{ "uniprot_canonical_ac": "A2ARA8-1", "sequence": { "header": "sp|A2ARA8-1|ITA8_MOUSE Isoform 1 of Integrin alpha-8 OS=Mus musculus OX=10090 GN=Itga8 PE=1 SV=1 CANONICAL=A2ARA8-1", "length": 1062, "sequence": "MSAGTHCGPPGNRAPPFARLCCVSAALGMLWSPACLAFNLDVDKLTVYSGPEGSYFGYSLDFYIPDARTASVLVGAPKANTSQPDIVEGGAVYYCPWPSERSAQCKQIPFDTTNNRKIRVNGTKEPIEFKSNQWFGATVRAHKGKVVACAPLYHWRTLKPNPAKDPVGTCYVAIQNFSAYAEHSPCRNSNADPEGQGYCQAGFSLDFYKNGDLIVGGPGSFYWQGQVITVSIADIIANYSFKDILRKLAAEKQTDVAPASYDDSYLGYSVAAGEFTGDSQQELVAGIPRGAQNFGYVSIINSTDMTFIQNFTGEQMASYFGYTVVVSDVNNDGMDDILVGAPLFMEREFESNPREVGQVYLYLQASALLFQDPQVLTGTETFGRFGSSVAHLGDLNQDGYNDIAIGVPFAGKDQRGKVLIYNGNPRGLHSKPSQVLQGIWGSQTIPSGFGFSLRGDADIDKNDYPDLLVGAFGKGKVAVYRARPVVTVDAQLLLHPMIINLENKTCQIPEFPTPVACFSVRVCASIAGQSISNTIALLAEVQLDFLKQKGAIKRTLFLHNHQSHFTFPFVMKQQKSLHCQDFMVYLRDETEFRDKLSPINISLNYSLDDSTFKDSLEVKPILNHYRDNVVTEQAHILVDCGEDNLCVPDLKLSARPDKHQIIIGDENHLMLIINARNEGEGAYEAELFVIIPEEADYVGIERNNKGLRPLSCEYKMENVTRMVVCDLGNPMVTGTNFSLGLRFAVPRLEKTNMSINFDLQIRSSNKDNPDSNFERVQINITAIAQVEIRGVSHPPQIVLPIHNWEPEKKPHKEEEVGPLVEHIYELHNIGPSTISDSILDVGWPFSARDEFLLYIFHLQTLGPLQCQTNPEINPQDIKPAASPEDTPELSAFLRNATIPHLVRKRDVPVVQLHRQSPARILNCTNIDCLQISCAVGRLGGGESAVLKVRSRLWAHTFLKRKNDHYALASLVSFEVKKMPYKEQPAKLPAGSTAVKTSVIWATPNVSFSIPLWVIILAILLGLLVLAILTLALWKCGFFDRARPPQDEMTDREQLTSDKTPEA" }, "uniprot_id": "ITA8_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "integrin alpha-8 preproprotein" ], "uniprotkb": [ "Integrin alpha-8" ] }, "gene": { "refseq": [ "Itga8", "AI447669" ], "uniprotkb": [ "Itga8", "AI447669" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Integrin alpha-8." }, "publication": [ { "title": "Wnt11 directs nephron progenitor polarity and motile behavior ultimately determining nephron endowment.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/30516471", "journal": "eLife", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001309.1", "id": "NP_001001309.1", "database": "RefSeq" } ], "authors": "O'Brien LL, Combes AN, Short KM, Lindstrom NO, Whitney PH, Cullen-McEwen LA, Ju A, Abdelhalim A, Michos O, Bertram JF, Smyth IM, Little MH, McMahon AP", "date": "2018", "pmid": "30516471" }, { "title": "Role of integrin alpha8 in murine model of lung fibrosis.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/29813125", "journal": "PloS one", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001309.1", "id": "NP_001001309.1", "database": "RefSeq" } ], "authors": "Hung CF, Wilson CL, Chow YH, Schnapp LM", "date": "2018", "pmid": "29813125" }, { "title": "Expression of the Alpha8 Integrin Chain Facilitates Phagocytosis by Renal Mesangial Cells.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/29544224", "journal": "Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001309.1", "id": "NP_001001309.1", "database": "RefSeq" } ], "authors": "Marek I, Becker R, Fahlbusch FB, Menendez-Castro C, Rascher W, Daniel C, Volkert G, Hartner A", "date": "2018", "pmid": "29544224" }, { "title": "Isolation of a unique hepatic stellate cell population expressing integrin alpha8 from embryonic mouse livers.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/29665133", "journal": "Developmental dynamics : an official publication of the American Association of Anatomists", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001309.1", "id": "NP_001001309.1", "database": "RefSeq" } ], "authors": "Ogawa T, Li Y, Lua I, Hartner A, Asahina K", "date": "2018", "pmid": "29665133" }, { "title": "Sex differences in the development of vascular and renal lesions in mice with a simultaneous deficiency of Apoe and the integrin chain Itga8.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/28572914", "journal": "Biology of sex differences", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001309.1", "id": "NP_001001309.1", "database": "RefSeq" } ], "authors": "Marek I, Canu M, Cordasic N, Rauh M, Volkert G, Fahlbusch FB, Rascher W, Hilgers KF, Hartner A, Menendez-Castro C", "date": "2017", "pmid": "28572914" }, { "title": "Expression and promoter analysis of a highly restricted integrin alpha gene in vascular smooth muscle.