{ "uniprot_canonical_ac": "A2AJ88-1", "sequence": { "header": "sp|A2AJ88-1|PLPL7_MOUSE Isoform 1 of Patatin-like phospholipase domain-containing protein 7 OS=Mus musculus OX=10090 GN=Pnpla7 PE=1 SV=1 CANONICAL=A2AJ88-1", "length": 1352, "sequence": "MQNEEDACLEAGYCLGTTLSSWRLHFMEEQSQSTMLMGIGIGALLTLAFVGITFFFVYRRVRRLRRAEPTPQYRFRKRDKVMFYGRKIMRKVTTLPHTLVGNTSAPRQRVRKRTKVLSLAKRILRFKKEYPTLQPKEPPPSLLEADLTEFDVKNSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHMVFVQLQEGEHVFQPGEPDISIYVVQDGRLEVCIQDADGTEVVVKEVLPGDSVHSLLSILDVITGHTAPYKTVSARAAVSSTVLWLPAAAFQGVFEKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTELFNPESQAIPLLSVASVAGRAKRQMSYGPEEQLERSLRPSEFSSSDHGSSCVTVSGPLLKRSCSVPLPSNHGEVDELRQSQGSGSNTSAFQESHEGATSDLGMAYNRARILPHSDEQLGNSLASKSKKSVVAETPSAIFHYSENFRDETGACGKTDAIFRAATKDLLTLMKLDDPSLLDGRVAFLHVPAGTLVSKQGDQDVNILFVVSGMLHVYQQKIDSLEDTCLFLTHPGEMVGQLAVLTGEPLMFTIRANRDCSFLSISKAHFYEIMRKRPDVVLGVAHTVVKRMSSFVRQIDFALDWMEVEAGRAIYRQGDKSDCTYIVLSGRLRSVIRKDDGKKRLAGEYGRGDLVGVVETLTHQARATTVHAVRDSELAKLPAGALTSIKRRYPQVVTRLIHLLGEKILGSLQQGSATGHQLGFNTASSKWDLGNPPGNLSTVAALPASEDVPLTAFALELQHALSAIGPVLLLTSDNIKQRLGSAALDSIHEYRLSSWLGQQEDIHRIVLYQADGTLTPWTQRCIRQADCILIVGLGEQEPAVGELEQMLESTAVRAQKQLILLHKEDGPVPSRTVEWLNMRSWCSGHLHLCCPRRVFSKRSLPKLVEMYTRVFQRPPDRHSDFSRLARMLTGNAIALVLGGGGARGCAQVGILRALAECGVPVDIIGGTSIGAFMGALFAEERSYSQTRIRAKQWAEGMTSMMKTILDLTYPITSMFSGTGFNSSISNIFKDRQIEDLWLPYFAITTDITASAMRVHTDGSLWRYVRASMSLSGYMPPLCDPKDGHLLMDGGYINNLPADVARSMGAKVVIAIDVGSRDETDLTNYGDALSGWWLLWKRWNPLATKVKVLNMAEIQTRLAYVCCVRQLEMVKNSDYCEYLRPPIDSYRTLDFGKFDEICEVGYQHGRTVFDIWVRSGVLEKMLQDQQGTSKRKDCGVFTCPNSSFTDLAEIVSRIEPAKVAAVDDESDYQTEYEEELPAIPKETYADFQSTGIELDSDSEYEPSMLQGPPSLTSPEQSQDSFPWLPNQDDQGPRLEHPS" }, "uniprot_id": "PLPL7_MOUSE", "enzyme_annotation": [ { "ec": "3.1.1.-", "activity": "" } ], "synonyms": { "protein": { "refseq": [ "patatin-like phospholipase domain-containing protein 7", "NTE-related esterase; neuropathy target esterase-related esterase" ], "uniprotkb": [ "Patatin-like phospholipase domain-containing protein 7", "3.1.1.-", "Neuropathy target esterase-related esterase", "NRE", "NTE-related esterase" ] }, "gene": { "refseq": [ "Pnpla7", "BC027342", "E430013P11Rik", "Nre" ], "uniprotkb": [ "Pnpla7", "BC027342", "E430013P11Rik", "Nre" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88", "id": "A2AJ88", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Patatin-like phospholipase domain-containing protein 7; 3.1.1.-; Neuropathy target esterase-related esterase; NRE; NTE-related esterase." }, "publication": [ { "title": "Identification of two novel splicing variants of murine NTE-related esterase.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22326266", "journal": "Gene", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666363.3", "id": "NP_666363.3", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2AJ88/publications", "id": "A2AJ88", "database": "UniProtKB" } ], "authors": "Chang PA, Wang ZX, Long DX, Qin WZ, Wei CY, Wu YJ", "date": "2012", "pmid": "22326266" }, { "title": "Degradation of mouse NTE-related esterase by macroautophagy and the proteasome.