNAILGSGVPLPKILNIDFSNADIDVLEDLLVLST"
    }, 
    "uniprot_id": "BPIB4_MOUSE", 
    "enzyme_annotation": [], 
    "synonyms": {
        "protein": {
            "refseq": [
                "BPI fold-containing family B member 4 precursor", 
                "LBP / BPI / CETP family, N-terminal domain containing protein; long palate, lung and nasal epithelium carcinoma-associated protein 4; ligand-binding protein RY2G5; Novel LBP/BPI/CETP family, N-terminal domain containing protein"
            ], 
            "uniprotkb": [
                "BPI fold-containing family B member 4", 
                "Long palate, lung and nasal epithelium carcinoma-associated protein 4"
            ]
        }, 
        "gene": {
            "refseq": [
                "Bpifb4", 
                "Gm1006", 
                "Lplunc4"
            ], 
            "uniprotkb": [
                "Bpifb4", 
                "Gm1006", 
                "Lplunc4"
            ]
        }
    }, 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2BGH0", 
                    "id": "A2BGH0", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "recommendedname": {
        "full": "BPI fold-containing family B member 4; Long palate, lung and nasal epithelium carcinoma-associated protein 4."
    }, 
    "publication": [
        {
            "title": "A rare genetic variant of BPIFB4 predisposes to high blood pressure via impairment of nitric oxide signaling.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/28852218", 
            "journal": "Scientific reports", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030047.2", 
                    "id": "NP_001030047.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Vecchione C, Villa F, Carrizzo A, Spinelli CC, Damato A, Ambrosio M, Ferrario A, Madonna M, Uccellatore A, Lupini S, Maciag A, Ryskalin L, Milanesi L, Frati G, Sciarretta S, Bellazzi R, Genovese S, Ceriello A, Auricchio A, Malovini A, Puca AA", 
            "date": "2017", 
            "pmid": "28852218"
        }, 
        {
            "title": "LAV-BPIFB4 isoform modulates eNOS signalling through Ca2+/PKC-alpha-dependent mechanism.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/28419216", 
            "journal": "Cardiovascular research", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030047.2", 
                    "id": "NP_001030047.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Spinelli CC, Carrizzo A, Ferrario A, Villa F, Damato A, Ambrosio M, Madonna M, Frati G, Fucile S, Sciaccaluga M, Capunzo M, Cali G, Milanesi L, Maciag A, Puca AA, Vecchione C", 
            "date": "2017", 
            "pmid": "28419216"
        }, 
        {
            "title": "Genetic Analysis Reveals a Longevity-Associated Protein Modulating Endothelial Function and Angiogenesis.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/26034043", 
            "journal": "Circulation research", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030047.2", 
                    "id": "NP_001030047.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Villa F, Carrizzo A, Spinelli CC, Ferrario A, Malovini A, Maciag A, Damato A, Auricchio A, Spinetti G, Sangalli E, Dang Z, Madonna M, Ambrosio M, Sitia L, Bigini P, Cali G, Schreiber S, Perls T, Fucile S, Mulas F, Nebel A, Bellazzi R, Madeddu P, Vecchione C, Puca AA", 
            "date": "2015", 
            "pmid": "26034043"
        }, 
        {
            "title": "Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/21787333", 
            "journal": "Biochemical Society transactions", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030047.2", 
                    "id": "NP_001030047.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Bingle CD, Seal RL, Craven CJ", 
            "date": "2011", 
            "pmid": "21787333"
        }, 
        {
            "title": "Phylogenetic and evolutionary analysis of the PLUNC gene family.", 
            "url": "https://www.ncbi.nlm.nih.gov/pubmed/14739326", 
            "journal": "Protein science : a publication of the Protein Society", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030047.2", 
                    "id": "NP_001030047.2", 
                    "database": "RefSeq"
                }, 
                {
                    "url": "https://www.uniprot.org/uniprot/A2BGH0/publications", 
                    "id": "A2BGH0", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Bingle CD, LeClair EE, Havard S, Bingle L, Gillingham P, Craven CJ", 
            "date": "2004", 
            "pmid": "14739326"
        }
    ], 
    "glycosylation": [
        {
            "residue": "Asn", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2BGH0", 
