{ "uniprot_canonical_ac": "A2AKQ8-1", "sequence": { "header": "sp|A2AKQ8-1|T30A2_MOUSE Isoform 1 of Tetratricopeptide repeat protein 30A2 OS=Mus musculus OX=10090 GN=Ttc30a2 PE=1 SV=1 CANONICAL=A2AKQ8-1", "length": 664, "sequence": "MAGLSNSQIPDGEFTAVVYRLIRDSRYSEAVQLLSAELQRSSRSRAGLSLLAYCYYRLQEFELAAECYEQLSQMHPELEQYRLYQAQALYKACLYPEATRVAFLLDNPTFYSRVLRLQAAIKYSEGDLPGARSLVEQLLSGEAGEDSGGENDPDGLVNMGCLLYKEGHYEAACSKFFAALQASGYQPDVSYNLALACYSNRHYAPALKHIANIIERGIRQHPELGVGMTTEGIDVRSVGNTVVLHQTALVEAFNLKAAIEYQLRNYEAAQEALTDMPPRAEEELDPVTLHNQALMNMDAKPTEGFEKLQFLLQQNPFPPETFGNLLLLYCKYEYFDLAADVLAENAHLTYKFLTPYLYDFLDAMITCQTAPEEAFIKLDGLAGMLTEQLRRLTKQVQEARHNRDDEVVIKAVNEYDETLEKYIPVLMAQAKIYWNLENYPMVEKIFRKSVEFCNDHDVWKLNVAHVLFMQENKYKEAIGFYEPIVKKNYDNILSVSAIVLANLCVSYIMTSQNEEAEELMRKIEKEEEQLSYGDPDKKIYHLCIVNLVIGTLYCAKGNYDFGISRVIKSLEPYHKKLGTDTWYYAKRCFLSLLENMSKHTIMLRDSVIQECVQFLEHCEIFGRNIPAVIEQPLEEERMHIGKNTVTYESRQLKALIYEIIGWNM" }, "uniprot_id": "T30A2_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "tetratricopeptide repeat protein 30A2", "novel tetratrico peptide repeat (TPR) containing protein; TPR repeat protein 30A2" ], "uniprotkb": [ "Tetratricopeptide repeat protein 30A2", "TPR repeat protein 30A2" ] }, "gene": { "refseq": [ "Ttc30a2" ], "uniprotkb": [ "Ttc30a2" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKQ8", "id": "A2AKQ8", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Tetratricopeptide repeat protein 30A2; TPR repeat protein 30A2.", "short": "TPR repeat protein 30A2" }, "publication": [ { "title": "High-throughput discovery of novel developmental phenotypes.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/27626380", "journal": "Nature", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074697.1", "id": "NP_001074697.1", "database": "RefSeq" } ], "authors": "Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M, Murray SA", "date": "2016", "pmid": "27626380" }, { "title": "The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/24194600", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074697.1", "id": "NP_001074697.1", "database": "RefSeq" } ], "authors": "Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H", "date": "2014", "pmid": "24194600" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AKQ8#A2AKQ8-1", "isoform_ac": "A2AKQ8-1", "locus": { "end_pos": 75976175, "start_pos": 75978166, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000099995", "id": "ENSMUST00000099995", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000097575", "id": "ENSMUSP00000097575", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AKQ8-1|T30A2_MOUSE Isoform 1 of Tetratricopeptide repeat protein 30A2 OS=Mus musculus OX=10090 GN=Ttc30a2 PE=1 SV=1 CANONICAL=A2AKQ8-1", "length": 664, "sequence": "MAGLSNSQIPDGEFTAVVYRLIRDSRYSEAVQLLSAELQRSSRSRAGLSLLAYCYYRLQEFELAAECYEQLSQMHPELEQYRLYQAQALYKACLYPEATRVAFLLDNPTFYSRVLRLQAAIKYSEGDLPGARSLVEQLLSGEAGEDSGGENDPDGLVNMGCLLYKEGHYEAACSKFFAALQASGYQPDVSYNLALACYSNRHYAPALKHIANIIERGIRQHPELGVGMTTEGIDVRSVGNTVVLHQTALVEAFNLKAAIEYQLRNYEAAQEALTDMPPRAEEELDPVTLHNQALMNMDAKPTEGFEKLQFLLQQNPFPPETFGNLLLLYCKYEYFDLAADVLAENAHLTYKFLTPYLYDFLDAMITCQTAPEEAFIKLDGLAGMLTEQLRRLTKQVQEARHNRDDEVVIKAVNEYDETLEKYIPVLMAQAKIYWNLENYPMVEKIFRKSVEFCNDHDVWKLNVAHVLFMQENKYKEAIGFYEPIVKKNYDNILSVSAIVLANLCVSYIMTSQNEEAEELMRKIEKEEEQLSYGDPDKKIYHLCIVNLVIGTLYCAKGNYDFGISRVIKSLEPYHKKLGTDTWYYAKRCFLSLLENMSKHTIMLRDSVIQECVQFLEHCEIFGRNIPAVIEQPLEEERMHIGKNTVTYESRQLKALIYEIIGWNM" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:620631", "resource": "KEGG Pathway", "id": "mmu:620631", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5620924", "resource": "Reactome", "id": "R-MMU-5620924", "name": "Intraflagellar transport" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2AKQ8#function", "annotation": "Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKQ8#function", "id": "A2AKQ8", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q4QQS2-1", "protein_name": "Tetratricopeptide