{ "uniprot_canonical_ac": "A2AIV8-1", "sequence": { "header": "sp|A2AIV8-1|CARD9_MOUSE Isoform 1 of Caspase recruitment domain-containing protein 9 OS=Mus musculus OX=10090 GN=Card9 PE=1 SV=1 CANONICAL=A2AIV8-1", "length": 536, "sequence": "MSDYENDDECWSTLESFRVKLISVIDPSRITPYLRQCKVLNPDDEEQVLSDPNLVIRKRKVGVLLDILQRTGHKGYVAFLESLELYYPQLYRKVTGKEPARVFSMIIDASGESGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECELSSAELKRCKDENYELAMCLAHLSEEKGAALMRNRDLQLEVDRLRHSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWELQQEKDLLQARVQELQVSVQEGKLDRNSPYIQVLEEDWRQALQEHQKQVSTIFSLRKDLRQAETLRARCTEEKEMFELQCLALRKDAKMYKDRIEAILLQMEEVSIERDQAMASREELHAQCTQSFQDKDKLRKLVRELGEKADELQLQLFQTESRLLAAEGRLKQQQLDMLILSSDLEDSSPRNSQELSLPQDLEEDAQLSDKGVLADRESPEQPFMALNKEHLSLTHGMGPSSSEPPEKERRRLKESFENYRRKRALRKMQNSWRQGEGDRGNTTGSDNTDTEGS" }, "uniprot_id": "CARD9_MOUSE", "enzyme_annotation": [], "synonyms": { "protein": { "refseq": [ "caspase recruitment domain-containing protein 9" ], "uniprotkb": [ "Caspase recruitment domain-containing protein 9" ] }, "gene": { "refseq": [ "Card9", "Gm782" ], "uniprotkb": [ "Card9", "Gm782" ] } }, "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "recommendedname": { "full": "Caspase recruitment domain-containing protein 9." }, "publication": [ { "title": "Deletion of hematopoietic Dectin-2 or CARD9 does not protect against atherosclerotic plaque formation in hyperlipidemic mice.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/30867470", "journal": "Scientific reports", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "id": "NP_001032836.1", "database": "RefSeq" } ], "authors": "Thiem K, Hoeke G, van den Berg S, Hijmans A, Jacobs CWM, Zhou E, Mol IM, Mouktaroudi M, Bussink J, Kanneganti TD, Lutgens E, Stienstra R, Tack CJ, Netea MG, Rensen PCN, Berbee JFP, van Diepen JA", "date": "2019", "pmid": "30867470" }, { "title": "CARD9(+) microglia promote antifungal immunity via IL-1beta- and CXCL1-mediated neutrophil recruitment.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/30996332", "journal": "Nature immunology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "id": "NP_001032836.1", "database": "RefSeq" } ], "authors": "Drummond RA, Swamydas M, Oikonomou V, Zhai B, Dambuza IM, Schaefer BC, Bohrer AC, Mayer-Barber KD, Lira SA, Iwakura Y, Filler SG, Brown GD, Hube B, Naglik JR, Hohl TM, Lionakis MS", "date": "2019", "pmid": "30996332" }, { "title": "The Adaptor Protein CARD9 Protects against Colon Cancer by Restricting Mycobiota-Mediated Expansion of Myeloid-Derived Suppressor Cells.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/30231984", "journal": "Immunity", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "id": "NP_001032836.1", "database": "RefSeq" } ], "authors": "Wang T, Fan C, Yao A, Xu X, Zheng G, You Y, Jiang C, Zhao X, Hou Y, Hung MC, Lin X", "date": "2018", "pmid": "30231984" }, { "title": "SYK-CARD9 Signaling Axis Promotes Gut Fungi-Mediated Inflammasome Activation to Restrict Colitis and Colon Cancer.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/30231985", "journal": "Immunity", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "id": "NP_001032836.1", "database": "RefSeq" } ], "authors": "Malik A, Sharma D, Malireddi RKS, Guy CS, Chang TC, Olsen SR, Neale G, Vogel P, Kanneganti TD", "date": "2018", "pmid": "30231985" }, { "title": "Subcutaneous infection with dematiaceous fungi in Card9 knockout mice reveals association of impair neutrophils and Th cell response.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/30190097", "journal": "Journal of dermatological science", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "id": "NP_001032836.1", "database": "RefSeq" } ], "authors": "Wu W, Zhang R, Wang X, Song Y, Li R", "date": "2018", "pmid": "30190097" }, { "title": "Interaction between NOD2 and CARD9 involves the NOD2 NACHT and the linker region between the NOD2 CARDs and NACHT domain.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/24960071", "journal": "FEBS Lett.