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/23142384", "journal": "Gene", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001309.1", "id": "NP_001001309.1", "database": "RefSeq" } ], "authors": "Kitchen CM, Cowan SL, Long X, Miano JM", "date": "2013", "pmid": "23142384" }, { "title": "The ECM protein nephronectin promotes kidney development via integrin alpha8beta1-mediated stimulation of Gdnf expression.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17537792", "journal": "Development", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8/publications", "id": "A2ARA8", "database": "UniProtKB" } ], "authors": "Reichardt L.F., Martin G.R., Linton J.M.", "date": "2007", "pmid": "17537792" }, { "title": "Expression of the integrin subunit alpha8 in murine lung development.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/14500699", "journal": "J. Histochem. Cytochem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8/publications", "id": "A2ARA8", "database": "UniProtKB" } ], "authors": "Schnapp L.M., Frevert C.W., Herzog E.L., Wagner T.E.", "date": "2003", "pmid": "14500699" }, { "title": "Role of alpha8 integrin in mesangial cell adhesion, migration, and proliferation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/12787402", "journal": "Kidney Int.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8/publications", "id": "A2ARA8", "database": "UniProtKB" } ], "authors": "Spessotto P., Colombatti A., Hartner A., Jahn A., Bieritz B., Prols F.", "date": "2003", "pmid": "12787402" }, { "title": "The alpha8 integrin chain affords mechanical stability to the glomerular capillary tuft in hypertensive glomerular disease.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/11891185", "journal": "Am. J. Pathol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8/publications", "id": "A2ARA8", "database": "UniProtKB" } ], "authors": "Mueller U., Hartner A., Sterzel R.B., Cordasic N., Hilgers K.F., Klanke B.", "date": "2002", "pmid": "11891185" }, { "title": "Identification and characterization of a novel extracellular matrix protein nephronectin that is associated with integrin alpha8beta1 in the embryonic kidney.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/11470831", "journal": "J. Cell Biol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8/publications", "id": "A2ARA8", "database": "UniProtKB" } ], "authors": "Wang D., Mueller U., Brandenberger R., Schmidt A., Reichardt L.F., Linton J., Backus C., Denda S.", "date": "2001", "pmid": "11470831" }, { "title": "Stereocilia defects in the sensory hair cells of the inner ear in mice deficient in integrin alpha8beta1.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/10742111", "journal": "Nat. Genet.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8/publications", "id": "A2ARA8", "database": "UniProtKB" } ], "authors": "Mueller U., Littlewood Evans A.", "date": "2000", "pmid": "10742111" }, { "title": "Integrin subunit gene expression is regionally differentiated in adult brain.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/10024342", "journal": "J. Neurosci.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8/publications", "id": "A2ARA8", "database": "UniProtKB" } ], "authors": "Detterich J., Gall C., Lynch G., Pinkstaff J.K.", "date": "1999", "pmid": "10024342" }, { "title": "Alpha8 integrin in glomerular mesangial cells and in experimental glomerulonephritis.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/10504498", "journal": "Kidney Int.