repeat protein 30A2; TPR repeat protein 30A2.", "sequence": { "length": 664, "sequence": "MAGLSSSQIPDGEFTAVVYRLIRDSRYSEAVQLLSAELQRSPRSRAGLSLLAYCYYRLQEFELAAECYEQLSQMHPELEQYRLYQAQALYKACLYPEATRVAFLLDNPSFYSRVLRLQAAIKYSEGDLPGARSLVEQLLSGEAGEDSGGENDPDGLVNMGCLLYKEGHYEAACSKFFAALQASGYQPDVSYNLALACYSNRHYAPALKHIANIIERGIRQHPELGVGMTTEGIDVRSVGNTVVLHQTALVEAFNLKAAIEYQLRNFEAAQEALTDMPPRAEEELDPVTLHNQALMNMDAKPTEGFEKLQFLLQQNPFPPETFGNLLLLYCKYEYFDLAADVLAENAHLTYKFLTPYLYDFLDAMITCQTAPEEAFIKLDGLAGMLTEQLRRLTKQVQEARHNRDDEVVIKAVNEYDETLEKYIPVLMAQAKIYWNLENYQMVEKIFRKSVEFCNDHDVWKLNVAHVLFMQENKYKEAIGFYEPIVKKNYDNILSVSAIVLANLCVSYIMTSQNEEAEELMRKIEKEEEQLSYGDPDKKIYHLCIVNLVIGTLYCAKGNYDFGISRVIKSLEPYHKKLGTDTWYYAKRCFLSLLENMSKHTIMLRDSVIQECVQFLEHCEIFGRSIPAVIEQPLEEERMHTGKNTVTYESRQLKALIYEIIGWNM" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/44342", "id": "44342", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074697.1", "ac": "NP_001074697.1", "name": "tetratricopeptide repeat protein 30A2; novel tetratrico peptide repeat (TPR) containing protein; TPR repeat protein 30A2.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120170", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKQ8", "id": "A2AKQ8", "database": "UniProtKB" } ], "name": "intraciliary transport particle B binding", "id": "GO:0120170" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKQ8", "id": "A2AKQ8", "database": "UniProtKB" } ], "name": "ciliary basal body", "id": "GO:0036064" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005879", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKQ8", "id": "A2AKQ8", "database": "UniProtKB" } ], "name": "axonemal microtubule", "id": "GO:0005879" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030992", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKQ8", "id": "A2AKQ8", "database": "UniProtKB" } ], "name": "intraciliary transport particle B", "id": "GO:0030992" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042073", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKQ8", "id": "A2AKQ8", "database": "UniProtKB" } ], "name": "intraciliary transport", "id": "GO:0042073" } ], "total": 1, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 597, "annotation": "n_glycosylation_sequon", "start_pos": 595 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074697.1", "id": "NP_001074697.1", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5620924", "id": "R-MMU-5620924", "database": "Reactome" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:620631", "id": "mmu:620631", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000075272", "id": "ENSMUSG00000075272", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/MRNHPEL/", "id": "MRNHPEL", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "id": "IPR011990", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "id": "IPR019734", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR039941", "id": "IPR039941", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF13176", "id": "PF13176", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20931", "id": "PTHR20931", "database": "PANTHER" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2AKQ8", "id": "PR_A2AKQ8", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/620631", "id": "620631", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:3700200", "id": "3700200", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A2AKQ8", "disease": [], "mass": { "monoisotopic_mass": 76120.0, "chemical_mass": 76120.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AKQ8", "name": "Ttc30a2.", "locus": { "end_pos": 75975740, "start_pos": 75978170, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000075272", "id": "ENSMUSG00000075272", "database": "Ensembl Gene" } ] } } ] }