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8/publications", "id": "A2AIV8", "database": "UniProtKB" } ], "authors": "Rittinger K., Boyle J.P., Mayle S., Monie T.P., Parkhouse R., Sawmynaden K.", "date": "2014", "pmid": "24960071" }, { "title": "CARD9 mediates dectin-2-induced IkappaBalpha kinase ubiquitination leading to activation of NF-kappaB in response to stimulation by the hyphal form of Candida albicans.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/20538615", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8/publications", "id": "A2AIV8", "database": "UniProtKB" } ], "authors": "Wu W., Zhu J., Lin X., Ariizumi K., Bi L., Hsu Y.M., Gojestani S.", "date": "2010", "pmid": "20538615" }, { "title": "Multiple ITAM-coupled NK-cell receptors engage the Bcl10/Malt1 complex via Carma1 for NF-kappaB and MAPK activation to selectively control cytokine production.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/18192506", "journal": "Blood", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "id": "NP_001032836.1", "database": "RefSeq" } ], "authors": "Gross O, Grupp C, Steinberg C, Zimmermann S, Strasser D, Hannesschlager N, Reindl W, Jonsson H, Huo H, Littman DR, Peschel C, Yokoyama WM, Krug A, Ruland J", "date": "2008", "pmid": "18192506" }, { "title": "The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17486093", "journal": "Nature immunology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "id": "NP_001032836.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2AIV8/publications", "id": "A2AIV8", "database": "UniProtKB" } ], "authors": "Hara H, Ishihara C, Takeuchi A, Imanishi T, Xue L, Morris SW, Inui M, Takai T, Shibuya A, Saijo S, Iwakura Y, Ohno N, Koseki H, Yoshida H, Penninger JM, Saito T", "date": "2007", "pmid": "17486093" }, { "title": "All roads lead to CARD9.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17514206", "journal": "Nat. Immunol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8/publications", "id": "A2AIV8", "database": "UniProtKB" } ], "authors": "Colonna M.", "date": "2007", "pmid": "17514206" }, { "title": "Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17450144", "journal": "Nature immunology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "id": "NP_001032836.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2AIV8/publications", "id": "A2AIV8", "database": "UniProtKB" } ], "authors": "LeibundGut-Landmann S, Gross O, Robinson MJ, Osorio F, Slack EC, Tsoni SV, Schweighoffer E, Tybulewicz V, Brown GD, Ruland J, Reis e Sousa C", "date": "2007", "pmid": "17450144" }, { "title": "The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/17187069", "journal": "Nature immunology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "id": "NP_001032836.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2AIV8/publications", "id": "A2AIV8", "database": "UniProtKB" } ], "authors": "Hsu YM, Zhang Y, You Y, Wang D, Li H, Duramad O, Qin XF, Dong C, Lin X", "date": "2007", "pmid": "17187069" }, { "title": "Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/16862125", "journal": "Nature", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "id": "NP_001032836.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2AIV8/publications", "id": "A2AIV8", "database": "UniProtKB" } ], "authors": "Gross O, Gewies A, Finger K, Schafer M, Sparwasser T, Peschel C, Forster I, Ruland J", "date": "2006", "pmid": "16862125" } ], "glycosylation": [], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8#A2AIV8-1", "isoform_ac": "A2AIV8-1", "locus": { "end_pos": 26352315, "start_pos": 26359547, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000100303", "id": "ENSMUST00000100303", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000097876", "id": "ENSMUSP00000097876", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AIV8-1|CARD9_MOUSE Isoform 1 of Caspase recruitment domain-containing protein 9 OS=Mus musculus OX=10090 GN=Card9 PE=1 SV=1 CANONICAL=A2AIV8-1", "length": 