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8/publications", "id": "A2ARA8", "database": "UniProtKB" } ], "authors": "Mueller U., Hartner A., Proels F., Schoecklmann H., Sterzel R.B.", "date": "1999", "pmid": "10504498" }, { "title": "Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor interactions with tenascin: murine alpha 8 beta 1 binds to the RGD site in tenascin-C fragments, but not to native tenascin-C.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/9548928", "journal": "Biochemistry", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8/publications", "id": "A2ARA8", "database": "UniProtKB" } ], "authors": "Mueller U., Reichardt L.F., Erickson H.P., Crossin K.L., Denda S.", "date": "1998", "pmid": "9548928" }, { "title": "Identification of osteopontin as a novel ligand for the integrin alpha8 beta1 and potential roles for this integrin-ligand interaction in kidney morphogenesis.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/9614184", "journal": "Mol. Biol. Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8/publications", "id": "A2ARA8", "database": "UniProtKB" } ], "authors": "Mueller U., Reichardt L.F., Denda S.", "date": "1998", "pmid": "9614184" }, { "title": "Integrin alpha8beta1 is critically important for epithelial-mesenchymal interactions during kidney morphogenesis.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/9054500", "journal": "Cell", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001309.1", "id": "NP_001001309.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2ARA8/publications", "id": "A2ARA8", "database": "UniProtKB" } ], "authors": "Muller U, Wang D, Denda S, Meneses JJ, Pedersen RA, Reichardt LF", "date": "1997", "pmid": "9054500" } ], "glycosylation": [ { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 779, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 176, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 752, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 718, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 238, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 604, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 310, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 922, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 600, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 301, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 1004, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 503, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 736, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 121, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 80, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 895, "glytoucan_ac": "", "type": "N-linked" } ], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8#A2ARA8-1", "isoform_ac": "A2ARA8-1", "locus": { "end_pos": 12109118, "start_pos": 12301782, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000028106", "id": "ENSMUST00000028106", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000028106", "id": "ENSMUSP00000028106", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2ARA8-1|ITA8_MOUSE Isoform 1 of Integrin alpha-8 OS=Mus musculus OX=10090 GN=Itga8 PE=1 SV=1 CANONICAL=A2ARA8-1", "length": 1062, "sequence": "MSAGTHCGPPGNRAPPFARLCCVSAALGMLWSPACLAFNLDVDKLTVYSGPEGSYFGYSLDFYIPDARTASVLVGAPKANTSQPDIVEGGAVYYCPWPSERSAQCKQIPFDTTNNRKIRVNGTKEPIEFKSNQWFGATVRAHKGKVVACAPLYHWRTLKPNPAKDPVGTCYVAIQNFSAYAEHSPCRNSNADPEGQGYCQAGFSLDFYKNGDLIVGGPGSFYWQGQVITVSIADIIANYSFKDILRKLAAEKQTDVAPASYDDSYLGYSVAAGEFTGDSQQELVAGIPRGAQNFGYVSIINSTDMTFIQNFTGEQMASYFGYTVVVSDVNNDGMDDILVGAPLFMEREFESNPREVGQVYLYLQASALLFQDPQVLTGTETFGRFGSSVAHLGDLNQDGYNDIAIGVPFAGKDQRGKVLIYNGNPRGLHSKPSQVLQGIWGSQTIPSGFGFSLRGDADIDKNDYPDLLVGAFGKGKVAVYRARPVVTVDAQLLLHPMIINLENKTCQIPEFPTPVACFSVRVCASIAGQSISNTIALLAEVQLDFLKQKGAIKRTLFLHNHQSHFTFPFVMKQQKSLHCQDFMVYLRDETEFRDKLSPINISLNYSLDDSTFKDSLEVKPILNHYRDNVVTEQAHILVDCGEDNLCVPDLKLSARPDKHQIIIGDENHLMLIINARNEGEGAYEAELFVIIPEEADYVGIERNNKGLRPLSCEYKMENVTRMVVCDLGNPMVTGTNFSLGLRFAVPRLEKTNMSINFDLQIRSSNKDNPDSNFERVQINITAIAQVEIRGVSHPPQIVLPIHNWEPEKKPHKEEEVGPLVEHIYELHNIGPSTISDSILDVGWPFSARDEFLLYIFHLQTLGPLQCQTNPEINPQDIKPAASPEDTPELSAFLRNATIPHLVRKRDVPVVQLHRQSPARILNCTNIDCLQISCAVGRLGGGESAVLKVRSRLWAHTFLKRKNDHYALASLVSFEVKKMPYKEQPAKLPAGSTAVKTSVIWATPNVSFSIPLWVIILAILLGLLVLAILTLALWKCGFFDRARPPQDEMTDREQLTSDKTPEA" } }, { "url": "https://www.uniprot.org/uniprot/A2ARA8#G3UYN5-1", "isoform_ac": "G3UYN5-1", "locus": { "end_pos": 