{ "uniprot_canonical_ac": "A2AKB9-1", "sequence": { "header": "sp|A2AKB9-1|DCA10_MOUSE Isoform 1 of DDB1- and CUL4-associated factor 10 OS=Mus musculus OX=10090 GN=Dcaf10 PE=1 SV=1 CANONICAL=A2AKB9-1", "length": 566, "sequence": "MFPFGPHSPGGDETAGAEEPPPLGGPAAASRPPSPAPRPASPQRGADAASPPPVAGSPRLPGGPAVSPAERAGEFAAPGALELSAATASASQAKLSPSSSPRRRSRPDWRAGGRSRQGLGAGLGGPGARLFGWLRERSLGRGLFVDPARDNFRTMTNLYGSIHPADSVYLSTRTHGAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLSEAHEDCVNNIRFLDNRLFATCSDDTTIALWDLRKLNTKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTNRCTEDGCPHKKFFHTRFLMRMRLTPDCSKMLISTSSGYLLILHELDLTKSLEVGSYPILRARRTTSSSDLTTTSSSSGSRVSGSPCHHNDSNSTEKHMSRASQREGVSPRNSLEVLTPEVPGERDRGNCITSLQLHPKGWATLLRCSSNTDDQEWTCVYEFQEGAPVRPVSPRCSLRLTHYIEEANVGRGYIKELCFSPDGRMISSPHGYGIRLLGFDKQCSELVDCLPKEASPLRVIRSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLYQPKF" }, "uniprot_id": "DCA10_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "DDB1- and CUL4-associated factor 10", "WD repeat domain 32; WD repeat-containing protein 32" ], "uniprotkb": [ "DDB1- and CUL4-associated factor 10", "WD repeat-containing protein 32" ] }, "gene": { "refseq": [ "Dcaf10", "AA959934", "Wdr32" ], "uniprotkb": [ "Dcaf10", "Wdr32", "AA959934" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKB9", "id": "A2AKB9", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "DDB1- and CUL4-associated factor 10; WD repeat-containing protein 32." }, "publication": [ { "title": "DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/30111536", "journal": "The EMBO journal", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694807.2", "id": "NP_694807.2", "database": "RefSeq" } ], "authors": "Zhang YL, Zhao LW, Zhang J, Le R, Ji SY, Chen C, Gao Y, Li D, Gao S, Fan HY", "date": "2018", "pmid": "30111536" }, { "title": "High-throughput discovery of novel developmental phenotypes.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/27626380", "journal": "Nature", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694807.2", "id": "NP_694807.2", "database": "RefSeq" } ], "authors": "Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M, Murray SA", "date": "2016", "pmid": "27626380" }, { "title": "Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/24129315", "journal": "Mol. Cell. Proteomics", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKB9/publications", "id": "A2AKB9", "database": "UniProtKB" } ], "authors": "Beausoleil S.A., Wang Y., Zhou J., Comb M.J., Guo A., Lee K.A., Aguiar M., Bedford M.T., Gu H., Jia X., Kornhauser J., Mulhern D., Ren J., Silva J.C., Vemulapalli V., Yang V.", "date": "2014", "pmid": "24129315" }, { "title": "The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/24194600", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694807.2", "id": "NP_694807.2", "database": "RefSeq" } ], "authors": "Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H", "date": "2014", "pmid": "24194600" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AKB9#A2AKB9-1", "isoform_ac": "A2AKB9-1", "locus": { "end_pos": 45342168, "start_pos": 45374274, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000155551", "id": "ENSMUST00000155551", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000117082", "id": "ENSMUSP00000117082", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AKB9-1|DCA10_MOUSE Isoform 1 of DDB1- and CUL4-associated factor 10 OS=Mus musculus OX=10090 GN=Dcaf10 PE=1 SV=1 CANONICAL=A2AKB9-1", "length": 566, "sequence": "MFPFGPHSPGGDETAGAEEPPPLGGPAAASRPPSPAPRPASPQRGADAASPPPVAGSPRLPGGPAVSPAERAGEFAAPGALELSAATASASQAKLSPSSSPRRRSRPDWRAGGRSRQGLGAGLGGPGARLFGWLRERSLGRGLFVDPARDNFRTMTNLYGSIHPADSVYLSTRTHGAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLSEAHEDCVNNIRFLDNRLFATCSDDTTIALWDLRKLNTKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTNRCTEDGCPHKKFFHTRFLMRMRLTPDCSKMLISTSSGYLLILHELDLTKSLEVGSYPILRARRTTSSSDLTTTSSSSGSRVSGSPCHHNDSNSTEKHMSRASQREGVSPRNSLEVLTPEVPGERDRGNCITSLQLHPKGWATLLRCSSNTDDQEWTCVYEFQEGAPVRPVSPRCSLRLTHYIEEANVGRGYIKELCFSPDGRMISSPHGYGIRLLGFDKQCSELVDCLPKEASPLRVIRSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLYQPKF" } }, { "url": "https://www.uniprot.org/uniprot/A2AKB9#Z4YN28-1", "isoform_ac": "Z4YN28-1", "locus": { "end_pos": 