                    "id": "A2BGH0", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/", 
                    "id": "", 
                    "database": "PubMed"
                }
            ], 
            "relation": "attached", 
            "position": 275, 
            "glytoucan_ac": "", 
            "type": "N-linked"
        }
    ], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2BGH0#A2BGH0-1", 
            "isoform_ac": "A2BGH0-1", 
            "locus": {
                "end_pos": 153940877, 
                "start_pos": 153963603, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000109759", 
                        "id": "ENSMUST00000109759", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000105381", 
                        "id": "ENSMUSP00000105381", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2BGH0-1|BPIB4_MOUSE Isoform 1 of BPI fold-containing family B member 4  OS=Mus musculus OX=10090 GN=Bpifb4 PE=2 SV=1 CANONICAL=A2BGH0-1", 
                "length": 617, 
                "sequence": "MWTAWCVAALSVAAVCGIRQDTTTVLRVTKDVLGNAISGTIQKSDAFRSALREVPVGVGGVPYNDFHVREPPPKYTNGRQLGGNYKYGHIKANDNRAQLGGKYRYGEILDSDGSLRDLRHEDYRPPDSAYHRGSGRYRSAADSSSVGRLYRRELRPGEIPAGVATGALGPGGLLGTGGMLANEGILAGQGGLLGGGGLLGDGGLLGGGGVLGVLGEGGILSTVQGITGLRIVELTLPRVSVRLLPGVGVYLSLYTRVAINGRSLIGFLDIAVEVNITAKVRLTMDRTGYPRLVIERCDTLLGGIKVKLLRGLLPNLVDNLVNRVLANVLPDLLCPIVDVVLGLVNDQLGLVDSLVPLGILGSVQYTFSSLPLVTGEFLELDLNTLVGEAGGDLIDYPLGRPAILPRPQMPELPPMGDNTNSQLAISANFLSSVLTMLQKQGAMDIDITDGMFEDLPPLTTSTLGALIPKVFQQYPESRPLTIRIQVPNPPTVTLQKDKALVKVFATSEVVVSQPNDVETTICLIDVDTDLLASFSVEGDKLMIDAKLDKTSLNLRTSNVGNFDVFILEMLVEKIFDLAFMPAMNAILGSGVPLPKILNIDFSNADIDVLEDLLVLST"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2BGH0#A2BGH0-2", 
            "isoform_ac": "A2BGH0-2", 
            "locus": {
                "end_pos": 153943944, 
                "start_pos": 153963603, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000099181", 
                        "id": "ENSMUST00000099181", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000096786", 
                        "id": "ENSMUSP00000096786", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2BGH0-2|BPIB4_MOUSE Isoform 2 of BPI fold-containing family B member 4  OS=Mus musculus OX=10090 GN=Bpifb4 PE=2 SV=1 CANONICAL=A2BGH0-1", 
                "length": 403, 
                "sequence": "MAAVASSSLLTACRLRIVELTLPRVSVRLLPGVGVYLSLYTRVAINGRSLIGFLDIAVEVNITAKVRLTMDRTGYPRLVIERCDTLLGGIKVKLLRGLLPNLVDNLVNRVLANVLPDLLCPIVDVVLGLVNDQLGLVDSLVPLGILGSVQYTFSSLPLVTGEFLELDLNTLVGEAGGDLIDYPLGRPAILPRPQMPELPPMGDNTNSQLAISANFLSSVLTMLQKQGAMDIDITDGMFEDLPPLTTSTLGALIPKVFQQYPESRPLTIRIQVPNPPTVTLQKDKALVKVFATSEVVVSQPNDVETTICLIDVDTDLLASFSVEGDKLMIDAKLDKTSLNLRTSNVGNFDVFILEMLVEKIFDLAFMPAMNAILGSGVPLPKILNIDFSNADIDVLEDLLVLST"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:381399", 
            "resource": "KEGG Pathway", 
            "id": "mmu:381399", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6803157", 
            "resource": "Reactome", 
            "id": "R-MMU-6803157", 
            "name": "Antimicrobial peptides"
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A2BGH0#function", 
            "annotation": "May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2BGH0#function", 
                    "id": "A2BGH0", 
                    "database": "UniProtKB"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030047.2", 
            "annotation": "RV-BPIFB4 acts directly on blood pressure homeostasis and may represent a novel biomarker of vascular dysfunction and hypertension. Erratum:[Sci Rep. 2019 Jun 28;9(1):9574. PMID: 31249326] Publication Status: Online-Only", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030047.2", 
                    "id": "NP_001030047.2", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030047.2", 
            "annotation": "LAV-BPIFB4 isoform modulates eNOS signalling through Ca2+/PKC-alpha-dependent mechanism.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030047.2", 
                    "id": "NP_001030047.2", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q05704-1", 
            "protein_name": "BPI fold-containing family B member 4; Ligand-binding protein RY2G5; Long palate, lung and nasal epithelium carcinoma-associated protein 4.", 
            "sequence": {
                "length": 617, 
                "sequence": "MWTAWCVAALSVAAVCGIRQDTTTVLRVTKDVLGDAISGTIQKSDAFRSALREVPVGVGGVPYNDFHVREPPPKYTNGRQLGGNYKYGHIEANDNTAQLGGKYRYGEILDSDGSLRDLRHEDYRPSDSAYHRGPGRYRSAADPSSAGRLHRRELRPGEIPAGVATGALGPGGLLGTGGILANEGILAGQGGLLGGGGLLGDGGLLGGGGVLGVLGEGGILSTVQGITGLRIVELTLPRVSVRLLPGVGVYLSLYTRVAINGKSLIGFLDIAVEVNITAKVRLTMDRTGYPRLVIERCDTLLGGIKVKLLRGLLPNLVDNLVNRVLANVLPDLLCPIVDVVLGLVNDQLGLVDSLVPLGILGSVQYTFSSLPLVTGEFLELDLNTLVGEAGGDLIDYPLGRPAMLPRPQMPELPPMGDNTNSQLAISANFLSSVLTMLQKQGALDIDITDGMFEDLPPLTTSTLGALIPKVFQQYPESRPLTIRIQVPNPPTVTLQKDKALVKVFATSEVVVSQPNDVETTICLIDVDTDLLASFSVEGDKLMIDAKLDKTSLNLRTSNVGNFDVFILEMLVEKIFDLAFMPAMNAILGSGVPLPKILNIDFSNADIDVLEDLLVLST"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/66971", 
