{ "uniprot_canonical_ac": "A2AU37-1", "sequence": { "header": "sp|A2AU37-1|RD21L_MOUSE Isoform 1 of Double-strand-break repair protein rad21-like protein 1 OS=Mus musculus OX=10090 GN=Rad21l1 PE=1 SV=2 CANONICAL=A2AU37-1", "length": 552, "sequence": "MFYTHVLMSKRGPLAKIWLAAHWEKKLTKAHVFECNLEITIQKIISPKVKIALRTSGHLLLGVVRIYNRKAKYLLADCSEAFLKMKMTFRPGLVDLPKENFEAAYNTITLPEEFHDFEIYNINEIDISEPLAQNQSRPEEITLREEYSNDLLFQAGSFGDEPEILRRHSFFDDNILMNSSGLVVEHSSGSFAEEKSLFFDNGDGFGDEGAAGEMIDNLLQDESTFLEEAYLNKEVSLPPELPSSIMVEPGNSDDQCIPEDEEINEITLLSNEDEGFTLDPIDDLDIADRRRRKKRRLLVDPVKEISSKAMHRQLASFMDTLMVLDLAPPTQRLMMWKKRGGVDMLLSTATQDLINDELKMLFTKCFLSSDYKLAKLTLKESVRKEVGNQQIAEPSVMGEPNSHSELDQPQDWKDVTDESVGSFQENVNMNVNSEQDILGMISPAVEGLSSMNGSLAQENCPAELESSGSKQNTEAEKWNQRLFQTLNVLREFNKMGMQSFSLKKLCRNSDRKQAAAKFYTLLILKKHRAIELSQSVPYADIIATVGPMFYKM" }, "uniprot_id": "RD21L_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "double-strand-break repair protein rad21-like protein 1" ], "uniprotkb": [ "Double-strand-break repair protein rad21-like protein 1" ] }, "gene": { "refseq": [ "Rad21l", "Gm14160", "MeiRAD21L", "Rad21l1" ], "uniprotkb": [ "Rad21l1", "Gm14160", "Rad21l", "MeiRAD21L" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AU37", "id": "A2AU37", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Double-strand-break repair protein rad21-like protein 1." }, "publication": [ { "title": "Ectopic expression of meiotic cohesin RAD21L promotes adjacency of homologous chromosomes in somatic cells.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/28239026", "journal": "The Journal of reproduction and development", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263329.1", "id": "NP_001263329.1", "database": "RefSeq" } ], "authors": "Rong M, Miyauchi S, Lee J", "date": "2017", "pmid": "28239026" }, { "title": "Sororin is enriched at the central region of synapsed meiotic chromosomes.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/28050734", "journal": "Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263329.1", "id": "NP_001263329.1", "database": "RefSeq" } ], "authors": "Jordan PW, Eyster C, Chen J, Pezza RJ, Rankin S", "date": "2017", "pmid": "28050734" }, { "title": "C14ORF39/SIX6OS1 is a constituent of the synaptonemal complex and is essential for mouse fertility.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/27796301", "journal": "Nature communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263329.1", "id": "NP_001263329.1", "database": "RefSeq" } ], "authors": "Gomez-H L, Felipe-Medina N, Sanchez-Martin M, Davies OR, Ramos I, Garcia-Tunon I, de Rooij DG, Dereli I, Toth A, Barbero JL, Benavente R, Llano E, Pendas AM", "date": "2016", "pmid": "27796301" }, { "title": "Distinct Roles of Meiosis-Specific Cohesin Complexes in Mammalian Spermatogenesis.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/27792785", "journal": "PLoS genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263329.1", "id": "NP_001263329.1", "database": "RefSeq" } ], "authors": "Biswas U, Hempel K, Llano E, Pendas A, Jessberger R", "date": "2016", "pmid": "27792785" }, { "title": "Meiotic cohesin subunits RAD21L and REC8 are positioned at distinct regions between lateral elements and transverse filaments in the synaptonemal complex of mouse spermatocytes.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/27665783", "journal": "The Journal of reproduction and development", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263329.1", "id": "NP_001263329.1", "database": "RefSeq" } ], "authors": "Rong M, Matsuda A, Hiraoka Y, Lee J", "date": "2016", "pmid": "27665783" }, { "title": "Meiotic cohesin complexes are essential for the formation of the axial element in mice.