{ "uniprot_canonical_ac": "A2AKX3-1", "sequence": { "header": "sp|A2AKX3-1|SETX_MOUSE Isoform 1 of Probable helicase senataxin OS=Mus musculus OX=10090 GN=Setx PE=1 SV=1 CANONICAL=A2AKX3-1", "length": 2646, "sequence": "MSTCCWCTPGGSSTIDVLKRYASSTGSSEFQTADEDLCYCLECVAEYHRARDEVPFLHEVLWELETLRLVSHFEKSMKAEAEDDDDLYIVDNNGEEQLFDCSGQDFENKLRVPLFEILKYPYLLLHERVNELCVEALCRMEQNNCSFQVFDKYPGIYLFLVHPNEMVRRWAILTARNLGKVDRDDYYDLQEVLTCLFKVIELGLLESPDIYTSSVLEKGKLILLPAHMYDTTNYKNYWLGICMLLTILEEQAMDSLLLGSDKQNDFMQSILHTMEKQSDDDSMDPFWPALHCFMVILDRLGSKVWGQLIDPIEAFQTIINNESYNREIQNIRNSSIRTKLEPEPHFDDMVTCSQIVYNFNPEKTKKDSGWRSAICPDYCPNMYEEMETLANVLQSDIGQDMRVHNSTFLWFIPFVQSLMDLKDLGVAYIVEVIHHLYSEVKDVLNQTDAVCDKVTEFFILILISVIELHRNKKCLHLLWVSSQQWVEAVVKCAKLPTTAFVRSCEKSPGSTSRGAAIMSSLALHSVQSNSVQLACVQLIRGLLKEGYQLGQQTLCKRFWDKLNLFLRGNLSLGWQLTGQETHELQMCLKQIIRNIKFKMPQYSTFGDSTSTFKTPPSFKEESDKIDRKHKKNIYCLENCSPVSSKEPMKADTHRVLMKVNTTEEENFKQHYIDLNEEEQEPLPAELCLKQKSEALFSESAQEQVKISAEKSGKESSSYAPSNSTSRNGPEWGCDRGVIMSAHSLTDSSSDFMEQVSTSNEDVSLKDGSVGKTSKPSFKLQKDEICAKLSHVIKKQIRKSTLVDNIIDLEENTAISDLENCSGTDGGALKEDSIGHNVPSDPVLDDKHEEQKSQNSSLFKKEIKSEELDNSSSDDEDKLQIQEGRADDDLVSFTEVTDTLVKAPCEGHVKMVVESRDKEMRESTALTSNLVEGQVPHDSSKPLVAGRQIDLCNITLISQTTVIQFPSGLSKQNSFQLQKGDKRCLTANQNSAATCRGQVIVISDSDEEEDEDEDERSSSEENIKQSKACIGKDCSEHRSLAVNASVEKQLVKEEERYPVEFEDSESQVFEFESSSEVFSVWQDHKIDSKNSLQGEQKSYVTHVADSTNNNLGCGDSVSEEVVRNKAEGVKEHAGPHSSVSAEEFCKTGVKKPKRKRYDKVTAEDPQRPSSSVGTDQLPDRRDLTESDLKSADMGMATPSSSVERDSTILQKSTKSRTHSKPVRKVPASKATKKTHSDTRRGQSKSSCYISCRTSPAIVPPKKLRQCPEPTSTVEKLGLKKAPRKAFELSQRSLECIVQLRDHGKTVGVVDAPKKAKLISPQTLSIKNNKKLLTSQDLQFQRLMRSRSHKKRDFDYKNTDTVRVSRIVQGSDVLEADSDEPDDHRVSEPLAISNEKQLAKCMLSKTEVAEASSDPWVTGITCLVNQCESRVLSGGVPTDVVMVSASEDPVDGGAVTVQVGEVASVKAAEPASSSDTDDDDNLFLTQHDPQDMDLCSQLENKTIIVAHKKDTVQREDSLSRPQLESLSITKCKYKDCVETTKNQGEYCPRHSEAKAADDGLFRKPGLPLSVARPLRPTTTKIFSSSSASRTANLSKSLESTTLQQSALKNKSSGAQPNLKVTPPSSMGSQKPVAEVKSLCNIFHFQTPSSSSKQSCKLTFSENRPTSAASPVNILLPSQSIFDTFIKEVLKWKYQMFLNFDKCGAPTSLCQSISRPVPVRFQDCAEYFNVFLPLIILNAFETVAQEWLSSPNKENFYQLQLRKFPADYKKYWEFLIYLNESELAKQLHPKENDLVFLAPEKSYMDRHGMQDCSHYYCGYVHKFRRTSVMRSGKAECSLCIQTQDTLPASVKNLTRCIVISSLVTTQRKLKAMSLLSSRNQLARAVLNPNPMDFCTKDLLTTTSERIVAYLKDFNEDQKKAIETAYAMVKHSPSVAKICLIHGPPGTGKSKTIVGLLYRLLTENQRKGHSDENFNAKIKQNRVLVCAPSNAAVDELMKKIILEFKEKCKDKKNPLGNCGDINLVRLGPEKSINTEVLKFSLDSQVNHRMKKDLPSHIQEMLRRKEILDAQLDELSRQRALCRGGREMQRQELDEHIAIVSKERQELASKIKEVQGRPQRAQNTIILESHVICCTLSTSGGLLLESAFRGQGGVPFSCVIVDEAGQSCEVETLSPLIHRCNKLILVGDPKQLPPTVISMKAQEYGYDQSMMARFCKLLEENVEQNMIGRLPVLQLTIQYRMHPDICLFPSNYVYNKNLKTNRLTESIRCSSEWPFQPYLVFDVGDGSERRDNDSYINVQEIKLVMEIIKLIKEKRKDISFRNIGIITHYKAQKTMIQKDLEKEFDKKGPAEVDTVDAFQGRQKDCIIVTCVRASAVQGSIGFLASLQRLNVTITRAKYSLFILGHLRTLMENQHWYELIQDAQKRGAIIKTSDPNYRHDAMKILKLKPVLQRSLTHPPATAPEAPRPQGGLPSNRLDSGLATTSFAASLYHTPSDTVTSKGPERPLLQDRLRDPRLLRRLDAEAKGTFLKDPQPVSPQLPGVVHLLGEPGFPVVFQDLGFVVPPSTAIVAPLGSHRSPMQAEPPPAHPAAAASTSKRKYSDPDAGLSHKREPRAFSGEQGRHGSVTHHVLRSTDWDRRRLDDSSAKRRQFL" }, "uniprot_id": "SETX_MOUSE", "enzyme_annotation": [ { "ec": "3.6.4.-", "activity": "" } ], "synonyms": { "protein": { "refseq": [ "probable helicase senataxin", "SEN1 homolog; amyotrophic lateral sclerosis 4 protein homolog; amyotrophic lateral sclerosis 4 homolog" ], "uniprotkb": [ "Probable helicase senataxin", "3.6.4.-", "Amyotrophic lateral sclerosis 4 protein homolog", "SEN1 homolog" ] }, "gene": { "refseq": [ "Setx", "A130090N03", "A930037J23Rik", "Als4", "AOA2", "AW060766", "mKIAA0625", "SCAR1", "Sen1" ], "uniprotkb": [ "Setx", "Als4", "Kiaa0625", "A130090N03", "A930037J23Rik", "AOA2", "AW060766", "mKIAA0625", "SCAR1", "Sen1" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Probable helicase senataxin; 3.6.4.