{ "uniprot_canonical_ac": "A2ALK8-1", "sequence": { "header": "sp|A2ALK8-1|PTN3_MOUSE Isoform 1 of Tyrosine-protein phosphatase non-receptor type 3 OS=Mus musculus OX=10090 GN=Ptpn3 PE=1 SV=1 CANONICAL=A2ALK8-1", "length": 913, "sequence": "MTSRLRALGGRINNTRTSELPKEKTRSEVICSIRFLDGLVQTFKVNKQDLGQSLLDMAYGHLGVTEKEYFGLQHGDDPVDSPRWLEASKPLRKQLKGGFPCTLHFRVRYFIPDPNTLQQEQTRHLYFLQLKMDVCEGRLTCPLNSAVVLASYAVQSHFGDFNSSIHHPGYLADSQFIPDQNDDFLSKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHGGRDLHNLDLMIGIASAGIAVYRKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHSFFQAKKLLPQEKNVLSQYWTLGSRNPKKSVNNQYCKKVIGGMVWNPVMRRSLSVERLETKSLPSRSPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGPLSPKDSDSEVSQNHSPHRESLSENNPAQSCLTQKSSSSVSPSSNAPGSCSPDGVDQRFLEDYHKVTKGGFVEDASQYYCDKSDDGDGYLVLIRITPDEEGRFGFNLKGGVDQKMPLVVSRINPESPADTCMPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRKAVRSLAEIRSEDELSQLFPEAMFPACPEGGDSLEGSMELLKKGLESGTVLIQFEQLYRKKPGLAVSFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEMPAANLVNKYIATQGPLPNTCAQFWQVVWDQKLSLVVMLTTLTERGRTKCHQYWPDPPDIMDHGIFHIQCQTEDCTIAYVSREMLVTNTETGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVKYVRSLRVDGEPALVHCSAGIGRTGVLVTMETAMCLIERNLPVYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQRLDPS" }, "uniprot_id": "PTN3_MOUSE", "enzyme_annotation": [ { "ec": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "ec": "3.1.3.48", "activity": "" } ], "synonyms": { "protein": { "refseq": [ "tyrosine-protein phosphatase non-receptor type 3", "protein-tyrosine phosphatase H1" ], "uniprotkb": [ "Tyrosine-protein phosphatase non-receptor type 3", "3.1.3.48" ] }, "gene": { "refseq": [ "Ptpn3", "9530011I20Rik", "PTP-H1", "PTPCL" ], "uniprotkb": [ "Ptpn3", "9530011I20Rik", "PTP-H1", "PTPCL" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Tyrosine-protein phosphatase non-receptor type 3; 3.1.3.48." }, "publication": [ { "title": "p38gamma Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22730326", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035337.2", "id": "NP_035337.2", "database": "RefSeq" } ], "authors": "Hou S, Suresh PS, Qi X, Lepp A, Mirza SP, Chen G", "date": "2012", "pmid": "22730326" }, { "title": "The FERM and PDZ domain-containing protein tyrosine phosphatases, PTPN4 and PTPN3, are both dispensable for T cell receptor signal transduction.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/19107198", "journal": "PloS one", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035337.2", "id": "NP_035337.2", "database": "RefSeq" } ], "authors": "Bauler TJ, Hendriks WJ, King PD", "date": "2008", "pmid": "19107198" }, { "title": "Protein-tyrosine phosphatase H1 controls growth hormone receptor signaling and systemic growth.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17921143", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035337.2", "id": "NP_035337.2", "database": "RefSeq" } ], "authors": "Pilecka I, Patrignani C, Pescini R, Curchod ML, Perrin D, Xue Y, Yasenchak J, Clark A, Magnone MC, Zaratin P, Valenzuela D, Rommel C, Hooft van Huijsduijnen R", "date": "2007", "pmid": "17921143" }, { "title": "BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/12520002", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035337.2", "id": "NP_035337.2", "database": "RefSeq" } ], "authors": "Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE", "date": "2003", "pmid": "12520002" }, { "title": "Cloning, characterization, and genomic structure of the mouse Ikbkap gene.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/11747609", "journal": "DNA and cell biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035337.2", "id": "NP_035337.2", "database": "RefSeq" } ], "authors": "Cuajungco MP, Leyne M, Mull J, Gill SP, Gusella JF, Slaugenhaupt SA", "date": "2001", "pmid": "11747609" }, { "title": "Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/9990064", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035337.2", "id": "NP_035337.2", "database": "RefSeq" } ], "authors": "Podsypanina K, Ellenson LH, Nemes A, Gu J, Tamura M, Yamada KM, Cordon-Cardo C, Catoretti G, Fisher PE, Parsons R", "date": "1999", "pmid": "9990064" }, { "title": "Cloning and characterization of PTP-K1, a novel nonreceptor protein tyrosine phosphatase highly expressed in bone marrow.