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22711701", "journal": "J. Cell Biol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AU37/publications", "id": "A2AU37", "database": "UniProtKB" } ], "authors": "Pendas A.M., Gutierrez-Caballero C., de Rooij D.G., Llano E., Sanchez-Martin M., Barbero J.L., Garcia-Tunon I., Schimenti J., Herran Y., de Alava E.", "date": "2012", "pmid": "22711701" }, { "title": "RAD21L, a novel cohesin subunit implicated in linking homologous chromosomes in mammalian meiosis.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/21242291", "journal": "The Journal of cell biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263329.1", "id": "NP_001263329.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2AU37/publications", "id": "A2AU37", "database": "UniProtKB" } ], "authors": "Lee J, Hirano T", "date": "2011", "pmid": "21242291" }, { "title": "Meiosis in mice without a synaptonemal complex.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22164254", "journal": "PloS one", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263329.1", "id": "NP_001263329.1", "database": "RefSeq" } ], "authors": "Kouznetsova A, Benavente R, Pastink A, Hoog C", "date": "2011", "pmid": "22164254" }, { "title": "The cohesin subunit RAD21L functions in meiotic synapsis and exhibits sexual dimorphism in fertility.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/21743440", "journal": "The EMBO journal", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263329.1", "id": "NP_001263329.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2AU37/publications", "id": "A2AU37", "database": "UniProtKB" } ], "authors": "Herran Y, Gutierrez-Caballero C, Sanchez-Martin M, Hernandez T, Viera A, Barbero JL, de Alava E, de Rooij DG, Suja JA, Llano E, Pendas AM", "date": "2011", "pmid": "21743440" }, { "title": "Identification and molecular characterization of the mammalian alpha-kleisin RAD21L.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/21527826", "journal": "Cell cycle (Georgetown, Tex.)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263329.1", "id": "NP_001263329.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2AU37/publications", "id": "A2AU37", "database": "UniProtKB" } ], "authors": "Gutierrez-Caballero C, Herran Y, Sanchez-Martin M, Suja JA, Barbero JL, Llano E, Pendas AM", "date": "2011", "pmid": "21527826" }, { "title": "A new meiosis-specific cohesin complex implicated in the cohesin code for homologous pairing.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/21274006", "journal": "EMBO reports", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263329.1", "id": "NP_001263329.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2AU37/publications", "id": "A2AU37", "database": "UniProtKB" } ], "authors": "Ishiguro K, Kim J, Fujiyama-Nakamura S, Kato S, Watanabe Y", "date": "2011", "pmid": "21274006" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AU37#A2AU37-1", "isoform_ac": "A2AU37-1", "locus": { "end_pos": 151645407, "start_pos": 151668533, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000180195", "id": "ENSMUST00000180195", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000136918", "id": "ENSMUSP00000136918", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AU37-1|RD21L_MOUSE Isoform 1 of Double-strand-break repair protein rad21-like protein 1 OS=Mus musculus OX=10090 GN=Rad21l1 PE=1 SV=2 CANONICAL=A2AU37-1", "length": 552, "sequence": "MFYTHVLMSKRGPLAKIWLAAHWEKKLTKAHVFECNLEITIQKIISPKVKIALRTSGHLLLGVVRIYNRKAKYLLADCSEAFLKMKMTFRPGLVDLPKENFEAAYNTITLPEEFHDFEIYNINEIDISEPLAQNQSRPEEITLREEYSNDLLFQAGSFGDEPEILRRHSFFDDNILMNSSGLVVEHSSGSFAEEKSLFFDNGDGFGDEGAAGEMIDNLLQDESTFLEEAYLNKEVSLPPELPSSIMVEPGNSDDQCIPEDEEINEITLLSNEDEGFTLDPIDDLDIADRRRRKKRRLLVDPVKEISSKAMHRQLASFMDTLMVLDLAPPTQRLMMWKKRGGVDMLLSTATQDLINDELKMLFTKCFLSSDYKLAKLTLKESVRKEVGNQQIAEPSVMGEPNSHSELDQPQDWKDVTDESVGSFQENVNMNVNSEQDILGMISPAVEGLSSMNGSLAQENCPAELESSGSKQNTEAEKWNQRLFQTLNVLREFNKMGMQSFSLKKLCRNSDRKQAAAKFYTLLILKKHRAIELSQSVPYADIIATVGPMFYKM" } }, { "url": "https://www.uniprot.org/uniprot/A2AU37#R4GML2-1", "isoform_ac": "R4GML2-1", "locus": { "end_pos": 151645407, "start_pos": 