12193274, "start_pos": 12301782, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000172791", "id": "ENSMUST00000172791", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000134154", "id": "ENSMUSP00000134154", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|G3UYN5-1|ITA8_MOUSE Computationally mapped isoform of Integrin alpha-8 OS=Mus musculus OX=10090 GN=Itga8 PE=1 SV=1 CANONICAL=A2ARA8-1", "length": 590, "sequence": "MSAGTHCGPPGNRAPPFARLCCVSAALGMLWSPACLAFNLDVDKLTVYSGPEGSYFGYSLDFYIPDARTASVLVGAPKANTSQPDIVEGGAVYYCPWPSERSAQCKQIPFDTTNNRKIRVNGTKEPIEFKSNQWFGATVRAHKGKVVACAPLYHWRTLKPNPAKDPVGTCYVAIQNFSAYAEHSPCRNSNADPEGQGYCQAGFSLDFYKNGDLIVGGPGSFYWQGQVITVSIADIIANYSFKDILRKLAAEKQTDVAPASYDDSYLGYSVAAGEFTGDSQQELVAGIPRGAQNFGYVSIINSTDMTFIQNFTGEQMASYFGYTVVVSDVNNDGMDDILVGAPLFMEREFESNPREVGQVYLYLQASALLFQDPQVLTGTETFGRFGSSVAHLGDLNQDGYNDIAIGVPFAGKDQRGKVLIYNGNPRGLHSKPSQVLQGIWGSQTIPSGFGFSLRGDADIDKNDYPDLLVGAFGKGKVAVYRARPVVTVDAQLLLHPMIINLENKTCQIPEFPTPVACFSVRVCASIAGQSISNTIALLAEVQLDFLKQKGAIKRTLFLHNHQSHFTFPFVMKQQKSLHCQDFMVYLRTLA" } }, { "url": "https://www.uniprot.org/uniprot/A2ARA8#A2ARA8-2", "isoform_ac": "A2ARA8-2", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A2ARA8-2|ITA8_MOUSE Isoform 2 of Integrin alpha-8 OS=Mus musculus OX=10090 GN=Itga8 PE=1 SV=1 CANONICAL=A2ARA8-1", "length": 286, "sequence": "MSAGTHCGPPGNRAPPFARLCCVSAALGMLWSPACLAFNLDVDKLTVYSGPEGSYFGYSLDFYIPDARTASVLVGAPKANTSQPDIVEGGAVYYCPWPSERSAQCKQIPFDTTNNRKIRVNGTKEPIEFKSNQWFGATVRAHKGKVVACAPLYHWRTLKPNPAKDPVGTCYVAIQNFSAYAEHSPCRNSNADPEGQGYCQAGFSLDFYKNGDLIVGGPGSFYWQGQVITVSIADIIANYSFKDILRKLAAEKQTDVAPASYDDSYLGYSVAAGEFTGDSQQGQRHP" } }, { "url": "https://www.uniprot.org/uniprot/A2ARA8#G3UYV5-1", "isoform_ac": "G3UYV5-1", "locus": { "end_pos": 12109162, "start_pos": 12132552, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000148055", "id": "ENSMUST00000148055", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000134238", "id": "ENSMUSP00000134238", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|G3UYV5-1|ITA8_MOUSE Computationally mapped isoform of Integrin alpha-8 OS=Mus musculus OX=10090 GN=Itga8 PE=1 SV=1 CANONICAL=A2ARA8-1", "length": 133, "sequence": "NCTNIDCLQISCAVGRLGGGESAVLKVRSRLWAHTFLKRKNDHYALASLVSFEVKKMPYKEQPAKLPAGSTAVKTSVIWATPNVSFSIPLWVIILAILLGLLVLAILTLALWKLVFLFSSVDSLIEQDLLRMK" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:241226", "resource": "KEGG Pathway", "id": "mmu:241226", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-216083", "resource": "Reactome", "id": "R-MMU-216083", "name": "Integrin cell surface interactions" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2129379", "resource": "Reactome", "id": "R-MMU-2129379", "name": "Molecules associated with elastic fibres" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-3000178", "resource": "Reactome", "id": "R-MMU-3000178", "name": "ECM proteoglycans" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8#function", "annotation": "Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8#function", "id": "A2ARA8", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001309.1", "annotation": "Role of integrin alpha8 in murine model of lung fibrosis Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001309.1", "id": "NP_001001309.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001309.1", "annotation": "Itga8-/- renal mesangial cells showed reduced phagocytosis of matrix-coated beads and apoptotic cells compared to WT renal mesangial cells.