536, "sequence": "MSDYENDDECWSTLESFRVKLISVIDPSRITPYLRQCKVLNPDDEEQVLSDPNLVIRKRKVGVLLDILQRTGHKGYVAFLESLELYYPQLYRKVTGKEPARVFSMIIDASGESGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECELSSAELKRCKDENYELAMCLAHLSEEKGAALMRNRDLQLEVDRLRHSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWELQQEKDLLQARVQELQVSVQEGKLDRNSPYIQVLEEDWRQALQEHQKQVSTIFSLRKDLRQAETLRARCTEEKEMFELQCLALRKDAKMYKDRIEAILLQMEEVSIERDQAMASREELHAQCTQSFQDKDKLRKLVRELGEKADELQLQLFQTESRLLAAEGRLKQQQLDMLILSSDLEDSSPRNSQELSLPQDLEEDAQLSDKGVLADRESPEQPFMALNKEHLSLTHGMGPSSSEPPEKERRRLKESFENYRRKRALRKMQNSWRQGEGDRGNTTGSDNTDTEGS" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:332579", "resource": "KEGG Pathway", "id": "mmu:332579", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5607764", "resource": "Reactome", "id": "R-MMU-5607764", "name": "CLEC7A (Dectin-1) signaling" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8#function", "annotation": "Adapter protein that plays a key role in innate immune response to a number of intracellular pathogens, such as C.albicans and L.monocytogenes. Is at the crossroads of ITAM-tyrosine kinase and the Toll-like receptors (TLR) and NOD2 signaling pathways (PubMed:17514206). Probably controls various innate immune response pathways depending on the intracellular pathogen. Controls CLEC7A (dectin-1)-mediated myeloid cell activation induced by the yeast cell wall component zymosan, leading to cytokine production and innate anti-fungal immunity: acts by regulating BCL10-MALT1-mediated NF-kappa-B activation pathway. Activates NF-kappa-B via BCL10 (PubMed:16862125). In response to the hyphal form of C.albicans, mediates CLEC6A (dectin-2)-induced I-kappa-B kinase ubiquitination, leading to NF-kappa-B activation via interaction with BCL10 (PubMed:20538615). In response to L.monocytogenes infection, acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B (PubMed:17187069). In response to fungal infection, may be required for the development and subsequent differentiation of interleukin 17-producing T helper (TH-17) cells (PubMed:17450144). Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B (PubMed:17486093).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8#function", "id": "A2AIV8", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "annotation": "Data suggest that microglia relied on caspase recruitment domain-containing protein 9 (CARD9) for production of interleukin-1beta (IL-1beta), inflammasome activation and of chemokine CXCL1 (CXCL1) in the fungus-infected central nervous system (CNS).", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "id": "NP_001032836.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "annotation": "Letter: Card9 deficiency could increase susceptibility to a variety of different dematiaceous fungi. The increased susceptibility correlated with lesser influx of PMNs and impaired specific Th1 and Th17-cell response in Card9 KO mice.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "id": "NP_001032836.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "annotation": "This study shows that SYK-CARD9 signaling promotes gut Fungi-mediated inflammasome activation to restrict colitis and colon cancer", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "id": "NP_001032836.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "annotation": "This study shows that the adaptor protein CARD9 protects against colon cancer by restricting mycobiota-mediated expansion of myeloid-derived suppressor cells", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "id": "NP_001032836.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "annotation": "Activation of lymphoid and myeloid cells through Immunoreceptor tyrosine-based activation motifs-associated receptors or Toll-like receptors is regulated by CARMA1-Bcl-10 and CARD9-Bcl-10, respectively", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "id": "NP_001032836.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "annotation": "Signaling through Syk and CARD9 can couple innate to adaptive immunity independently of Toll-like receptor signals", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "id": "NP_001032836.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "annotation": "CARD9 has a critical function in Nod2-mediated activation of p38 and Jnk in innate immune responses to intracellular pathogens", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "id": "NP_001032836.