45370346, "start_pos": 45374274, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000153803", "id": "ENSMUST00000153803", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000121616", "id": "ENSMUSP00000121616", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|Z4YN28-1|DCA10_MOUSE Computationally mapped isoform of DDB1- and CUL4-associated factor 10 OS=Mus musculus OX=10090 GN=Dcaf10 PE=1 SV=1 CANONICAL=A2AKB9-1", "length": 225, "sequence": "TRFLMRMRLTPDCSKMLISTSSGYLLILHELDLTKSLEVGSYPILRARRTTSSSGVSPRNSLEVLTPEVPGERDRGNCITSLQLHPKGWATLLRCSSNTDDQEWTCVYEFQEGAPVRPVSPRCSLRLTHYIEEANVGRGYIKELCFSPDGRMISSPHGYGIRLLGFDKQCSELVDCLPKEASPLRVIRSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLYQPKF" } }, { "url": "https://www.uniprot.org/uniprot/A2AKB9#A2AKB9-2", "isoform_ac": "A2AKB9-2", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A2AKB9-2|DCA10_MOUSE Isoform 2 of DDB1- and CUL4-associated factor 10 OS=Mus musculus OX=10090 GN=Dcaf10 PE=1 SV=1 CANONICAL=A2AKB9-1", "length": 529, "sequence": "MFPFGPHSPGGDETAGAEEPPPLGGPAAASRPPSPAPRPASPQRGADAASPPPVAGSPRLPGGPAVSPAERAGEFAAPGALELSAATASASQAKLSPSSSPRRRSRPDWRAGGRSRQGLGAGLGGPGARLFGWLRERSLGRGLFVDPARDNFRTMTNLYGSIHPADSVYLSTRTHGAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLSEAHEDCVNNIRFLDNRLFATCSDDTTIALWDLRKLNTKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTNRCTEDGCPHKKFFHTRFLMRMRLTPDCSKMLISTSSGYLLILHELDLTKSLEVGSYPILRARRTTSSSGVSPRNSLEVLTPEVPGERDRGNCITSLQLHPKGWATLLRCSSNTDDQEWTCVYEFQEGAPVRPVSPRCSLRLTHYIEEANVGRGYIKELCFSPDGRMISSPHGYGIRLLGFDKQCSELVDCLPKEASPLRVIRSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLYQPKF" } }, { "url": "https://www.uniprot.org/uniprot/A2AKB9#A2AKB9-3", "isoform_ac": "A2AKB9-3", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A2AKB9-3|DCA10_MOUSE Isoform 3 of DDB1- and CUL4-associated factor 10 OS=Mus musculus OX=10090 GN=Dcaf10 PE=1 SV=1 CANONICAL=A2AKB9-1", "length": 258, "sequence": "MRMRLTPDCSKMLISTSSGYLLILHELDLTKSLEVGSYPILRARRTTSSSDLTTTSSSSGSRVSGSPCHHNDSNSTEKHMSRASQREGVSPRNSLEVLTPEVPGERDRGNCITSLQLHPKGWATLLRCSSNTDDQEWTCVYEFQEGAPVRPVSPRCSLRLTHYIEEANVGRGYIKELCFSPDGRMISSPHGYGIRLLGFDKQCSELVDCLPKEASPLRVIRSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLYQPKF" } }, { "url": "https://www.uniprot.org/uniprot/A2AKB9#A2AKB9-4", "isoform_ac": "A2AKB9-4", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A2AKB9-4|DCA10_MOUSE Isoform 4 of DDB1- and CUL4-associated factor 10 OS=Mus musculus OX=10090 GN=Dcaf10 PE=1 SV=1 CANONICAL=A2AKB9-1", "length": 225, "sequence": "MFPFGPHSPGGDETAGAEEPPPLGGPAAASRPPSPAPRPASPQRGADAASPPPVAGSPRLPGGPAVSPAERAGEFAAPGALELSAATASASQAKLSPSSSPRRRSRPDWRAGGRSRQGLGAGLGGPGARLFGWLRERSLGRGLFVDPARDNFRTMTNLYGSIHPADSVYLSTRTHGAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLSEAHEDCVNNIR" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:242418", "resource": "KEGG Pathway", "id": "mmu:242418", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8951664", "resource": "Reactome", "id": "R-MMU-8951664", "name": "Neddylation" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2AKB9#function", "annotation": "May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKB9#function", "id": "A2AKB9", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "D4A8G6-1", "protein_name": "WD repeat domain 32 (Predicted); DDB1 and CUL4-associated factor 10.", "sequence": { "length": 