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/22307796", "journal": "Molecular biology reports", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666363.3", "id": "NP_666363.3", "database": "RefSeq" } ], "authors": "Chang PA, Chen YY, Long DX, Qin WZ, Mou XL", "date": "2012", "pmid": "22307796" }, { "title": "Identification of an insulin-regulated lysophospholipase with homology to neuropathy target esterase.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/18086666", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666363.3", "id": "NP_666363.3", "database": "RefSeq" } ], "authors": "Kienesberger PC, Lass A, Preiss-Landl K, Wolinski H, Kohlwein SD, Zimmermann R, Zechner R", "date": "2008", "pmid": "18086666" }, { "title": "Identification and characterization of a splice variant of the catalytic domain of mouse NTE-related esterase.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/18486363", "journal": "Gene", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666363.3", "id": "NP_666363.3", "database": "RefSeq" } ], "authors": "Chang PA, Long DX, Sun Q, Wang Q, Bu YQ, Wu YJ", "date": "2008", "pmid": "18486363" }, { "title": "Large-scale phosphorylation analysis of mouse liver.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17242355", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88/publications", "id": "A2AJ88", "database": "UniProtKB" } ], "authors": "Beausoleil S.A., Gerber S.A., Gygi S.P., Villen J.", "date": "2007", "pmid": "17242355" }, { "title": "Genomic analysis of mouse retinal development.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/15226823", "journal": "PLoS biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666363.3", "id": "NP_666363.3", "database": "RefSeq" } ], "authors": "Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL", "date": "2004", "pmid": "15226823" }, { "title": "BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/12520002", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666363.3", "id": "NP_666363.3", "database": "RefSeq" } ], "authors": "Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE", "date": "2003", "pmid": "12520002" }, { "title": "Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/12640454", "journal": "Nature genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666363.3", "id": "NP_666363.3", "database": "RefSeq" } ], "authors": "Winrow CJ, Hemming ML, Allen DM, Quistad GB, Casida JE, Barlow C", "date": "2003", "pmid": "12640454" } ], "glycosylation": [ { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88", "id": "A2AJ88", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 1036, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88", "id": "A2AJ88", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 401, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88", "id": "A2AJ88", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 750, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88", "id": "A2AJ88", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 102, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88", "id": "A2AJ88", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ], "relation": "attached", "position": 1255, "glytoucan_ac": "", "type": "N-linked" } ], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88#A2AJ88-1", "isoform_ac": "A2AJ88-1", "locus": { "end_pos": 24976284, "start_pos": 25053790, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000045295", "id": "ENSMUST00000045295", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000044078", "id": "ENSMUSP00000044078", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AJ88-1|PLPL7_MOUSE Isoform 1 of Patatin-like phospholipase domain-containing protein 7 OS=Mus musculus OX=10090 GN=Pnpla7 PE=1 SV=1 CANONICAL=A2AJ88-1", "length": 1352, "sequence": "MQNEEDACLEAGYCLGTTLSSWRLHFMEEQSQSTMLMGIGIGALLTLAFVGITFFFVYRRVRRLRRAEPTPQYRFRKRDKVMFYGRKIMRKVTTLPHTLVGNTSAPRQRVRKRTKVLSLAKRILRFKKEYPTLQPKEPPPSLLEADLTEFDVKNSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHMVFVQLQEGEHVFQPGEPDISIYVVQDGRLEVCIQDADGTEVVVKEVLPGDSVHSLLSILDVITGHTAPYKTVSARAAVSSTVLWLPAAAFQGVFEKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTELFNPESQAIPLLSVASVAGRAKRQMSYGPEEQLERSLRPSEFSSSDHGSSCVTVSGPLLKRSCSVPLPSNHGEVDELRQSQGSGSNTSAFQESHEGATSDLGMAYNRARILPHSDEQLGNSLASKSKKSVVAETPSAIFHYSENFRDETGACGKTDAIFRAATKDLLTLMKLDDPSLLDGRVAFLHVPAGTLVSKQGDQDVNILFVVSGMLHVYQQKIDSLEDTCLFLTHPGEMVGQLAVLTGEPLMFTIRANRDCSFLSISKAHFYEIMRKRPDVVLGVAHTVVKRMSSFVRQIDFALDWMEVEAGRAIYRQGDKSDCTYIVLSGRLRSVIRKDDGKKRLAGEYGRGDLVGVVETLTHQARATTVHAVRDSELAKLPAGALTSIKRRYPQVVTRLIHLLGEKILGSLQQGSATGHQLGFNTASSKWDLGNPPGNLSTVAALPASEDVPLTAFALELQHALSAIGPVLLLTSDNIKQRLGSAALDSIHEYRLSSWLGQQEDIHRIVLYQADGTLTPWTQRCIRQADCILIVGLGEQEPAVGELEQMLESTAVRAQKQLILLHKEDGPVPSRTVEWLNMRSWCSGHLHLCCPRRVFSKRSLPKLVEMYTRVFQRPPDRHSDFSRLARMLTGNAIALVLGGGGARGCAQVGILRALAECGVPVDIIGGTSIGAFMGALFAEERSYSQTRIRAKQWAEGMTSMMKTILDLTYPITSMFSGTGFNSSISNIFKDRQIEDLWLPYFAITTDITASAMRVHTDGSLWRYVRASMSLSGYMPPLCDPKDGHLLMDGGYINNLPADVARSMGAKVVIAIDVGSRDETDLTNYGDALSGWWLLWKRWNPLATKVKVLNMAEIQTRLAYVCCVRQLEMVKNSDYCEYLRPPIDSYRTLDFGKFDEICEVGYQHGRTVFDIWVRSGVLEKMLQDQQGTSKRKDCGVFTCPNSSFTDLAEIVSRIEPAKVAAVDDESDYQTEYEEELPAIPKETYADFQSTGIELDSDSEYEPSMLQGPPSLTSPEQSQDSFPWLPNQDDQGPRLEHPS" } }, { "url": "https://www.uniprot.org/uniprot/A2AJ88#A0A0A6YWJ6-1", "isoform_ac": "A0A0A6YWJ6-1", "locus": { "end_pos": 24980082, "start_pos": 24987191, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000137913", "id": "ENSMUST00000137913", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000141577", "id": "ENSMUSP00000141577", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0A6YWJ6-1|PLPL7_MOUSE Computationally mapped isoform of Patatin-like phospholipase domain-containing protein 7 OS=Mus musculus OX=10090 GN=Pnpla7 PE=1 SV=1 CANONICAL=A2AJ88-1", "length": 