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "annotation": "Card9 is a key transducer of Dectin-1 signalling, where Dectin-1 is the major mammalian pattern recognition receptor for the fungal component zymosan, in antifungal immunity", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "id": "NP_001032836.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q9EPY0-1", "protein_name": "Caspase recruitment domain-containing protein 9; rCARD9.", "sequence": { "length": 536, "sequence": "MSDYENDDECWSALESFRVKLISVIDPSRITPYLRQCKVLNPDDEEQVLSDPNLVIRKRKVGVLLDILQRTGHKGYVAFLESLELYYPQLYRKVTGKEPARVFSMIIDASGESGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECELSSAELKRCKDENYDLAMRLAHLSEEKGAALMRNRDLQLEVDQLRHSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWDLQQERDLLQARVQELEVSVQEGKLHRNSPYIQVLEEDWRQALQEHQEQASTIFSLRKDLRQAEALRTRCMEEKEMFELQCLALRKDAKMYKDRIEAILQQMEEVSIERDQAMTSREELHAQCAQSFQDKDKLRKQVRELDEKADELQLQLFQTESRLLAAEGRLKQQQLDMLILSSDLEDSSPRNSQELSLPQDLEEDAQLSDKGVLADRESPEQPFVVLNKKHLSQTHDTVPSSSEPPEKERRRLKESFENYRRKRALRKMQNSWRQGEGDHGNTTGSDNTDTEGS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/14150", "id": "14150", "database": "MGI" } ], "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q9H257-1", "protein_name": "Caspase recruitment domain-containing protein 9; hCARD9.", "sequence": { "length": 536, "sequence": "MSDYENDDECWSVLEGFRVTLTSVIDPSRITPYLRQCKVLNPDDEEQVLSDPNLVIRKRKVGVLLDILQRTGHKGYVAFLESLELYYPQLYKKVTGKEPARVFSMIIDASGESGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHDAGLSSGEPPEKERRRLKESFENYRRKRALRKMQKGWRQGEEDRENTTGSDNTDTEGS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/14150", "id": "14150", "database": "MGI" } ], "organism": "Homo sapiens", "tax_id": 9606 } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "ac": "NP_001032836.1", "name": "caspase recruitment domain-containing protein 9.", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "protein domain specific binding", "id": "GO:0019904" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "protein homodimerization activity", "id": "GO:0042803" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050700", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "CARD domain binding", "id": "GO:0050700" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "protein-containing complex", "id": "GO:0032991" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042493", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "response to drug", "id": "GO:0042493" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046330", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "positive regulation of JNK cascade", "id": "GO:0046330" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050830", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "defense response to Gram-positive bacterium", "id": "GO:0050830" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051607", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "defense response to virus", "id": "GO:0051607" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032755", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "positive regulation of interleukin-6 production", "id": "GO:0032755" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043123", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "positive regulation of I-kappaB kinase/NF-kappaB signaling", "id": "GO:0043123" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032760", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "positive regulation of tumor necrosis factor production", "id": "GO:0032760" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043330", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "response to exogenous dsRNA", "id": "GO:0043330" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009620", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "response to fungus", "id": "GO:0009620" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045089", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "positive regulation of innate immune response", "id": "GO:0045089" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032494", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "response 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