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001309.1", "id": "NP_001001309.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001309.1", "annotation": "Study observed that in the Apoe-deficient model of atherosclerosis, the female sex is a risk factor to develop more severe atherosclerotic lesions, although serum fat levels are not higher in females than in males. In contrast, female mice are protected from renal damage induced by the concomitant deficiency of Apoe and Itga8 Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001309.1", "id": "NP_001001309.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "B5DEG1-1", "protein_name": "Integrin subunit alpha 8; RGD1564327 protein.", "sequence": { "length": 1062, "sequence": "MSARTHRGPPENWAPPFACLCCVSAVLGMLWSPVSLAFNLDVDKLTVYSGPEGSYFGYSLDFYIPDARTASVLVGAPKANTSQPDIVEGGAVYYCPWPAERSAQCKQIPFDTTNNRKIRVNGTKEPIEFKSNQWFGATVRAHKGKVVACAPLYHWRTLKPNPAKDPVGTCYVAIQNFSAYAEHSPCRNSNVDPEGQGYCQAGFSLDFYKNGDLIVGGPGSFYWQGQVITVSVADIIANYSFKDILRKLAAEKQTDVAPASYDDSYLGYSVAAGEFTGDSLQELVAGIPRGAQNFGYVSIINSTDMTFIQNFTGEQMASYFGYTVVVSDVNNDGMDDILVGAPLFMEREFESNPREVGQVYLYLQVSALLFQDPQVLTGTETFGRFGSSVAHLGDLNQDGYNDIAIGVPFAGKDQRGKVLIYNGNARGLHSKPSQVLQGIWGSQTIPSGFGFSLRGDADIDKNDYPDLLVGAFGEGKVAVYRARPVVTVDAQLLLHPMIINLENKTCQIPEFPTPVACFSLRVCASIAGQSISNTVALMAEVQLDFLKQKGAIKRTLFLHNHQSHLIFPFVMRQQKSLHCQDFMVYLRDETEFRDKLSPINVSLNYSLDDSTFEDGLEVKPILNHYRENVVTEQAHILVDCGEDNLCVPDLRLSARPDKQEIIIGDENHLMLIINARNEGEGAYEAELFVMIPEEADYVGIERNNKGLRLLSCEYKMENVTRMVVCDLGNPMVTGTNFSLGLRFAVPRLEKTNMSINFDLQIRSSNKDNPDSNFVSVQINVTAVAQVEIRGVSHPPQIVLPIHNWEPAEEPHKEEEVGPLVEHIYELHNIGPSTISDSILEVGWPFSAREEFLLYVFHLQTLGPLQCQTNPEINPQDIKPAASPEDTPELSAFLRNATIPHLVRKRDVPVVQPHRQSPAKILNCTNIDCLQISCAVGRLGGGESAVLKVRSRLWAHTFLQRKNDPYALASLVSFEVKKIPYKEQPAKLPAGSTAIKTSVIWATPNVSFSIPLWVIILAILLGLLVLAILTLALWKCGFFDRARPPQDEMTDREQLTSDKTPEA" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/37396", "id": "37396", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2ARA8/", "id": "A2ARA8", "database": "OMA" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "P53708-1", "protein_name": "Integrin alpha-8.", "sequence": { "length": 1063, "sequence": "MSPGASRGPRGSQAPLIAPLCCAAAALGMLLWSPACQAFNLDVEKLTVYSGPKGSYFGYAVDFHIPDARTASVLVGAPKANTSQPDIVEGGAVYYCPWPAEGSAQCRQIPFDTTNNRKIRVNGTKEPIEFKSNQWFGATVKAHKGKVVACAPLYHWRTLKPTPEKDPVGTCYVAIQNFSAYAEFSPCRNSNADPEGQGYCQAGFSLDFYKNGDLIVGGPGSFYWQGQVITASVADIIANYSFKDILRKLAGEKQTEVAPASYDDSYLGYSVAAGEFTGDSQQELVAGIPRGAQNFGYVSIINSTDMTFIQNFTGEQMASYFGYTVVVSDVNSDGLDDVLVGAPLFMEREFESNPREVGQIYLYLQVSSLLFRDPQILTGTETFGRFGSAMAHLGDLNQDGYNDIAIGVPFAGKDQRGKVLIYNGNKDGLNTKPSQVLQGVWASHAVPSGFGFTLRGDSDIDKNDYPDLIVGAFGTGKVAVYRARPVVTVDAQLLLHPMIINLENKTCQVPDSMTSAACFSLRVCASVTGQSIANTIVLMAEVQLDSLKQKGAIKRTLFLDNHQAHRVFPLVIKRQKSHQCQDFIVYLRDETEFRDKLSPINISLNYSLDESTFKEGLEVKPILNYYRENIVSEQAHILVDCGEDNLCVPDLKLSARPDKHQVIIGDENHLMLIINARNEGEGAYEAELFVMIPEEADYVGIERNNKGFRPLSCEYKMENVTRMVVCDLGNPMVSGTNYSLGLRFAVPRLEKTNMSINFDLQIRSSNKDNPDSNFVSLQINITAVAQVEIRGVSHPPQIVLPIHNWEPEEEPHKEEEVGPLVEHIYELHNIGPSTISDTILEVGWPFSARDEFLLYIFHIQTLGPLQCQPNPNINPQDIKPAASPEDTPELSAFLRNSTIPHLVRKRDVHVVEFHRQSPAKILNCTNIECLQISCAVGRLEGGESAVLKVRSRLWAHTFLQRKNDPYALASLVSFEVKKMPYTDQPAKLPEGSIVIKTSVIWATPNVSFSIPLWVIILAILLGLLVLAILTLALWKCGFFDRARPPQEDMTDREQLTNDKTPEA" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/37396", "id": "37396", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2ARA8/", "id": "A2ARA8", "database": "OMA" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001309.1", "ac": "NP_001001309.1", "name": "integrin alpha-8 preproprotein.", "summary": "This gene encodes a member of the integrin family of cell surface proteins that mediate cellular interactions with the extracellular matrix and other cells. The encoded protein undergoes proteolytic processing to generate the disulfide-linked heterodimeric alpha subunit which, in turn associates with a beta subunit to form the functional integrin receptor. Mice lacking the encoded