{ "uniprot_canonical_ac": "A2BDX4-1", "sequence": { "header": "sp|A2BDX4-1|KCNG1_MOUSE Isoform 1 of Potassium voltage-gated channel subfamily G member 1 OS=Mus musculus OX=10090 GN=Kcng1 PE=3 SV=1 CANONICAL=A2BDX4-1", "length": 514, "sequence": "MTLLPGDNSHYDYSALSCASDTSFHPAFFPQRQAIKGVFYRRAQRLRPQDDLHQSCSLGDRRRQIIINVGGIKYSLPWTTLDEFPLTRLGQLKACTNFDDILSVCDDYDVTCNEFFFDRNPGAFGTILTFLRAGKLRLLREMCALSFQEELLYWGIAEDHLDGCCKRRYLQKIEEFAEMMEREEEEEPLDSEDQESEGPSASEGRLSRCMRRLRDMVERPHSGLPGKVFACLSVLFVTVTAVNLSVSTLPSLREEEEQGQCSQMCHNVFIVESVCVGWFSLEFLLRFIQAPSKFAFLRSPLTLIDLVAILPYYVTLLVDGAASSRRKPSTGNSYLDKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTARRCTREFGLLLLFLCVAIALFAPLLYVIENEMADSPEFTSIPACYWWAVITMTTVGYGDMVPRSTPGQVVALSSILSGILLMAFPVTSIFHTFSRSYLELKQEQERVLIRRAQYLIKTKSQLSGMSQDSDILFGSASSDTRDNN" }, "uniprot_id": "KCNG1_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "potassium voltage-gated channel subfamily G member 1", "orthologue of H. sapiens potassium voltage-gated channel, subfamily G, member 1 (KCNG1); voltage-gated potassium channel subunit Kv6.1" ], "uniprotkb": [ "Potassium voltage-gated channel subfamily G member 1", "Voltage-gated potassium channel subunit Kv6.1" ] }, "gene": { "refseq": [ "Kcng1", "AW536275" ], "uniprotkb": [ "Kcng1", "AW536275" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BDX4", "id": "A2BDX4", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Potassium voltage-gated channel subfamily G member 1; Voltage-gated potassium channel subunit Kv6.1." }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2BDX4#A2BDX4-1", "isoform_ac": "A2BDX4-1", "locus": { "end_pos": 168262383, "start_pos": 168269242, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000109191", "id": "ENSMUST00000109191", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000104815", "id": "ENSMUSP00000104815", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2BDX4-1|KCNG1_MOUSE Isoform 1 of Potassium voltage-gated channel subfamily G member 1 OS=Mus musculus OX=10090 GN=Kcng1 PE=3 SV=1 CANONICAL=A2BDX4-1", "length": 514, "sequence": "MTLLPGDNSHYDYSALSCASDTSFHPAFFPQRQAIKGVFYRRAQRLRPQDDLHQSCSLGDRRRQIIINVGGIKYSLPWTTLDEFPLTRLGQLKACTNFDDILSVCDDYDVTCNEFFFDRNPGAFGTILTFLRAGKLRLLREMCALSFQEELLYWGIAEDHLDGCCKRRYLQKIEEFAEMMEREEEEEPLDSEDQESEGPSASEGRLSRCMRRLRDMVERPHSGLPGKVFACLSVLFVTVTAVNLSVSTLPSLREEEEQGQCSQMCHNVFIVESVCVGWFSLEFLLRFIQAPSKFAFLRSPLTLIDLVAILPYYVTLLVDGAASSRRKPSTGNSYLDKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTARRCTREFGLLLLFLCVAIALFAPLLYVIENEMADSPEFTSIPACYWWAVITMTTVGYGDMVPRSTPGQVVALSSILSGILLMAFPVTSIFHTFSRSYLELKQEQERVLIRRAQYLIKTKSQLSGMSQDSDILFGSASSDTRDNN" } }, { "url": "https://www.uniprot.org/uniprot/A2BDX4#A2BDX5-1", "isoform_ac": "A2BDX5-1", "locus": { "end_pos": 168269099, "start_pos": 168269242, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000131749", "id": "ENSMUST00000131749", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000120939", "id": "ENSMUSP00000120939", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2BDX5-1|KCNG1_MOUSE Computationally mapped isoform of Potassium voltage-gated channel subfamily G member 1 OS=Mus musculus OX=10090 GN=Kcng1 PE=3 SV=1 CANONICAL=A2BDX4-1", "length": 48, "sequence": "MTLLPGDNSHYDYSALSCASDTSFHPAFFPQRQAIKGVFYRRAQRLRP" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:241794", "resource": "KEGG Pathway", "id": "mmu:241794", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1296072", "resource": "Reactome", "id": "R-MMU-1296072", "name": "Voltage gated Potassium channels" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2BDX4#function", "annotation": "Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BDX4#function", "id": "A2BDX4", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q9UIX4-1", "protein_name": "Potassium voltage-gated channel subfamily G member 1; Voltage-gated potassium channel subunit Kv6.1; kH2.", "sequence": { "length": 513, "sequence": "MTLLPGDNSDYDYSALSCTSDASFHPAFLPQRQAIKGAFYRRAQRLRPQDEPRQGCQPEDRRRRIIINVGGIKYSLPWTTLDEFPLTRLGQLKACTNFDDILNVCDDYDVTCNEFFFDRNPGAFGTILTFLRAGKLRLLREMCALSFQEELLYWGIAEDHLDGCCKRRYLQKIEEFAEMVEREEEDDALDSEGRDSEGPAEGEGRLGRCMRRLRDMVERPHSGLPGKVFACLSVLFVTVTAVNLSVSTLPSLREEEEQGHCSQMCHNVFIVESVCVGWFSLEFLLRLIQAPSKFAFLRSPLTLIDLVAILPYYITLLVDGAAAGRRKPGAGNSYLDKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTARRCTREFGLLLLFLCVAIALFAPLLYVIENEMADSPEFTSIPACYWWAVITMTTVGYGDMVPRSTPGQVVALSSILSGILLMAFPVTSIFHTFSRSYLELKQEQERVMFRRAQFLIKTKSQLSVSQDSDILFGSASSDTRDNN" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/20515", "id": "20515", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "D4AD53-1", "protein_name": "Potassium voltage-gated channel subfamily G member 1; Voltage-gated potassium channel subunit Kv6.1.", "sequence": { "length": 