222, "sequence": "MEEQSQSTMLMGIGIGALLTLAFVGITFFFVYRRVRRLRRAEPTPQYRFRKRDKVMFYGRKIMRKVTTLPHTLVGNTSAPRQRVRKRTKVLSLAKRILRFKKEYPTLQPKEPPPSLLEADLTEFDVKNSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHMVFVQLQEGEHVFQPGEPDISIYVVQDGRLEVCIQDAHRMAPKWWSKRSCQGTVSTVSSAFWM" } }, { "url": "https://www.uniprot.org/uniprot/A2AJ88#A2AJ88-2", "isoform_ac": "A2AJ88-2", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A2AJ88-2|PLPL7_MOUSE Isoform 2 of Patatin-like phospholipase domain-containing protein 7 OS=Mus musculus OX=10090 GN=Pnpla7 PE=1 SV=1 CANONICAL=A2AJ88-1", "length": 1326, "sequence": "MQNEEDACLEAGYCLGTTLSSWRLHFMEEQSQSTMLMGIGIGALLTLAFVGITFFFVYRRVRRLRRAEPTPQYRFRKRDKVMFYGRKIMRKVTTLPHTLVGNTSAPRQRVRKRTKVLSLAKRILRFKKEYPTLQPKEPPPSLLEADLTEFDVKNSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHMVFVQLQEGEHVFQPGEPDISIYVVQDGRLEVCIQDADGTEVVVKEVLPGDSVHSLLSILDVITGHTAPYKTVSARAAVSSTVLWLPAAAFQGVFEKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTELFNPESQAIPLLSVASVAGRAKRQMSYGPEEQLERSLRPSEFSSSDHGSSCVTVSGPLLKRSCSVPLPSNHGEVDELRQSQGSGSNTSAFQESHEGATSDLGMAYNRARILPHSDEQLGNSLASKSKKSVVAETPSAIFHYSENFRDETGACGKTDAIFRAATKDLLTLMKLDDPSLLDGRVAFLHVPAGTLVSKQGDQDVNILFVVSGMLHVYQQKIDSLEDTCLFLTHPGEMVGQLAVLTGEPLMFTIRANRDCSFLSISKAHFYEIMRKRPDVVLGVAHTVVKRMSSFVRQIDFALDWMEVEAGRAIYRQGDKSDCTYIVLSGRLRSVIRKDDGKKRLAGEYGRGDLVGVVETLTHQARATTVHAVRDSELAKLPAGALTSIKRRYPQVVTRLIHLLGEKILGSLQQGSATGHQLGFNTASSKWDLGNPPGNLSTVAALPASEDVPLTAFALELQHALSAIGPVLLLTSDNIKQRLGSAALDSIHEYRLSSWLGQQEDIHRIVLYQADGTLTPWTQRCIRQADCILIVGLGEQEPAVGELEQMLESTAVRAQKQLILLHKEDGPVPSRTVEWLNMRSWCSGHLHLCCPRRVFSKRSLPKLVEMYTRVFQRPPDRHSDFSRLARMLTGNAIALVLGGGGARGCAQVGILRALAECGVPVDIIGGTSIGAFMGALFAEERSYSQTRIRAKQWAEGMTSMMKTILDLTYPITSMFSGTGFNSSISNIFKDRQIEDLWLPYFAITTDITASAMRVHTDGSLWRYVRASMSLSGYMPPLCDPKDGHLLMDGGYINNLPADVARSMGAKVVIAIDVGSRDETDLTNYGDALSGWWLLWKRWNPLATKVKVLNMAEIQTRLAYVCCVRQLEMVKNSDYCEYLRPPIDSYRTLDFGKFDEICEVGYQHGRTVFDIWVRSGVLEKMLQDQQGTSKRKDCGVFTCPNSSFTDLAEIVSRIEPAKVAAVDDESDYQTEYEEELPAIPKETYADFQSTGIELDSDSVRNMSLRCCKDPPA" } }, { "url": "https://www.uniprot.org/uniprot/A2AJ88#B0R010-1", "isoform_ac": "B0R010-1", "locus": { "end_pos": 24980763, "start_pos": 24995310, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000152777", "id": "ENSMUST00000152777", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000122394", "id": "ENSMUSP00000122394", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|B0R010-1|PLPL7_MOUSE Computationally mapped isoform of Patatin-like phospholipase domain-containing protein 7 OS=Mus musculus OX=10090 GN=Pnpla7 PE=1 SV=1 CANONICAL=A2AJ88-1", "length": 179, "sequence": "MFYGRKIMRKVTTLPHTLVGNTSAPRQRVRKRTKVLSLAKRILRFKKEYPTLQPKEPPPSLLEADLTEFDVKNSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHMVFVQLQEGEHVFQPGEPDISIYVVQDGRLEVCIQDADGTEVVVKEVLPGDSVHSLLSILDVITGHTAPYKTVSA" } }, { "url": "https://www.uniprot.org/uniprot/A2AJ88#A2AJ88-3", "isoform_ac": "A2AJ88-3", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "", "evidence": [] }, "sequence": { "header": "sp|A2AJ88-3|PLPL7_MOUSE Isoform 3 of