563, "sequence": "MFPFGPHSPGGDGAAGAEEPPPLGGPAAASRPPSPAPRPASPQRGADAASPPPATGSPRLRGSPAVSPAERAGELAAPEALELSAAASQAELSPSSSPRRRSRPDCKAGSWSRQGLSAGLGGPGARLFGWLRERSLGRGLFVDPARDNFRTMTNLYGSIHPADSVYLSTRTHGAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLSEAHEDCVNNIRFLDNRLFATCSDDTTIALWDLRKLNTKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTNRCTEDGCPHKKFFHTRFLMRMRLTPDCSKMLISTSSGYLLILHDLDLTKSLEVGSYPILRARRTTSSSDLTTSSSSSGSRVSGSPCHHNDSNSTEKHVSRASQREGVSPRNSLEVLTPEVPGERDRGNCITSLQLHPKGWATLLRCSSNTDDQEWTCVYEFQEGAPVRPVSPRCSLRLTHYIEEANVGRGYIKELCFSPDGRMISSPHGYGIRLLGFDKQCSELVDCLPKEASPLRVIRSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLYQPKF" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/32581", "id": "32581", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2AKB9/", "id": "A2AKB9", "database": "OMA" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q5QP82-1", "protein_name": "DDB1- and CUL4-associated factor 10; WD repeat-containing protein 32.", "sequence": { "length": 559, "sequence": "MFPFGPHSPGGDGSAGAGAEEPTPHEGQAAATGPPSPLHPGADATHPPPPARSPRRPGAPSLSPAPRSGELGLPGAPESSTASAPGEPSPPSPPCRRPGPDCRAKSRGRHGLGAGLGGPGARLFGWLKERSLGRGLFVDPARDNFRTMTSLYGSIHPADSVYLSTRTHGAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLSEAHEDCVNNIRFLDNRLFATCSDDTTIALWDLRKLNTKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTNRYTEDGCPHKKFFHTRFLMRMRLTPDCSKMLISTSSGYLLILHDLDLTKSLEVGSYPILRARRTTSSSDLTTSSSSSGPRVSGSPCHHSDSNSSEKHMSRASQREGVSPRNSLEVVTPEVLGESDHGNCITSLQLHPKGWATLLRCSSNSDDEECTCVYEFQEGAPVRPVSPRCSLRLTHYIEEANVGRGYIKELCFSPDGRMISSPHGYGIRLLGFDKQCSELVDCLPKEASPLRVIRSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLYQPKF" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/32581", "id": "32581", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2AKB9/", "id": "A2AKB9", "database": "OMA" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694807.2", "ac": "NP_694807.2", "name": "DDB1- and CUL4-associated factor 10; WD repeat domain 32; WD repeat-containing protein 32.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0080008", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKB9", "id": "A2AKB9", "database": "UniProtKB" } ], "name": "Cul4-RING E3 ubiquitin ligase complex", "id": "GO:0080008" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKB9", "id": "A2AKB9", "database": "UniProtKB" } ], "name": "protein ubiquitination", "id": "GO:0016567" } ], "total": 1, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 381, "annotation": "n_glycosylation_sequon", "start_pos": 379 }, { "end_pos": 384, "annotation": "n_glycosylation_sequon", "start_pos": 382 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694807.2", "id": "NP_694807.2", "database": "RefSeq" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8951664", "id": "R-MMU-8951664", "database": "Reactome" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:242418", "id": "mmu:242418", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000035572", "id": "ENSMUSG00000035572", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/CHHNDSN/", "id": "CHHNDSN", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "id": "IPR001680", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "id": "IPR015943", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017986", "id": "IPR017986", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "id": "IPR019775", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "id": "IPR036322", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000772", "id": "IPR000772", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR039085", "id": "IPR039085", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00400", "id": "PF00400", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14588", "id": "PTHR14588", "database": "PANTHER" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2AKB9", "id": "PR_A2AKB9", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/242418", "id": "242418", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:2140179", "id": "2140179", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A2AKB9", "disease": [], "mass": { "monoisotopic_mass": 61558.0, "chemical_mass": 61558.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AKB9", "name": "Dcaf10; Wdr32; AA959934.", "locus": { "end_pos": 45379759, "start_pos": 45342101, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000035572", "id": "ENSMUSG00000035572", "database": "Ensembl Gene" } ] } } ] }