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/8875997", "journal": "Oncogene", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035337.2", "id": "NP_035337.2", "database": "RefSeq" } ], "authors": "Huang K, Sommers CL, Grinberg A, Kozak CA, Love PE", "date": "1996", "pmid": "8875997" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8#A2ALK8-1", "isoform_ac": "A2ALK8-1", "locus": { "end_pos": 57194288, "start_pos": 57270160, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000075637", "id": "ENSMUST00000075637", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000075063", "id": "ENSMUSP00000075063", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2ALK8-1|PTN3_MOUSE Isoform 1 of Tyrosine-protein phosphatase non-receptor type 3 OS=Mus musculus OX=10090 GN=Ptpn3 PE=1 SV=1 CANONICAL=A2ALK8-1", "length": 913, "sequence": "MTSRLRALGGRINNTRTSELPKEKTRSEVICSIRFLDGLVQTFKVNKQDLGQSLLDMAYGHLGVTEKEYFGLQHGDDPVDSPRWLEASKPLRKQLKGGFPCTLHFRVRYFIPDPNTLQQEQTRHLYFLQLKMDVCEGRLTCPLNSAVVLASYAVQSHFGDFNSSIHHPGYLADSQFIPDQNDDFLSKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHGGRDLHNLDLMIGIASAGIAVYRKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHSFFQAKKLLPQEKNVLSQYWTLGSRNPKKSVNNQYCKKVIGGMVWNPVMRRSLSVERLETKSLPSRSPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGPLSPKDSDSEVSQNHSPHRESLSENNPAQSCLTQKSSSSVSPSSNAPGSCSPDGVDQRFLEDYHKVTKGGFVEDASQYYCDKSDDGDGYLVLIRITPDEEGRFGFNLKGGVDQKMPLVVSRINPESPADTCMPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRKAVRSLAEIRSEDELSQLFPEAMFPACPEGGDSLEGSMELLKKGLESGTVLIQFEQLYRKKPGLAVSFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEMPAANLVNKYIATQGPLPNTCAQFWQVVWDQKLSLVVMLTTLTERGRTKCHQYWPDPPDIMDHGIFHIQCQTEDCTIAYVSREMLVTNTETGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVKYVRSLRVDGEPALVHCSAGIGRTGVLVTMETAMCLIERNLPVYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQRLDPS" } }, { "url": "https://www.uniprot.org/uniprot/A2ALK8#A2ALK9-1", "isoform_ac": "A2ALK9-1", "locus": { "end_pos": 57245052, "start_pos": 57270160, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000153926", "id": "ENSMUST00000153926", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000122490", "id": "ENSMUSP00000122490", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2ALK9-1|PTN3_MOUSE Computationally mapped isoform of Tyrosine-protein phosphatase non-receptor type 3 OS=Mus musculus OX=10090 GN=Ptpn3 PE=1 SV=1 CANONICAL=A2ALK8-1", "length": 229, "sequence": "MTSRLRALGGRINNTRTSELPKEKTRSEVICSIRFLDGLVQTFKVNKQDLGQSLLDMAYGHLGVTEKEYFGLQHGDDPVDSPRWLEASKPLRKQLKGGFPCTLHFRVRYFIPDPNTLQQEQTRHLYFLQLKMDVCEGRLTCPLNSAVVLASYAVQSHFGDFNSSIHHPGYLADSQFIPDQNDDFLSKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHGGRDLHN" } }, { "url": "https://www.uniprot.org/uniprot/A2ALK8#A2ALL0-1", "isoform_ac": "A2ALL0-1", "locus": { "end_pos": 57265058, "start_pos": 57270160, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000130900", "id": "ENSMUST00000130900", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000114805", "id": "ENSMUSP00000114805", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2ALL0-1|PTN3_MOUSE Computationally mapped isoform of Tyrosine-protein phosphatase non-receptor type 3 OS=Mus musculus OX=10090 GN=Ptpn3 PE=1 SV=1 CANONICAL=A2ALK8-1", "length": 57, "sequence": "MTSRLRALGGRINNTRTSELPKEKTRSEVICSIRFLDGLVQTFKVNKQDLGQSLLDM" } }, { "url": "https://www.uniprot.org/uniprot/A2ALK8#A2ALL1-1", "isoform_ac": "A2ALL1-1", "locus": { "end_pos": 57270050, "start_pos": 57270160, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000151964", "id": "ENSMUST00000151964", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000120111", "id": "ENSMUSP00000120111", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2ALL1-1|PTN3_MOUSE