Patatin-like phospholipase domain-containing protein 7 OS=Mus musculus OX=10090 GN=Pnpla7 PE=1 SV=1 CANONICAL=A2AJ88-1", "length": 833, "sequence": "MQNEEDACLEAGYCLGTTLSSWRLHFMEEQSQSTMLMGIGIGALLTLAFVGITFFFVYRRVRRLRRAEPTPQYRFRKRDKVMFYGRKIMRKVTTLPHTLVGNTSAPRQRVRKRTKVLSLAKRILRFKKEYPTLQPKEPPPSLLEADLTEFDVKNSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHMVFVQLQEGEHVFQPGEPDISIYVVQDGRLEVCIQDADGTEVVVKEVLPGDSVHSLLSILDVITGHTAPYKTVSARAAVSSTVLWLPAAAFQGVFEKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTELFNPESQAIPLLSVASVAGRAKRQMSYGPEEQLERSLRPSEFSSSDHGSSCVTVSGPLLKRSCSVPLPSNHGEVDELRQSQGSGSNTSAFQESHEGATSDLGMAYNRARILPHSDEQLGNSLASKSKKSVVAETPSAIFHYSENFRDETGACGKTDAIFRAATKDLLTLMKLDDPSLLDGRVAFLHVPAGTLVSKQGDQDVNILFVVSGMLHVYQQKIDSLEDTCLFLTHPGEMVGQLAVLTGEPLMFTIRANRDCSFLSISKAHFYEIMRKRPDVVLGVAHTVVKRMSSFVRQIDFALDWMEVEAGRAIYRQGDKSDCTYIVLSGRLRSVIRKDDGKKRLAGEYGRGDLVGVVETLTHQARATTVHAVRDSELAKLPAGALTSIKRRYPQVVTRLIHLLGEKILGSLQQGSATGHQLGFNTASSKWDLGNPPGNLSTVAALPASEDVPLTAFALELQHALSAIASMSTGSPVGWASRRTSNGLCCIRQTAHSHRGPSAASGRLTASSSWAWVSKSQQ" } }, { "url": "https://www.uniprot.org/uniprot/A2AJ88#B0R009-1", "isoform_ac": "B0R009-1", "locus": { "end_pos": 24979874, "start_pos": 24981868, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000153618", "id": "ENSMUST00000153618", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000117428", "id": "ENSMUSP00000117428", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|B0R009-1|PLPL7_MOUSE Computationally mapped isoform of Patatin-like phospholipase domain-containing protein 7 OS=Mus musculus OX=10090 GN=Pnpla7 PE=1 SV=1 CANONICAL=A2AJ88-1", "length": 120, "sequence": "MPGLLSCLAGYCLGTTLSSWRLHFMEEQSQSTMLMGIGIGALLTLAFVGITFFFVYRRVRRLRRAEPTPQYRFRKRDKVMFYGRKIMRKVTTLPHTLVGNTSAPRQRVRKRTKVLSLAKR" } }, { "url": "https://www.uniprot.org/uniprot/A2AJ88#B0R011-1", "isoform_ac": "B0R011-1", "locus": { "end_pos": 24996157, "start_pos": 25010743, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000146153", "id": "ENSMUST00000146153", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000117907", "id": "ENSMUSP00000117907", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|B0R011-1|PLPL7_MOUSE Computationally mapped isoform of Patatin-like phospholipase domain-containing protein 7 OS=Mus musculus OX=10090 GN=Pnpla7 PE=1 SV=1 CANONICAL=A2AJ88-1", "length": 187, "sequence": "IIMVRLQRVTFLALHNYLGLTTELFNPESQAIPLLSVASVAGRAKRQMSYGPEEQLERSLRPSEFSSSVPLPSNHGEVDELRQSQGSGSNTSAFQESHEGATSDLGMAYNRARILPHSDEQLGNSLASKSKKSVVAETPSAIFHYSENFRDETGACGKTDAIFRAATKDLLTLMKLDDPSLLDGRVA" } }, { "url": "https://www.uniprot.org/uniprot/A2AJ88#F6UDU9-1", "isoform_ac": "F6UDU9-1", "locus": { "end_pos": 25051666, "start_pos": 25053031, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000155601", "id": "ENSMUST00000155601", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000115952", "id": "ENSMUSP00000115952", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F6UDU9-1|PLPL7_MOUSE Computationally mapped isoform of