151668533, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000096439", "id": "ENSMUST00000096439", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000094174", "id": "ENSMUSP00000094174", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|R4GML2-1|RD21L_MOUSE Computationally mapped isoform of Double-strand-break repair protein rad21-like protein 1 OS=Mus musculus OX=10090 GN=Rad21l1 PE=1 SV=1 CANONICAL=A2AU37-1", "length": 549, "sequence": "MFYTHVLMSKRGPLAKIWLAAHWEKKLTKAHVFECNLEITIQKIISPKVKIALRTSGHLLLGVVRIYNRKAKYLLADCSEAFLKMKMTFRPGLVDLPKENFEAAYNTITLPEEFHDFEIYNINEIDISEPLAQNQSRPEEITLREEYSNDLLFQAGSFGDEPEILRRHSFFDDNILMNSSGLVVEHSSGSFAEEKSLFFDNGDGFGDEGAAGEMIDNLLQDESTFLEEAYLNKEVSLPPELPSSIMGNSDDQCIPEDEEINEITLLSNEDEGFTLDPIDDLDIADRRRRKKRRLLVDPVKEISSKAMHRQLASFMDTLMVLDLAPPTQRLMMWKKRGGVDMLLSTATQDLINDELKMLFTKCFLSSDYKLAKLTLKESVRKEVGNQQIAEPSVMGEPNSHSELDQPQDWKDVTDESVGSFQENVNMNVNSEQDILGMISPAVEGLSSMNGSLAQENCPAELESSGSKQNTEAEKWNQRLFQTLNVLREFNKMGMQSFSLKKLCRNSDRKQAAAKFYTLLILKKHRAIELSQSVPYADIIATVGPMFYKM" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:668929", "resource": "KEGG Pathway", "id": "mmu:668929", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2AU37#function", "annotation": "Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. Probably required during early meiosis in males for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I. Involved in synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I. Not required for meiosis in females in young mice, while it is required later as mice age.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AU37#function", "id": "A2AU37", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263329.1", "annotation": "When ectopically expressed in somatic cells, can promote homologous chromosome adjacency, which resembles the homolog pairing normally seen during meiosis", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263329.1", "id": "NP_001263329.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263329.1", "annotation": "These results strongly support the previous proposition that RAD21L is an atypical cohesin that establishes the association between homologs rather than sister chromatids.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263329.1", "id": "NP_001263329.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263329.1", "annotation": "Super resolution microscopy revealed synapsis-associated SYCP1 aberrantly deposited between sister chromatids and on single chromatids in Smc1b-/-Rad21L-/- cells. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263329.1", "id": "NP_001263329.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263329.1", "annotation": "These results provide in vivo evidence that RAD21L is essential for male fertility and in females for the maintenance of fertility during natural aging. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263329.1", "id": "NP_001263329.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263329.1", "annotation": "RAD21L is identified as a novel subunit of the cohesin complex with homology to the RAD21/REC8/alpha-kleisin subfamily expressed in mouse testis.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263329.1", "id": "NP_001263329.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263329.1", "annotation": "Study identifes a new mammalian cohesin subunit, RAD21L, with sequence similarity to RAD21 and REC8; RAD21L localizes along axial elements in early meiotic prophase, in a manner that is spatiotemporally different to either REC8 or RAD21", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263329.1", "id": "NP_001263329.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263329.1", "annotation": "The results suggest that cohesin complexes containing RAD21L may be involved in synapsis initiation and crossover recombination between homologous chromosomes.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263329.1", "id": "NP_001263329.