-; Amyotrophic lateral sclerosis 4 protein homolog; SEN1 homolog." }, "publication": [ { "title": "A senataxin-associated exonuclease SAN1 is required for resistance to DNA interstrand cross-links.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/29968717", "journal": "Nature communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150.2", "id": "NP_932150.2", "database": "RefSeq" } ], "authors": "Andrews AM, McCartney HJ, Errington TM, D'Andrea AD, Macara IG", "date": "2018", "pmid": "29968717" }, { "title": "Combined deficiency of Senataxin and DNA-PKcs causes DNA damage accumulation and neurodegeneration in spinal muscular atrophy.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/30010942", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150.2", "id": "NP_932150.2", "database": "RefSeq" } ], "authors": "Kannan A, Bhatia K, Branzei D, Gangwani L", "date": "2018", "pmid": "30010942" }, { "title": "Senataxin mutations elicit motor neuron degeneration phenotypes and yield TDP-43 mislocalization in ALS4 mice and human patients.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/29725819", "journal": "Acta neuropathologica", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150.2", "id": "NP_932150.2", "database": "RefSeq" } ], "authors": "Bennett CL, Dastidar SG, Ling SC, Malik B, Ashe T, Wadhwa M, Miller DB, Lee C, Mitchell MB, van Es MA, Grunseich C, Chen Y, Sopher BL, Greensmith L, Cleveland DW, La Spada AR", "date": "2018", "pmid": "29725819" }, { "title": "Elongator and codon bias regulate protein levels in mammalian peripheral neurons.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/29497044", "journal": "Nature communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150.2", "id": "NP_932150.2", "database": "RefSeq" } ], "authors": "Goffena J, Lefcort F, Zhang Y, Lehrmann E, Chaverra M, Felig J, Walters J, Buksch R, Becker KG, George L", "date": "2018", "pmid": "29497044" }, { "title": "High-throughput discovery of novel developmental phenotypes.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/27626380", "journal": "Nature", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150.2", "id": "NP_932150.2", "database": "RefSeq" } ], "authors": "Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M, Murray SA", "date": "2016", "pmid": "27626380" }, { "title": "Senataxin plays an essential role with DNA damage response proteins in meiotic recombination and gene silencing.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/23593030", "journal": "PLoS genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150.2", "id": "NP_932150.2", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2AKX3/publications", "id": "A2AKX3", "database": "UniProtKB" } ], "authors": "Becherel OJ, Yeo AJ, Stellati A, Heng EY, Luff J, Suraweera AM, Woods R, Fleming J, Carrie D, McKinney K, Xu X, Deng C, Lavin MF", "date": "2013", "pmid": "23593030" }, { "title": "Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22767893", "journal": "Science (New York, N.Y.)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150.2", "id": "NP_932150.2", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2AKX3/publications", "id": "A2AKX3", "database": "UniProtKB" } ], "authors": "Padmanabhan K, Robles MS, Westerling T, Weitz CJ", "date": "2012", "pmid": "22767893" }, { "title": "Senataxin, the yeast Sen1p orthologue: characterization of a unique protein in which recessive mutations cause ataxia and dominant mutations cause motor neuron disease.