Patatin-like phospholipase domain-containing protein 7 OS=Mus musculus OX=10090 GN=Pnpla7 PE=1 SV=1 CANONICAL=A2AJ88-1", "length": 158, "sequence": "TDLTNYGDALSGWWLLWKRWNPLATKVKVLNMAEIQTRLAYVCCVRQLEMVKNSDYCEYLRPPIDSYRTLDFGKFDEICEVGYQHGRTVFDIWVRSGVLEKMLQDQQGTSKRKDCGVFTCPNSSFTDLAEIVSRIEPAKVAAVDEQHVLQNSLLHVPS" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:241274", "resource": "KEGG Pathway", "id": "mmu:241274", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88#function", "annotation": "Serine hydrolase, whose specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy (By similarity). Isoform 1 and isoform 2 have equal enzyme activity. Isoform 3 has no enzyme activity.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88#function", "id": "A2AJ88", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666363.3", "annotation": "The transmembrane and regulatory domain played a role in the degradation of mouse NTE-related esterase by macroautophagy and the proteasome respectively.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666363.3", "id": "NP_666363.3", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666363.3", "annotation": "There was a nutritional regulation of murine NTE-related esterase expression at the mRNA levels via alternative splicing.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666363.3", "id": "NP_666363.3", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666363.3", "annotation": "A splice variant of the catalytic domain of mouse NRE (mNRECV) was identified in multiple adult tissues, including brain, kidney, liver and testis.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666363.3", "id": "NP_666363.3", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q6ZV29-1", "protein_name": "Patatin-like phospholipase domain-containing protein 7; 3.1.1.-.", "sequence": { "length": 1317, "sequence": "MEEEKDDSPQLTGIAVGALLALALVGVLILFMFRRLRQFRQAQPTPQYRFRKRDKVMFYGRKIMRKVTTLPNTLVENTALPRQRARKRTKVLSLAKRILRFKKEYPALQPKEPPPSLLEADLTEFDVKNSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHIVFVQLQEGEHVFQPREPDPSICVVQDGRLEVCIQDTDGTEVVVKEVLAGDSVHSLLSILDIITGHAAPYKTVSVRAAIPSTILRLPAAAFHGVFEKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTELFNAESQAIPLVSVASVAAGKAKKQVFYGEEERLKKPPRLQESCDSDHGGGRPAAAGPLLKRSHSVPAPSIRKQILEELEKPGAGDPDPSAPQGGPGSATSDLGMACDRARVFLHSDEHPGSSVASKSRKSVMVAEIPSTVSQHSESHTDETLASRKSDAIFRAAKKDLLTLMKLEDSSLLDGRVALLHVPAGTVVSRQGDQDASILFVVSGLLHVYQRKIGSQEDTCLFLTRPGEMVGQLAVLTGEPLIFTVKANRDCSFLSISKAHFYEIMRKQPTVVLGVAHTVVKRMSSFVRQIDFALDWVEVEAGRAIYRQGDKSDCTYIMLSGRLRSVIRKDDGKKRLAGEYGRGDLVGVVETLTHQARATTVHAVRDSELAKLPAGALTSIKRRYPQVVTRLIHLLGEKILGSLQQGPVTGHQLGLPTEGSKWDLGNPAVNLSTVAVMPVSEEVPLTAFALELEHALSAIGPTLLLTSDNIKRRLGSAALDSVHEYRLSSWLGQQEDTHRIVLYQADGTLTPWTQRCVRQADCILIVGLGDQEPTVGELERMLESTAVRAQKQLILLHREEGPAPARTVEWLNMRSWCSGHLHLCCPRRVFSRRSLPKLVEMYKHVFQRPPDRHSDFSRLARVLTGNAIALVLGGGGARGCAQVGVLKALAECGIPVDMVGGTSIGAFVGALYSEERNYSQMRIRAKQWAEGMTSLMKAALDLTYPITSMFSGAGFNSSIFSVFKDQQIEDLWIPYFAITTDITASAMRVHTDGSLWWYVRASMSLSGYMPPLCDPKDGHLLMDGGYINNLPADVARSMGAKVVIAIDVGSRDETDLTNYGDALSGWWLLWKRWNPLATKVKVLNMAEIQTRLAYVCCVRQLEVVKSSDYCEYLRPPIDSYSTLDFGKFNEICEVGYQHGRTVFDIWGRSGVLEKMLRDQQGPSKKPASAVLTCPNASFTDLAEIVSRIEPAKPAMVDDESDYQTEYEEELLDVPRDAYADFQSTSAQQGSDLEDESSLRHRHPSLAFPKLSEGSSDQDG" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/62431", "id": "62431", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q5BK26-1", "protein_name": "Patatin-like