protein mostly die after birth due to kidney defects, but some of animals that survive exhibit defects in the sensory hair cells of the inner ear. [provided by RefSeq, Aug 2016]." }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" } ], "name": "metal ion binding", "id": "GO:0046872" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" } ], "name": "endoplasmic reticulum", "id": "GO:0005783" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" } ], "name": "cell surface", "id": "GO:0009986" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014069", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" } ], "name": "postsynaptic density", "id": "GO:0014069" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008305", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" } ], "name": "integrin complex", "id": "GO:0008305" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045177", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" } ], "name": "apical part of cell", "id": "GO:0045177" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043204", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" } ], "name": "perikaryon", "id": "GO:0043204" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032591", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" } ], "name": "dendritic spine membrane", "id": "GO:0032591" } ], "total": 8, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007613", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" } ], "name": "memory", "id": "GO:0007613" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030198", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" } ], "name": "extracellular matrix organization", "id": "GO:0030198" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030030", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" } ], "name": "cell projection organization", "id": "GO:0030030" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001656", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" } ], "name": "metanephros development", "id": "GO:0001656" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007229", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" } ], "name": "integrin-mediated signaling pathway", "id": "GO:0007229" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001822", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" } ], "name": "kidney development", "id": "GO:0001822" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007160", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" } ], "name": "cell-matrix adhesion", "id": "GO:0007160" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007420", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" } ], "name": "brain development", "id": "GO:0007420" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042472", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" } ], "name": "inner ear morphogenesis", "id": "GO:0042472" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045184", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" } ], "name": "establishment of protein localization", "id": "GO:0045184" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030511", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" } ], "name": "positive regulation of transforming growth factor beta receptor signaling pathway", "id": "GO:0030511" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048745", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" } ], "name": "smooth muscle tissue development", "id": "GO:0048745" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000721", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" } ], "name": "positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation", "id": "GO:2000721" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034446", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" } ], "name": "substrate