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/16644229", "journal": "Neurobiol. Dis.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3/publications", "id": "A2AKX3", "database": "UniProtKB" } ], "authors": "Huang Y., Bennett C.L., Chance P.F., Glass I.A., Moreira M.-C., Lynch D.R., Anderson S.K., Hashemi S.H., Chen Y.-Z.", "date": "2006", "pmid": "16644229" }, { "title": "Senataxin, the ortholog of a yeast RNA helicase, is mutant in ataxia-ocular apraxia 2.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/14770181", "journal": "Nature genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150.2", "id": "NP_932150.2", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2AKX3/publications", "id": "A2AKX3", "database": "UniProtKB" } ], "authors": "Moreira MC, Klur S, Watanabe M, Nemeth AH, Le Ber I, Moniz JC, Tranchant C, Aubourg P, Tazir M, Schols L, Pandolfo M, Schulz JB, Pouget J, Calvas P, Shizuka-Ikeda M, Shoji M, Tanaka M, Izatt L, Shaw CE, M'Zahem A, Dunne E, Bomont P, Benhassine T, Bouslam N, Stevanin G, Brice A, Guimaraes J, Mendonca P, Barbot C, Coutinho P, Sequeiros J, Durr A, Warter JM, Koenig M", "date": "2004", "pmid": "14770181" }, { "title": "BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/12520002", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150.2", "id": "NP_932150.2", "database": "RefSeq" } ], "authors": "Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE", "date": "2003", "pmid": "12520002" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3#A2AKX3-1", "isoform_ac": "A2AKX3-1", "locus": { "end_pos": 29126887, "start_pos": 29180122, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000061578", "id": "ENSMUST00000061578", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000051492", "id": "ENSMUSP00000051492", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AKX3-1|SETX_MOUSE Isoform 1 of Probable helicase senataxin OS=Mus musculus OX=10090 GN=Setx PE=1 SV=1 CANONICAL=A2AKX3-1", "length": 2646, "sequence": "MSTCCWCTPGGSSTIDVLKRYASSTGSSEFQTADEDLCYCLECVAEYHRARDEVPFLHEVLWELETLRLVSHFEKSMKAEAEDDDDLYIVDNNGEEQLFDCSGQDFENKLRVPLFEILKYPYLLLHERVNELCVEALCRMEQNNCSFQVFDKYPGIYLFLVHPNEMVRRWAILTARNLGKVDRDDYYDLQEVLTCLFKVIELGLLESPDIYTSSVLEKGKLILLPAHMYDTTNYKNYWLGICMLLTILEEQAMDSLLLGSDKQNDFMQSILHTMEKQSDDDSMDPFWPALHCFMVILDRLGSKVWGQLIDPIEAFQTIINNESYNREIQNIRNSSIRTKLEPEPHFDDMVTCSQIVYNFNPEKTKKDSGWRSAICPDYCPNMYEEMETLANVLQSDIGQDMRVHNSTFLWFIPFVQSLMDLKDLGVAYIVEVIHHLYSEVKDVLNQTDAVCDKVTEFFILILISVIELHRNKKCLHLLWVSSQQWVEAVVKCAKLPTTAFVRSCEKSPGSTSRGAAIMSSLALHSVQSNSVQLACVQLIRGLLKEGYQLGQQTLCKRFWDKLNLFLRGNLSLGWQLTGQETHELQMCLKQIIRNIKFKMPQYSTFGDSTSTFKTPPSFKEESDKIDRKHKKNIYCLENCSPVSSKEPMKADTHRVLMKVNTTEEENFKQHYIDLNEEEQEPLPAELCLKQKSEALFSESAQEQVKISAEKSGKESSSYAPSNSTSRNGPEWGCDRGVIMSAHSLTDSSSDFMEQVSTSNEDVSLKDGSVGKTSKPSFKLQKDEICAKLSHVIKKQIRKSTLVDNIIDLEENTAISDLENCSGTDGGALKEDSIGHNVPSDPVLDDKHEEQKSQNSSLFKKEIKSEELDNSSSDDEDKLQIQEGRADDDLVSFTEVTDTLVKAPCEGHVKMVVESRDKEMRESTALTSNLVEGQVPHDSSKPLVAGRQIDLCNITLISQTTVIQFPSGLSKQNSFQLQKGDKRCLTANQNSAATCRGQVIVISDSDEEEDEDEDERSSSEENIKQSKACIGKDCSEHRSLAVNASVEKQLVKEEERYPVEFEDSESQVFEFESSSEVFSVWQDHKIDSKNSLQGEQKSYVTHVADSTNNNLGCGDSVSEEVVRNKAEGVKEHAGPHSSVSAEEFCKTGVKKPKRKRYDKVTAEDPQRPSSSVGTDQLPDRRDLTESDLKSADMGMATPSSSVERDSTILQKSTKSRTHSKPVRKVPASKATKKTHSDTRRGQSKSSCYISCRTSPAIVPPKKLRQCPEPTSTVEKLGLKKAPRKAFELSQRSLECIVQLRDHGKTVGVVDAPKKAKLISPQTLSIKNNKKLLTSQDLQFQRLMRSRSHKKRDFDYKNTDTVRVSRIVQGSDVLEADSDEPDDHRVSEPLAISNEKQLAKCMLSKTEVAEASSDPWVTGITCLVNQCESRVLSGGVPTDVVMVSASEDPVDGGAVTVQVGEVASVKAAEPASSSDTDDDDNLFLTQHDPQDMDLCSQLENKTIIVAHKKDTVQREDSLSRPQLESLSITKCKYKDCVETTKNQGEYCPRHSEAKAADDGLFRKPGLPLSVARPLRPTTTKIFSSSSASRTANLSKSLESTTLQQSALKNKSSGAQPNLKVTPPSSMGSQKPVAEVKSLCNIFHFQTPSSSSKQSCKLTFSENRPTSAASPVNILLPSQSIFDTFIKEVLKWKYQMFLNFDKCGAPTSLCQSISRPVPVRFQDCAEYFNVFLPLIILNAFETVAQEWLSSPNKENFYQLQLRKFPADYKKYWEFLIYLNESELAKQLHPKENDLVFLAPEKSYMDRHGMQDCSHYYCGYVHKFRRTSVMRSGKAECSLCIQTQDTLPASVKNLTRCIVISSLVTTQRKLKAMSLLSSRNQLARAVLNPNPMDFCTKDLLTTTSERIVAYLKDFNEDQKKAIETAYAMVKHSPSVAKICLIHGPPGTGKSKTIVGLLYRLLTENQRKGHSDENFNAKIKQNRVLVCAPSNAAVDELMKKIILEFKEKCKDKKNPLGNCGDINLVRLGPEKSINTEVLKFSLDSQVNHRMKKDLPSHIQEMLRRKEILDAQLDELSRQRALCRGGREMQRQELDEHIAIVSKERQELASKIKEVQGRPQRAQNTIILESHVICCTLSTSGGLLLESAFRGQGGVPFSCVIVDEAGQSCEVETLSPLIHRCNKLILVGDPKQLPPTVISMKAQEYGYDQSMMARFCKLLEENVEQNMIGRLPVLQLTIQYRMHPDICLFPSNYVYNKNLKTNRLTESIRCSSEWPFQPYLVFDVGDGSERRDNDSYINVQEIKLVMEIIKLIKEKRKDISFRNIGIITHYKAQKTMIQKDLEKEFDKKGPAEVDTVDAFQGRQKDCIIVTCVRASAVQGSIGFLASLQRLNVTITRAKYSLFILGHLRTLMENQHWYELIQDAQKRGAIIKTSDPNYRHDAMKILKLKPVLQRSLTHPPATAPEAPRPQGGLPSNRLDSGLATTSFAASLYHTPSDTVTSKGPERPLLQDRLRDPRLLRRLDAEAKGTFLKDPQPVSPQLPGVVHLLGEPGFPVVFQDLGFVVPPSTAIVAPLGSHRSPMQAEPPPAHPAAAASTSKRKYSDPDAGLSHKREPRAFSGEQGRHGSVTHHVLRSTDWDRRRLDDSSAKRRQFL" } }, { "url": "https://www.uniprot.org/uniprot/A2AKX3#F6R186-1", "isoform_ac": "F6R186-1", "locus": { "end_pos": 29164458, "start_pos": 29179540, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000145422", "id": "ENSMUST00000145422", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000119176", "id": "ENSMUSP00000119176", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F6R186-1|SETX_MOUSE Computationally mapped isoform of Probable helicase senataxin OS=Mus musculus OX=10090 GN=Setx PE=1 SV=1 CANONICAL=A2AKX3-1", "length": 381, "sequence": "XCCTLSTSGGLLLESAFRGQGGVPFSCVIVDEAGQSCEVETLSPLIHRCNKLILVGDPKQLPPTVISMKAQEYGYDQSMMARFCKLLEENVEQNMIGRLPVLQLTIQYRMHPDICLFPSNYVYNKNLKTNRLTESIRCSSEWPFQPYLVFDVGDGSERRDNDSYINVQEIKLVMEIIKLIKEKRKDISFRNIGIITHYKAQKTMIQKDLEKEFDKKGLLQPIMMGESRQQDSEASKQQQKSSEFMHASDELGSSTVTQSGISSLENGATHTGPAEVDTVDAFQGRQKDCIIVTCVRASAVQGSIGFLASLQRLNVTITRAKYSLFILGHLRTLMENQHWYELIQDAQKRGAIIKTSDPNYRHDAMKILKLKPVLQRSLTHP" } }, { "url": "https://www.uniprot.org/uniprot/A2AKX3#A2AKX3-2", "isoform_ac": "A2AKX3-2", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A2AKX3-2|SETX_MOUSE Isoform 2 of Probable helicase senataxin OS=Mus musculus OX=10090 GN=Setx PE=1 SV=1 CANONICAL=A2AKX3-1", "length": 2265, "sequence": "MYEEMETLANVLQSDIGQDMRVHNSTFLWFIPFVQSLMDLKDLGVAYIVEVIHHLYSEVKDVLNQTDAVCDKVTEFFILILISVIELHRNKKCLHLLWVSSQQWVEAVVKCAKLPTTAFVRSCEKSPGSTSRGAAIMSSLALHSVQSNSVQLACVQLIRGLLKEGYQLGQQTLCKRFWDKLNLFLRGNLSLGWQLTGQETHELQMCLKQIIRNIKFKMPQYSTFGDSTSTFKTPPSFKEESDKIDRKHKKNIYCLENCSPVSSKEPMKADTHRVLMKVNTTEEENFKQHYIDLNEEEQEPLPAELCLKQKSEALFSESAQEQVKISAEKSGKESSSYAPSNSTSRNGPEWGCDRGVIMSAHSLTDSSSDFMEQVSTSNEDVSLKDGSVGKTSKPSFKLQKDEICAKLSHVIKKQIRKSTLVDNIIDLEENTAISDLENCSGTDGGALKEDSIGHNVPSDPVLDDKHEEQKSQNSSLFKKEIKSEELDNSSSDDEDKLQIQEGRADDDLVSFTEVTDTLVKAPCEGHVKMVVESRDKEMRESTALTSNLVEGQVPHDSSKPLVAGRQIDLCNITLISQTTVIQFPSGLSKQNSFQLQKGDKRCLTANQNSAATCRGQVIVISDSDEEEDEDEDERSSSEENIKQSKACIGKDCSEHRSLAVNASVEKQLVKEEERYPVEFEDSESQVFEFESSSEVFSVWQDHKIDSKNSLQGEQKSYVTHVADSTNNNLGCGDSVSEEVVRNKAEGVKEHAGPHSSVSAEEFCKTGVKKPKRKRYDKVTAEDPQRPSSSVGTDQLPDRRDLTESDLKSADMGMATPSSSVERDSTILQKSTKSRTHSKPVRKVPASKATKKTHSDTRRGQSKSSCYISCRTSPAIVPPKKLRQCPEPTSTVEKLGLKKAPRKAFELSQRSLECIVQLRDHGKTVGVVDAPKKAKLISPQTLSIKNNKKLLTSQDLQFQRLMRSRSHKKRDFDYKNTDTVRVSRIVQGSDVLEADSDEPDDHRVSEPLAISNEKQLAKCMLSKTEVAEASSDPWVTGITCLVNQCESRVLSGGVPTDVVMVSASEDPVDGGAVTVQVGEVASVKAAEPASSSDTDDDDNLFLTQHDPQDMDLCSQLENKTIIVAHKKDTVQREDSLSRPQLESLSITKCKYKDCVETTKNQGEYCPRHSEAKAADDGLFRKPGLPLSVARPLRPTTTKIFSSSSASRTANLSKSLESTTLQQSALKNKSSGAQPNLKVTPPSSMGSQKPVAEVKSLCNIFHFQTPSSSSKQSCKLTFSENRPTSAASPVNILLPSQSIFDTFIKEVLKWKYQMFLNFDKCGAPTSLCQSISRPVPVRFQDCAEYFNVFLPLIILNAFETVAQEWLSSPNKENFYQLQLRKFPADYKKYWEFLIYLNESELAKQLHPKENDLVFLAPEKSYMDRHGMQDCSHYYCGYVHKFRRTSVMRSGKAECSLCIQTQDTLPASVKNLTRCIVISSLVTTQRKLKAMSLLSSRNQLARAVLNPNPMDFCTKDLLTTTSERIVAYLKDFNEDQKKAIETAYAMVKHSPSVAKICLIHGPPGTGKSKTIVGLLYRLLTENQRKGHSDENFNAKIKQNRVLVCAPSNAAVDELMKKIILEFKEKCKDKKNPLGNCGDINLVRLGPEKSINTEVLKFSLDSQVNHRMKKDLPSHIQEMLRRKEILDAQLDELSRQRALCRGGREMQRQELDEHIAIVSKERQELASKIKEVQGRPQRAQNTIILESHVICCTLSTSGGLLLESAFRGQGGVPFSCVIVDEAGQSCEVETLSPLIHRCNKLILVGDPKQLPPTVISMKAQEYGYDQSMMARFCKLLEENVEQNMIGRLPVLQLTIQYRMHPDICLFPSNYVYNKNLKTNRLTESIRCSSEWPFQPYLVFDVGDGSERRDNDSYINVQEIKLVMEIIKLIKEKRKDISFRNIGIITHYKAQKTMIQKDLEKEFDKKGPAEVDTVDAFQGRQKDCIIVTCVRASAVQGSIGFLASLQRLNVTITRAKYSLFILGHLRTLMENQHWYELIQDAQKRGAIIKTSDPNYRHDAMKILKLKPVLQRSLTHPPATAPEAPRPQGGLPSNRLDSGLATTSFAASLYHTPSDTVTSKGPERPLLQDRLRDPRLLRRLDAEAKGTFLKDPQPVSPQLPGVVHLLGEPGFPVVFQDLGFVVPPSTAIVAPLGSHRSPMQAEPPPAHPAAAASTSKRKYSDPDAGLSHKREPRAFSGEQGRHGSVTHHVLRSTDWDRRRLDDSSAKRRQFL" } }, { "url": "https://www.uniprot.org/uniprot/A2AKX3#A0A0A0MQJ0-1", "isoform_ac": "A0A0A0MQJ0-1", "locus": { "end_pos": 29126887, "start_pos": 29130245, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000129544", "id": "ENSMUST00000129544", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000119521", "id": "ENSMUSP00000119521", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0A0MQJ0-1|SETX_MOUSE Computationally mapped isoform of Probable helicase senataxin OS=Mus musculus OX=10090 GN=Setx PE=1 SV=1 CANONICAL=A2AKX3-1", "length": 81, "sequence": "MSTCCWCTPGGSSTIDVLKRYASSTGSSEFQTADEDLCYCLECVAEYHRARDEVPFLHEVLWELETLRLVSHFEKSMKAEA" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:269254", "resource": "KEGG Pathway", "id": "mmu:269254", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3#function", "annotation": "Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription. Contributes to the mRNA splicing efficiency and splice site selection. Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (By similarity). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (PubMed:22767893). Involved in DNA double-strand breaks damage response generated by oxidative stress. In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (By similarity). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (PubMed:23593030). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis. May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3#function", "id": "A2AKX3", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150.2", "annotation": "Senataxin (SETX)-deficiency results in increased RNA-DNA hybrids (R-loops) and DNA double-strand breaks (DSBs), and deficiency of DNA-activated protein kinase-catalytic subunit (DNA-PKcs), which impairs DSB repair. SETX overexpression in SMA neurons reduces R-loops and DNA damage, and rescues neurodegeneration.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150.2", "id": "NP_932150.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150.2", "annotation": "SETX ALS4 mice thus recapitulated ALS disease phenotypes in association with TDP-43 mislocalization and provided insight into the basis for TDP-43 histopathology, linking SETX dysfunction to common pathways of ALS motor neuron degeneration.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150.2", "id": "NP_932150.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150.2", "annotation": "Study report a previously uncharacterized protein, SAN1, the Fam120b gene product, as a 5' exonuclease that acts independently of the Fanconi anemia pathway in response to inter-strand DNA cross-links (ICLs). Deletion of SAN1 in HeLa cells and mouse embryonic fibroblasts causes sensitivity to ICLs. SAN1 binds to senataxin (SETX). SAN1-SETX binding is increased by ICLs and is required to prevent cross-link sensitivity. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150.2", "id": "NP_932150.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150.2", "annotation": "These data support key roles for senataxin in coordinating meiotic crossing-over with transcription and in gene silencing to protect the integrity of the genome.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150.2", "id": "NP_932150.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q7Z333-1", "protein_name": "Probable helicase senataxin; 3.6.4.-; Senataxin; Amyotrophic lateral sclerosis 4 protein; SEN1 homolog.", "sequence": { "length": 2677, "sequence": "MSTCCWCTPGGASTIDFLKRYASNTPSGEFQTADEDLCYCLECVAEYHKARDELPFLHEVLWELETLRLINHFEKSMKAEIGDDDELYIVDNNGEMPLFDITGQDFENKLRVPLLEILKYPYLLLHERVNELCVEALCRMEQANCSFQVFDKHPGIYLFLVHPNEMVRRWAILTARNLGKVDRDDYYDLQEVLLCLFKVIELGLLESPDIYTSSVLEKGKLILLPSHMYDTTNYKSYWLGICMLLTILEEQAMDSLLLGSDKQNDFMQSILHTMEREADDDSVDPFWPALHCFMVILDRLGSKVWGQLMDPIVAFQTIINNASYNREIRHIRNSSVRTKLEPESYLDDMVTCSQIVYNYNPEKTKKDSGWRTAICPDYCPNMYEEMETLASVLQSDIGQDMRVHNSTFLWFIPFVQSLMDLKDLGVAYIAQVVNHLYSEVKEVLNQTDAVCDKVTEFFLLILVSVIELHRNKKCLHLLWVSSQQWVEAVVKCAKLPTTAFTRSSEKSSGNCSKGTAMISSLSLHSMPSNSVQLAYVQLIRSLLKEGYQLGQQSLCKRFWDKLNLFLRGNLSLGWQLTSQETHELQSCLKQIIRNIKFKAPPCNTFVDLTSACKISPASYNKEESEQMGKTSRKDMHCLEASSPTFSKEPMKVQDSVLIKADNTIEGDNNEQNYIKDVKLEDHLLAGSCLKQSSKNIFTERAEDQIKISTRKQKSVKEISSYTPKDCTSRNGPERGCDRGIIVSTRLLTDSSTDALEKVSTSNEDFSLKDDALAKTSKRKTKVQKDEICAKLSHVIKKQHRKSTLVDNTINLDENLTVSNIESFYSRKDTGVQKGDGFIHNLSLDPSGVLDDKNGEQKSQNNVLPKEKQLKNEELVIFSFHENNCKIQEFHVDGKELIPFTEMTNASEKKSSPFKDLMTVPESRDEEMSNSTSVIYSNLTREQAPDISPKSDTLTDSQIDRDLHKLSLLAQASVITFPSDSPQNSSQLQRKVKEDKRCFTANQNNVGDTSRGQVIIISDSDDDDDERILSLEKLTKQDKICLEREHPEQHVSTVNSKEEKNPVKEEKTETLFQFEESDSQCFEFESSSEVFSVWQDHPDDNNSVQDGEKKCLAPIANTTNGQGCTDYVSEVVKKGAEGIEEHTRPRSISVEEFCEIEVKKPKRKRSEKPMAEDPVRPSSSVRNEGQSDTNKRDLVGNDFKSIDRRTSTPNSRIQRATTVSQKKSSKLCTCTEPIRKVPVSKTPKKTHSDAKKGQNRSSNYLSCRTTPAIVPPKKFRQCPEPTSTAEKLGLKKGPRKAYELSQRSLDYVAQLRDHGKTVGVVDTRKKTKLISPQNLSVRNNKKLLTSQELQMQRQIRPKSQKNRRRLSDCESTDVKRAGSHTAQNSDIFVPESDRSDYNCTGGTEVLANSNRKQLIKCMPSEPETIKAKHGSPATDDACPLNQCDSVVLNGTVPTNEVIVSTSEDPLGGGDPTARHIEMAALKEGEPDSSSDAEEDNLFLTQNDPEDMDLCSQMENDNYKLIELIHGKDTVEVEEDSVSRPQLESLSGTKCKYKDCLETTKNQGEYCPKHSEVKAADEDVFRKPGLPPPASKPLRPTTKIFSSKSTSRIAGLSKSLETSSALSPSLKNKSKGIQSILKVPQPVPLIAQKPVGEMKNSCNVLHPQSPNNSNRQGCKVPFGESKYFPSSSPVNILLSSQSVSDTFVKEVLKWKYEMFLNFGQCGPPASLCQSISRPVPVRFHNYGDYFNVFFPLMVLNTFETVAQEWLNSPNRENFYQLQVRKFPADYIKYWEFAVYLEECELAKQLYPKENDLVFLAPERINEEKKDTERNDIQDLHEYHSGYVHKFRRTSVMRNGKTECYLSIQTQENFPANLNELVNCIVISSLVTTQRKLKAMSLLGSRNQLARAVLNPNPMDFCTKDLLTTTSERIIAYLRDFNEDQKKAIETAYAMVKHSPSVAKICLIHGPPGTGKSKTIVGLLYRLLTENQRKGHSDENSNAKIKQNRVLVCAPSNAAVDELMKKIILEFKEKCKDKKNPLGNCGDINLVRLGPEKSINSEVLKFSLDSQVNHRMKKELPSHVQAMHKRKEFLDYQLDELSRQRALCRGGREIQRQELDENISKVSKERQELASKIKEVQGRPQKTQSIIILESHIICCTLSTSGGLLLESAFRGQGGVPFSCVIVDEAGQSCEIETLTPLIHRCNKLILVGDPKQLPPTVISMKAQEYGYDQSMMARFCRLLEENVEHNMISRLPILQLTVQYRMHPDICLFPSNYVYNRNLKTNRQTEAIRCSSDWPFQPYLVFDVGDGSERRDNDSYINVQEIKLVMEIIKLIKDKRKDVSFRNIGIITHYKAQKTMIQKDLDKEFDRKGPAEVDTVDAFQGRQKDCVIVTCVRANSIQGSIGFLASLQRLNVTITRAKYSLFILGHLRTLMENQHWNQLIQDAQKRGAIIKTCDKNYRHDAVKILKLKPVLQRSLTHPPTIAPEGSRPQGGLPSSKLDSGFAKTSVAASLYHTPSDSKEITLTVTSKDPERPPVHDQLQDPRLLKRMGIEVKGGIFLWDPQPSSPQHPGATPPTGEPGFPVVHQDLSHIQQPAAVVAALSSHKPPVRGEPPAASPEASTCQSKCDDPEEELCHRREARAFSEGEQEKCGSETHHTRRNSRWDKRTLEQEDSSSKKRKLL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/41003", "id": "41003", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "D4AEB3-1", "protein_name": "Senataxin.", "sequence": { "length": 