Computationally mapped isoform of Tyrosine-protein phosphatase non-receptor type 3 OS=Mus musculus OX=10090 GN=Ptpn3 PE=1 SV=1 CANONICAL=A2ALK8-1", "length": 37, "sequence": "MTSRLRALGGRINNTRTSELPKEKTRSEVICSIRFLD" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:545622", "resource": "KEGG Pathway", "id": "mmu:545622", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-182971", "resource": "Reactome", "id": "R-MMU-182971", "name": "EGFR downregulation" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8#function", "annotation": "May act at junctions between the membrane and the cytoskeleton.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8#function", "id": "A2ALK8", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035337.2", "annotation": "P38gamma Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035337.2", "id": "NP_035337.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035337.2", "annotation": "PTPN3 and PTPN4 are dispensable for TCR signal transduction.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035337.2", "id": "NP_035337.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035337.2", "annotation": "PTP-H1 has a role in modulating GHR signaling and systemic growth through insulin-like growth factor 1 secretion", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035337.2", "id": "NP_035337.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "F1LQQ5-1", "protein_name": "Tyrosine-protein phosphatase non-receptor type; 3.1.3.48.", "sequence": { "length": 1018, "sequence": "MGRKVQSERRKAGVGGGGRGRLERRPLGALKALGRANLPGVLGPAKEPRDSQLSHGAAGVGATPNSATEPPSKARCHFRFVVRQALAIPRHAIPESQAHSYSAAVMTSRLRALGGRINNIRTSELPKEKTRSEVTCSIRFLDGLVQTFKVNKQDLGQSLLDMAYGHLGVTEKEYFGLQHGDDPVDSPRWLEASKPLRKQLKGGLPCILHFRVRYFIPDPNTLQQEQTRHLYFLQLKMDVCEGRLTCPLNSAVVLASYAVQSHIGDFNSSIHHPGYLADSQFIPDQNDDFLSKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHGGRDLHNLDLMIGIASAGIAVYRKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHSFFQAKKLLPQEKNVLSQYWTLGSRNPKKSVNNQYCKKVIGGMVWNPVMRRSLSVERLETKSLPSRSPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSLSPKDSDSEVSQNHSPHRGSLSENNPAQSCLTQKSSSSVSPCSNAPGSFSPDGVDQQFLEDYHKVTKGGSIEEASQYYCDKNDDGDGYLVLIRITPDKEGRFGFNLKGGVDQKMPLVVSRINPESPADTCMPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRKAVRSLAEIRSEDELSQLFPEAMFPACPEGGDSLEGSMELLKKGLESGTVLIQFEQLYRKKPGLAVTFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLVVMLTTLTERGRTKCHQYWPDPPDIMDHGIFHIQCQAEDCTIAYVSREMLVTNTETGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVKYVRSLRVGGEPALVHCSAGIGRTGVLVTMETAMCLIERNLPVYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQTLDPS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/74451", "id": "74451", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2ALK8/", "id": "A2ALK8", "database": "OMA" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "P26045-1", "protein_name": "Tyrosine-protein phosphatase non-receptor type 3; 3.1.3.48; Protein-tyrosine phosphatase H1; PTP-H1.", "sequence": { "length": 913, "sequence": "MTSRLRALGGRINNIRTSELPKEKTRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSRSPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLDPS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/74451", "id": "74451", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2ALK8/", "id": "A2ALK8", "database": "OMA" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035337.2", "ac": "NP_035337.2", "name": "tyrosine-protein phosphatase non-receptor type 3; protein-tyrosine phosphatase H1.