{ "uniprot_canonical_ac": "A2AJ15-1", "sequence": { "header": "sp|A2AJ15-1|MA1B1_MOUSE Isoform 1 of Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase OS=Mus musculus OX=10090 GN=Man1b1 PE=1 SV=1 CANONICAL=A2AJ15-1", "length": 658, "sequence": "MYPPPAPPPAPHRDFISVTLSLGESYDNSKSRRRRSCWRKWKQLSRLQRNVILFVLGFLILCGFLYSLHTADQWKALSGRPAEVEKMKQEVLPVLPAPQKESAEQEGFADILSQKRQRHFRRGPPHLQIRPPNTVSKDGMQDDAKEREAALGKAQQEENTQRTVISWRGAVIEPEQATELPYKRAEASIKPLVLASKIWKEPAPPNERQKGVIEAFLHAWKGYQKFAWGHDELKPVSKTFSEWFGLGLTLIDALDTMWILGLKQEFKQARKWVSENLDFQKNVDVNLFESTIRILGGLLSTYHLSGDSLFLTKAEDFGKRLMPAFTTPSKIPYSDVNIGTGFAHSPQWTSDSTVAEVTSIQLEFRELSRLTGIKKFQEAVEEVTKHIHSLSGKKDGLVPMFINTNSGLFTHPGVFTLGARADSYYEYLLKQWIQGGKKETQLLEDYVKAIEGIKAHLLRQSQPRKLTFVGELAHGRFSAKMDHLVCFLPGTLALGVHHGLPADHMDLARALMETCYQMNQQMETGLSPEIAHFNMYPRADHKDVEVKPADRHNLLRPETVESLFYLYRVTRDRKYQDWGWEILQSFNKYTRVPSGGYSSINNVQNSHKPEPRDKMESFFVGETLKYLYLLFSDDLELLSLDSCVFNTEAHPLPIWAPA" }, "uniprot_id": "MA1B1_MOUSE", "enzyme_annotation": [ { "ec": "3.2.1.113", "activity": "Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2)." }, { "ec": "3.2.1.113", "activity": "" } ], "synonyms": { "protein": { "refseq": [ "endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase", "ER mannosidase 1; ER alpha-1,2-mannosidase; man9GlcNAc2-specific-processing alpha-mannosidase" ], "uniprotkb": [ "Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase", "3.2.1.113", "ER mannosidase 1", "ERMan1", "Mannosidase alpha class 1B member 1", "ER alpha-1,2-mannosidase", "Man9GlcNAc2-specific-processing alpha-mannosidase" ] }, "gene": { "refseq": [ "Man1b1", "E430019H13Rik", "ERMan1", "Gm108", "MANA-ER" ], "uniprotkb": [ "Man1b1", "E430019H13Rik", "ERMan1", "Gm108", "MANA-ER" ] } }, "keywords": [ "glycohydrolase-activity" ], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ15", "id": "A2AJ15", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; 3.2.1.113; ER mannosidase 1; ERMan1; Mannosidase alpha class 1B member 1; ER alpha-1,2-mannosidase; Man9GlcNAc2-specific-processing alpha-mannosidase." }, "publication": [], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AJ15#A2AJ15-1", "isoform_ac": "A2AJ15-1", "locus": { "end_pos": 25332860, "start_pos": 25350562, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000042390", "id": "ENSMUST00000042390", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000036996", "id": "ENSMUSP00000036996", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AJ15-1|MA1B1_MOUSE Isoform 1 of Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase OS=Mus musculus OX=10090 GN=Man1b1 PE=1 SV=1 CANONICAL=A2AJ15-1", "length": 658, "sequence": "MYPPPAPPPAPHRDFISVTLSLGESYDNSKSRRRRSCWRKWKQLSRLQRNVILFVLGFLILCGFLYSLHTADQWKALSGRPAEVEKMKQEVLPVLPAPQKESAEQEGFADILSQKRQRHFRRGPPHLQIRPPNTVSKDGMQDDAKEREAALGKAQQEENTQRTVISWRGAVIEPEQATELPYKRAEASIKPLVLASKIWKEPAPPNERQKGVIEAFLHAWKGYQKFAWGHDELKPVSKTFSEWFGLGLTLIDALDTMWILGLKQEFKQARKWVSENLDFQKNVDVNLFESTIRILGGLLSTYHLSGDSLFLTKAEDFGKRLMPAFTTPSKIPYSDVNIGTGFAHSPQWTSDSTVAEVTSIQLEFRELSRLTGIKKFQEAVEEVTKHIHSLSGKKDGLVPMFINTNSGLFTHPGVFTLGARADSYYEYLLKQWIQGGKKETQLLEDYVKAIEGIKAHLLRQSQPRKLTFVGELAHGRFSAKMDHLVCFLPGTLALGVHHGLPADHMDLARALMETCYQMNQQMETGLSPEIAHFNMYPRADHKDVEVKPADRHNLLRPETVESLFYLYRVTRDRKYQDWGWEILQSFNKYTRVPSGGYSSINNVQNSHKPEPRDKMESFFVGETLKYLYLLFSDDLELLSLDSCVFNTEAHPLPIWAPA" } }, { "url": "https://www.uniprot.org/uniprot/A2AJ15#A2AJ14-1", "isoform_ac": "A2AJ14-1", "locus": { "end_pos": 25332415, "start_pos": 25343279, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000136245", "id": "ENSMUST00000136245", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000114989", "id": "ENSMUSP00000114989", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2AJ14-1|MA1B1_MOUSE Computationally mapped isoform of Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase OS=Mus musculus OX=10090 GN=Man1b1 PE=1 SV=1 CANONICAL=A2AJ15-1", "length": 238, "sequence": "MPAPRDRAQDSGKGDSPQLKPDVTATKNTSPNRSQSAPNRESAGRLQWSGCARFSDKWKQLSRLQRNVILFVLGFLILCGFLYSLHTADQWKALSGRPAEVEKMKQEVLPVLPAPQKESAEQEGFADILSQKRQRHFRRGPPHLQIRPPNTVSKDGMQDDAKEREAALGKAQQEENTQRTVISWRGAVIEPEQATELPYKRAEASIKPLVLASKIWKEPAPPNERQKGVIEAFLHAWK" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:227619", "resource": "KEGG Pathway", "id": "mmu:227619", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2AJ15#function", "annotation": "Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2) (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ15#function", "id": "A2AJ15", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "B2GUY0-1", "protein_name": "Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; 3.2.1.113; ER mannosidase 1; ERMan1; Mannosidase alpha class 1B member 1; ER alpha-1,2-mannosidase.", "sequence": { "length": 657, "sequence": "MYPPPPAPAPHRDFISVTLSLGESYDNSKSRRRRSCWRKWKQLSRLQRNVILFVLGFLILCGFLYSLQVSDQWKALSGSRAEVEKMKLEVLPVLPAPQKESAEPEGFADILSQKRQRHLRRGPPHLQIRPPNTVSKDGMQDDAKEREAALGKAQQEENTQRTVISWRGAVIEPEQATEPPSKRAEASIKPLFLASRIWKEPAPPNERQKGVIEAFLHAWKGYQKFAWGHDELKPVSKTFSEWFGLGLTLIDALDTMWILGLKQEFKEARKWVSENLDFQKNVDVNLFESTIRILGGLLSAYHLSGDSLFLSKAEDFGNRLMPAFTTPSKIPYSDVNIGTGFAHSPQWTSDSTVAEVTSIQLEFRELSRLTGIKKFQEAVEEVTKHIHSLSGKKDGLVPMFINTNSGLFTHPGVFTLGARADSYYEYLLKQWIQGGKKETQLLEDYVRAIEGIKAHLLRQSQPRKLTFVGELAHGRFSAKMDHLVCFLPGTLALGVHHGLPADHMDLARALMETCYQMNQQMETGLSPEIAHFNMYPRADHKDVEVKPADRHNLLRPETVESLFYLYRVTKDRKYQDWGWEILQSFNKYTRVPSGGYSSINNVQNSHKPEPRDKMESFFVGETLKYLYLLFSDDLELLGLDTCVFNTEAHPLPIWSPA" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2AJ15/", "id": "A2AJ15", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/5230", "id": "5230", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q9UKM7-1", "protein_name": "Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; 3.2.1.113; ER mannosidase 1; ERMan1; Mannosidase alpha class 1B member 1; ER alpha-1,2-mannosidase; Man9GlcNAc2-specific-processing alpha-mannosidase.", "sequence": { "length": 699, "sequence": "MAACEGRRSGALGSSQSDFLTPPVGGAPWAVATTVVMYPPPPPPPHRDFISVTLSFGENYDNSKSWRRRSCWRKWKQLSRLQRNMILFLLAFLLFCGLLFYINLADHWKALAFRLEEEQKMRPEIAGLKPANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDGTQEEATKRQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPARTQGTPVHLNYRQKGVIDVFLHAWKGYRKFAWGHDELKPVSRSFSEWFGLGLTLIDALDTMWILGLRKEFEEARKWVSKKLHFEKDVDVNLFESTIRILGGLLSAYHLSGDSLFLRKAEDFGNRLMPAFRTPSKIPYSDVNIGTGVAHPPRWTSDSTVAEVTSIQLEFRELSRLTGDKKFQEAVEKVTQHIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGGKQETQLLEDYVEAIEGVRTHLLRHSEPSKLTFVGELAHGRFSAKMDHLVCFLPGTLALGVYHGLPASHMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGRRDVEVKPADRHNLLRPETVESLFYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSINNVQDPQKPEPRDKMESFFLGETLKYLFLLFSDDPNLLSLDAYVFNTEAHPLPIWTPA" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2AJ15/", "id": "A2AJ15", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/5230", "id": "5230", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025154.1", "ac": "NP_001025154.1", "name": "endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; ER mannosidase 1; ER alpha-1,2-mannosidase; man9GlcNAc2-specific-processing alpha-mannosidase.