514, "sequence": "MTLLPGDNSDYDYSALSCASDTSFHPAFFPQRQAIKGVFYRRAQRLGPQDDLHQSISLGDRRRQIIINVGGIKYSLPWTTLDEFPLTRLGQLKACTNFDDILSVCDDYDVTCNEFFFDRNPGAFGTILTFLRAGKLRLLREMCALSFQEELLYWGIAEDHLDGCCKRRYLQKIEEFAEMMEREDEEEALDSEDQESEGPSTSEGRLSRCMRRLRDMVEKPHSGLPGKVFACLSVLFVTVTAVNLSVSTLPSLREEEEQGQCSQMCHNVFIVESVCVGWFSLEFLLRFIQAPSKFAFLRSPLTLIDLVAILPYYVTLLVDGAASSRRKPSTGNSYLDKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTARRCTREFGLLLLFLCVAIALFAPLLYVIENEMADSPEFTSIPACYWWAVITMTTVGYGDMVPRSTPGQVVALSSILSGILLMAFPVTSIFHTFSRSYLELKQEQERVLIRRAQYLIKTKSQLSGMSQDSDILFGSASSDTRDNN" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/20515", "id": "20515", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074603.1", "ac": "NP_001074603.1", "name": "potassium voltage-gated channel subfamily G member 1; orthologue of H. sapiens potassium voltage-gated channel, subfamily G, member 1 (KCNG1); voltage-gated potassium channel subunit Kv6.1.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005249", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BDX4", "id": "A2BDX4", "database": "UniProtKB" } ], "name": "voltage-gated potassium channel activity", "id": "GO:0005249" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005251", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BDX4", "id": "A2BDX4", "database": "UniProtKB" } ], "name": "delayed rectifier potassium channel activity", "id": "GO:0005251" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BDX4", "id": "A2BDX4", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008076", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BDX4", "id": "A2BDX4", "database": "UniProtKB" } ], "name": "voltage-gated potassium channel complex", "id": "GO:0008076" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BDX4", "id": "A2BDX4", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902259", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BDX4", "id": "A2BDX4", "database": "UniProtKB" } ], "name": "regulation of delayed rectifier potassium channel activity", "id": "GO:1902259" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051260", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BDX4", "id": "A2BDX4", "database": "UniProtKB" } ], "name": "protein homooligomerization", "id": "GO:0051260" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006813", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BDX4", "id": "A2BDX4", "database": "UniProtKB" } ], "name": "potassium ion transport", "id": "GO:0006813" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071805", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BDX4", "id": "A2BDX4", "database": "UniProtKB" } ], "name": "potassium ion transmembrane transport", "id": "GO:0071805" } ], "total": 4, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 245, "annotation": "n_glycosylation_sequon", "start_pos": 243 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074603.1", "id": "NP_001074603.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1296072", "id": "R-MMU-1296072", "database": "Reactome" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:241794", "id": "mmu:241794", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000074575", "id": "ENSMUSG00000074575", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/GQCSQMC/", "id": "GQCSQMC", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR003969", "id": "IPR003969", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "id": "IPR000210", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "id": "IPR011333", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR003968", "id": "IPR003968", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR003131", "id": "IPR003131", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR005821", "id": "IPR005821", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR028325", "id": "IPR028325", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027359", "id": "IPR027359", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF02214", "id": "PF02214", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00520", "id": "PF00520", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537", "id": "PTHR11537", "database": "PANTHER" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2BDX4", "id": "PR_A2BDX4", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/241794", "id": "241794", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:3616086", "id": "3616086", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A2BDX4", "disease": [], "mass": { "monoisotopic_mass": 58176.0, "chemical_mass": 58176.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2BDX4", "name": "Kcng1; AW536275.", "locus": { "end_pos": 168260117, "start_pos": 168281736, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000074575", "id": "ENSMUSG00000074575", "database": "Ensembl Gene" } ] } } ] }