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001784", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "name": "phosphotyrosine residue binding", "id": "GO:0001784" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051117", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "name": "ATPase binding", "id": "GO:0051117" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017080", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "name": "sodium channel regulator activity", "id": "GO:0017080" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008092", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "name": "cytoskeletal protein binding", "id": "GO:0008092" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004725", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "name": "protein tyrosine phosphatase activity", "id": "GO:0004725" } ], "total": 5, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "name": "cytoskeleton", "id": "GO:0005856" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009898", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "name": "cytoplasmic side of plasma membrane", "id": "GO:0009898" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051045", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "name": "negative regulation of membrane protein ectodomain proteolysis", "id": "GO:0051045" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000649", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "name": "regulation of sodium ion transmembrane transporter activity", "id": "GO:2000649" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045930", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "name": "negative regulation of mitotic cell cycle", "id": "GO:0045930" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006470", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "name": "protein dephosphorylation", "id": "GO:0006470" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097421", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "name": "liver regeneration", "id": "GO:0097421" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098902", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "name": "regulation of membrane depolarization during action potential", "id": "GO:0098902" } ], "total": 6, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 15, "annotation": "n_glycosylation_sequon", "start_pos": 13 }, { "end_pos": 164, "annotation": "n_glycosylation_sequon", "start_pos": 162 }, { "end_pos": 434, "annotation": "n_glycosylation_sequon", "start_pos": 432 }, { "end_pos": 699, "annotation": "n_glycosylation_sequon", "start_pos": 697 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035337.2", "id": "NP_035337.2", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-182971", "id": "R-MMU-182971", "database": "Reactome" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:545622", "id": "mmu:545622", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000038764", "id": "ENSMUSG00000038764", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/RKLICTS/", "id": "RKLICTS", "database": "OMA" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14473", "id": "cd14473", "database": "CDD" }, { "url": 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"https://www.ebi.ac.uk/interpro/entry/IPR041783", "id": "IPR041783", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00373", "id": "PF00373", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF09379", "id": "PF09379", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF09380", "id": "PF09380", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00595", "id": "PF00595", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00102", "id": "PF00102", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2ALK8", "id": "PR_A2ALK8", "database": "PRO" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2ALK8*", "id": "A2ALK8", "database": "IntAct" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/545622", "id": "545622", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:105307", "id": "105307", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A2ALK8", "disease": [], "mass": { "monoisotopic_mass": 103896.0, "chemical_mass": 103896.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "name": "Ptpn3; 9530011I20Rik; PTP-H1; PTPCL.", "locus": { "end_pos": 57190841, "start_pos": 57301837, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000038764", "id": "ENSMUSG00000038764", "database": "Ensembl Gene" } ] } } ] }