                    "id": "66971", 
                    "database": "MGI"
                }
            ], 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "P59827-1", 
            "protein_name": "BPI fold-containing family B member 4; Ligand-binding protein RY2G5; Long palate, lung and nasal epithelium carcinoma-associated protein 4.", 
            "sequence": {
                "length": 614, 
                "sequence": "MWMAWCVAALSVVAVCGTSHETNTVLRVTKDVLSNAISGMLQQSDALHSALREVPLGVGDIPYNDFHVRGPPPVYTNGKKLDGIYQYGHIETNDNTAQLGGKYRYGEILESEGSIRDLRNSGYRSAENAYGGHRGLGRYRAAPVGRLHRRELQPGEIPPGVATGAVGPGGLLGTGGMLAADGILAGQGGLLGGGGLLGDGGLLGGGGVLGVLGEGGILSTVQGITGLRIVELTLPRVSVRLLPGVGVYLSLYTRVAINGKSLIGFLDIAVEVNITAKVRLTMDRTGYPRLVIERCDTLLGGIKVKLLRGLLPNLVDNLVNRVLADVLPDLLCPIVDVVLGLVNDQLGLVDSLIPLGILGSVQYTFSSLPLVTGEFLELDLNTLVGEAGGGLIDYPLGWPAVSPKPMPELPPMGDNTKSQLAMSANFLGSVLTLLQKQHALDLDITNGMFEELPPLTTATLGALIPKVFQQYPESCPLIIRIQVLNPPSVMLQKDKALVKVLATAEVMVSQPKDLETTICLIDVDTEFLASFSTEGDKLMIDAKLEKTSLNLRTSNVGNFDIGLMEVLVEKIFDLAFMPAMNAVLGSGVPLPKILNIDFSNADIDVLEDLLVLSA"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/66971", 
                    "id": "66971", 
                    "database": "MGI"
                }
            ], 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030047.2", 
        "ac": "NP_001030047.2", 
        "name": "BPI fold-containing family B member 4 precursor; LBP / BPI / CETP family, N-terminal domain containing protein; long palate, lung and nasal epithelium carcinoma-associated protein 4; ligand-binding protein RY2G5; Novel LBP/BPI/CETP family, N-terminal domain containing protein.", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2BGH0", 
                                "id": "A2BGH0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "lipid binding", 
                        "id": "GO:0008289"
                    }
                ], 
                "total": 1, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2BGH0", 
                                "id": "A2BGH0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "extracellular region", 
                        "id": "GO:0005576"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2BGH0", 
                                "id": "A2BGH0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytoplasm", 
                        "id": "GO:0005737"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 277, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 275
        }
    ], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030047.2", 
            "id": "NP_001030047.2", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6803157", 
            "id": "R-MMU-6803157", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:381399", 
            "id": "mmu:381399", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000074665", 
            "id": "ENSMUSG00000074665", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/PESCPLI/", 
            "id": "PESCPLI", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001124", 
            "id": "IPR001124", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017942", 
            "id": "IPR017942", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017943", 
            "id": "IPR017943", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF01273", 
            "id": "PF01273", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF02886", 
            "id": "PF02886", 
            "database": "Pfam"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2BGH0", 
            "id": "PR_A2BGH0", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/381399", 
            "id": "381399", 
            "database": "GeneID"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:2685852", 
            "id": "2685852", 
            "database": "MGI"
        }
    ], 
    "expression_disease": [], 
    "uniprot_ac": "A2BGH0", 
    "disease": [], 
    "mass": {
        "monoisotopic_mass": 65723.0, 
        "chemical_mass": 65723.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2BGH0", 
            "name": "Bpifb4; Gm1006; Lplunc4.", 
            "locus": {
                "end_pos": 153964101, 
                "start_pos": 153938212, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000074665", 
                        "id": "ENSMUSG00000074665", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ]
}