phospholipase domain-containing protein 7; 3.1.1.-; Liver NTE-related protein 1; NTE-related esterase.", "sequence": { "length": 1349, "sequence": "MQKEEDVCPEAGYCLGTALSSWGLHFMEEHSQSTMLMGIGIGVLLTLAFVGLAAFFVYRKVSRFRRAEPIPQYRFRKRDKVMFYGRKIMRKVTTLPHTLVGNTAAPRQRVRKRTKVLSLAKRILRFKKEYPTLQPKEPPPSLLEADLTEFDVKNSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHMVFVQLQEGEHVFQPGEPDISIYVVQDGRLEVCIQDADGTEVVVKEVLPGDSVHSLLSILDVITGHTAPYKTVSARAAVASTVLWLPAAAFQGVFEKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTELFNPESQAIPLLSVASVAGRAKRQMSYGPEEQLERSPRLSEFNSSDQRSVAVSGPLLKRSCSVPLPPIHGEIDELRQAQGSGSNTSAFQESQEGATSDLGMAYNRARILPHSEEQLGSSLASKSKKSVVAETSAVFHYSEKPRDEPGPSGRTDAIFRAATKDLLTLMKLDDPSLLDGRVAFLHVPAGTIVSKQGDQDVNILFVVSGMLHVYQQKIDSLEDTCLFLTHPGEMVGQLAVLTGEPLMFTIRANRDCSFLSISKAHFYEIMRKRPDVVLGVAHTVVRRMSSFVRQIDFALDWMEVEAGRAIYRQGDKSDCTYIVLSGRLRSVIRKDDGKKRLAGEYGRGDLVGVVEMLTHQARATTVHAVRDSELAKLPAGALTSIKRRYPQVVTRLIHLLGEKILGSLQQGSGTGHQLGFNTASSKWDLGNPPGNLSTVAAMPVSEDVPLTAFALELQHALSAIGPVLLLTSDNIKQRLGSAALDSIHEYRLSSWLGQQEDIHRIVLYQADSTLTPWTQRCIRQADCILIVGLGDQEPALGELEQMLESTAVRAQKQLILLHKEEGPAPSRTVEWLNMRSWCSGHLHLCCPRRVFSKRSLPKLVEMYTRIFQRPPDRHSDFSRLARILTGNAIALVLGGGGARGCAQVGILRALAECGIPVDIIGGTSIGAFMGALFAEERSYSQIRIRAKQWAEDMTSMVKTILDLTYPITSMFSGTGFNSSISNIFKDRQIEDLWLPYFAITTDITASAMRVHTDGALWRYVRASMSLSGYMPPLCDPKDGHLLMDGGYINNLPADVARSMGAKVVIAIDVGSRDETDLTNYGDALSGWWLLWKRWNPLATKVKVLNMAEIQTRLAYVCCVRQLEMVKNSDYCEYLRPPIDSYRTLDFGKFDEICEVGYQHGPAGFDIWVRSGVLEKMLQDQQGTSKRMDCGVFTCPNSSFTDLAEIVSRIEPAKVAAVDDESDYQTEYEEELPAIPKETYADFQSTGIELDSDSECEPSMSQGPHSLTSPKQSQDSFPWLPNQDDQGPRLYRPS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/62431", "id": "62431", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666363.3", "ac": "NP_666363.3", "name": "patatin-like phospholipase domain-containing protein 7; NTE-related esterase; neuropathy target esterase-related esterase.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004622", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88", "id": "A2AJ88", "database": "UniProtKB" } ], "name": "lysophospholipase activity", "id": "GO:0004622" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052689", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88", "id": "A2AJ88", "database": "UniProtKB" } ], "name": "carboxylic ester hydrolase activity", "id": "GO:0052689" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88", "id": "A2AJ88", "database": "UniProtKB" } ], "name": "endoplasmic