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004571", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ15", "id": "A2AJ15", "database": "UniProtKB" } ], "name": "mannosyl-oligosaccharide 1,2-alpha-mannosidase activity", "id": "GO:0004571" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ15", "id": "A2AJ15", "database": "UniProtKB" } ], "name": "calcium ion binding", "id": "GO:0005509" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ15", "id": "A2AJ15", "database": "UniProtKB" } ], "name": "endoplasmic reticulum", "id": "GO:0005783" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ15", "id": "A2AJ15", "database": "UniProtKB" } ], "name": "membrane", "id": "GO:0016020" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ15", "id": "A2AJ15", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ15", "id": "A2AJ15", "database": "UniProtKB" } ], "name": "endoplasmic reticulum membrane", "id": "GO:0005789" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044322", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ15", "id": "A2AJ15", "database": "UniProtKB" } ], "name": "endoplasmic reticulum quality control compartment", "id": "GO:0044322" } ], "total": 5, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030433", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ15", "id": "A2AJ15", "database": "UniProtKB" } ], "name": "ubiquitin-dependent ERAD pathway", "id": "GO:0030433" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006491", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ15", "id": "A2AJ15", "database": "UniProtKB" } ], "name": "N-glycan processing", "id": "GO:0006491" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006486", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ15", "id": "A2AJ15", "database": "UniProtKB" } ], "name": "protein glycosylation", "id": "GO:0006486" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904380", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ15", "id": "A2AJ15", "database": "UniProtKB" } ], "name": "endoplasmic reticulum mannose trimming", "id": "GO:1904380" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036509", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ15", "id": "A2AJ15", "database": "UniProtKB" } ], "name": "trimming of terminal mannose on B branch", "id": "GO:0036509" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904382", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ15", "id": "A2AJ15", "database": "UniProtKB" } ], "name": "mannose trimming involved in glycoprotein ERAD pathway", "id": "GO:1904382" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036508", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ15", "id": "A2AJ15", "database": "UniProtKB" } ], "name": "protein alpha-1,2-demannosylation", "id": "GO:0036508" } ], "total": 7, "name": "Biological Process" } ] }, "site_annotation": [], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025154.1", "id": "NP_001025154.1", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:227619", "id": "mmu:227619", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000036646", "id": "ENSMUSG00000036646", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/AAFKHSW/", "id": "AAFKHSW", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001382", "id": "IPR001382", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036026", "id": "IPR036026", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR012341", "id": "IPR012341", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF01532", "id": "PF01532", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2AJ15", "id": "PR_A2AJ15", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/227619", "id": "227619", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:2684954", "id": "2684954", "database": "MGI" } ], "expression_disease": [], "uniprot_ac": "A2AJ15", "disease": [], "mass": { "monoisotopic_mass": 75150.0, "chemical_mass": 75150.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AJ15", "name": "Man1b1; E430019H13Rik; ERMan1; Gm108; MANA-ER.", "locus": { "end_pos": 25352212, "start_pos": 25332338, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000036646", "id": "ENSMUSG00000036646", "database": "Ensembl Gene" } ] } } ] }