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q9H4I0-1", "protein_name": "Double-strand-break repair protein rad21-like protein 1.", "sequence": { "length": 556, "sequence": "MFYTHVLMSKRGPLAKIWLAAHWEKKLTKAHVFECNLEITIEKILSPKVKIALRTSGHLLLGVVRIYNRKAKYLLADCSEAFLKMKMTFCPGLVDLPKENFEASYNAITLPEEFHDFDTQNMNAIDVSEHFTQNQSRPEEITLRENFDNDLIFQAESFGEESEILRRHSFFDDNILLNSSGPLIEHSSGSLTGERSLFYDSGDGFGDEGAAGEMIDNLLQDDQNILLEDMHLNREISLPSEPPNSLAVEPDNSECICVPENEKMNETILLSTEEEGFTLDPIDISDIAEKRKGKKRRLLIDPIKELSSKVIHKQLTSFADTLMVLELAPPTQRLMMWKKRGGVHTLLSTAAQDLIHAELKMLFTKCFLSSGFKLGRKMIQKESVREEVGNQNIVETSMMQEPNYQQELSKPQTWKDVIGGSQHSSHEDTNKNINSEQDIVEMVSLAAEESSLMNDLFAQEIEYSPVELESLSNEENIETERWNGRILQMLNRLRESNKMGMQSFSLMKLCRNSDRKQAAAKFYSFLVLKKQLAIELSQSAPYADIIATMGPMFYNI" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/82650", "id": "82650", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2AU37/", "id": "A2AU37", "database": "OMA" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "D4ADQ7-1", "protein_name": "RAD21 cohesin complex component-like 1.", "sequence": { "length": 553, "sequence": "MFYTHVLMSKRGPLAKIWLAAHWEKKLTKAHVFECNLEITIQKIISPKVKIALRTSGHLLLGVVRIYNRKAKYLLADCSEAFLKMKMTFRPGLVDLPKENFEAAYNTITLPEEFHDFDIYNTNDIDISEPXIAQNQSRPEEITLREEYSTDLLFQTGSFGDEPELLRRHSFFDDNILMNSSGLVVEHSSGSLTEEKSLFFDNGDGFGDEGAAGEMIDHLLQDENTFFEDTYLNKEVFLPPEVPSSVMVEPGNSDDHYIPEDEKINEITLISNEEEGFTLDPIDGLDIADRRKRKKRRLLIDPVKEISSKTMHKQLTSFMDTLMVLDLAPPTQRLMMWKKRGGVETLLSTATQDLINEDLKMLFANCFLSSDYKLAKLTLKESLRKEVGNQHILDPSVVEEPNSHSELGQPQDGKDVTDESMGSFQENINRNINSKQDILEMISPAAEGFSLVSASSAQENHPAELESSGSKQNTEAEKWNQRLFQTLNELREFNKMGMQFFSLIKLCRNSDRKQAAAKFYTLLILKKHRAIELSQSAPYADVIATVGPMFHKL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/82650", "id": "82650", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2AU37/", "id": "A2AU37", "database": "OMA" } ], "organism": "Rattus norvegicus", "tax_id": 10116 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263329.1", "ac": "NP_001263329.1", "name": "double-strand-break repair protein rad21-like protein 1.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AU37", "id": "A2AU37", "database": "UniProtKB" } ], "name": "chromatin binding", "id": "GO:0003682" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030893", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AU37", "id": "A2AU37", "database": "UniProtKB" } ], "name": "meiotic cohesin complex", "id": "GO:0030893" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030893", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AU37", "id": "A2AU37", "database": "UniProtKB" } ], "name": "meiotic cohesin complex", "id": "GO:0030893" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034991", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AU37", "id": "A2AU37", "database": "UniProtKB" } ], "name": "nuclear meiotic cohesin complex", "id": "GO:0034991" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000794", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AU37", "id": "A2AU37", "database": "UniProtKB" } ], "name": "condensed nuclear chromosome", "id": "GO:0000794" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AU37", "id": "A2AU37", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AU37", "id": "A2AU37", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AU37", "id": "A2AU37", "database": "UniProtKB" } ], "name": "chromosome", "id": "GO:0005694" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000800", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AU37", "id": "A2AU37", "database": "UniProtKB" } ], "name": "lateral element", "id": "GO:0000800" } ], "total": 8, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AU37", "id": "A2AU37", "database": "UniProtKB" } ], "name": "spermatogenesis", "id": "GO:0007283" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009566", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AU37", "id": "A2AU37", "database": "UniProtKB" } ], "name": "fertilization", "id": "GO:0009566" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006302", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AU37", "id": "A2AU37", "database": "UniProtKB" } ], "name": "double-strand