2647, "sequence": "MSTCCWCTPGGSSTIDVLKCYASSTGSSEFQTADEDLCYCLECVAEYHRARDEVPFLHEVLWELETLRLISHFEKSMKAEAEDDDELYIVDNNGEEQLFDCSGQDFENRLRVPLFEILKYPYLLLHERVNELCVEALCRMEQNNCSFQVFDKYPGIYLFLVHPNEMVRRWAILTARNLGKVDRDDYYDLQEVLTCLFKVIELGLLESPDIYTSSVLEKGKLILLPAHMYDTTNYKNYWLGICMLLTILEEQAMDSLLLGSDKQNDFMQSILHTMEKQSDDDSMDPFWPALHCFMVILDRLGSKVWGQLIDPIEAFQTIINNESYNREIQNIRNSSIRTKLEPEPHFDDMVTCSQIVYNYNPEKTKKDSGWRSAICPDYCPNMYEEMETLANVLQSDIGQDMRVHNSTFLWFIPFVQSLMDLKDLGVAYIVEVIHHLYSEVKDVLNQTDAVCDKVTEFFILILVSVIELHRNKKCLHLLWVSSQQWVDAVVKCAKLPTTAFVRSCEKSPGSTPRGAAIMSSLALHSVPSNSVQLACVQLIRGLLKEGYQLGQQTLCKRFWDKLNLFLRGNSSLGWQLTGQETHELQMCLKQIIRNIKIKMPQYSTFGDTTSTFKTPPSFKEESEQIDRKPKKDIHSLGNCSPIPSKEPMKADSHRVPTKASATEEEDFTQHYIDLNEEEPLPAELGVKQKSEALLSESAPEQVKISTEKSGKENSSYTAPNSTSRSGPEWGCDRGVIISTHSLTDSSSDFLEKVSTSNGDVPLKDGTVGKTSKPNFKVQKDEICAKLSHVLKKQHRKSTLVNNIIDLEENAATSDLENCSGTDRGALKKDTIEHDVSSDSVLNDDHEEQKSKNSSLFKKEIKSEKLDNSSFDDEDKLQIQEGHADDDLISFTEVTDTLVKKTPCEGSVKVAVESRDNEMRVLTSNLEGQVPHDSNKALVAGPQVDLCNITLISQTTVIQFPSGLSKQNSFQLQKDDKKCLTANHNRDATCHEQVIIISDSDDEDDADEQDEDKRCGIEGNIEQSKVSRENDCSEQHDLVVNTSVEKKLVKEEETNCPIEFEDSESQVFEFESSSEVFSVWQDHKIDSKSSLQEDQKSCIAHVADSTNNNLGCGADSVSEEVVRNKEKGVKEHAEPHSSVSAEGFCKIGVRKPKRKRCDKVTAEDPQRPSSSVRTEQLAEHRDLPERDLESADVDMAAPSSSVERDSTVLQKKSTKPRPHSKPVRKVPASKATKKTHPDTRRGQTKSSCYISCRTSPAIVPPKKFRQCPEPTSTVEKLGLKKGPRKAFELSQRSLECIVQLRDHGKTVGVVEAPKKTKLISPQTLSIKNNKKLLTSQDLQFQRLMRSRSHQKRDFDYKNTDSVRAVSRVVQGSDVLAADSDEPDNPGGSEPLAISSEKQLAKGTLSKAEVAEAASGPWGTGITCLVNQCESRVLSGGVPTDVLMGSASEDPVGGGALTVQVGEVAAVRAAEPESSSDTDDDDNLFLTQHDPQDMDLCSQLENSKAIIVAHKDTVQREDSLSRPQLESLSIIKCKYKDCVETTKNQGEYCPKHSEAKAADDDVFRKPGLPLSVARSSRPTTTKIFSSSSASRTANLSKSLESTTLQSALKNKSSGAQSNLKMTPSSSLGSQKPVAEVKSLCNIFHFQTPSSSSKQSYKFTFSENRPASAASSVDILLPSQSIFDTFIKEVLKWKYQMFLNFDKCGAPTSLCQSISRPVPVRFQDCAEYFNVFLPLIILNAFETVAQEWLNSPNKENFYQLHLRKFPADYKKYWEFLIYLEESELAKQLHPKENDLVFLVPEKKYMDRHSVQDRSHYYCGYVHKFRRTSVMRSGKTECSLCIQTQDNMPASVKELTKCIVISSLVTTQRKLKAMSLLSGRNQLARAVLNPNPMDFCTKDLLTTTSERIIAYLKDFNEDQKKAIETAYAMVKHSPSVAKICLIHGPPGTGKSKTIVGLLYRLLTESQRKGHSDENFNAKIKQNRVLVCAPSNAAVDELMKKIILEFKEKCKDKKNPLGNCGDINLVRLGPEKSINTEVLKFSLDSQVSHRMKKDLPSHIQEMLRRKEILDAQLDELSRQRALCRGGREMQRQELDEHIVIVSKERQELASKIKEVQGRPQRAQNTIILESHVICCTLSTSGGLLLESAFRGQGGVPFSCVIVDEAGQSCEVETLSPLIHRCNKLVLVGDPKQLPPTVISMKAQEYGYDQSMMARFCKLLEENVEQNMIGRLPVLQLTIQYRMHPDICLFPSNYVYNKNLKTNRLTETIRCSSEWPFQPYLVFDVGDGSEQRDNDSYINVQEIKLVMEIIKLIKEKRKDISFRNIGIITHYKAQKTMIQKDLEKEFDKKGPAEVDTVDAFQGRQKDCIIVTCVRASAVQGSIGFLASLQRLNVTITRAKYSLFILGHLRTLMENQHWYELIQDAQKRGAIIKTCDPNYRHDAMKILKLKPVLQRSLTHPPATAPEAPRPQGGLPSNRLDSGLATTSFAPSLYHTPSDTVTSKEPERPLLQDRLRDPRLLRRLDAEAKGTFLRDPQPESPQLPGVVHLLGESGCPVLFQDLGFVVPPSTAIVAPLGSHRSPIQAEPRPAHPAAAASTSKRKYSDPDAGLSHRREPRAFAGEQGRHGSVTHHALRSTDLDRRRLDDSSAKRRRFL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/41003", "id": "41003", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150.2", "ac": "NP_932150.2", "name": "probable helicase senataxin; SEN1 homolog; amyotrophic lateral sclerosis 4 protein homolog; amyotrophic lateral sclerosis 4 homolog.