adhesion-dependent cell spreading", "id": "GO:0034446" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048333", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8", "database": "UniProtKB" } ], "name": "mesodermal cell differentiation", "id": "GO:0048333" } ], "total": 15, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 82, "annotation": "n_glycosylation_sequon", "start_pos": 80 }, { "end_pos": 123, "annotation": "n_glycosylation_sequon", "start_pos": 121 }, { "end_pos": 178, "annotation": "n_glycosylation_sequon", "start_pos": 176 }, { "end_pos": 240, "annotation": "n_glycosylation_sequon", "start_pos": 238 }, { "end_pos": 303, "annotation": "n_glycosylation_sequon", "start_pos": 301 }, { "end_pos": 312, "annotation": "n_glycosylation_sequon", "start_pos": 310 }, { "end_pos": 505, "annotation": "n_glycosylation_sequon", "start_pos": 503 }, { "end_pos": 602, "annotation": "n_glycosylation_sequon", "start_pos": 600 }, { "end_pos": 606, "annotation": "n_glycosylation_sequon", "start_pos": 604 }, { "end_pos": 720, "annotation": "n_glycosylation_sequon", "start_pos": 718 }, { "end_pos": 738, "annotation": "n_glycosylation_sequon", "start_pos": 736 }, { "end_pos": 754, "annotation": "n_glycosylation_sequon", "start_pos": 752 }, { "end_pos": 781, "annotation": "n_glycosylation_sequon", "start_pos": 779 }, { "end_pos": 897, "annotation": "n_glycosylation_sequon", "start_pos": 895 }, { "end_pos": 924, "annotation": "n_glycosylation_sequon", "start_pos": 922 }, { "end_pos": 1006, "annotation": "n_glycosylation_sequon", "start_pos": 1004 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001309.1", "id": "NP_001001309.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-216083", "id": "R-MMU-216083", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2129379", "id": "R-MMU-2129379", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-3000178", "id": "R-MMU-3000178", "database": "Reactome" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:241226", "id": "mmu:241226", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000026768", "id": "ENSMUSG00000026768", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/IRTSVIW/", "id": "IRTSVIW", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000413", "id": "IPR000413", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013519", "id": "IPR013519", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013517", "id": "IPR013517", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013649", "id": "IPR013649", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR018184", "id": "IPR018184", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR032695", "id": "IPR032695", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR028994", "id": "IPR028994", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00357", "id": "PF00357", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF01839", "id": "PF01839", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF08441", "id": "PF08441", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2ARA8", "id": "PR_A2ARA8", "database": "PRO" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2ARA8*", "id": "A2ARA8", "database": "IntAct" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/241226", "id": "241226", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:109442", "id": "109442", "database": "MGI" }, { "url": "https://acgg.asia/gpdb2/GPDB0001717", "id": "GPDB0001717", "database": "GlycoProtDB" } ], "expression_disease": [], "uniprot_ac": "A2ARA8", "disease": [], "mass": { "monoisotopic_mass": 117556.0, "chemical_mass": 117556.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2ARA8", "name": "Itga8; AI447669.", "locus": { "end_pos": 12106632, "start_pos": 12301922, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000026768", "id": "ENSMUSG00000026768", "database": "Ensembl Gene" } ] } } ] }