reticulum", "id": "GO:0005783" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88", "id": "A2AJ88", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88", "id": "A2AJ88", "database": "UniProtKB" } ], "name": "nuclear membrane", "id": "GO:0031965" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88", "id": "A2AJ88", "database": "UniProtKB" } ], "name": "mitochondrial membrane", "id": "GO:0031966" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88", "id": "A2AJ88", "database": "UniProtKB" } ], "name": "lysosomal membrane", "id": "GO:0005765" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88", "id": "A2AJ88", "database": "UniProtKB" } ], "name": "endoplasmic reticulum membrane", "id": "GO:0005789" } ], "total": 6, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016042", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88", "id": "A2AJ88", "database": "UniProtKB" } ], "name": "lipid catabolic process", "id": "GO:0016042" } ], "total": 1, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 104, "annotation": "n_glycosylation_sequon", "start_pos": 102 }, { "end_pos": 403, "annotation": "n_glycosylation_sequon", "start_pos": 401 }, { "end_pos": 752, "annotation": "n_glycosylation_sequon", "start_pos": 750 }, { "end_pos": 1038, "annotation": "n_glycosylation_sequon", "start_pos": 1036 }, { "end_pos": 1257, "annotation": "n_glycosylation_sequon", "start_pos": 1255 } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666363.3", "id": "NP_666363.3", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:241274", "id": "mmu:241274", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000036833", "id": "ENSMUSG00000036833", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/YPKATAH/", "id": "YPKATAH", "database": "OMA" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00038", "id": "cd00038", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR014710", "id": "IPR014710", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002641", "id": "IPR002641", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR016035", "id": "IPR016035", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000595", "id": "IPR000595", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR018490", "id": "IPR018490", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF01734", "id": "PF01734", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00027", "id": "PF00027", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2AJ88", "id": "PR_A2AJ88", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/241274", "id": "241274", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:2385325", "id": "2385325", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A2AJ88", "disease": [], "mass": { "monoisotopic_mass": 150494.0, "chemical_mass": 150494.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88", "name": "Pnpla7; BC027342; E430013P11Rik; Nre.", "locus": { "end_pos": 25054057, "start_pos": 24976033, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000036833", "id": "ENSMUSG00000036833", "database": "Ensembl Gene" } ] } } ] }