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "RNA binding", "id": "GO:0003723" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "identical protein binding", "id": "GO:0042802" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004386", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "helicase activity", "id": "GO:0004386" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001147", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "transcription termination site sequence-specific DNA binding", "id": "GO:0001147" } ], "total": 5, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "nucleolus", "id": "GO:0005730" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "axon", "id": "GO:0030424" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030426", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "growth cone", "id": "GO:0030426" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045171", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "intercellular bridge", "id": "GO:0045171" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "nuclear body", "id": "GO:0016604" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000228", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "nuclear chromosome", "id": "GO:0000228" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000781", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "chromosome, telomeric region", "id": "GO:0000781" } ], "total": 10, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007623", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "circadian rhythm", "id": "GO:0007623" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006369", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "termination of RNA polymerase II transcription", "id": "GO:0006369" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033120", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "positive regulation of RNA splicing", "id": "GO:0033120" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006310", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "DNA recombination", "id": "GO:0006310" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "spermatogenesis", "id": "GO:0007283" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010976", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "positive regulation of neuron projection development", "id": "GO:0010976" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "negative regulation of apoptotic process", "id": "GO:0043066" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071300", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "cellular response to retinoic acid", "id": "GO:0071300" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000165", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "MAPK cascade", "id": "GO:0000165" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "cellular response to DNA damage stimulus", "id": "GO:0006974" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006302", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "double-strand break repair", "id": "GO:0006302" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034599", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "cellular response to oxidative stress", "id": 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"https://www.ebi.ac.uk/QuickGO/term/GO:0044344", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "cellular response to fibroblast growth factor stimulus", "id": "GO:0044344" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060566", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "positive regulation of DNA-templated transcription, termination", "id": "GO:0060566" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000806", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled", "id": "GO:2000806" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000144", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "positive regulation of 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