break repair", "id": "GO:0006302" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072520", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AU37", "id": "A2AU37", "database": "UniProtKB" } ], "name": "seminiferous tubule development", "id": "GO:0072520" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007130", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AU37", "id": "A2AU37", "database": "UniProtKB" } ], "name": "synaptonemal complex assembly", "id": "GO:0007130" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007130", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AU37", "id": "A2AU37", "database": "UniProtKB" } ], "name": "synaptonemal complex assembly", "id": "GO:0007130" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000724", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AU37", "id": "A2AU37", "database": "UniProtKB" } ], "name": "double-strand break repair via homologous recombination", "id": "GO:0000724" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070197", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AU37", "id": "A2AU37", "database": "UniProtKB" } ], "name": "meiotic attachment of telomere to nuclear envelope", "id": "GO:0070197" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007129", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AU37", "id": "A2AU37", "database": "UniProtKB" } ], "name": "synapsis", "id": "GO:0007129" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051321", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AU37", "id": "A2AU37", "database": "UniProtKB" } ], "name": "meiotic cell cycle", "id": "GO:0051321" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007062", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AU37", "id": "A2AU37", "database": "UniProtKB" } ], "name": "sister chromatid cohesion", "id": "GO:0007062" } ], "total": 11, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 136, "annotation": "n_glycosylation_sequon", "start_pos": 134 }, { "end_pos": 180, "annotation": "n_glycosylation_sequon", "start_pos": 178 }, { "end_pos": 454, "annotation": "n_glycosylation_sequon", "start_pos": 452 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263329.1", "id": "NP_001263329.1", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:668929", "id": "mmu:668929", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000074704", "id": "ENSMUSG00000074704", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/TRRLMMW/", "id": "TRRLMMW", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "id": "IPR036390", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR006910", "id": "IPR006910", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR006909", "id": "IPR006909", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR039781", "id": "IPR039781", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF04825", "id": "PF04825", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF04824", "id": "PF04824", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12585", "id": "PTHR12585", "database": "PANTHER" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2AU37", "id": "PR_A2AU37", "database": "PRO" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2AU37*", "id": "A2AU37", "database": "IntAct" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/668929", "id": "668929", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:3652039", "id": "3652039", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A2AU37", "disease": [], "mass": { "monoisotopic_mass": 62670.0, "chemical_mass": 62670.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AU37", "name": "Rad21l1; Gm14160; Rad21l; MeiRAD21L.", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "0", "evidence": [] } } ] }